Abstract:
:YKL-40 is secreted by macrophages and neutrophils and patients with bacterial infections have elevated circulating YKL-40. The aim was to evaluate changes in plasma YKL-40 (determined by enzyme-linked immunosorbent assay (ELISA) at 0, 2, 4, 8, 24 and 32 h) in eight healthy volunteers after injection with Esherichia coli endotoxin or saline. Plasma YKL-40 increased after endotoxin injection from 31 microg/l (range 19-39 microg/l) to a maximum of 159 microg/l (61-552 microg/l, P < 0.01) at 24 h. The finding that plasma YKL-40 increased after endotoxin injection compared with saline (P < 0.001) suggests that YKL-40 has a functional role in infections.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Johansen JS,Krabbe KS,Møller K,Pedersen BKdoi
10.1111/j.1365-2249.2005.02763.xsubject
Has Abstractpub_date
2005-05-01 00:00:00pages
343-8issue
2eissn
0009-9104issn
1365-2249pii
CEI2763journal_volume
140pub_type
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