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Human peripheral blood T lymphocyte subpopulations isolated on the basis of their affinity for sheep red blood cells differ in angiogenesis-inducing capability.

Abstract：

:Human peripheral blood lymphocytes injected intradermally into X-ray immunosuppressed mice were tested for angiogenesis-inducing capacity. Both T and B lymphocytes evoked angiogenesis of the same intensity. The total T cell population was fractionated into three subpopulations on the basis of their different affinities for sheep red blood cells (SRBC). Cells belonging to the subpopulation of T lymphocytes displaying moderate affinity for SRBC induced angiogenesis of the higher intensity, higher than that induced by cells of the total T lymphocyte population. However, lymphocytes both with the highest and with moderate affinity for SRBC, mixed together, evoked angiogenesis no different from that evoked by cells of the total T lymphocyte population, suggesting that inhibitory interactions occur among T cells.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Kamiński MJ,Nowacyk M,Skopińska-Rozewska E,Kamińska G,Bem W

subject

Has Abstract

pub_date

1981-11-01 00:00:00

pages

327-31

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

46

pub_type

杂志文章

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