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Quantitation of HLA-DR expression by cells involved in the skin lesions of tuberculoid and lepromatous leprosy.

Abstract：

:A method is described which can be used to quantitate class II MHC antigens (HLA-DR) expressed by cells within tissue sections. A mouse anti-human HLA-DR monoclonal antibody is directly conjugated to the fungal enzyme glucose oxidase. The enzyme, in the presence of its substrate can be used to reduce tetrazolium salts to insoluble coloured formazans. The coloured reaction product is proportional to the amount of antigen and can be eluted from cells and measured spectrophotometrically. The application of this technique to a study of the expression of HLA-DR antigens, functionally significant molecules, by mononuclear cells in the cutaneous lesions of leprosy, is described. When a quantitative measure of the HLA-DR expression was related to the area of the granulomata, significant differences in the HLA-DR expression by cells in the infiltrates associated with lesions of tuberculoid and lepromatous leprosy were observed.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Collings LA,Tidman N,Poulter LW

subject

Has Abstract

pub_date

1985-07-01 00:00:00

pages

58-66

issue

1

eissn

0009-9104

issn

1365-2249

journal_volume

61

pub_type

杂志文章

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