Abstract：
:The aim of this study was to investigate the role of IL-12 in patients with RA. IL-12 (p70) and its associated cytokines were measured in sera and synovial fluid (SF) using an enzyme-linked immunosorbent method. Seven American College of Rheumatology (ACR) core set measures as well as IL-12 levels were sequentially monitored at the commencement and 4 months after treatment with a low-dose steroid and disease-modifying anti-rheumatic drugs (DMARDs). In sera, 64 (42.2%) of 152 RA patients had detectable concentrations of IL-12 (p70), whereas one (1.4%) of 69 osteoarthritis (OA) patients and five (10%) of 50 healthy controls had detectable IL-12 (P < 0.001). The median level of circulating IL-12 was also higher in RA patients (P < 0.001). In SF, the number of patients with detectable IL-12 and the median IL-12 levels were significantly higher in RA patients (n = 53) than in OA patients (n = 22). In paired samples (n = 53) of sera and SF from RA patients, IL-12 levels were higher in the SF than in sera (P < 0.001). Patients with detectable IL-12 (n = 51) in sera had higher tender joint scores (P = 0.003), swollen joint scores (P < 0.001) and C-reactive protein (CRP; P = 0.036), than those without (n = 55). Four months after treatment with DMARDs, the improved group showed a larger IL-12 decrease than the non-improved group (P = 0.017). The levels of IL-12 correlated positively with those of IL-2, interferon-gamma, IL-6, and tumour necrosis factor-alpha, but were correlated inversely with those of IL-10. Our results demonstrate that IL-12 levels reflect RA disease activity and that IL-12 is involved in the production of proinflammatory cytokines. An IL-12 blockade could be useful for the treatment of RA.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Kim W,Min S,Cho M,Youn J,Min J,Lee S,Park S,Cho C,Kim Hdoi
10.1046/j.1365-2249.2000.01095.xsubject
Has Abstractpub_date
2000-01-01 00:00:00pages
175-81issue
1eissn
0009-9104issn
1365-2249pii
cei1095journal_volume
119pub_type
杂志文章abstract：:Incubation with thymosin fraction 5, (TMS F5 at 300 micrograms/ml) a partially purified thymic factor, reduced the steroid binding activity of human infant thymocytes from 9.6 +/- 2.1 fmole/ml to 5.0 +/- 2.0 fmole/ml. The glucocorticoid receptor activity in normal infant thymocytes was found to be 2,146 +/- 726 (s.d.)...
journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1984-02-01 00:00:00
abstract：:Adoptive immunotherapy with in vitro expanded antigen-specific cytotoxic T lymphocytes (CTLs) may be an effective approach to prevent, or even treat, Aspergillus (Asp) infections. Such lines can be generated using monocyte-derived dendritic cells (DC) as antigen-presenting cells (APC) but requires a relatively high vo...
journal_title：Clinical and experimental immunology
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：10.1111/cei.12787
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章,多中心研究
doi：10.1111/cei.12866
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
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abstract：:Autoimmunity may contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). Studies have identified disease-specific autoantibodies (DSAAbs) in COPD patients, but natural autoantibodies (NAAbs) may also play a role. Previous studies have concentrated on circulating autoantibodies, but lung-associa...
journal_title：Clinical and experimental immunology
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2015-04-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1987-03-01 00:00:00
abstract：:We report the immunological studies on three transplantable lymphoma lines that developed when CAF1 mice were injected with busulfan and chloramphenicol. The lymphoma cells displayed Thy-1.2, brain associated antigen, and H-2d alloantigen. They were negative for surface IgM and Ia antigens. Expression of T cell differ...
journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type：
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更新日期：2012-04-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Comparisons of the results obtained in a study of fifty-two patients with genitourinary malignancies using three assays to monitor the thymus-dependent immune system (delayed cutaneous hypersensitivity to DNCB, PHA-induced lymphocyte blastogenesis, and peripheral blood E rosette-forming lymphocyte counts) yielded stat...
journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1975-02-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1980-11-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
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更新日期：2011-07-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
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journal_title：Clinical and experimental immunology
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doi：10.1111/j.1365-2249.1994.tb06560.x
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journal_title：Clinical and experimental immunology
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
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journal_title：Clinical and experimental immunology
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1982-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-03-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1984-05-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Clinical and experimental immunology
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
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更新日期：1991-07-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Recently we showed the in vivo relevance of chemokines in cases of bacterial peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients. Mesothelial cells, the most numerous cells in the peritoneal cavity, are hypothesized to function as a main source of chemokine production. We investigated the time- an...
journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2249.1998.00592.x
更新日期：1998-05-01 00:00:00
