Pathogenic function of IL-1 beta in psoriasiform skin lesions of flaky skin (fsn/fsn) mice.

abstract：:We determined the histamine release from basophils in patients suffering from cystic fibrosis (CF) (median 17.2 years of age) and compared the data with an age-matched group of healthy donors. No significant differences in the basophil counts were determined between the CF and control groups. However, the absolute his...

journal_title：Clinical and experimental immunology

authors： Schönfeld W,Saak A,Steinkamp G,Van der Hardt H,König W

更新日期：1989-06-01 00:00:00

abstract：:Severe thrombocytopenia and increased vascular permeability are two major characteristics of dengue haemorrhagic fever (DHF). To develop a better understanding of the roles of platelet-associated IgG (PAIgG) and IgM (PAIgM) in inducing thrombocytopenia and its severity of disease in patients with secondary dengue viru...

journal_title：Clinical and experimental immunology

authors： Saito M,Oishi K,Inoue S,Dimaano EM,Alera MT,Robles AM,Estrella BD Jr,Kumatori A,Moji K,Alonzo MT,Buerano CC,Matias RR,Morita K,Natividad FF,Nagatake T

更新日期：2004-11-01 00:00:00

abstract：:We have investigated the T-cell antigen receptor constant beta and alpha chain genes (TCR-C beta, -C alpha) and the immunoglobulin (Ig) heavy chain switch regions of patients with Graves' disease (GD) using restriction fragment length polymorphism (RFLP) analysis. No significant associations were found with RFLPs of e...

journal_title：Clinical and experimental immunology

authors： Demaine AG,Ratanachaiyavong S,Pope R,Ewins D,Millward BA,McGregor AM

更新日期：1989-07-01 00:00:00

abstract：:Specific activation of resting lymphocytes for tumour targeting can be achieved by bispecific monoclonal antibodies (bi-MoAbs) with specificity for tumour antigens and T cell-activating antigens in combination with a costimulatory anti-CD28 antibody. In this study we focus on the immunomodulatory function of an anti-C...

journal_title：Clinical and experimental immunology

authors： Hombach A,Tillmann T,Jensen M,Heuser C,Sircar R,Diehl V,Kruis W,Pohl C

更新日期：1997-05-01 00:00:00

abstract：:PHA activated human peripheral blood mononuclear cells (MNC) were incubated with human interleukin 2 (IL-2) in the absence or in the presence of 10(-6)-10(-9) M hydrocortisone (HC). HC suppressed the proliferative response of the activated MNC to highly purified human leucocyte IL-2 in a dose dependent manner. This su...

journal_title：Clinical and experimental immunology

authors： Horst HJ,Flad HD

更新日期：1987-04-01 00:00:00

abstract：:Autoimmune Addison's disease (AAD), or primary adrenocortical insufficiency, is a classical organ-specific autoimmune disease with 160 years of history. AAD is remarkably homogeneous with one major dominant self-antigen, the cytochrome P450 21-hydroxylase enzyme, which is targeted by both autoantibodies and autoreacti...

journal_title：Clinical and experimental immunology

authors： Hellesen A,Bratland E

更新日期：2019-01-01 00:00:00

abstract：:Autoreactivity to heat shock protein 60 (Hsp60) has been implicated in the pathogenesis and regulation of chronic inflammation, especially in autoimmune diseases. In transplantation, there is a lack of information regarding the cytokine profile and specificity of cells that recognize self-Hsp60 as well as the kinetics...

journal_title：Clinical and experimental immunology

authors： Caldas C,Luna E,Spadafora-Ferreira M,Porto G,Iwai LK,Oshiro SE,Monteiro SM,Fonseca JA,Lemos F,Hammer J,Ho PL,Kalil J,Coelho V

更新日期：2006-10-01 00:00:00

abstract：:Polyclonal B cell activation has been thought to play the critical role in production of autoantibodies, and possible activation of autoreactive T cells in murine lupus, especially abnormal expansion of CD5+ B cells, is one of the characteristic findings in these mice. The aim of this study was to investigate further ...

journal_title：Clinical and experimental immunology

authors： Ye YL,Chuang YH,Chiang BL

更新日期：1996-11-01 00:00:00

abstract：:A growing body of evidence points to autophagy as an essential component in the immune response to tuberculosis. Autophagy is a direct mechanism of killing intracellular Mycobacterium tuberculosis and also acts as a modulator of proinflammatory cytokine secretion. In addition, autophagy plays a key role in antigen pro...

journal_title：Clinical and experimental immunology

authors： Ní Cheallaigh C,Keane J,Lavelle EC,Hope JC,Harris J

更新日期：2011-06-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) and prostaglandins (PG) regulate the cell-mediated immune response, so it has been proposed that they affect the progression of pulmonary tuberculosis. Here we report that the administration of soluble betaglycan, a potent TGF-beta antagonist, and niflumic acid, a PG synthesi...

journal_title：Clinical and experimental immunology

authors： Hernández-Pando R,Orozco-Esteves H,Maldonado HA,Aguilar-León D,Vilchis-Landeros MM,Mata-Espinosa DA,Mendoza V,López-Casillas F

更新日期：2006-05-01 00:00:00

abstract：:Autoantigens in canine autoimmune haemolytic anaemia (AIHA) were identified by immunoprecipitation using autoantibody eluted from the erythrocytes of affected dogs. At least three patterns of precipitated antigen were identified in six cases of AIHA. The most commonly precipitated antigen pattern was a combination of ...

journal_title：Clinical and experimental immunology

authors： Barker RN,Gruffydd-Jones TJ,Stokes CR,Elson CJ

更新日期：1991-07-01 00:00:00

abstract：:Previous studies in this laboratory have shown that efficient activation of complement (C) on HIV isolates and HIV-infected cells requires the binding of specific anti-HIV antibodies, while other investigators have observed 'antibody-independent' C activation. In an attempt to clarify these disparate findings, we inve...

journal_title：Clinical and experimental immunology

authors： Saarloos MN,Lint TF,Spear GT

更新日期：1995-02-01 00:00:00

abstract：:Purified proteins (Pa-1 and Pa-2) from pokeweed have been compared with commercial pokeweed mitogen (PWM-G) and other mitogens in their ability to stimulate human lymphocytes. With cultures of T and B cells separated from tonsil lymphocytes, thymidine uptake, blast transformation and immunoglobulin (Ig) synthesis have...

journal_title：Clinical and experimental immunology

authors： Janossy G,Gomez De La Concha E,Waxdal MJ,Platts-Mills T

更新日期：1976-10-01 00:00:00

abstract：:Eleven Norwegian patients (aged 2-33 years, seven males and four females) with Ataxia-telangiectasia (A-T) and their parents were investigated. Five of the patients were homozygous for the same ATM mutation, 3245delATCinsTGAT, a Norwegian founder mutation. They had the lowest IgG2 levels; mean (95% confidence interval...

journal_title：Clinical and experimental immunology

authors： Stray-Pedersen A,Jónsson T,Heiberg A,Lindman CR,Widing E,Aaberge IS,Borresen-Dale AL,Abrahamsen TG

更新日期：2004-07-01 00:00:00

abstract：:Heavy C3 glomerular deposits were observed in rabbits injected intravenously with C5 streptococcal vaccine. Immunoglobulin deposits appeared later in a few rabbits. Although some data favour the presence of circulating immune complexes during the course of this glomerulonephritis, no evidence for their initiating role...

journal_title：Clinical and experimental immunology

authors： Bellon B,Kuhn J,Ayed K,Girard JF,Druet P

更新日期：1979-08-01 00:00:00

abstract：:Human peripheral blood B lymphocytes, when cultured for 6 days with ovalbumin in the presence of T cells and monocytes, can differentiate into plaque-forming cells (PFC) secreting small amounts of antigen-specific IgM. Phenotype analysis using Ig-isotype and B-cell specific monoclonal antibodies revealed that the PFC ...

journal_title：Clinical and experimental immunology

authors： Hart LA,Heijnen CJ,Zijlstra J,Ballieux RE

更新日期：1985-09-01 00:00:00

abstract：:In recent years galectin-3 has gained attention as a signalling molecule, mainly in inflammatory diseases. Data on galectin-3 expression in neonates, however, are limited, and expression of this lectin in cord blood has not yet been reported. The aim of this study was to determine galectin-3 levels in cord blood of te...

journal_title：Clinical and experimental immunology

authors： Demmert M,Faust K,Bohlmann MK,Tröger B,Göpel W,Herting E,Härtel C

更新日期：2012-02-01 00:00:00

abstract：:Anticardiolipin antibodies (ACA) belong to a heterogeneous group of antibodies directed against negatively charged phospholipids. In patients with rheumatic disorders, their presence has been correlated to the occurrence of thromboembolic complications, thrombocytopenia, abortions and other disease manifestations. Sev...

journal_title：Clinical and experimental immunology

authors： Rubbert A,Bock E,Schwab J,Marienhagen J,Nüsslein H,Wolf F,Kalden JR

更新日期：1994-12-01 00:00:00

abstract：:Dysfunction of T cells is a common feature in chronic persistent viral infections, including hepatitis C virus (HCV), and although hepatic and peripheral T cells have been studied extensively in chronic HCV hepatitis, the role of splenic T cell responses in such patients is poorly defined. This is an important issue, ...

journal_title：Clinical and experimental immunology

authors： Hashimoto N,Shimoda S,Kawanaka H,Tsuneyama K,Uehara H,Akahoshi T,Kinjo N,Taketomi A,Shirabe K,Akashi K,Lleo A,Ansari AA,Gershwin ME,Maehara Y

更新日期：2011-08-01 00:00:00

abstract：:Previous studies have shown that male mice of strains with high target organ responsiveness to androgen, the C57L/J and RF/J, have lower plasma immunoglobulin levels and weaker antibody responses to protein and polysaccharide antigens than mice of low androgen responder (LAR) strains, the A/J and 129/J. In the current...

journal_title：Clinical and experimental immunology

authors： Cohn DA

更新日期：1986-01-01 00:00:00

abstract：:One approach to study the role of distinct cellular mechanisms in susceptibility/resistance to tuberculosis (TB) is to compare parameters of response to infection in the lungs of mouse strains exhibiting genetically determined differences in TB susceptibility/severity. Interstrain differences in antimycobacterial macr...

journal_title：Clinical and experimental immunology

authors： Eruslanov EB,Majorov KB,Orlova MO,Mischenko VV,Kondratieva TK,Apt AS,Lyadova IV

更新日期：2004-01-01 00:00:00

abstract：:CBA/KlJms-lprcg/lprcg mice with a novel mutation producing systemic lymphoproliferation were investigated for their serological and histological characteristics. The mutant mice showed elevated levels of serum immunoglobulin, C1q-binding immune complexes and antibodies to nuclear antigens such as dsDNA and ssDNA and p...

journal_title：Clinical and experimental immunology

authors： Kimura M,Mohri H,Shimada K,Wakabayashi T,Kanai Y,Matsuzawa A

更新日期：1990-01-01 00:00:00

abstract：:CSF-1 plays an important role in female reproduction and normal embryo development. To understand further CSF-1 function in normal and, especially, in compromised pregnancy, we studied the pattern of its mRNA expression as well as expression of its receptor (c-fms) in the uteroplacental units of mice with induced (cyc...

journal_title：Clinical and experimental immunology

authors： Gorivodsky M,Torchinsky A,Shepshelovich J,Savion S,Fein A,Carp H,Toder V

更新日期：1999-09-01 00:00:00

abstract：:Lidocaine, bupivacaine or ropivacaine are used routinely to manage perioperative pain. Sparse data exist evaluating the effects of local anaesthetics (LA) on fibroblasts, which are involved actively in wound healing. Therefore, we investigated the effects of the three LA to assess the survival, viability and prolifera...

journal_title：Clinical and experimental immunology

authors： Fedder C,Beck-Schimmer B,Aguirre J,Hasler M,Roth-Z'graggen B,Urner M,Kalberer S,Schlicker A,Votta-Velis G,Bonvini JM,Graetz K,Borgeat A

更新日期：2010-11-01 00:00:00

abstract：:We have studied the effect of the probiotic strain Lactobacillus plantarum 299v on the immune functions of gnotobiotic rats. One group of germ-free rats was colonized with the type 1-fimbriated Escherichia coli O6:K13:H1 and another group with the same E. coli strain together with L. plantarum 299v. One and 5 weeks af...

journal_title：Clinical and experimental immunology

authors： Herías MV,Hessle C,Telemo E,Midtvedt T,Hanson LA,Wold AE

更新日期：1999-05-01 00:00:00

abstract：:Autoantibody production increases with ageing. However, the pathological significance of this increase as well as the corresponding underlying mechanisms are poorly understood. To further our understanding of the role that ageing plays in the development of autoantibody responses, we used a novel nonhuman primate mode...

journal_title：Clinical and experimental immunology

authors： Attanasio R,Brasky KM,Robbins SH,Jayashankar L,Nash RJ,Butler TM

更新日期：2001-03-01 00:00:00

abstract：:The possibility that shared idiotypes may be present on antibodies of different specificities was explored using sera from 13 patients with systemic lupus erythematosus. Eleven sera had anti-DNA and seven carried the 16/6 idiotype (ID). Two of the sera with 16/6 ID also had lymphocytotoxic antibodies, the activity of ...

journal_title：Clinical and experimental immunology

authors： Lydyard PM,Isenberg D,de Sousa B,Mackenzie L,Cooke A

更新日期：1987-03-01 00:00:00

abstract：:Four human B cell lines with a mature phenotype (immunoglobulin secretion and expression of membrane markers associated with maturation) were cultured in the presence of phorbol ester (PMA), dimethyl sulphoxide (DMSO) and two conditioned media. PMA and DMSO led to changes in phenotype which suggested the cells were be...

journal_title：Clinical and experimental immunology

authors： Zola H,Griffith V,Hunter I,Koh L,Bradley J

更新日期：1986-11-01 00:00:00

abstract：:The La/SSB autoantigen is a major target of long-term humoral autoimmunity in primary Sjögren's Syndrome (SS) and systemic lupus erythematosus. A majority of patients with linked anti-Ro60/Ro52/La responses target an NH2-terminal epitope designated LaA that is expressed on Ro/La ribonucleoprotein complexes and the sur...

journal_title：Clinical and experimental immunology

authors： Thurgood LA,Arentz G,Lindop R,Jackson MW,Whyte AF,Colella AD,Chataway TK,Gordon TP

更新日期：2013-11-01 00:00:00

abstract：:By using OKT monoclonal antibodies; OKT3(pan T), OKT4(inducer/helper), OKT8 (suppressor/cytotoxic) and OKIa1, T lymphocyte subsets were examined in lymphocytes of patients with tuberculosis both before and after in vitro stimulation with purified protein derivative of tuberculin (PPD). In freshly obtained lymphocytes ...

journal_title：Clinical and experimental immunology

authors： Shiratsuchi H,Tsuyuguchi I

更新日期：1984-08-01 00:00:00