Autoantibodies to intermediate filaments in sera of patients with Schistosoma mansoni infection.

Abstract:

:Autoantibodies to the intermediate filament proteins vimentin and keratin were studied in sera of 50 Caribbean patients with Schistosoma mansoni infection and 50 control subjects. Autoantibodies were detected by indirect immunofluorescence on HEp-2 cells pretreated with colchicine. The incidence of anti-vimentin antibodies in patients' sera was 94% for IgM, 12% for IgG, and 4% for IgA; in the control subjects incidence was 52%, 0%, and 4%, respectively. Anti-keratin antibodies were found in 82%, 4%, and 4% of patients' sera and 42%, 0%, and 2% in controls, respectively. The difference between the geometric means of titres for patients (1:150) and controls (1:26) was highly significant (P less than 0.001). The possible role and genesis of autoantibodies to intermediate filaments is discussed.

journal_name

Clin Exp Immunol

authors

Boehme MW,Kataaha PK,Holborow EJ

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

230-3

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

77

pub_type

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