L-ficolin in children with recurrent respiratory infections.

Abstract:

:The lectin pathway of complement activation is used by a collectin, mannan-binding lectin (MBL), and two ficolins, L-ficolin and H-ficolin, to opsonize microorganisms for phagocytosis. We published evidence recently that MBL insufficiency is associated with recurrent respiratory infections in childhood. We have now measured serum L-ficolin in 313 respiratory infection patients and 74 healthy control children. L-ficolin concentrations below the lower limit of the control group were found in 6% of the patients (P <0.02) and were associated most strongly with children having co-existing atopic disorders (11%; P=0.002). We suggest that L-ficolin may have a role in protection from microorganisms complicating allergic disease.

journal_name

Clin Exp Immunol

authors

Atkinson AP,Cedzynski M,Szemraj J,St Swierzko A,Bak-Romaniszyn L,Banasik M,Zeman K,Matsushita M,Turner ML,Kilpatrick DC

doi

10.1111/j.1365-2249.2004.02634.x

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

517-20

issue

3

eissn

0009-9104

issn

1365-2249

pii

CEI2634

journal_volume

138

pub_type

杂志文章
  • Lack of complement activation by human IgA immune complexes.

    abstract::Complement activation may play an important role in renal injury associated with glomerular deposition of IgA immune complexes. The ability of naturally occurring human IgA immune complexes (IgA-IC) and covalently cross-linked human IgA oligomers (X-IgA) to activate complement were examined in vitro and in vivo. Large...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Imai H,Chen A,Wyatt RJ,Rifai A

    更新日期:1988-09-01 00:00:00

  • Antibodies to extractable nuclear antigens in rheumatoid arthritis: relationship to vasculitis and circulating immune complexes.

    abstract::Antibodies to extractable nuclear antigens (ENA) were analysed in the sera of fifty-two patients with severe rheumatoid arthritis (RA) who were divided into two categories: twenty-five with arthritis only and twenty-seven with extra-articular disease. Using haemagglutination, counterimmunoelectropheresis (CIE) and dou...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Venables PJ,Erhardt CC,Maini RN

    更新日期:1980-01-01 00:00:00

  • Long-term serological evaluation of patients with cystic echinococcosis treated with benzimidazole carbamates.

    abstract::Seeking better immunological markers indicating the long-term outcome of cystic echinococcosis (CE) after chemotherapy we studied 23 patients receiving albendazole, clinically followed for 8 years, and grouped ultrasonographically according to therapeutic outcome. Antibody responses against a partially purified fracti...

    journal_title:Clinical and experimental immunology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-2249.2002.01925.x

    authors: Riganò R,Ioppolo S,Ortona E,Margutti P,Profumo E,Ali MD,Di Vico B,Teggi A,Siracusano A

    更新日期:2002-09-01 00:00:00

  • Autoimmunity to endometrium and ovary in endometriosis.

    abstract::Antibody titres to whole ovary, theca cells, granulosa cells and endometrium were determined by passive haemagglutination and immunofluorescence assays in sera and in cervical and vaginal secretions from 13 patients with endometriosis. Antibody titres to endometrium (mean log2 +/- s.e.m., 7.08 +/- 0.80; P less than 0....

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Mathur S,Peress MR,Williamson HO,Youmans CD,Maney SA,Garvin AJ,Rust PF,Fudenberg HH

    更新日期:1982-11-01 00:00:00

  • Human blood dendritic cells: binding to vascular endothelium and expression of adhesion molecules.

    abstract::To investigate the binding properties of dendritic cells (DC) to vascular endothelium, a comparative analysis was undertaken of DC, monocytes and lymphocytes isolated from the blood of 25 healthy subjects using monolayers of human umbilical vein endothelial cells as the adherence substrate. More blood DC (mean 24% adh...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1997.d01-951.x

    authors: Brown KA,Bedford P,Macey M,McCarthy DA,Leroy F,Vora AJ,Stagg AJ,Dumonde DC,Knight SC

    更新日期:1997-03-01 00:00:00

  • CXCR3 axis in patients with primary biliary cirrhosis: a possible novel mechanism of the effect of ursodeoxycholic acid.

    abstract::The CXC chemokines, monokine induced by interferon (IFN)-gamma (MIG) (CXCL9), IFN-gamma-induced protein 10 (IP-10) (CXCL10) and IFN-inducible T cell alpha chemoattractant (I-TAC) (CXCL11), are known to attract CXCR3- (CXCR3A and CXCR3B) T lymphocytes. We investigated MIG, IP-10 and I-TAC mRNAs expression by semi-quant...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12032

    authors: Manousou P,Kolios G,Drygiannakis I,Koulentaki M,Pyrovolaki K,Voumvouraki A,Notas G,Bourikas L,Papadaki HA,Kouroumalis E

    更新日期:2013-04-01 00:00:00

  • Pathogenic function of IL-1 beta in psoriasiform skin lesions of flaky skin (fsn/fsn) mice.

    abstract::IL-1 acts on many cells as an inflammatory mediator. Its two forms, IL-1 alpha and IL-1 beta, are regulated differentially within hyperproliferative inflammatory skin conditions, such as psoriasis. While IL-1 alpha is down-regulated within psoriatic lesions, the levels of IL-1 beta are increased. However, some investi...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2001.01421.x

    authors: Schön M,Behmenburg C,Denzer D,Schön MP

    更新日期:2001-03-01 00:00:00

  • Characterization of cold reactive lymphocytotoxic antibodies in malaria.

    abstract::Characterization of cold reactive lymphocytotoxic antibodies present in sera from Thai adults with malaria revealed that the antibodies are predominantly 19S (IgM), directed against both autologous and allogeneic mononuclear cells, complement-dependent, present in titres ranging from 1:2 to 1:16, and exhibit greater l...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Gilbreath MJ,Pavanand K,MacDermott RP,Wells RA,Ussery MA

    更新日期:1983-02-01 00:00:00

  • Virus-specific cytotoxic T cell responses are associated with immunity of the cottontop tamarin to Epstein-Barr virus (EBV).

    abstract::The cytotoxic responses of peripheral blood lymphocytes from cottontop tamarins to in vitro restimulation with autologous lymphoblastoid cell lines (LCL) were assayed. Lymphocytes from immune tamarins that had recovered from EBV challenge developed potent cytotoxicity for natural killer (NK) cell targets and for autol...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1996.d01-607.x

    authors: Wilson AD,Shooshstari M,Finerty S,Watkins P,Morgan AJ

    更新日期:1996-02-01 00:00:00

  • The role of interferon-gamma in lymphocytic thyroiditis: its functional and pathological effect on human thyrocytes in culture.

    abstract::Interferon-gamma (IFN-gamma) has been recognized to possess diverse non-immunological effects on epithelial cells such as cellular growth and differentiation. We have previously demonstrated that IFN-gamma suppressed thyroid-stimulating hormone (TSH)-stimulated thyroglobulin (TG) synthesis in human thyrocytes through ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1992.tb02985.x

    authors: Kung AW,Ma L,Lau KS

    更新日期:1992-02-01 00:00:00

  • Protein biochip array technology to monitor rituximab in rheumatoid arthritis.

    abstract::In rheumatoid arthritis (RA) there are currently no good indicators to predict a clinical response to rituximab. The purpose of this study was to monitor and determine the role of peripheral blood cytokine profiling in differentiating between a good versus poor response to rituximab in RA. Blood samples were collected...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2008.03804.x

    authors: Fabre S,Guisset C,Tatem L,Dossat N,Dupuy AM,Cohen JD,Cristol JP,Daures JP,Jorgensen C

    更新日期:2009-03-01 00:00:00

  • Chronic Chlamydia pneumoniae infection may promote coronary artery disease in humans through enhancing secretion of interleukin-4.

    abstract::Atherosclerosis is an inflammatory response, probably to a range of initiating causes. Chronic infection with Chlamydia pneumoniae (C.pn) has been suggested as one cause, but the nature of the association is controversial, in large part due to lack of an identified mechanism to link infection with the atherosclerotic ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2006.03185.x

    authors: Clancy R,Ren Z,Pang G,Fletcher P,D'Este C

    更新日期:2006-11-01 00:00:00

  • Subclass distribution and IgE responses after treatment in human schistosomiasis.

    abstract::The IgG and IgA subclass distribution of specific antibodies as well as the distribution of total and specific IgE in 15 patients with schistosomiasis was determined in consecutive samples before and after initiation of treatment. An adult worm antigen preparation and a soluble egg antigen preparation were used as ant...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Evengård B,Hammarström L,Smith CI,Johansson SG,Linder E

    更新日期:1988-09-01 00:00:00

  • Expression of costimulatory molecules CD80 and CD86 and their receptors CD28, CTLA-4 on malignant ascites CD3+ tumour-infiltrating lymphocytes (TIL) from patients with ovarian and other types of peritoneal carcinomatosis.

    abstract::Costimulation of T lymphocytes by the leucocyte surface molecules CD80 and CD86 expressed on antigen-presenting cells (APC) is required for the development of T cell responses. The CD28 and CTLA-4 molecules on T cells serve as receptors for the CD80 and CD86 costimulatory antigens. We have examined the frequency of ex...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2000.01105.x

    authors: Melichar B,Nash MA,Lenzi R,Platsoucas CD,Freedman RS

    更新日期:2000-01-01 00:00:00

  • Prevalence in myositis of antibodies recognizing anti-U3 RNA probably in a novel complex with 22/25 kD protein and not fibrillarin.

    abstract::New antibodies against a U3 snRNP, which were named anti-Myo 22/25 antibodies, were detected in four (8%) of 53 serum samples from patients with polymyositis/dermatomyositis (PM/DM) by RNA immunoprecipitation. In the protein immunoprecipitation analysis, all four serum samples precipitated 22 kDa and 25 kDa proteins, ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2001.01650.x

    authors: Kubo M,Ihn H,Kuwana M,Yamane K,Yazawa N,Tamaki K

    更新日期:2001-11-01 00:00:00

  • Complement-induced mixed aggregation of T and B lymphocytes and myeloid cells and the effect of adjuvant.

    abstract::Complement induces mixed aggregation of murine spleen cells bearing C3 receptors. In the present studies, we show with immunofluorescent techniques that these aggregates are formed by T and B lymphocytes and myeloid cells, B cells constituting the predominant component in normal mice. There are striking changes in the...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Arnaiz-Villena A,Roitt IM

    更新日期:1975-07-01 00:00:00

  • Alterations in mononuclear cell tumour necrosis factor-alpha (TNF-alpha) response in patients on long term cuprophane haemodialysis.

    abstract::We have investigated TNF-alpha secretory response of peripheral blood mononuclear cells (PBMC) from 13 uraemic patients undergoing regular haemodialysis with cuprophane membrane (CM). Sixteen healthy subjects and five uraemic patients under conservative therapy were also studied as controls. Cells of haemodialysis pat...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1992.tb05830.x

    authors: Annenkov AY,Strokov AG,Baranova FS

    更新日期:1992-10-01 00:00:00

  • Proliferative and cytotoxic responses to mannoproteins of Candida albicans by peripheral blood lymphocytes of HIV-infected subjects.

    abstract::Mucosal candidiasis is one of the first opportunistic diseases in HIV-infected subjects. In order to understand the relationship between this disease and immunodeficiency to chemically defined, immunodominant Candida antigens, a mannoprotein fraction from C. albicans cell wall (GMP) was used to analyse proliferative a...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1991.tb05754.x

    authors: Quinti I,Palma C,Guerra EC,Gomez MJ,Mezzaroma I,Aiuti F,Cassone A

    更新日期:1991-09-01 00:00:00

  • Antigen processing for MHC class I restricted presentation of exogenous influenza A virus nucleoprotein by B-lymphoblastoid cells.

    abstract::In general, exogenous proteins are processed by antigen-presenting cells in the endosomes for major histocompatibility complex (MHC) class II presentation to CD4+ T cells, while proteins synthesized endogenously are processed in the cytoplasm for MHC class I presentation to CD8+ T cells. However, it is recognized that...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2001.01613.x

    authors: Voeten JT,Rimmelzwaan GF,Nieuwkoop NJ,Fouchier RA,Osterhaus AD

    更新日期:2001-09-01 00:00:00

  • Late diagnosis of chronic granulomatous disease.

    abstract::Modern era advancements in medical care, with improved treatment of infections, can result in delayed diagnosis of congenital immunodeficiencies. In this study we present a retrospective cohort of 16 patients diagnosed with Chronic Granulomatous Disease (CGD) at adulthood. Some of the patients had a milder clinical ph...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.13474

    authors: Barkai T,Somech R,Broides A,Gavrieli R,Wolach B,Marcus N,Hagin D,Stauber T

    更新日期:2020-09-01 00:00:00

  • Effect of protein deprivation on immunoregulatory cells in the rat mucosal immune response.

    abstract::Secretory IgA antibody responses such as those directed against respiratory and enteric pathogens, may be impaired in protein-calorie malnutrition. In previous studies using a rat model of the mucosal immune response to cholera toxin, as little as 2 weeks of severe protein deprivation markedly impaired mucosal anti-to...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Koster F,Pierce NF

    更新日期:1985-04-01 00:00:00

  • Induction of cutaneous graft-versus-host disease by local injection of unprimed T cells.

    abstract::The skin is a major target organ in human graft-versus-host disease (GVHD) after bone-marrow transplantation. GVHD can be induced in mice by i.v. injection of T cells into unirradiated semi-allogeneic or lethally irradiated allogeneic recipients. However, in the murine systemic GVHD model, cutaneous lesions occur only...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1991.tb08173.x

    authors: Kawai K,Matsumoto Y,Watanabe H,Ito M,Fujiwara M

    更新日期:1991-05-01 00:00:00

  • Effects of cyclosporin A on immunoglobulin production by EB virus stimulated lymphocytes.

    abstract::Cyclosporin A (Cy A) enhances immunoglobulin (Ig) production by EB virus stimulated peripheral blood lymphocytes from normal subjects with prior immunity to EB virus. In 11 normal adults, this enhancement of Ig production correlated with T cell-mediated cytotoxic regression. Cultures from normal healthy adults without...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Pereira RS,Gear AJ,Doré CJ,Webster AD

    更新日期:1983-07-01 00:00:00

  • Reactivity of normal rat epiphyseal chondrocytes with monoclonal antibodies recognizing different leucocyte markers.

    abstract::The aim of the study was to test whether normal rat epiphyseal chondrocytes react with monoclonal antibodies (MoAbs) detecting different markers of lymphoid cells. For this purpose, isolated chondrocyte and, for comparison, splenocyte cytosmears were exposed to a battery of different MoAbs followed by indirect immunop...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Malejczyk J,Romaniuk A

    更新日期:1989-03-01 00:00:00

  • Purification of normal human eosinophils using the different binding capacities of blood leucocytes for complexed rabbit IgG.

    abstract::A method has been developed for separating eosinophils from other types of leucocyte in normal individuals. Erythrocytes are sedimented with dextran, and mononuclear cells are removed on an isotonic density gradient of ficoll and sodium diatrizoate. The eosinophils and neutrophils are then washed and sedimented onto p...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Tai PC,Spry CJ

    更新日期:1977-05-01 00:00:00

  • Pathogenesis of cutaneous T-cell lymphoma: implications for the use of recombinant cytokines and photopheresis.

    abstract::Cutaneous T-cell lymphoma (CTCL) is a clonally derived, skin invasive malignancy of CD4+ cells with the phenotype of mature helper T cells. We previously demonstrated that the leukaemic form of CTCL (Sézary), is characterized by prominent immunological defects including depressed cell-mediated immunity. We also demons...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审

    doi:

    authors: Rook AH,Gottlieb SL,Wolfe JT,Vowels BR,Sood SS,Niu Z,Lessin SR,Fox FE

    更新日期:1997-01-01 00:00:00

  • Kupffer cell depletion in vivo results in preferential elimination of IgG aggregates and immune complexes via specific Fc receptors on rat liver endothelial cells.

    abstract::In the present study we have investigated the clearance kinetics and tissue distribution of monomeric (m) IgG and soluble aggregates of IgG (AIgG) and immune complexes (IC) in normal and Kupffer cell (KC) depleted rats. In normal rats, clearance of mIgG occurred in a biphasic manner with a first half-life (T1/2) (T1) ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1991.tb05818.x

    authors: Bogers WM,Stad RK,Janssen DJ,van Rooijen N,van Es LA,Daha MR

    更新日期:1991-11-01 00:00:00

  • Subcutaneous immunoglobulin (16 or 20%) therapy in obese patients with primary immunodeficiency: a retrospective analysis of administration by infusion pump or subcutaneous rapid push.

    abstract::A retrospective chart review was conducted at a single centre, capturing data on 173 primary immunodeficiency disease (PIDD) patients, including 40 obese patients, using subcutaneous administration of immunoglobulin (Ig) (SCIG) (16 or 20%) delivered by infusion pump or subcutaneous (s.c.) rapid push. Patients previous...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12099

    authors: Shapiro R

    更新日期:2013-08-01 00:00:00

  • Suppressor activity of splenic macrophages in murine plasmacytoma (PC) is inhibited by PC specific ligands.

    abstract::Spleens of BALB/c mice with plasmacytoma contain macrophages (M phi) which were found to suppress the in vitro immune function of normal splenic cells through a diffusible factor. The suppressor activity of these macrophages was reversibly inhibited by ligands specific for the corresponding PC globulin, but not by ant...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Chen YH,Heller P

    更新日期:1982-11-01 00:00:00

  • Polyclonal activation of murine B cells by a membrane proteoglycan of Klebsiella pneumoniae.

    abstract::The lymphocyte activating properties of a membrane proteoglycan (MPG) extracted from a mutant non-encapsulated strain of Klebsiella pneumoniae (Kp) (biotype a I-145) were investigated. Kp MPG induced a strong proliferative response of BALB/c spleen cells and Peyer's patches cells. Thymidine incorporation was dose-rela...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Millet I,Lafont S,de Fraissinette A,Jeannin M,Revillard JP,Normier G,Dussourd d'Hinterland L

    更新日期:1987-10-01 00:00:00