Changes in serum immunoglobulin patterns in adults with common variable immunodeficiency.

abstract：:Humans immunized intramuscularly with one dose of tetanus toxoid exhibited IgG, and in some cases IgA antibody, in their bile as well as serum. Both isotypes appeared in bile transiently with titres declining after about day 10 for both classes. These kinetics resembled those of the serum IgA response but were markedl...

journal_title：Clinical and experimental immunology

authors： Hansen PG,Hennessy EJ,Blake H,Clancy RL,Kamath R,Molenaar C,Cripps AW,Jackson GD

更新日期：1989-08-01 00:00:00

abstract：:Human polymorphonuclear cells (PMN) were found to adhere to a novel model of blood vessel wall-associated IgG. The internal surfaces of cellulose acetate hollow fibres, of comparable internal diameter to small blood vessels, were coated with normal serum human IgG, heat-aggregated IgG (HAIgG), laminin or fibrinogen. U...

journal_title：Clinical and experimental immunology

authors： D'Arrigo C,Candal-Couto JJ,Greer M,Veale DJ,Woof JM

更新日期：1995-04-01 00:00:00

abstract：:Serum levels and liver expression of CCL2 are increased in patients with alcoholic hepatitis (AH). In an experimental model of alcoholic liver disease (ALD), CCL2 was implicated in proinflammatory cytokines activation and hepatic lipid metabolism, but its role in human disease is currently unknown. In a large cohort o...

journal_title：Clinical and experimental immunology

authors： Degré D,Lemmers A,Gustot T,Ouziel R,Trépo E,Demetter P,Verset L,Quertinmont E,Vercruysse V,Le Moine O,Devière J,Moreno C

更新日期：2012-09-01 00:00:00

abstract：:Seeking better immunological markers indicating the long-term outcome of cystic echinococcosis (CE) after chemotherapy we studied 23 patients receiving albendazole, clinically followed for 8 years, and grouped ultrasonographically according to therapeutic outcome. Antibody responses against a partially purified fracti...

journal_title：Clinical and experimental immunology

authors： Riganò R,Ioppolo S,Ortona E,Margutti P,Profumo E,Ali MD,Di Vico B,Teggi A,Siracusano A

更新日期：2002-09-01 00:00:00

abstract：:The ability of lymphocytes from a patient suffering from the acquired immune deficiency syndrome (AIDS) to produce interleukin-2 (IL-2) was found to be comparable to that of his healthy sex partner and to that of a normal control. Addition of exogenous IL-2 to lymphocyte cultures did not improve the poor mitogen respo...

journal_title：Clinical and experimental immunology

authors： Hauser GJ,Bino T,Rosenberg H,Zakuth V,Geller E,Spirer Z

更新日期：1984-04-01 00:00:00

abstract：:Monocyte-depleted mononuclear cells (MNC) from healthy subjects synthesized IgM-class antibody to single-stranded DNA (anti-ssDNA) at significantly higher levels than unfractionated MNC. The increased production of IgM anti-ssDNA by monocyte-depleted normal MNC was inhibited to a greater degree than total IgM by addit...

journal_title：Clinical and experimental immunology

authors： Okawa-Takatsuji M,Aotsuka S,Uwatoko S,Kinoshita M,Yokohari R

更新日期：1989-09-01 00:00:00

abstract：:Psoriasis is a chronic, inflammatory, hyperproliferative skin disease, in which autoimmunity plays a great role. Natural killer T cells (NK T cells), are suggested to be involved in the pathogenesis of different autoimmune diseases. To examine the involvement of CD3+CD56+ NK T cells in the pathogenesis of psoriasis, w...

journal_title：Clinical and experimental immunology

authors： Koreck A,Surányi A,Szöny BJ,Farkas A,Bata-Csörgö Z,Kemény L,Dobozy A

更新日期：2002-01-01 00:00:00

abstract：:We recently developed an animal model in order to study the pulmonary and systemic reactions following exposure to environmental pollutants. In this model, conscious sheep received repeated intratracheal instillations of a suspension of 0 (controls), 2mg (low dose) or 128 mg (high dose) of chrysotile asbestos fibres o...

journal_title：Clinical and experimental immunology

authors： Rola-Pleszczynski M,Lemaire I,Sirois P,Massé S,Bégin R

更新日期：1982-08-01 00:00:00

abstract：:This report is focused on the functional capacity of Langerhans cells (LC) in the epithelium of skin and oral mucosa, which both meet different antigenic challenges. The capacity of LC from human oral and skin epithelium to provide co-stimulatory signals to T cells in vitro was compared. LC in a crude suspension of or...

journal_title：Clinical and experimental immunology

authors： Hasséus B,Jontell M,Bergenholtz G,Dahlgren UI

更新日期：2004-06-01 00:00:00

abstract：:Many cellular stresses and inflammatory stimuli can activate p38 mitogen-activated protein kinase (MAPK), a serine/threonine kinase in the MAPK family. The different stimuli act via different receptors or signalling pathways to induce phosphorylation of the cytosolic protein p47(phox), one subunit of the nicotinamide ...

journal_title：Clinical and experimental immunology

authors： Lu HW,He GN,Ma H,Wang JK

更新日期：2010-06-01 00:00:00

abstract：:2-Chlorodeoxyadenosine (cladribine, CdA) is an immunosuppressive drug that is licensed to treat hairy cell leukaemia, and has been shown recently to have beneficial effects in patients with multiple sclerosis (MS). The therapeutic effects of CdA have been suggested to be mediated partly through its potent toxicity tow...

journal_title：Clinical and experimental immunology

authors： Singh V,Prajeeth CK,Gudi V,Bénardais K,Voss EV,Stangel M

更新日期：2013-08-01 00:00:00

abstract：:The hydrodynamic (gel filtration and sedimentation) properties of an isolated monoclonal IgM-K cryoglobulin (McE.) and five non-cryoglobulin cold-soluble proteins, as well as their constituent monomeric subunits and (Fc)5mu and Fabmu fragments, are compared under both native and partially denaturing conditions. It is ...

journal_title：Clinical and experimental immunology

authors： Middaugh CR,Oshman RG,Litman GW

更新日期：1978-01-01 00:00:00

abstract：:Chronic bone infection is associated with bone resorption. From animal studies, CD3/CD28-activated T cells are known to enhance osteoclastogenesis and bone resorption. Because CD28 is expressed constitutively on T cells and its expression is down-regulated by chronic exposure to the inflammatory environment, we charac...

journal_title：Clinical and experimental immunology

authors： Kumar G,Roger PM,Ticchioni M,Trojani C,Bernard de Dompsur R,Bronsard N,Carles M,Bernard E

更新日期：2014-04-01 00:00:00

abstract：:Breakpoint cluster region-Abelson murine leukaemia viral oncogene homologue 1 (BCR-ABL1), encoded by the Philadelphia (Ph) chromosome, is the characteristic of chronic myeloid leukaemia (CML) and a subset of acute lymphoblastic leukaemia (ALL). We demonstrated that expression of the Ik6 transcript, which lacked exons ...

journal_title：Clinical and experimental immunology

authors： Dong Y,Liu F,Wu C,Li S,Zhao X,Zhang P,Jiao J,Yu X,Ji Y,Zhang M

更新日期：2016-09-01 00:00:00

abstract：:Serum cytokine levels and peripheral T cell subpopulations of HIV-1-infected patients before, during and after active visceral leishmaniasis (VL) were analysed and compared with appropriate controls. At VL diagnosis, co-infected patients showed higher serum levels of interferon-gamma (IFN-gamma) than matched HIV-1 con...

journal_title：Clinical and experimental immunology

authors： Medrano FJ,Rey C,Leal M,Cañavate C,Rubio A,Sánchez-Quijano A,Alvar J,Lissen E

更新日期：1998-12-01 00:00:00

abstract：:Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas exp...

journal_title：Clinical and experimental immunology

authors： Das G,Vohra H,Saha B,Agrewala JN,Mishra GC

更新日期：1999-02-01 00:00:00

abstract：:Tuberculosis (TB) is usually more severe in HIV-infected patients, and the immune derangement found in co-infected patients may differ from that in each isolated disease. Following mitogen stimulation of peripheral blood mononuclear cells (PBMC), interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha production...

journal_title：Clinical and experimental immunology

authors： de Castro Cunha RM,Kallas EG,Rodrigues DS,Nascimento Burattini M,Salomao R

更新日期：2005-06-01 00:00:00

abstract：:Human mononuclear leucocytes (MNL) or the adherent fraction (monocytes) produced tumour necrosis factor-alpha (TNF-alpha) (by ELISA) in culture when stimulated with killed Staphylococcus aureus. The bisbenzylisoquinoline alkaloid, tetrandrine inhibited the capacity of MNL and monocytes to produce TNF-alpha at a concen...

journal_title：Clinical and experimental immunology

authors： Ferrante A,Seow WK,Rowan-Kelly B,Thong YH

更新日期：1990-05-01 00:00:00

abstract：:After 3-4 weeks culture of human bone marrow cells in medium supplemented with IL-3, macrophage- (M-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF), the firmly adherent cells exhibited the morphologic features of mononuclear phagocytes and were strongly esterase-positive. Flow cytometric analysis r...

journal_title：Clinical and experimental immunology

authors： Keller R,Keist R,Joller P,Groscurth P

更新日期：1993-01-01 00:00:00

abstract：:Serum samples from 64 apparently healthy individuals (32 men and 32 women, mean age 81.0 years) were examined for the prevalence of several autoantibodies, including rheumatoid factor (RF), antinuclear antibodies (ANA), antibodies to extracted cellular antigens Ro (SSA), La (SSB), Sm, U1nRNP and Scl-70. IgG and IgM is...

journal_title：Clinical and experimental immunology

authors： Manoussakis MN,Tzioufas AG,Silis MP,Pange PJ,Goudevenos J,Moutsopoulos HM

更新日期：1987-09-01 00:00:00

abstract：:The prolonged generalized lymphadenopathy syndrome (PGL) has been considered a prodromal condition to the Acquired immunodeficiency syndrome (AIDS), but the clinical, virological and immunological characteristics of patients who will develop AIDS are not known. We report on the immunological profile of intravenous dru...

journal_title：Clinical and experimental immunology

authors： De Paoli P,Reitano M,Battistin S,Martelli P,Villalata D,Bergamo F,Tirelli U,Carbone A,Diodato S,Bosio R

更新日期：1986-06-01 00:00:00

abstract：:Asthma is a chronic inflammatory disease affecting the airways. Increased levels of T cells are found in the lungs after the induction of an allergic-like inflammation in rats, and flow cytometry studies have shown that these levels are reduced in CD26-deficient rats. However, the precise anatomical sites where these ...

journal_title：Clinical and experimental immunology

authors： Schade J,Schmiedl A,Kehlen A,Veres TZ,Stephan M,Pabst R,von Hörsten S

更新日期：2009-10-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an idiopathic systemic autoimmune disease. It is characterized by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction in SSc is characterized by the activation and recruitment of immune cells and the production of autoantibodies and cytokines. How immune ...

journal_title：Clinical and experimental immunology

authors： Brown M,O'Reilly S

更新日期：2019-03-01 00:00:00

abstract：:Tuberculosis is a worldwide health problem, and multidrug-resistant (MDR) and extensively multidrug-resistant (XMDR) strains are rapidly emerging and threatening the control of this disease. These problems motivate the search for new treatment strategies. One potential strategy is immunotherapy using cationic anti-mic...

journal_title：Clinical and experimental immunology

authors： Rivas-Santiago CE,Rivas-Santiago B,León DA,Castañeda-Delgado J,Hernández Pando R

更新日期：2011-04-01 00:00:00

abstract：:Features of tissue damage in invasive amoebiasis, in particular polymorphonuclear neutrophil (PMN) degranulation and vasculitis, bear resemblance to that seen in Wegener's granulomatosis, the latter being associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA). We therefore tested sera from patie...

journal_title：Clinical and experimental immunology

authors： Pudifin DJ,Duursma J,Gathiram V,Jackson TF

更新日期：1994-07-01 00:00:00

abstract：:Clinically, corticosteroids (CS) are among the first line drugs in the therapy of autoimmune and allergic diseases and potently inhibit the activation of immune cells. However, due to their pleiotropic mode of action, the prolonged use of CS is generally associated with a range of undesirable side-effects. In this stu...

journal_title：Clinical and experimental immunology

authors： Kalthoff FS,Chung J,Musser P,Stuetz A

更新日期：2003-09-01 00:00:00

abstract：:A method enabling direct enumeration of mouse T and B cells from cytocentrifuged cell smears is described. The acid alpha-naphthyl acetate esterase (ANAE) staining was used as marker for T cells. The distribution of the ANAE marker-carrying lymphocytes closely followed the percentual distribution of T cells in spleen ...

journal_title：Clinical and experimental immunology

authors： Ranki A,Tötterman TH,Häyry P

更新日期：1976-12-01 00:00:00

abstract：:Sjögren's syndrome (SS) is a chronic autoimmune disease that mainly damages the salivary and lacrimal glands. Immune complex (IC) formation triggers local inflammation through IC deposition and decreased antigen function. Some ICs can leak from the lesion and into the saliva but no salivary ICs have been reported to d...

journal_title：Clinical and experimental immunology

authors： Yamane K,Nakamura H,Hamasaki M,Minei Y,Aibara N,Shimizu T,Kawakami A,Nakashima M,Kuroda N,Ohyama K

更新日期：2021-01-12 00:00:00

abstract：:Neutrophils have the shortest half-life among circulating leucocytes and rapidly undergo apoptosis in vitro. The homologous Bcl-2 and Bax proteins have opposing effects, with Bcl-2 extending cellular survival and Bax promoting cell death following an apoptotic stimulus. We determined Bcl-2 to Bax expression ratios in ...

journal_title：Clinical and experimental immunology

authors： Van Der Vliet HJ,Wever PC,Van Diepen FN,Yong SL,Ten Berge IJ

更新日期：1997-11-01 00:00:00

abstract：:The HLA phenotype of fifty-four patients with myasthenia gravis (MG) was compared to that of 600 controls. When male and female patients were compared separately with the control group, HLA-B12 was increased in MG males (P less than 0-023) and HLA-A1, B8 in MG females (P less than 0-023). In addition, HLA-A1, B8 was c...

journal_title：Clinical and experimental immunology

authors： Gross WL,Krüger J,Gröschel-Stewart U,Friedrich H,Kunze K

更新日期：1977-01-01 00:00:00