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Abnormal liver function in common variable immunodeficiency disorders due to nodular regenerative hyperplasia.

Abstract：

:Patients with common variable immunodeficiency disorders are monitored for liver function test abnormalities. A proportion of patients develop deranged liver function and some also develop hepatomegaly. We investigated the prevalence of abnormalities and types of liver disease, aiming to identify those at risk and determine outcomes. The local primary immunodeficiency database was searched for patients with a common variable immunodeficiency disorder and abnormal liver function and/or a liver biopsy. Patterns of liver dysfunction were determined and biopsies reviewed. A total of 47 of 108 patients had deranged liver function, most commonly raised alkaline phosphatase levels. Twenty-three patients had liver biopsies. Nodular regenerative hyperplasia was found in 13 of 16 with unexplained pathology. These patients were more likely to have other disease-related complications of common variable immunodeficiency disorders, in particular non-coeliac (gluten insensitive) lymphocytic enteropathy. However, five had no symptoms of liver disease and only one died of liver complications. Nodular regenerative hyperplasia is a common complication of common variable immunodeficiency disorders but was rarely complicated by portal hypertension.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Ward C,Lucas M,Piris J,Collier J,Chapel H

doi

10.1111/j.1365-2249.2008.03711.x

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

331-7

issue

3

eissn

0009-9104

issn

1365-2249

pii

CEI3711

journal_volume

153

pub_type

杂志文章

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