Human anti-mouse antibody response to the injection of murine monoclonal antibodies against IL-6.

abstract：:The lymphokine profiles were determined in the skin lesions of the three distinct clinical forms of American cutaneous leishmaniasis (ACL), using a reverse transcriptase polymerase chain reaction (RT-PCR) and primers for various lymphokines. The message for interferon-gamma (IFN-gamma), tumour necrosis factor-beta (TN...

journal_title：Clinical and experimental immunology

authors： Cáceres-Dittmar G,Tapia FJ,Sánchez MA,Yamamura M,Uyemura K,Modlin RL,Bloom BR,Convit J

更新日期：1993-03-01 00:00:00

abstract：:The aim of this study was to investigate the role of IL-12 in patients with RA. IL-12 (p70) and its associated cytokines were measured in sera and synovial fluid (SF) using an enzyme-linked immunosorbent method. Seven American College of Rheumatology (ACR) core set measures as well as IL-12 levels were sequentially mo...

journal_title：Clinical and experimental immunology

authors： Kim W,Min S,Cho M,Youn J,Min J,Lee S,Park S,Cho C,Kim H

更新日期：2000-01-01 00:00:00

abstract：:It has been demonstrated immunohistologically using cryostat sections that the lectins PHA and Con A bind to human placentae. Both lectins stain trophoblastic basement membrane (TBM), perivascular tissue and stroma. No staining of trophoblasts was observed. It has been shown by blocking experiments that the lectin bin...

journal_title：Clinical and experimental immunology

authors： Johnson PM,Faulk WP

更新日期：1976-06-01 00:00:00

abstract：:The predominance of Th2 cytokine-secreting pattern in allergic asthma has been known as a cause and an accelerating factor, and Th1 suppresses these allergic phenomena, but the role of Th0 clones is obscure. Because Th1/Th2 differentiation has been determined by cytokine environment, we investigated how mite-specific ...

journal_title：Clinical and experimental immunology

authors： Yamashita N,Takeno M,Kaneko S,Mizushima Y,Sakane T

更新日期：1997-08-01 00:00:00

abstract：:While most of our understanding of immune dysfunction in dialysis patients involves alterations in CD28-CD80/86 signalling, nothing is known of CD46-mediated co-stimulation of T cells in these patients. Because C3b/C4b bind to CD46 and complement activation occurs during haemodialysis (HD), we addressed whether CD46-m...

journal_title：Clinical and experimental immunology

authors： Brinkkoetter PT,Marinaki S,Gottmann U,Fleckenstein S,Stump C,Van Der Woude FJ,Braun C,Yard BA

更新日期：2005-03-01 00:00:00

abstract：:Lymphocyte subpopulations in thirty-nine patients with the tropical splenomegaly syndrome (TSS) were studied using the E-rosette, EAC rosette and direct immunofluorescent staining techniques. In the peripheral blood a decrease in the percentage of T-lymphocytes was found which was accompanied by an increase in the per...

journal_title：Clinical and experimental immunology

authors： Fakunle YM,Oduloju AJ,Greenwood BM

更新日期：1978-08-01 00:00:00

abstract：:We have investigated the T-cell antigen receptor constant beta and alpha chain genes (TCR-C beta, -C alpha) and the immunoglobulin (Ig) heavy chain switch regions of patients with Graves' disease (GD) using restriction fragment length polymorphism (RFLP) analysis. No significant associations were found with RFLPs of e...

journal_title：Clinical and experimental immunology

authors： Demaine AG,Ratanachaiyavong S,Pope R,Ewins D,Millward BA,McGregor AM

更新日期：1989-07-01 00:00:00

abstract：:Different genetic mutations have been described in complement component C7 deficiency, a molecular defect which is clinically associated with an increased susceptibility to neisserial recurrent infections, although some cases remain asymptomatic. In this work we report the genetic bases of C7 deficiency in one Spanish...

journal_title：Clinical and experimental immunology

authors： Vázquez-Bermúdez MF,Barroso S,Walter K,Alvarez AJ,Alarcón A,López-Trascasa M,Wichmann I,Aguilar F,Núñez-Roldán A,Sánchez B

更新日期：2003-08-01 00:00:00

abstract：:Human thymic stromal lymphopoietin (TSLP) promotes CD4(+) T-cell proliferation both directly and indirectly through dendritic cell (DC) activation. Although human TSLP-activated DCs induce CD8(+) T-cell proliferation, it is not clear whether TSLP acts directly on CD8(+) T cells. In this study, we show that human CD8(+...

journal_title：Clinical and experimental immunology

authors： Akamatsu T,Watanabe N,Kido M,Saga K,Tanaka J,Kuzushima K,Nishio A,Chiba T

更新日期：2008-10-01 00:00:00

abstract：:Nine patients with active systemic lupus erythematosus entered a double-blind randomized trial to study the therapeutic effect of vigorous versus sham reinfusion plasmapheresis. Four of them received real plasmapheresis while five received sham reinfusion plasmapheresis. In the present communication we report the effe...

journal_title：Clinical and experimental immunology

authors： Tsokos GC,Balow JE,Huston DP,Wei N,Decker JL

更新日期：1982-05-01 00:00:00

abstract：:Salivary gland biopsies from 12 patients with primary Sjögren's syndrome and 10 controls were examined for Epstein-Barr virus (EBV) DNA by in-situ hybridization and for EBV proteins by immunofluorescence and peroxidase techniques. Viral DNA was found in biopsies from two out of 12 patients with primary Sjögren's syndr...

journal_title：Clinical and experimental immunology

authors： Venables PJ,Teo CG,Baboonian C,Griffin BE,Hughes RA

更新日期：1989-03-01 00:00:00

abstract：:The La/SSB autoantigen is a major target of long-term humoral autoimmunity in primary Sjögren's Syndrome (SS) and systemic lupus erythematosus. A majority of patients with linked anti-Ro60/Ro52/La responses target an NH2-terminal epitope designated LaA that is expressed on Ro/La ribonucleoprotein complexes and the sur...

journal_title：Clinical and experimental immunology

authors： Thurgood LA,Arentz G,Lindop R,Jackson MW,Whyte AF,Colella AD,Chataway TK,Gordon TP

更新日期：2013-11-01 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) is an X-linked platelet/immunodeficiency disease. The affected gene encodes WASP, a multidomain protein that regulates cytoskeletal assembly in blood cells. Patients have recurring infections, and their lymphocytes exhibit deficient proliferative responses in vitro. We report an evaluati...

journal_title：Clinical and experimental immunology

authors： Park JY,Kob M,Prodeus AP,Rosen FS,Shcherbina A,Remold-O'Donnell E

更新日期：2004-04-01 00:00:00

abstract：:Since thyroid follicular epithelial cells (thyrocytes) have been shown to express a number of functions similar to monocytes, they were further examined for their potency in secreting thymocyte-stimulating activity (TSA). Although spontaneous production of TSA could not be detected when thyrocytes were cultured in the...

journal_title：Clinical and experimental immunology

authors： Hirose W,Kawagoe M,Hara M,Kitani A,Hirose T,Norioka K,Harigai M,Nakamura H

更新日期：1987-10-01 00:00:00

abstract：:We describe the adoptive transfer of erosive arthritis to an immunodeficient host. Spleen cells from arthritic DBA/1 mice (H-2q), immunized 4-6 weeks previously with bovine type II collagen in adjuvant, were transferred intraperitoneally into SCID mice (H-2d). SCID recipient mice also received native or denatured type...

journal_title：Clinical and experimental immunology

authors： Williams RO,Plater-Zyberk C,Williams DG,Maini RN

更新日期：1992-06-01 00:00:00

abstract：:A rabbit antiserum has been prepared using peripheral mononuclear cells from a patient with common variable hypogammaglobulinaemia (CVH) who had demonstrable suppressor cells in vitro. This antiserum (anti-Ck), after absorption with pooled normal glass-non-adherent cells and platelets, showed selective reactivity with...

journal_title：Clinical and experimental immunology

authors： Rizzoli AJ,Bankhurst AD

更新日期：1981-12-01 00:00:00

abstract：:The capacity of microbial products to inhibit allergic inflammation make them logical candidates for novel therapies in allergic diseases such as atopic dermatitis. To assess the effects of intradermal Mycobacterium vaccae derivative on allergen-specific immune responses in children with moderate to severe atopic derm...

journal_title：Clinical and experimental immunology

authors： Dunstan JA,Brothers S,Bauer J,Hodder M,Jaksic MM,Asher MI,Prescott SL

更新日期：2011-06-01 00:00:00

abstract：:We previously demonstrated that high levels of IL-6/sIL-6R complexes are present in sera of patients with systemic juvenile idiopathic arthritis (s-JIA) and that the amount of IL-6 estimated in the IL-6/sIL-6R complexes is markedly higher than that measured by the B9 assay. Here, we show that two additional bioassays,...

journal_title：Clinical and experimental immunology

authors： Pignatti P,Ciapponi L,Galle P,Hansen MB,Massa M,Meazza C,Paonessa G,Novick D,Ciliberto G,Martini A,De Benedetti F

更新日期：2003-02-01 00:00:00

abstract：:Immune repopulation, despite virological failure, often occurs in children under highly active anti-retroviral therapy (HAART). The aim of this study was to analyse the characteristics of immune repopulation and activation in children with and without virological response to HAART. Fourteen human immunodeficiency viru...

journal_title：Clinical and experimental immunology

authors： Anselmi A,Vendrame D,Rampon O,Giaquinto C,Zanchetta M,De Rossi A

更新日期：2007-12-01 00:00:00

abstract：:Recent studies have suggested that a high percentage of Epstein-Barr virus (EBV)-infected lymphocytes in peripheral blood of patients with chronic, active EBV infection (CAEBV) is of T cell origin. Although T cells are expanded oligoclonally in CAEBV, it is not clear whether the restricted diversity of T cells arise f...

journal_title：Clinical and experimental immunology

authors： Toyabe S,Harada W,Uchiyama M

更新日期：2003-10-01 00:00:00

abstract：:Interleukin-6 (IL-6, BSF-2 or IFN-beta 2) is thought to be the major regulator of the acute-phase protein response that follows tissue injury and inflammation, with interleukin-1 (IL-1), tumour necrosis factor and more recently, LIF or HSF III, slightly stimulatory on only certain acute phase proteins. The synthesis o...

journal_title：Clinical and experimental immunology

authors： Raynes JG,Eagling S,McAdam KP

更新日期：1991-03-01 00:00:00

abstract：:Previous findings have indicated that the major surface molecule of Leishmania, lipophosphoglycan (LPG), could abrogate HIV-1-induced syncytium formation and virus replication. In the present work, we were interested in characterizing this inhibitory process. Data from a new luciferase-based semiquantitative assay for...

journal_title：Clinical and experimental immunology

authors： Genois N,Barbeau B,Olivier M,Tremblay MJ

更新日期：2001-04-01 00:00:00

abstract：:Depression of one or more parameters of cellular and/or humoral immune responses was found in 60% of general hospital patients treated with phenytoin and 47% of patients treated with carbamazepine. Phenytoin-treated patients failed to manifest delayed hypersensitivity (DHS) reactions to common antigens, and to make an...

journal_title：Clinical and experimental immunology

authors： Sorrell TC,Forbes IJ

更新日期：1975-05-01 00:00:00

abstract：:A full-length cDNA coding a human beta 2-glycoprotein I (beta 2-GPI) was introduced into the baculovirus genome to construct a recombinant baculovirus. Spodoptera frugiperda (Sf9) cells were infected with the recombinant baculovirus. A protein (mol. wt 43,000) reactive with anti-beta 2-GPI antisera was produced in the...

journal_title：Clinical and experimental immunology

authors： Igarashi M,Matsuura E,Igarashi Y,Nagae H,Matsuura Y,Ichikawa K,Yasuda T,Voelker DR,Koike T

更新日期：1993-07-01 00:00:00

abstract：:The chronic fatigue syndrome (CFS) is characterized by severe persistent fatigue and neuropsychiatric symptoms. It has been proposed that the abnormalities in cell-mediated immunity which have been documented in patients with CFS may be attributable to a clinical depression, prevalent in patients with this disorder. C...

journal_title：Clinical and experimental immunology

authors： Lloyd A,Hickie I,Hickie C,Dwyer J,Wakefield D

更新日期：1992-01-01 00:00:00

abstract：:Several studies in murine systems have suggested a role of apoptosis in the pathogenesis of leishmaniasis. However, the role of apoptosis in visceral leishmaniasis in man has not been explored. In this study, we show that patients with visceral leishmaniasis demonstrate significant dysregulation of Fas and Fas ligand....

journal_title：Clinical and experimental immunology

authors： Eidsmo L,Wolday D,Berhe N,Sabri F,Satti I,El Hassan AM,Sundar S,Chiodi F,Akuffo H

更新日期：2002-11-01 00:00:00

abstract：:CD4+ lymphocytes are a primary target of the human immunodeficiency virus (HIV), and CD4 counts are one of the factors used to measure disease progression in HIV-positive individuals. CD4 counts vary in uninfected individuals and across populations due to a variety of demographic, environmental, immunological and gene...

journal_title：Clinical and experimental immunology

authors： Mair C,Hawes SE,Agne HD,Sow PS,N'doye I,Manhart LE,Fu PL,Gottlieb GS,Kiviat NB

更新日期：2008-03-01 00:00:00

abstract：:A system has been established to produce in vitro IgG specific for cell wall determinants of S. aureus by human peripheral blood mononuclear cells (PBMC). PBMC of healthy individuals, of patients with S. aureus infections and of patients with other bacterial infections were cultured for 12 days. In the culture superna...

journal_title：Clinical and experimental immunology

authors： Hauser C,Wilhelm JA,Matter L,Schopfer K

更新日期：1984-07-01 00:00:00

abstract：:In the present study we examined the role of thymic stromal lymphopoietin (TSLP) in experimental autoimmune encephalomyelitis (EAE). Here, we report that TSLP knock-out (KO) mice display a delayed onset of disease and an attenuated form of EAE. This delayed onset was accompanied by a reduced number of encephalitogenic...

journal_title：Clinical and experimental immunology

authors： Eckhardt J,Döbbeler M,König C,Kuczera K,Kuhnt C,Ostalecki C,Zinser E,Mak TW,Steinkasserer A,Lechmann M

更新日期：2015-07-01 00:00:00

abstract：:Antibody responses in immunoglobulin G1, G2, G3, G4, A (IgA1) and M isotypes were studied in 10 patients with an acute influenza A and in another 10 patients with a parainfluenza type 1 virus infection using radioimmunoassay with standardized monoclonal anti-immunoglobulins. A four-fold or greater increase of antibody...

journal_title：Clinical and experimental immunology

authors： Julkunen I,Hovi T,Seppälä I,Mäkelä O

更新日期：1985-04-01 00:00:00