Quantification of Bax/Bcl-2 ratios in peripheral blood lymphocytes, monocytes and granulocytes and their relation to susceptibility to anti-Fas (anti-CD95)-induced apoptosis.

abstract：:The introduction of 25 mg of a new protein antigen into the diets of mice produced transient increases in PVP clearance which reached a maximum 60 hr after the change of diet and had disappeared by 4 days. At the same time the immune responsiveness to unrelated antigens given parenterally was also raised transiently, ...

journal_title：Clinical and experimental immunology

authors： Newby TJ,Stokes CR,Bourne FJ

更新日期：1980-02-01 00:00:00

abstract：:Factor H and the FHL-1/reconectin protein are two human plasma proteins that act as important regulators of the alternative complement pathway. Each protein is encoded by a unique transcript, but both mRNAs are derived from the factor H gene by means of alternative processing. In order to address potential functional ...

journal_title：Clinical and experimental immunology

authors： Friese MA,Hellwage J,Jokiranta TS,Meri S,Müller-Quernheim HJ,Peter HH,Eibel H,Zipfel PF

更新日期：2000-08-01 00:00:00

abstract：:A number of studies done in the last 10 years demonstrate the importance of iron in regulating the expression of T lymphoid cell surface markers, in influencing the expansion of different T cell subsets and in affecting different immune cell functions in vitro. It has been argued that some of the results obtained coul...

journal_title：Clinical and experimental immunology

authors： de Sousa M

更新日期：1989-01-01 00:00:00

abstract：:Circulating immunoglobulin (Ig)G antibodies against M(2) muscarinic acetylcholine receptors (M(2) mAChR) have been implicated in Chagas' disease (ChD) pathophysiology. These antibodies bind to and activate their target receptor, displaying agonist-like activity through an unclear mechanism. This study tested the abili...

journal_title：Clinical and experimental immunology

authors： Beltrame SP,Auger SR,Bilder CR,Waldner CI,Goin JC

更新日期：2011-05-01 00:00:00

abstract：:A technique is described which shows how to obtain a suspension of only progressively motile spermatozoa, from semen, by active penetration into an overlying buffer layer. About 60% of the number of motile spermatozoa in the original semen sample can be obtained as an output in the removed buffer layer. With this meth...

journal_title：Clinical and experimental immunology

authors： Hellema HW,Rümke P

更新日期：1978-01-01 00:00:00

abstract：:Complement C6 has a common charge polymorphism designated A and B with gene frequencies of 0.65 and 0.35. The probable molecular basis for this is a Glu (C6A) for Ala (C6B) substitution at amino acid position 98, and is detected by digestion with the restriction enzyme Dde I of a polymerase chain reaction (PCR)-amplif...

journal_title：Clinical and experimental immunology

authors： Fernie BA,Hobart MJ,Delbridge G,Potter PC,Orren A,Lachmann PJ

更新日期：1994-02-01 00:00:00

abstract：:IFN-gamma is known to be a major inhibitor of IgE synthesis in vitro. Recent studies demonstrating reduced production of IFN-gamma in children and adults with atopic dermatitis and elevated serum IgE suggest a similar role for this cytokine in vivo. The reasons for this reduced IFN-gamma production are not known. One ...

journal_title：Clinical and experimental immunology

authors： Tang M,Kemp A

更新日期：1994-01-01 00:00:00

abstract：:Complement receptor type 1 (CR1) is an integral membrane protein of many haematopoietic cells and plays an important role in the clearance of complement-associated immune complexes, favouring their transport to liver and spleen macrophages. A small amount of soluble CR1 (sCR1) is also found in plasma and might origina...

journal_title：Clinical and experimental immunology

authors： Di Bona D,Montalto G,Clemenza L,Bascone F,Accardo P,Bellavia D,Craxì A,Brai M

更新日期：1998-10-01 00:00:00

abstract：:Donor-specific CTL present within the cardiac allograft during a rejection episode are distinct from those that populate the cardiac allograft in the absence of rejection. Whereas the former generally have a high avidity for donor cells, the latter mainly have a low avidity for donor cells. This observation made us re...

journal_title：Clinical and experimental immunology

authors： Van Emmerik NE,Daane CR,Knoop CJ,Hesse C,Vaessen LM,Balk AH,Mochtar B,Claas FH,Weimar W

更新日期：1997-12-01 00:00:00

abstract：:Malignant rabbit fibroma virus (MV) directly suppresses generation of antibody responses and mitogen induced T and B lymphocyte proliferation. We investigated whether this phenomenon required expression of the complete viral genome. Phosphonoacetic acid (PAA) inhibits poxvirus specific DNA polymerases. Adding PAA to c...

journal_title：Clinical and experimental immunology

authors： Strayer DS,Skaletsky E,Leibowitz JL

更新日期：1986-10-01 00:00:00

abstract：:Patients with acquired hypogammaglobulinaemia usually have near normal numbers of B cells and normal T cell function. When hypogammaglobulinaemia occurs in association with thymoma, then B cell numbers have been reported as low, and distinctive T cells are present which inhibit immunoglobulin production by normal cell...

journal_title：Clinical and experimental immunology

authors： Brenner MK,Reittie JG,Chadda HR,Pollock A,Asherson GL

更新日期：1984-12-01 00:00:00

abstract：:Aspergillus fumigatus, a ubiquitous fungus, is implicated in the pathogenesis of a number of clinically different allergic diseases in man, including allergic bronchopulmonary aspergillosis. Peptide-based immunotherapy may offer an alternative treatment strategy for the management of allergic disease. The objective of...

journal_title：Clinical and experimental immunology

authors： Svirshchevskaya EV,Alekseeva L,Marchenko A,Viskova N,Andronova TM,Benevolenskii SV,Kurup VP

更新日期：2002-02-01 00:00:00

abstract：:A solid-phase platelet membrane enzyme linked immunosorbent assay (ELISA) was developed for the detection of circulating platelet binding IgG in serum. 18 out of 28 (64%) sera from patients with chronic idiopathic thrombocytopenic purpura (ITP) and 10 out of 21 (48%) sera from patients with acute ITP contained more pl...

journal_title：Clinical and experimental immunology

authors： Winiarski J,Ekelund E

更新日期：1986-02-01 00:00:00

abstract：:The number of NK T cells was measured in relation to the Th1/Th2 imbalance observed in RA. Peripheral blood samples of patients with RA (n = 60) and healthy controls (n = 36) were stained with anti-NK receptor 1A (anti-NKR-P1A), anti-CD56, and anti-CD3 MoAbs, and examined by three-colour flow cytometry. NK T (NKR-P1A+...

journal_title：Clinical and experimental immunology

authors： Yanagihara Y,Shiozawa K,Takai M,Kyogoku M,Shiozawa S

更新日期：1999-10-01 00:00:00

abstract：:A retrospective chart review was conducted at a single centre, capturing data on 173 primary immunodeficiency disease (PIDD) patients, including 40 obese patients, using subcutaneous administration of immunoglobulin (Ig) (SCIG) (16 or 20%) delivered by infusion pump or subcutaneous (s.c.) rapid push. Patients previous...

journal_title：Clinical and experimental immunology

authors： Shapiro R

更新日期：2013-08-01 00:00:00

abstract：:Thymic biopsies taken under general anaesthetic prior to partial thyroidectomy for non-toxic nodular goitre were studied with histometric techniques: evidence is presented that the tissue studied is representative of the normal adult human thymus. The pattern of age involution of the normal adult thymus is described: ...

journal_title：Clinical and experimental immunology

authors： Simpson JG,Gray ES,Beck JS

更新日期：1975-02-01 00:00:00

abstract：:Current therapies for inflammatory bowel diseases (IBD) are aimed at controlling the exacerbated response in the gut, but no treatment is fully effective for many refractory patients. Mesenchymal stromal cells (MSC) are multi-potent cells with regulatory immunosuppressive activity that may control inflammatory disease...

journal_title：Clinical and experimental immunology

authors： Alves VBF,de Sousa BC,Fonseca MTC,Ogata H,Caliári-Oliveira C,Yaochite JNU,Rodrigues Júnior V,Chica JEL,da Silva JS,Malmegrim KCR,Pernomian L,Cardoso CR

更新日期：2019-05-01 00:00:00

abstract：:Autoantigens in canine autoimmune haemolytic anaemia (AIHA) were identified by immunoprecipitation using autoantibody eluted from the erythrocytes of affected dogs. At least three patterns of precipitated antigen were identified in six cases of AIHA. The most commonly precipitated antigen pattern was a combination of ...

journal_title：Clinical and experimental immunology

authors： Barker RN,Gruffydd-Jones TJ,Stokes CR,Elson CJ

更新日期：1991-07-01 00:00:00

abstract：:Lipoarabinomannan (LAM), purified from the cell walls of Mycobacterium leprae and M. tuberculosis, is a potent inhibitor of interferon-gamma (IFN-gamma) mediated activation of macrophages. The capability of LAM to inhibit IFN-gamma activation of macrophages in vitro was dose dependent and required a 24-h pre-exposure....

journal_title：Clinical and experimental immunology

authors： Sibley LD,Adams LB,Krahenbuhl JL

更新日期：1990-04-01 00:00:00

abstract：:There is currently scarce knowledge of the immunological profile of patients with latent autoimmune diabetes mellitus in the adult (LADA) when compared with healthy controls (HC) and patients with classical type 1 diabetes (T1D) and type 2 diabetes (T2D). The objective of this study was to investigate the cellular imm...

journal_title：Clinical and experimental immunology

authors： Singh K,Martinell M,Luo Z,Espes D,Stålhammar J,Sandler S,Carlsson PO

更新日期：2019-07-01 00:00:00

abstract：:The supernatants of hybrids produced by fusion of splenocytes from normal, germ free, nude and neonatal BALB/c mice with mouse NS-1 myeloma cells were examined for immunofluorescence reactivity with viable and acetone fixed monolayers of syngeneic mouse fibroblasts and mouse 3T3 cells and with viable cell suspensions ...

journal_title：Clinical and experimental immunology

authors： Underwood JR,Pedersen JS,Chalmers PJ,Toh BH

更新日期：1985-05-01 00:00:00

abstract：:Antibody-dependent cellular cytotoxicity (ADCC) was investigated as s possible mechanism of pathogenesis in recurrent aphthous ulceration (RAU). ADCC induced by mononuclear cells from patients at various stages of RAU was compared with ADCC induced by mononuclear cells from paired controls. Chicken red blood cells (Ch...

journal_title：Clinical and experimental immunology

authors： Greenspan JS,Gadol N,Olson JA,Talal N

更新日期：1981-06-01 00:00:00

abstract：:Circulating immune complexes (CIC) have been postulated to contribute to the development of secondary complications in diabetes mellitus. In this study, CIC were measured in control rats and both insulin deficient and insulin treated streptozotocin-induced diabetic rats. CIC were more prevalent in both groups of diabe...

journal_title：Clinical and experimental immunology

authors： Abrass CK

更新日期：1984-07-01 00:00:00

abstract：:CD44 is an adhesion molecule involved in a wide range of cell-cell and cell-matrix interactions. The standard form of CD44 (CD44S) is a 85-90-kD glycoprotein, but alternative splicing of RNA encoding 10 variable exons (V1-V10) can give rise to many different CD44 variant protein isoforms of higher molecular weight. CD...

journal_title：Clinical and experimental immunology

authors： Takazoe K,Foti R,Tesch GH,Hurst LA,Lan HY,Atkins RC,Nikolic-Paterson DJ

更新日期：2000-09-01 00:00:00

abstract：:The sera of patients with histologically proven carcinomata of the gastrointestinal tract were fractionated by gel filtration and the fractions assayed for the presence of free carcinoembryonic antigen (CEA) binding immunoglobulins and CEA immune complexes by radioimmuno-double-diffusion, using 125I-CEA as a marker. I...

journal_title：Clinical and experimental immunology

authors： Kapsopoulou-Dominos K,Anderer FA

更新日期：1979-02-01 00:00:00

abstract：:Soluble histocompatibility antigens of the class II region have been detected in synovial fluids obtained from patients with rheumatoid arthritis. A capture immunoassay involving two monoclonal antibodies was used; interference by rheumatoid factor, which is a feature of such assays, was overcome by mild pretreatment ...

journal_title：Clinical and experimental immunology

authors： Stevenson FK,Douglass WA,Spellerberg MB,Walters MT,Cawley MI

更新日期：1990-04-01 00:00:00

abstract：:Mucous membrane pemphigoid (MMP) (also known as cicatricial pemphigoid) is a rare autoimmune mucocutaneous blistering disease that affects mucous membranes derived from stratified squamous epithelium and the skin. A subset of MMP affects only the oral cavity and is referred to as the oral pemphigoid (OP). MMP and OP a...

journal_title：Clinical and experimental immunology

authors： Mignogna M,Lanza A,Rossiello L,Ruocco V,Ahmed AR

更新日期：2006-07-01 00:00:00

abstract：:Many cellular stresses and inflammatory stimuli can activate p38 mitogen-activated protein kinase (MAPK), a serine/threonine kinase in the MAPK family. The different stimuli act via different receptors or signalling pathways to induce phosphorylation of the cytosolic protein p47(phox), one subunit of the nicotinamide ...

journal_title：Clinical and experimental immunology

authors： Lu HW,He GN,Ma H,Wang JK

更新日期：2010-06-01 00:00:00

abstract：:A major goal in organ transplantation has been to safely exploit the natural processes of immune tolerance in order to minimize the dose and duration of drug immunosuppression. In this commentary, I argue that we can learn from how tumours avoid rejection, to evolve a three-stage tolerance-inducing strategy for transp...

journal_title：Clinical and experimental immunology

authors： Waldmann H

更新日期：2017-08-01 00:00:00

abstract：:Serum from patients suffering from the autoimmune skin disease pemphigus vulgaris has been used to demonstrate the presence of intercellular substance (ICS) on the surface of these chistosomula of Schistosoma mansoni which has penetrated mouse skin in vitro or during a percutaneous infection. ICS was absent from mecha...

journal_title：Clinical and experimental immunology

authors： Smith HV,Kusel JR

更新日期：1979-06-01 00:00:00