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Activation of human peripheral blood lymphocytes by a trypanosome-derived mitogen.

Abstract：

:Activation of human peripheral blood lymphocytes from unsensitized donors by fractions of T.b rhodesiense has been demonstrated in vitro. Both T and B cells were stimulated to differentiate into blast cells. Purified T cells failed to proliferate, but did so when mitomycin C-treated non-T cells were added. Non-T cell proliferation (weak in comparison to the T cell response) was shown to be T-dependent. In unseparated cell cultures. cultures, IgM synthesis was enhanced, whilst IgG synthesis was unaltered. However, reconstitution of non-T cells with equal number of irradiated T cells resulted in enhanced IgG synthesis. Thus neither T nor B cells were activated directly, but required the co-operation of accessory cells to proliferate. The role of monocytes in the regulation of this response requires further assessment.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Selkirk ME,Ogilvie BM,Platts-Mills TA

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

615-20

issue

3

eissn

0009-9104

issn

1365-2249

journal_volume

45

pub_type

杂志文章

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