Localization of a conformational anomaly to the Fabmu region of a monoclonal IgM cryoglobulin.

abstract：:Cell transfer experiments were carried out with phytohaemagglutinin-induced normal human T lymphocyte colonies after 2--10 days of primary colony growth. The cells gave a cloning efficiency of 15% after 2 days of incubation and this decreased to 0.2% with the progressive growth of the colonies. The primary colonies ha...

journal_title：Clinical and experimental immunology

authors： Smith SD,Sachs L

更新日期：1979-08-01 00:00:00

abstract：:The effects of 2.5-40 mg/kg nandrolone decanoate (ND) on the development and growth of mononuclear cell infiltrations in the submandibular glands of NZB/W (B/W) mice have been studied using a quantitative histological method. Injections with ND for 9 months, once every 3 weeks, starting at 4 weeks of age, reduced the ...

journal_title：Clinical and experimental immunology

authors： Schot LP,Verheul HA,Schuurs AH

更新日期：1984-09-01 00:00:00

abstract：:Type 1 IFN is thought to be implicated in the autoimmune process of SLE. Plasmacytoid dendric cells (DC), which are natural IFN-alpha producing cells, play a pivotal epipathogenic role in SLE. The present study was undertaken to investigate the phenotypic characteristics of peripheral blood DC in SLE patients in compa...

journal_title：Clinical and experimental immunology

authors： Migita K,Miyashita T,Maeda Y,Kimura H,Nakamura M,Yatsuhashi H,Ishibashi H,Eguchi K

更新日期：2005-10-01 00:00:00

abstract：:The HLA haplotype A 10,B18 has been associated with hereditary deficiency of the second component of complement(C2). In an effort to detect individuals homozygous for C2 deficiency, a thorough audit of HLA serotyping results in 3,100 individuals was performed, and a single patient homozygous for the A10, B18 haplotype...

journal_title：Clinical and experimental immunology

authors： Zeitz HJ,Gewurz A,Jonasson O,Geis WP,Gewurz H

更新日期：1981-11-01 00:00:00

abstract：:Recent evidence suggests that T cell apoptosis could be involved in the pathogenesis of HIV-1 infection. As the progression of HIV-2 associated disease appears to be slower than that of HIV-1, we investigated whether there were differences in the degree of T cell death and apoptosis in peripheral blood mononuclear cel...

journal_title：Clinical and experimental immunology

authors： Jaleco AC,Covas MJ,Victorino RM

更新日期：1994-11-01 00:00:00

abstract：:IgA nephropathy (IgAN), the most common form of glomerulonephritis, is characterized by normal to elevated levels of serum IgA. In order to understand the molecular mechanism(s) involved in the production of IgA in IgAN, peripheral blood mononuclear cells (PBMC) from these patients were analysed in this study. IL-10, ...

journal_title：Clinical and experimental immunology

authors： Baskin B,Pettersson E,Rekola S,Smith CI,Islam KB

更新日期：1996-12-01 00:00:00

abstract：:Immune repopulation, despite virological failure, often occurs in children under highly active anti-retroviral therapy (HAART). The aim of this study was to analyse the characteristics of immune repopulation and activation in children with and without virological response to HAART. Fourteen human immunodeficiency viru...

journal_title：Clinical and experimental immunology

authors： Anselmi A,Vendrame D,Rampon O,Giaquinto C,Zanchetta M,De Rossi A

更新日期：2007-12-01 00:00:00

abstract：:The aim of this study was to investigate the role of IL-12 in patients with RA. IL-12 (p70) and its associated cytokines were measured in sera and synovial fluid (SF) using an enzyme-linked immunosorbent method. Seven American College of Rheumatology (ACR) core set measures as well as IL-12 levels were sequentially mo...

journal_title：Clinical and experimental immunology

authors： Kim W,Min S,Cho M,Youn J,Min J,Lee S,Park S,Cho C,Kim H

更新日期：2000-01-01 00:00:00

abstract：:The regulation of cytokine production and T cell proliferation by other cytokines is mandatory in mediating inflammatory responses but the full understanding is far from complete. We have previously reported increased production of IL-2 and IL-2 receptors (IL-2R) in IgA nephropathy. The present study was undertaken to...

journal_title：Clinical and experimental immunology

authors： Lai KN,Leung JC,Li PK,Lui SF

更新日期：1991-08-01 00:00:00

abstract：:A technique is described which shows how to obtain a suspension of only progressively motile spermatozoa, from semen, by active penetration into an overlying buffer layer. About 60% of the number of motile spermatozoa in the original semen sample can be obtained as an output in the removed buffer layer. With this meth...

journal_title：Clinical and experimental immunology

authors： Hellema HW,Rümke P

更新日期：1978-01-01 00:00:00

abstract：:Capsular polysaccharide from Actinobacillus actinomycetemcomitans Y4 (Y4 CP) induces bone resorption in a mouse organ culture system and osteoclast formation in mouse bone marrow cultures, as reported in previous studies. We also found that Y4 CP inhibits the release of interleukin (IL)-6 and IL-8 from human gingival ...

journal_title：Clinical and experimental immunology

authors： Iwata T,Mitani A,Ishihara Y,Tanaka S,Yamamoto G,Kikuchi T,Naganawa T,Matsumura Y,Suga T,Koide M,Sobue T,Suzuki T,Noguchi T

更新日期：2005-08-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) is known for its capacity to induce CD11c(+) myeloid dendritic cells to promote T helper type 2 (Th2)-skewed inflammatory responses. Although increased expression of TSLP was reported in the lesional skin of limited numbers of patients with atopic dermatitis (AD), the relationships...

journal_title：Clinical and experimental immunology

authors： Sano Y,Masuda K,Tamagawa-Mineoka R,Matsunaka H,Murakami Y,Yamashita R,Morita E,Katoh N

更新日期：2013-03-01 00:00:00

abstract：:Stress known to stimulate sympathetic activity, as well as the hypothalamic-pituitary-adrenal axis (HPA), produces a significant increase in adrenomedullin (AdM) levels, suggesting a regulatory or protective role for AdM in countering HPA activation that follows a variety of stressors. Stressors can modulate the secre...

journal_title：Clinical and experimental immunology

authors： Yildirim NC,Yurekli M

更新日期：2010-07-01 00:00:00

abstract：:Clinical evidence implicates polymorphonuclear leucocytes in the pathogenesis of vasculitis in Kawasaki disease. We examined modulation of expression of adhesion molecules (CD11b and CD62L) on polymorphonuclear leucocytes and how this expression is related to serum cytokine concentrations. In 18 patients with Kawasaki...

journal_title：Clinical and experimental immunology

authors： Kobayashi T,Kimura H,Okada Y,Inoue Y,Kobayashi T,Shinohara M,Morikawa A

更新日期：2007-04-01 00:00:00

abstract：:The capacity of human T cell subsets, CD4+ or CD8+ T cells, to produce tumour necrosis factors (TNF-alpha and TNF-beta) upon stimulation with toxic shock syndrome toxin-1 (TSST-1) and the requirement for MHC class II molecules on accessory cells (AC) in the response were investigated. The capacity of CD4+ T cells was ...

journal_title：Clinical and experimental immunology

authors： Akatsuka H,Imanishi K,Inada K,Yamashita H,Yoshida M,Uchiyama T

更新日期：1994-06-01 00:00:00

abstract：:Lyme borreliosis is a complex infection, where some individuals develop so-called 'chronic borreliosis'. The pathogenetic mechanisms are unknown, but the type of immune response is probably important for healing. A strong T helper cell type 1 (Th1)-like response has been suggested as crucial for eradication of Borreli...

journal_title：Clinical and experimental immunology

authors： Ekerfelt C,Andersson M,Olausson A,Bergström S,Hultman P

更新日期：2007-10-01 00:00:00

abstract：:Two facts support the definition of idiopathic thrombocytopenic purpura (ITP) as an immune disorder. First, antibodies against platelets, which often appear after a viral infection, provoke the increased elimination of these cells. Viral disease may change the complex immune response of the host at different levels. I...

journal_title：Clinical and experimental immunology

authors： Imbach PA

更新日期：1994-07-01 00:00:00

abstract：:The proliferative response of preparations of whole PBMC populations from 20 healthy individuals and 28 multiple sclerosis (MS) patients to purified protein derivative (PPD) and myelin basic protein (MBP) was monitored in a kinetic assay over a period of up to 10 days. PPD produced a classical secondary response in bo...

journal_title：Clinical and experimental immunology

authors： Ponsford M,Mazza G,Coad J,Campbell MJ,Zajicek J,Wraith DC

更新日期：2001-05-01 00:00:00

abstract：:Monoclonal anti-dermatan sulphate antibodies were produced with hybridization after immunizing BALB/c mice with dermatan sulphate (DS). These antibodies were tested for cross-reactivity to double-stranded DNA (dsDNA) and heat-denatured DNA (ssDNA). Five clones had binding activity to DS, dsDNA and ssDNA in enzyme-link...

journal_title：Clinical and experimental immunology

authors： Ohnishi K,Sagawa A,Nakabayashi T,Ohmoto A,Megumi,Yoshikawa M,Watanabe I,Mukai M,Yasuda I,Nakagawa S

更新日期：1989-01-01 00:00:00

abstract：:Muscle is an attractive target for gene therapy and for immunization with DNA vaccines and is also the target of immunological injury in myositis. It is important therefore to understand the immunologic capabilities of muscle cells themselves. In this study, we show that proinflammatory stimuli induce the expression o...

journal_title：Clinical and experimental immunology

authors： Nagaraju K,Raben N,Merritt G,Loeffler L,Kirk K,Plotz P

更新日期：1998-09-01 00:00:00

abstract：:To investigate the possible role of IL-6 in the activation of the autoimmune process in systemic lupus erythematosus (SLE), we serially measured concentrations of IL-6, IgG, and anti-dsDNA antibodies before and during exacerbations in patients with SLE. In addition, we serially related the IL-6 response to the generat...

journal_title：Clinical and experimental immunology

authors： Spronk PE,ter Borg EJ,Limburg PC,Kallenberg CG

更新日期：1992-10-01 00:00:00

abstract：:Ulcerative colitis (UC) and Crohn's disease (CD) are considered to be immunologically mediated disorders that share certain features with murine models of colitis. Whether any of these models are physiologically relevant to the human condition remains controversial. The hypothesis is that increased amounts of antibodi...

journal_title：Clinical and experimental immunology

authors： Ebert EC,Panja A,Das KM,Praveen R,Geng X,Rezac C,Bajpai M

更新日期：2009-01-01 00:00:00

abstract：:Tuberculosis is a worldwide health problem, and multidrug-resistant (MDR) and extensively multidrug-resistant (XMDR) strains are rapidly emerging and threatening the control of this disease. These problems motivate the search for new treatment strategies. One potential strategy is immunotherapy using cationic anti-mic...

journal_title：Clinical and experimental immunology

authors： Rivas-Santiago CE,Rivas-Santiago B,León DA,Castañeda-Delgado J,Hernández Pando R

更新日期：2011-04-01 00:00:00

abstract：:The number of thymic epithelial cells containing the serum thymic factor (FTS or thymulin), assessed by indirect immunofluorescence using an anti-FTS monoclonal antibody, was studied in the thymus of normal and autoimmune mice as a function of age. In normal mice the number of FTS+ cells was constant until the age of ...

journal_title：Clinical and experimental immunology

authors： Savino W,Dardenne M,Bach JF

更新日期：1983-04-01 00:00:00

abstract：:In patients with ANCA-associated vasculitis (AAV), CD25 expression is increased on circulating T cells. Although in animal experiments the role of CD4(+) CD25(+) T-regulatory-cells (T(reg)) in protection against autoimmunity is well established, the role of these cells in AAV is unknown. To investigate the hypothesis ...

journal_title：Clinical and experimental immunology

authors： Marinaki S,Neumann I,Kälsch AI,Grimminger P,Breedijk A,Birck R,Schmitt W,Waldherr R,Yard BA,Van Der Woude FJ

更新日期：2005-04-01 00:00:00

abstract：:The chemotactic responsiveness of peripheral blood monocytes was evaluated in three groups of subjects: 32 patients with multiple myeloma, 27 subjects with benign monoclonal gammapathy, and 64 normal controls. Monocyte chemotactic responsiveness was significantly depressed both in multiple myeloma patients (P less tha...

journal_title：Clinical and experimental immunology

authors： Dammacco F,Miglietta A,Ventura MT,Bonomo L

更新日期：1982-02-01 00:00:00

abstract：:Haemorrhage produces alterations in macrophage, T and B cell function. In order to better define the mechanism for the effects of blood loss on immune response, we examined function of and cytokine production by purified T cells, CD4+ and CD8+ subpopulations after blood loss. Whereas T and CD4+ cells from control, unh...

journal_title：Clinical and experimental immunology

authors： Abraham E,Chang YH

更新日期：1992-12-01 00:00:00

abstract：:Histone can mediate the binding of both free DNA and DNA complexed to anti-DNA antibody to the glomerular capillary wall. We tested whether performed histone-DNA-anti-DNA immune complexes (IC) could bind to the glomerular capillary wall. The immune complex, generated with anti-DNA antibody derived from an SLE patient ...

journal_title：Clinical and experimental immunology

authors： Morioka T,Fujigaki Y,Batsford SR,Woitas R,Oite T,Shimizu F,Vogt A

更新日期：1996-04-01 00:00:00

abstract：:In normal subjects, factor B and C3b inactivator (KAF) levels were linearly related (r = 0-71); factor B levels in subjects with low normal levels of KAF were significantly lower than in those with high normal levels of KAF. This relationship is postulated to be the result of modulation by the level of KAF of the avai...

journal_title：Clinical and experimental immunology

authors： Forristal J,Iitaka K,Vallota EH,West CD

更新日期：1977-04-01 00:00:00

abstract：:In stimulated cultures, a proportion of human T lymphocytes form multilayer rosettes with sheep red blood cells (SRBC) and they can be easily separated from common E rosettes by velocity sedimentation. We have developed a simplified method for harvesting multilayer rosettes and quantifying them. Practical applications...

journal_title：Clinical and experimental immunology

authors： Abuaf N,Leynadier F,Luce H,Dry J

更新日期：1981-04-01 00:00:00