Successful transfer of collagen-induced arthritis to severe combined immunodeficient (SCID) mice.

abstract：:To define glucocorticoid (GC)-regulated genes contributing to the anti-inflammatory and immunosuppressive effects of GC, previous work from our laboratory revealed up-regulation of transcripts from endogenous type B mouse mammary tumour virus (Mtv) and type C murine leukaemia virus (Emv) loci by high dose GC treatment...

journal_title：Clinical and experimental immunology

authors： Fiegl M,Strasser-Wozak E,Geley S,Gsur A,Drach J,Kofler R

更新日期：1995-08-01 00:00:00

abstract：:Cellular sensitization to rabbit liver specific lipoprotein (RLSP) has been investigated using a lymphocyte transformation test in patients with chronic active hepatitis (CAH). A stimulation index greater than 2 was recorded in twenty out of twenty-five cases (eight of ten HBsAg positive and twelve of fiteen HBsAg neg...

journal_title：Clinical and experimental immunology

authors： Ortona L,Laghi V,Cauda R,Nervo P

更新日期：1979-11-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4), which recognizes lipopolysaccharides, plays an important role in the innate immune response. In this study, we investigated the role of TLR4 in the development of experimental colitis with regard to the biological actions of macrophage migration inhibitory factor (MIF) using TLR4 null ((-/...

journal_title：Clinical and experimental immunology

authors： Ohkawara T,Takeda H,Nishihira J,Miyashita K,Nihiwaki M,Ishiguro Y,Takeda K,Akira S,Iwanaga T,Sugiyama T,Asaka M

更新日期：2005-09-01 00:00:00

abstract：:The effects of cyclophosphamide an antinuclear antibody levels, immune complex deposition in renal glomeruli, glomerular cell proliferation and glomerulosclerosis in the (NZB x NZW)F1 hybrid mouse have been investigated in order to better understand the mechanism of action of this drug on nephritis. Five groups of mic...

journal_title：Clinical and experimental immunology

authors： Hurd ER,Ziff M

更新日期：1977-07-01 00:00:00

abstract：:This report is focused on the functional capacity of Langerhans cells (LC) in the epithelium of skin and oral mucosa, which both meet different antigenic challenges. The capacity of LC from human oral and skin epithelium to provide co-stimulatory signals to T cells in vitro was compared. LC in a crude suspension of or...

journal_title：Clinical and experimental immunology

authors： Hasséus B,Jontell M,Bergenholtz G,Dahlgren UI

更新日期：2004-06-01 00:00:00

abstract：:Podocytes, the main target of immune complex, participate actively in the development of glomerular injury as immune cells. Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is an innate immune molecular that has an immune recognition function, and is involved in mediation of ce...

journal_title：Clinical and experimental immunology

authors： Cai M,Zhou T,Wang X,Shang M,Zhang Y,Luo M,Xu C,Yuan W

更新日期：2016-03-01 00:00:00

abstract：:Normal T cells bearing receptors for the Fc portion of IgG that were incubated in anti-RNP or anti-DNA at the time of activation with phytohaemagglutinin showed different effects on this activation as determined by flow cytometric analysis of acridine orange stained cells. Incubation in anti-RNP caused an arrest in th...

journal_title：Clinical and experimental immunology

authors： Alarcón-Segovia D,Llorente L

更新日期：1983-05-01 00:00:00

abstract：:A complete functional deficiency of C1q is described in a patient suffering from SLE. From reduced plasma C1 activity of the parents a hereditary trait was assumed. The defective C1q molecule was haemolytically inactive, did not bind to immune complexes, and was not recognized by the monocyte C1q receptor. C1 activity...

journal_title：Clinical and experimental immunology

authors： Kirschfink M,Petry F,Khirwadkar K,Wigand R,Kaltwasser JP,Loos M

更新日期：1993-11-01 00:00:00

abstract：:Previous studies show that endoplasmic reticulum-associated aminopeptidase (ERAP1/ERAP2) and runt-related transcription factor 3 (RUNX3) gene polymorphisms are associated with AS (ankylosing spondylitis) in European Caucasians. However, contradictory results were reported in different Asian populations. The purpose of...

journal_title：Clinical and experimental immunology

authors： Su W,Du L,Liu S,Deng J,Cao Q,Yuan G,Kijlstra A,Yang P

更新日期：2018-07-01 00:00:00

abstract：:The circulating and cervical B cell responses to Chlamydia trachomatis plasmid protein pgp3 were characterized in children and adults with ocular or genital chlamydial infection using the enzyme-linked immunospot assay (ELISPOT) and ELISA. No pgp3-specific ASCs were detected in healthy controls, but predominantly IgA ...

journal_title：Clinical and experimental immunology

authors： Ghaem-Maghami S,Ratti G,Ghaem-Maghami M,Comanducci M,Hay PE,Bailey RL,Mabey DC,Whittle HC,Ward ME,Lewis DJ

更新日期：2003-06-01 00:00:00

abstract：:Successful T cell activation via the T cell receptor (TCR)/CD3 complex requires at least one contact-dependent second signal delivered by costimulatory molecules, including the B7/BB1 molecule, that are present on antigen-presenting cells (APC). SLE is characterized by multiple complex lymphocyte abnormalities of unde...

journal_title：Clinical and experimental immunology

authors： Sfikakis PP,Oglesby R,Sfikakis P,Tsokos GC

更新日期：1994-04-01 00:00:00

abstract：:Human T-cell lines (MOLT-4 and SOMMER-T) were injected into rabbits and monkeys (stumptail and squirrel monkeys). Rabbit anti-MOLT serum was absorbed with human liver and cultured B cells. Absorbed anti-MOLT serum was cytotoxic to lymphocytes of baboons and stumptail monkeys. Rabbit anti-MOLT and SOMMER-T sera after a...

journal_title：Clinical and experimental immunology

authors： Takada A,Babbitt H,Hayata I,Takada Y

更新日期：1976-04-01 00:00:00

abstract：:Dogs can develop systemic lupus erythematosus syndromes that are clinically similar to those seen in humans. In contrast, previous observations suggest differences in their autoantibody reactivity patterns against histones and DNA which are components of the nucleosome in chromatin. The objective of this study was to ...

journal_title：Clinical and experimental immunology

authors： Monestier M,Novick KE,Karam ET,Chabanne L,Monier JC,Rigal D

更新日期：1995-01-01 00:00:00

abstract：:The CXC chemokines, monokine induced by interferon (IFN)-gamma (MIG) (CXCL9), IFN-gamma-induced protein 10 (IP-10) (CXCL10) and IFN-inducible T cell alpha chemoattractant (I-TAC) (CXCL11), are known to attract CXCR3- (CXCR3A and CXCR3B) T lymphocytes. We investigated MIG, IP-10 and I-TAC mRNAs expression by semi-quant...

journal_title：Clinical and experimental immunology

authors： Manousou P,Kolios G,Drygiannakis I,Koulentaki M,Pyrovolaki K,Voumvouraki A,Notas G,Bourikas L,Papadaki HA,Kouroumalis E

更新日期：2013-04-01 00:00:00

abstract：:The reproducibility of a simplified, sensitive and rapid agarose-cell droplet assay for leucocyte migration inhibition factor (LIF) activity was studied. Removal of T cells with anti-T-cell serum eliminated LIF activity, indicating that in humans it is probably the T cell that produces LIF. Cord blood lymphocytes prod...

journal_title：Clinical and experimental immunology

authors： Hahn T,Levin S,Handzel ZT

更新日期：1976-06-01 00:00:00

abstract：:Circulating immunoglobulin (Ig)G antibodies against M(2) muscarinic acetylcholine receptors (M(2) mAChR) have been implicated in Chagas' disease (ChD) pathophysiology. These antibodies bind to and activate their target receptor, displaying agonist-like activity through an unclear mechanism. This study tested the abili...

journal_title：Clinical and experimental immunology

authors： Beltrame SP,Auger SR,Bilder CR,Waldner CI,Goin JC

更新日期：2011-05-01 00:00:00

abstract：:Type 1 diabetes (T1D) is often considered the prototype organ-specific autoimmune disease in clinical immunology circles. The key disease features - precise destruction of a single endocrine cell type occurring on a distinct genetic and autoimmune background - have been unravelled in recent years to such an extent tha...

journal_title：Clinical and experimental immunology

authors： Staeva-Vieira T,Peakman M,von Herrath M

更新日期：2007-04-01 00:00:00

abstract：:The role of suppressive anti-retroviral therapy (ART) in eliciting restoration of dysregulated immune function remains unclear in HIV-1 infection. Also, due to tailoring of therapeutic regimens towards HIV-1, this possible impairment of therapy may be even more pronounced in HIV-2 and dual (HIV-D) infection. Thus, we ...

journal_title：Clinical and experimental immunology

authors： Salwe S,Padwal V,Nagar V,Patil P,Patel V

更新日期：2019-11-01 00:00:00

abstract：:Based on what is known about the biology of HIV-1 vertical transmission, the HIV burden of the mother, maternal immune factors and the integrity of the placental barrier are likely to play major roles. We therefore sought to determine whether the presence of antibodies in sera from 47 HIV-1-infected mothers, including...

journal_title：Clinical and experimental immunology

authors： Mabondzo A,Rouvier P,Raoul H,Le Naour R,Courpotin C,Hervé F,Parnet-Mathieu F,Lasfargues G,Dormont D

更新日期：1995-12-01 00:00:00

abstract：:Endothelial cells (ECs) are a target in inflammation, and the death of EC is regulated by various factors. Although intravenous immunoglobulin (IVIG) preparations are known to be beneficial therapeutic agents for the treatment of autoimmune diseases and systemic inflammatory disorders, their mechanism of action have n...

journal_title：Clinical and experimental immunology

authors： Nakatani K,Takeshita S,Tsujimoto H,Sekine I

更新日期：2002-03-01 00:00:00

abstract：:Human red cells (RBC) coated with IgG anti-D are cleared from the circulation to the spleen by macrophages which express IgG receptors (Fcgamma R). Polymorphisms of Fcgamma RIIa and Fcgamma RIIIa affect IgG binding in vitro, and may alter the efficiency of clearance of immune complexes in vivo. In a RBC clearance stud...

journal_title：Clinical and experimental immunology

authors： Kumpel BM,De Haas M,Koene HR,Van De Winkel JG,Goodrick MJ

更新日期：2003-04-01 00:00:00

abstract：:T and B cell function, in particular IgD production in vitro, were studied across the spectrum of HIV infection in homosexual men and compared with seronegative homosexual and heterosexual male controls. Proliferation to phytohaemagglutinin (PHA) was reduced most strikingly in symptomatic HIV infection; it was also im...

journal_title：Clinical and experimental immunology

authors： Rogers LA,Forster SM,Pinching AJ

更新日期：1989-01-01 00:00:00

abstract：:Bone marrow (BM) lymphocytes were obtained by sucrose density gradient centrifugation of the nucleated cells from adult human BM. BM was obtained from rib sections removed routinely during thoracotomy from thirteen patients with a localized lung tumour and from two other patients without tumour (mean age 47 years). Th...

journal_title：Clinical and experimental immunology

authors： De Gast GC,Platts-Mills TA

更新日期：1979-10-01 00:00:00

abstract：:Significant levels of EAC-rosette inhibition compared to control subjects were found in the sera of patients with focal and segmental hyalinosis (FSH), membranoproliferative glomerulonephritis (MPGN) and extra-membranous glomerulonephritis (EGN). In patients with IgA disease, although some sera produced high levels of...

journal_title：Clinical and experimental immunology

authors： Smith MD,Verroust PJ,Adam C,Galceran M,Morel-Maroger L

更新日期：1977-12-01 00:00:00

abstract：:Neutrophil phagocytosis and killing of Candida albicans were examined using a radiometric assay in 25 patients with insulin-dependent diabetes and 17 controls under various in vitro metabolic conditions. Glucose was present at 5, 10 and 50 mM, beta-hydroxybutyrate at 1, 5 and 20 mM and glucose with beta-hydroxybutyrat...

journal_title：Clinical and experimental immunology

authors： Wilson RM,Reeves WG

更新日期：1986-02-01 00:00:00

abstract：:Experiments to evaluate the effect of the level and duration of endotoxaemia on the meningeal inflammatory response were performed in order to determine if systemic inflammation alters meningitis. Rabbits received either saline or Escherichia coli O111:B4 lipopolysacharide (LPS) intravenously at various doses (1, 3 or...

journal_title：Clinical and experimental immunology

authors： O'Reilly T,Ostergaard C,Vaxelaire J,Zak O

更新日期：2007-01-01 00:00:00

abstract：:Previous studies have shown that neutralization of macrophage migration inhibitory factor (MIF) by anti-MIF antibody reduces intestinal inflammation in mice. In this study we tested whether or not anti-MIF autoantibody induced by DNA vaccine targeting MIF protects mice against experimental colitis. Mice were administe...

journal_title：Clinical and experimental immunology

authors： Ohkawara T,Koyama Y,Onodera S,Takeda H,Kato M,Asaka M,Nishihira J

更新日期：2011-01-01 00:00:00

abstract：:Elevated levels of IgA containing circulating immune complexes (IgA-CIC) and IgG containing (IgG-) CIC were detected in patients with obstructive jaundice due to biliary tract stones and/or tumour of biliary tract or pancreas. Levels of serum IgA were also elevated, and correlated with the levels of IgA-CIC. The level...

journal_title：Clinical and experimental immunology

authors： Ohshio G,Furukawa F,Sekita K,Manabe T,Tobe T,Hamashima Y

更新日期：1985-02-01 00:00:00

abstract：:An immunoglobulin phage display library constructed from a tumour-associated pericolic lymph node was panned against the extracellular domain of the oncoprotein c-erbB-2. Sixteen independent clones were confirmed as positive binders based on ELISA analysis of soluble Fabs. Nucleotide sequencing demonstrated that the V...

journal_title：Clinical and experimental immunology

authors： Clark MA,Hawkins NJ,Papaioannou A,Fiddes RJ,Ward RL

更新日期：1997-07-01 00:00:00

abstract：:The prevalence of atopic diseases in children has increased during the last decades. Atopic symptoms usually appear early in life. This implies an early priming for atopic disease, possibly even at the fetal level. We therefore compared the presence and production of IgE in the local in utero environment during pregna...

journal_title：Clinical and experimental immunology

authors： Sverremark Ekstrom E,Nilsson C,Holmlund U,van der Ploeg I,Sandstedt B,Lilja G,Scheynius A

更新日期：2002-02-01 00:00:00