Effect of plasmapheresis on T anc B lymphocyte functions in patients with systemic lupus erythematosus: a double blind study.

abstract：:Interleukin-6 (IL-6) is a key cytokine featuring redundancy and pleiotropic activity. It plays a central role in host defence against environmental stress such as infection and injury. Dysregulated, persistent interleukin (IL)-6 production has been implicated in the development of various autoimmune, chronic inflammat...

journal_title：Clinical and experimental immunology

authors： Mesquida M,Leszczynska A,Llorenç V,Adán A

更新日期：2014-06-01 00:00:00

abstract：:Measles-specific IgA antibody titres were determined by radioimmunoassay (RIA) for serial serum, saliva and tear samples obtained from 21 children with measles infection, from onset of rash until up to 14 months later. Serum IgA titres rose rapidly after onset of illness and remained detectable throughout the follow-u...

journal_title：Clinical and experimental immunology

authors： Friedman MG,Phillip M,Dagan R

更新日期：1989-01-01 00:00:00

abstract：:T cells from systemic lupus erythematosus (SLE) patients display a wide array of anomalies in peripheral immune tolerance mechanisms. The role of ubiquitin ligases such as Cbl-b has been described recently in these phenomena. However, its role in resistance to suppression phenotype in SLE has not been characterized, w...

journal_title：Clinical and experimental immunology

authors： Romo-Tena J,Rajme-López S,Aparicio-Vera L,Alcocer-Varela J,Gómez-Martín D

更新日期：2018-01-01 00:00:00

abstract：:In this paper we describe the clinical and molecular features of a new case (GOR) of homozygous human TAP2 deficiency, analysing the phenotype and function of NK cells. The patient presented from infancy with recurrent sinopulmonary infections; a selective IgG2 deficiency, negative antibody response to polysaccharide ...

journal_title：Clinical and experimental immunology

authors： Matamoros N,Milà J,Llano M,Balas A,Vicario JL,Pons J,Crespí C,Martinez N,Iglesias-Alzueta J,López-Botet M

更新日期：2001-08-01 00:00:00

abstract：:Membranous nephropathy (MN), the leading cause of nephrotic syndrome in adults, is characterized by the deposition of subepithelial immune deposits that consist mainly of immunoglobulin (Ig)G and complement. Most of the cases are primary or idiopathic (iMN), while only approximately 25% of the cases are secondary to s...

journal_title：Clinical and experimental immunology

authors： Sinico RA,Mezzina N,Trezzi B,Ghiggeri GM,Radice A

更新日期：2016-02-01 00:00:00

abstract：:A subpopulation of human B lymphocytes forms rosettes with mouse erythrocytes through a glycoprotein-dependent bond. Further studies of this bond show that the lymphocyte receptor is not immunoglobulin, although the binding of antisera or staphylococci to surface immunoglobulin inhibits the formation of mouse rosettes...

journal_title：Clinical and experimental immunology

authors： Zalewski PD,Forbes IJ

更新日期：1979-06-01 00:00:00

abstract：:Binding of lymphocytes to human umbilical vein endothelial cells (EC) was quantitated by measuring adhesion of 51Cr labelled lymphocytes to endothelial cell monolayers and rosette formation between lymphocytes and EC in suspension. Mitogen stimulated human peripheral blood mononuclear cell culture supernatants and mix...

journal_title：Clinical and experimental immunology

authors： Yu CL,Haskard DO,Cavender D,Johnson AR,Ziff M

更新日期：1985-12-01 00:00:00

abstract：:Organ transplantation is the treatment of choice for patients with end-stage organ failure, but chronic immunosuppression is taking its toll in terms of morbidity and poor efficacy in preventing late graft loss. Therefore, a drug-free state would be desirable where the recipient permanently accepts a donor organ while...

journal_title：Clinical and experimental immunology

authors： Mahr B,Wekerle T

更新日期：2017-08-01 00:00:00

abstract：:T and B cell function, in particular IgD production in vitro, were studied across the spectrum of HIV infection in homosexual men and compared with seronegative homosexual and heterosexual male controls. Proliferation to phytohaemagglutinin (PHA) was reduced most strikingly in symptomatic HIV infection; it was also im...

journal_title：Clinical and experimental immunology

authors： Rogers LA,Forster SM,Pinching AJ

更新日期：1989-01-01 00:00:00

abstract：:Antibody response and antigen specific suppression to bovine serum albumin (BSA) in uremic rats have been investigated. Primary immune response was found to be significantly reduced independent of the route of administration or adjuvant while secondary response was affected only in animals in which a weak adjuvant suc...

journal_title：Clinical and experimental immunology

authors： Mezzano S,Pesce A,Peters T Jr,Pollak VE,Reed R,Michael G

更新日期：1982-04-01 00:00:00

abstract：:Adjuvant arthritis in Lewis rats is a model of T cell-mediated autoimmune arthritis resembling human rheumatoid arthritis. A nonapeptide from the 65-kD heat-shock protein of Mycobacterium bovis BCG, amino acid sequence 180-188, has been described to carry the dominant immunogenic epitope(s) for both arthritis-protecti...

journal_title：Clinical and experimental immunology

authors： Yang XD,Gasser J,Feige U

更新日期：1990-08-01 00:00:00

abstract：:The complement (C)-activating capabilities in human serum of 32 mouse and 10 mouse/human chimeric MoAbs of different isotypes, and their fragments, were tested in vitro. Activation of C via the classical pathway (CP) was performed in 1% factor D-deficient serum in gelatin containing Veronal buffer in the presence of c...

journal_title：Clinical and experimental immunology

authors： Seino J,Eveleigh P,Warnaar S,van Haarlem LJ,van Es LA,Daha MR

更新日期：1993-11-01 00:00:00

abstract：:To gain some insight into the pathogenesis of proliferative lupus nephritis in MRL/lpr mice we investigated the kinetics of removal of immune complexes from the circulation, the carrier state of blood cells, the uptake of complexes by the mononuclear phagocyte system, and the localization of complexes in kidneys. In n...

journal_title：Clinical and experimental immunology

authors： Granholm NA,Cavallo T

更新日期：1990-11-01 00:00:00

abstract：:In this study we have looked at the effect of lipopolysaccharide (LPS) on the surface antigen expression of cultured monocytes. Monocytes were purified from peripheral blood mononuclear cells (PBMC) and cultured in the presence or absence of LPS. The cultured cells were then stained with anti-MO3, anti-IL-2R and anti-...

journal_title：Clinical and experimental immunology

authors： Neate EV,Greenhalgh AM,McPhee DA,Crowe SM

更新日期：1992-12-01 00:00:00

abstract：:Anaemia of chronic disease (ACD) is frequently found in rheumatoid arthritis (RA). In the pathogenesis of ACD both cytokines, such as tumour necrosis factor-alpha (TNF-alpha), IL-1 and IL-6 as well as a relative deficiency of erythropoietin (EPO), are thought to play a key role. In the present study the role of IL-6 i...

journal_title：Clinical and experimental immunology

authors： Jongen-Lavrencic M,Peeters HR,Rozemuller H,Rombouts WJ,Martens AC,Vreugdenhil G,Pillay M,Cox PH,Bijser M,Brutel G,Breedveld FC,Swaak AJ

更新日期：1996-02-01 00:00:00

abstract：:Factor H and the FHL-1/reconectin protein are two human plasma proteins that act as important regulators of the alternative complement pathway. Each protein is encoded by a unique transcript, but both mRNAs are derived from the factor H gene by means of alternative processing. In order to address potential functional ...

journal_title：Clinical and experimental immunology

authors： Friese MA,Hellwage J,Jokiranta TS,Meri S,Müller-Quernheim HJ,Peter HH,Eibel H,Zipfel PF

更新日期：2000-08-01 00:00:00

abstract：:This study was performed to determine whether or not IL-18, formerly called IFN-gamma-inducing factor, is involved in the pathogeneses of allergic disorders. Peripheral blood mononuclear cells (PBMC) were obtained from patients with allergic bronchial asthma (BA), patients with atopic dermatitis (AD) and controls who ...

journal_title：Clinical and experimental immunology

authors： El-Mezzein RE,Matsumoto T,Nomiyama H,Miike T

更新日期：2001-11-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial fibroblast hyperplasia and bone erosion. Fibroblast-like synoviocytes (FLS) play a pivotal role in RA pathogenesis through aggressive migration and matrix invasion, and certain proinflammatory cytokines may affect synoviocyte invasio...

journal_title：Clinical and experimental immunology

authors： Xing R,Jin Y,Sun L,Yang L,Li C,Li Z,Liu X,Zhao J

更新日期：2016-05-01 00:00:00

abstract：:An injection of human renal tubular fraction, Fx1A, with Freund's complete adjuvant in rats induces Heymann nephritis (HN) with clinical and morphological features similar to rat Fx1A-induced HN. The present study was undertaken to characterize antibody specificities and the corresponding antigen involved in human Fx1...

journal_title：Clinical and experimental immunology

authors： Natori Y,Hayakawa I,Shibata S

更新日期：1987-07-01 00:00:00

abstract：:BALB/c mice made tolerant to A/J alloantigens by neonatal injection of (A/J x BALB/c)F1 spleen cells develop a host-versus-graft (HVG) disease due to the activation of donor B cells by a subset of host alloreactive helper T cells. We have investigated the effects of a single neonatal injection of the 145-2C11 anti-mou...

journal_title：Clinical and experimental immunology

authors： Wissing M,Marchant A,Moser M,Flamand V,Leo O,Abramowicz D,Urbain J,Goldman M

更新日期：1991-02-01 00:00:00

abstract：:Muscle is an attractive target for gene therapy and for immunization with DNA vaccines and is also the target of immunological injury in myositis. It is important therefore to understand the immunologic capabilities of muscle cells themselves. In this study, we show that proinflammatory stimuli induce the expression o...

journal_title：Clinical and experimental immunology

authors： Nagaraju K,Raben N,Merritt G,Loeffler L,Kirk K,Plotz P

更新日期：1998-09-01 00:00:00

abstract：:Expression of the adhesion molecule, CD146/MCAM/MelCAM, on T cells has been associated with recent activation, memory subsets and T helper type 17 (Th17) effector function, and is elevated in inflammatory arthritis. Th17 cells have been implicated in the pathogenesis of rheumatoid arthritis (RA) and spondyloarthritide...

journal_title：Clinical and experimental immunology

authors： Wu C,Goodall JC,Busch R,Gaston JS

更新日期：2015-03-01 00:00:00

abstract：:During routine immunofluorescence studies of the serum of a patient with Sjögren's syndrome and lymphoma we detected antibodies giving a cytoplasmic pattern which did not correspond to previously described patterns found for autoantibodies. Using different cells and tissues as substrates for indirect immunofluorescenc...

journal_title：Clinical and experimental immunology

authors： Rodríguez JL,Gelpi C,Thomson TM,Real FJ,Fernández J

更新日期：1982-09-01 00:00:00

abstract：:Peripheral blood mononuclear cells from 14 healthy donors and 22 allergic patients were incubated with 51Cr-labelled chicken erythrocytes coated with an IgE myeloma protein or rabbit IgG antibodies. Mononuclear cells from patients with severe atopic disorders released a significantly greater percentage of 51Cr (P less...

journal_title：Clinical and experimental immunology

authors： Melewicz FM,Zeiger RS,Mellon MH,O'Connor RD,Spiegelberg HL

更新日期：1981-03-01 00:00:00

abstract：:We report on the experience of establishing a national network for a quality control programme in evaluating CD4 cell counts in most Italian centres involved in the care of patients with HIV disease. The 68 centres were divided according to their geographical location into eight groups, and twice a year (tests A and B...

journal_title：Clinical and experimental immunology

authors： Pandolfi F,Alario C,Girardi E,Rava L,Ippolito G,Kunkl A,Aiuti F

更新日期：1998-03-01 00:00:00

abstract：:Saimiri sciureus monkeys have been successfully immunized against a human malaria parasite, Plasmodium falciparum, using soluble antigens purified from schizont and merozoite extracts. High levels of antibodies reacting with schizont and merozoite specific polypeptides of 140 and 200 kdaltons were detected in the sera...

journal_title：Clinical and experimental immunology

authors： Perrin LH,Loche M,Dedet JP,Roussilhon C,Fandeur T

更新日期：1984-04-01 00:00:00

abstract：:The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of ...

journal_title：Clinical and experimental immunology

authors： Shephard EG,Anderson R,Strachan AF,Kühn SH,De Beer FC

更新日期：1986-03-01 00:00:00

abstract：:Vulnerability to Streptococcus pneumoniae is most pronounced in children. The microbial virulence factors and the features of the host immune response contributing to this phenomenon are not completely understood. In the current study, the humoral immune response to separated Strep. pneumoniae surface proteins and the...

journal_title：Clinical and experimental immunology

authors： Lifshitz S,Dagan R,Shani-Sekler M,Grossman N,Fleminger G,Friger M,Nebenzahl YM

更新日期：2002-02-01 00:00:00

abstract：:Chlorazole fast pink 2BL inhibited the classical complement pathway in rat serum both in vivo and in vitro. The in vitro potency of chlorazole fast pink against the alternative pathway could not be assessed accurately but it was clearly less than that against the classical pathway. The compound appears to bind strongl...

journal_title：Clinical and experimental immunology

authors： Doherty NS

更新日期：1981-02-01 00:00:00

abstract：:During pathogenesis of diabetes, pancreatic islets are exposed to high levels of cytokines and other inflammatory mediators that induce deterioration of insulin-producing beta cells. Macrophage migration inhibitory factor (MIF) plays a key role in the onset and development of several immunoinflammatory diseases and al...

journal_title：Clinical and experimental immunology

authors： Stojanovic I,Saksida T,Nikolic I,Nicoletti F,Stosic-Grujicic S

更新日期：2012-08-01 00:00:00