Antibody penetration into living cells. IV. Different effects of anti-native DNA and anti-ribonucleoprotein IgG on the cell cycle of activated T gamma cells.

abstract：:Human thymic stromal lymphopoietin (TSLP) promotes CD4(+) T-cell proliferation both directly and indirectly through dendritic cell (DC) activation. Although human TSLP-activated DCs induce CD8(+) T-cell proliferation, it is not clear whether TSLP acts directly on CD8(+) T cells. In this study, we show that human CD8(+...

journal_title：Clinical and experimental immunology

authors： Akamatsu T,Watanabe N,Kido M,Saga K,Tanaka J,Kuzushima K,Nishio A,Chiba T

更新日期：2008-10-01 00:00:00

abstract：:In order to gain information about the nature of the defect in X-linked severe combined immunodeficiency (XSCID), we investigated gene expression in different lymphoid and haematopoietic cells of female carriers by looking for non-random X chromosome usage. We have shown non-random X chromosome usage in T lymphocyte e...

journal_title：Clinical and experimental immunology

authors： Goodship J,Malcolm S,Levinsky RJ

更新日期：1991-01-01 00:00:00

abstract：:Activation of human umbilical vein endothelial (HUVE) cells with the inflammatory mediators tumour necrosis factor-alpha (TNF), interleukin-1 (IL-1), lipopolysaccharide (LPS) and phorbol esters enhanced their adhesiveness for leucocytes. The appearance of an activation antigen ELAM-1, recognized by a monoclonal antibo...

journal_title：Clinical and experimental immunology

authors： Leeuwenberg JF,Jeunhomme GM,Buurman WA

更新日期：1990-09-01 00:00:00

abstract：:Neutrophils are often exclusively considered as a first-line innate immune defence, able to rapidly kill or trap pathogens and causing in case of over-activation tissue damage. In the female reproductive tract, however, the presence and activity of neutrophils seems to be tightly regulated. Major players in orchestrat...

journal_title：Clinical and experimental immunology

authors： Hahn S,Hasler P,Vokalova L,van Breda SV,Lapaire O,Than NG,Hoesli I,Rossi SW

更新日期：2019-10-01 00:00:00

abstract：:In ANCA-associated vasculitis the activation of primed leucocytes by autoantibodies with subsequent release of proteases such as myeloperoxidase (MPO), proteinase 3 (PR3) and elastase is thought to play an important pathogenetic role. Whether these proteases contribute to the vascular lesions by stimulating the procoa...

journal_title：Clinical and experimental immunology

authors： Haubitz M,Gerlach M,Kruse HJ,Brunkhorst R

更新日期：2001-12-01 00:00:00

abstract：:Macrophages separated from lavage samples obtained from lungs removed at transplantation from patients with cystic fibrosis (CF) and other lung diseases, have been compared with circulating monocytes from the same patients for their ability to stimulate allogeneic normal circulating lymphocytes and to present antigen ...

journal_title：Clinical and experimental immunology

authors： Knight RA,Kollnberger S,Madden B,Yacoub M,Hodson ME

更新日期：1997-03-01 00:00:00

abstract：:We have shown previously that IgG2a anti-Thy-1 MoAb (ER4G) induces apoptosis of rat mesangial cells (GMC) in vitro. Since the classical complement pathway plays an essential role in Thy-1 nephritis, we analysed whether C1q, a subunit of the first component of complement, enhances the ER4G-mediated apoptosis of rat GMC...

journal_title：Clinical and experimental immunology

authors： Sato T,van Dixhoorn MG,Heemskerk E,van Es LA,Daha MR

更新日期：1997-09-01 00:00:00

abstract：:Serum from 98 Thai adults infected with Plasmodium falciparum were examined for the presence of autoantibodies. Malarial containing antibodies sera were also revealed positive for anti-nuclear antibodies with fluorescence speckled pattern, anti-smooth muscle antibodies, anti-mitochondria antibodies and rheumatoid fact...

journal_title：Clinical and experimental immunology

authors： Boonpucknavig S,Ekapanyakul G

更新日期：1984-10-01 00:00:00

abstract：:The effect of various exogenous cells on the in-vitro PWM stimulation of immunoglobulin synthesis by normal human peripheral blood mononuclear cells was investigated. The accessory cells tested were bovine and human endothelial cells, bovine and human fibroblasts, normal human monocytes, and a monocyte cell line U937....

journal_title：Clinical and experimental immunology

authors： King MA,Roche WR,Nelson DS

更新日期：1986-09-01 00:00:00

abstract：:The modulatory effect of human milk proteins from colostrum and late milk on the proliferative response of human T lymphocytes activated by mitogens (OKT3 and leucoagglutinin from Phaseolus vulgaris) and alloantigens was studied. High concentrations (10-100 micrograms/ml) of crude colostral milk proteins had an inhibi...

journal_title：Clinical and experimental immunology

authors： Mincheva-Nilsson L,Hammarström ML,Juto P,Hammarström S

更新日期：1990-03-01 00:00:00

abstract：:The immunoregulatory role of histamine is presumably mediated by specific receptors on the plasma membrane of lymphocytes. However, using murine spleen cells and a whole cell assay commonly applied in hormone receptor studies, specific histamine receptors with an affinity higher than that of non-specific binding could...

journal_title：Clinical and experimental immunology

authors： Wang Y,Kristensen F,Joncourt F,Slauson DO,De Weck AL

更新日期：1983-11-01 00:00:00

abstract：:The introduction of 25 mg of a new protein antigen into the diets of mice produced transient increases in PVP clearance which reached a maximum 60 hr after the change of diet and had disappeared by 4 days. At the same time the immune responsiveness to unrelated antigens given parenterally was also raised transiently, ...

journal_title：Clinical and experimental immunology

authors： Newby TJ,Stokes CR,Bourne FJ

更新日期：1980-02-01 00:00:00

abstract：:Skin nuclear speckled IgG deposition was noted in seven patients. The patients' clinical courses satisfied at least four of the preliminary criteria of the American Rheumatism Association for the diagnosis of systemic lupus erthematosus (SLE). Examination of approximately 700 additional biopsies from patiets with SLE,...

journal_title：Clinical and experimental immunology

authors： Shu S,Provost T,Croxdale MB,Reichlin M,Beutner EH

更新日期：1977-02-01 00:00:00

abstract：:Serum specimens from 66 HIV-1-infected subjects were tested by ELISA for the presence of IgA antibodies to HIV-1: 44 samples were found positive and 37 were confirmed by immunoblot. In these subjects, the presence of anti-HIV IgA antibodies was studied in relation to the total count of circulating CD4+ lymphocytes and...

journal_title：Clinical and experimental immunology

authors： Quesnel A,Pozzetto B,Moja P,Grattard F,Lucht FR,Touraine JL,Gaudin OG,Genin C

更新日期：1993-02-01 00:00:00

abstract：:Premature atherosclerosis has been observed during the course of different systemic inflammatory diseases such as rheumatoid arthritis and sytemic lupus erythematosus. Remarkably, relatively few studies have been published on the occurrence of accelerated atherosclerosis in patients with vasculitis. In giant cell arte...

journal_title：Clinical and experimental immunology

authors： Tervaert JW

更新日期：2009-06-01 00:00:00

abstract：:An association between mannan-binding lectin (MBL) status and severity of lung function impairment in cystic fibrosis (CF) has been found in several studies, but not in others. To explore the possible basis for discrepancies in the literature, we related both MBL and L-ficolin concentrations to lung function and exami...

journal_title：Clinical and experimental immunology

authors： Muhlebach MS,MacDonald SL,Button B,Hubbard JJ,Turner ML,Boucher RC,Kilpatrick DC

更新日期：2006-08-01 00:00:00

abstract：:Pneumocystis carinii is a major opportunistic pathogen and leading cause of morbidity in patients with AIDS. The major surface glycoprotein (MSG) of P. carinii, represented by a family of related proteins encoded by unique genes, is highly immunogenic and contains T cell-protective epitopes. We undertook the present s...

journal_title：Clinical and experimental immunology

authors： Theus SA,Smulian AG,Sullivan DW,Walzer PD

更新日期：1997-08-01 00:00:00

abstract：:The purpose of the present study was to elucidate the role of oestrogen in the pathogenesis of Mycobacterium avium complex (MAC) pulmonary disease, which occurs most frequently in postmenopausal women. The study was carried out in a murine infectious model using ovariectomized DBA/2 female mice. Infection with MAC was...

journal_title：Clinical and experimental immunology

authors： Tsuyuguchi K,Suzuki K,Matsumoto H,Tanaka E,Amitani R,Kuze F

更新日期：2001-03-01 00:00:00

abstract：:Antibody levels specific for capsular polysaccharides of Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) and to tetanus toxoid (TT), were measured in serum samples of 750 age-stratified subjects from the UK. The study subjects comprised healthy adult volunteers and hospitalized children undergoing ele...

journal_title：Clinical and experimental immunology

authors： Hazlewood M,Nusrat R,Kumararatne DS,Goodall M,Raykundalia C,Wang DG,Joyce HJ,Milford-Ward A,Forte M,Pahor A

更新日期：1993-08-01 00:00:00

abstract：:Human peripheral blood lymphocytes injected intradermally into X-ray immunosuppressed mice were tested for angiogenesis-inducing capacity. Both T and B lymphocytes evoked angiogenesis of the same intensity. The total T cell population was fractionated into three subpopulations on the basis of their different affinitie...

journal_title：Clinical and experimental immunology

authors： Kamiński MJ,Nowacyk M,Skopińska-Rozewska E,Kamińska G,Bem W

更新日期：1981-11-01 00:00:00

abstract：:The lectin pathway of complement activation is used by a collectin, mannan-binding lectin (MBL), and two ficolins, L-ficolin and H-ficolin, to opsonize microorganisms for phagocytosis. We published evidence recently that MBL insufficiency is associated with recurrent respiratory infections in childhood. We have now me...

journal_title：Clinical and experimental immunology

authors： Atkinson AP,Cedzynski M,Szemraj J,St Swierzko A,Bak-Romaniszyn L,Banasik M,Zeman K,Matsushita M,Turner ML,Kilpatrick DC

更新日期：2004-12-01 00:00:00

abstract：:Anaemia of chronic disease (ACD) is frequently found in rheumatoid arthritis (RA). In the pathogenesis of ACD both cytokines, such as tumour necrosis factor-alpha (TNF-alpha), IL-1 and IL-6 as well as a relative deficiency of erythropoietin (EPO), are thought to play a key role. In the present study the role of IL-6 i...

journal_title：Clinical and experimental immunology

authors： Jongen-Lavrencic M,Peeters HR,Rozemuller H,Rombouts WJ,Martens AC,Vreugdenhil G,Pillay M,Cox PH,Bijser M,Brutel G,Breedveld FC,Swaak AJ

更新日期：1996-02-01 00:00:00

abstract：:The clinical use of dendritic cells (DCs) to induce antigen-specific immune tolerance has been hampered by the lack of a widely acknowledged method for generating human regulatory DCs but even more so by the non-existence of reliable markers. Thus, we set out to find reliable markers that can be measured with simple m...

journal_title：Clinical and experimental immunology

authors： Pedersen AW,Holmstrøm K,Jensen SS,Fuchs D,Rasmussen S,Kvistborg P,Claesson MH,Zocca MB

更新日期：2009-07-01 00:00:00

abstract：:Haematopoietic stem cell transplantation (HSCT) is an immunological treatment that has been used for more than 40 years to cure a variety of diseases. The procedure is associated with serious side effects, due to the severe impairment of the immune system induced by the treatment. After a conditioning regimen with hig...

journal_title：Clinical and experimental immunology

authors： Bemark M,Holmqvist J,Abrahamsson J,Mellgren K

更新日期：2012-01-01 00:00:00

abstract：:Delayed hypersensitivity skin reactions to tuberculin when injected alone or in mixture with antigens of M. leprae were examined in leprosy patients and in healthy controls. The tuberculin reaction was significantly inhibited in more than one half of both LL and BT patients by the soluble extract of M. leprae (leprosi...

journal_title：Clinical and experimental immunology

authors： Sengupta U,Sinha S,Ramu G,Lamb J,Ivanyi J

更新日期：1987-04-01 00:00:00

abstract：:Groups of subjects during acute (0-3 days) and convalescent (2-3 weeks) phase of recurrent herpes labialis (RHL), and other subjects seropositive or seronegative for herpes simplex virus type 1 (HSV-1) antibody without any history of RHL, were tested for the appearance of cell-mediated cytotoxic responses by stimulati...

journal_title：Clinical and experimental immunology

authors： Tsutsumi H,Bernstein JM,Riepenhoff-Talty M,Cohen E,Orsini F,Ogra PL

更新日期：1986-12-01 00:00:00

abstract：:Human thymoma is a thymic epithelial cell tumour which often contains a large number of immature T cells and is frequently associated with autoimmune diseases. Since thymic epithelial cells play key roles in the development and selection of T cells in the normal thymus, we hypothesized that the neoplastic thymic epith...

journal_title：Clinical and experimental immunology

authors： Inoue M,Fujii Y,Okumura M,Takeuchi Y,Shiono H,Miyoshi S,Matsuda H,Shirakura R

更新日期：1998-06-01 00:00:00

abstract：:Autoreactivity to heat shock protein 60 (Hsp60) has been implicated in the pathogenesis and regulation of chronic inflammation, especially in autoimmune diseases. In transplantation, there is a lack of information regarding the cytokine profile and specificity of cells that recognize self-Hsp60 as well as the kinetics...

journal_title：Clinical and experimental immunology

authors： Caldas C,Luna E,Spadafora-Ferreira M,Porto G,Iwai LK,Oshiro SE,Monteiro SM,Fonseca JA,Lemos F,Hammer J,Ho PL,Kalil J,Coelho V

更新日期：2006-10-01 00:00:00

abstract：:Allergic disorders are viewed generally as organ diseases and thus referred to organ specialists, such as the ear, nose and throat specialist for rhinitis, the pulmonologist for asthma, the dermatologist for dermatitis, and so on. Indeed, the systemic nature of allergy is made evident by the fact that the same individ...

journal_title：Clinical and experimental immunology

authors： Pucci S,Incorvaia C

更新日期：2008-09-01 00:00:00

abstract：:It has been suggested that the immune system may be responsible for the destruction of insulin secreting cells in some types of diabetes. In order to test this hypothesis, we studied the consequences of immune-mediated reactions on the function of pancreatic islet cells in vitro. A model was set up in vitro where mous...

journal_title：Clinical and experimental immunology

authors： Boitard C,Saï P,Debray-Sachs M,Assan R,Hamburger J

更新日期：1984-03-01 00:00:00