Abstract：
:Autoantigens in canine autoimmune haemolytic anaemia (AIHA) were identified by immunoprecipitation using autoantibody eluted from the erythrocytes of affected dogs. At least three patterns of precipitated antigen were identified in six cases of AIHA. The most commonly precipitated antigen pattern was a combination of 42-kD and 29-kD peptides, associated with up to three other membrane components. These autoantigens may be canine glycophorins, which are of similar molecular mass, or may possibly represent an equivalent of the human Rhesus complex. An autoantigen identical in molecular mass to band 3, the erythrocyte anion channel protein, was precipitated in one case of AIHA, and unknown peptides of 37 kD and 100 kD were isolated by autoantibody from another dog. In one case, no antigens were precipitated by the eluted antibody, indicating that the autoantibody may have bound a non-protein membrane component such as phospholipid. Overall it is considered that the different patterns observed may reflect differences in the aetiology of the condition. In other studies, sera from dogs with AIHA failed to immunoprecipitate autoantigens, but were shown by immunoblotting to contain autoantibodies to proteins of the erythrocyte cytoskeleton. Such autoantibodies were also demonstrated in normal canine sera and it is suggested that they are unlikely to play a role in the pathogenesis of AIHA, but may be part of a normal clearance mechanism for damaged red blood cells.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Barker RN,Gruffydd-Jones TJ,Stokes CR,Elson CJdoi
10.1111/j.1365-2249.1991.tb05678.xsubject
Has Abstractpub_date
1991-07-01 00:00:00pages
33-40issue
1eissn
0009-9104issn
1365-2249journal_volume
85pub_type
杂志文章abstract：:The aim of this study was to characterize the proinflammatory and T helper (Th)1/Th2 cytokine responses during acute parvovirus B19 (B19) infection and determine whether an imbalance of the Th1/Th2 cytokine pattern is related to persistent B19 infection. Cytokines were quantified by multiplex beads immunoassay in seru...
journal_title：Clinical and experimental immunology
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journal_title：Clinical and experimental immunology
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doi：10.1111/j.1365-2249.1993.tb07959.x
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journal_title：Clinical and experimental immunology
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更新日期：1996-11-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
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更新日期：1983-05-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
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更新日期：1989-02-01 00:00:00
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journal_title：Clinical and experimental immunology
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doi：
更新日期：1985-08-01 00:00:00
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更新日期：1999-02-01 00:00:00
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更新日期：1980-01-01 00:00:00
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更新日期：2019-05-01 00:00:00
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更新日期：2007-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1046/j.1365-2249.2001.01507.x
更新日期：2001-05-01 00:00:00
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更新日期：2008-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2249.1997.d01-1015.x
更新日期：1997-05-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1982-12-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1976-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1365-2249.1994.tb06123.x
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
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更新日期：2000-08-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1983-02-01 00:00:00
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journal_title：Clinical and experimental immunology
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doi：
更新日期：1986-11-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章,评审
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更新日期：2008-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1365-2249.1995.tb06656.x
更新日期：1995-10-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：10.1111/cei.13393
更新日期：2020-03-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2249.1998.00626.x
更新日期：1998-07-01 00:00:00
