当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL IMMUNOLOGY期刊下所有文献 > Acquired but reversible loss of erythrocyte complement receptor 1 (CR1, CD35) and its longitudinal alteration in patients with severe acute respiratory syndrome.

Acquired but reversible loss of erythrocyte complement receptor 1 (CR1, CD35) and its longitudinal alteration in patients with severe acute respiratory syndrome.

Abstract：

:This longitudinal study investigates the change of erythrocyte complement receptor (E-CR1) expression in patients with severe acute respiratory syndrome (SARS). Circulating E-CR1 expression was semiquantified by flow cytometric analyses in 54 SARS patients and in 212 healthy individuals as a control. Since E-CR1 expression is influenced by the genetic polymorphisms in the CR1 gene, a major genetic polymorphism located within intron 27 of the CR1 gene was simultaneously analysed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The results showed that the expression level of E-CR1 (referred to as net fluorescence intensity values, NFI) was statistically correlated with the relevant genetic genotypes among the Chinese population including the healthy individuals (NFI: 5.14 +/- 0.82, 3.57 +/- 0.66 and 2.67 +/- 0.32 for HH, HL and LL genotypes, respectively) and SARS patients (NFI: 3.52 +/- 0.91 and 2.63 +/- 0.70 for HH and HL genotypes, respectively). Interestingly, the expression density of E-CR1 was found to fall significantly during the initiation and progressive phases (weeks 1 and 2 after the disease onset) and gradually returned close to normal through their whole convalescent phase (beginning from weeks 2 or 3 to weeks 7 or 8) in SARS patients irrespective CR1 genotype. In conclusion, our findings, at least, suggest that E-CR1 is likely involved in immune pathogenesis of SARS disease.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Wang FS,Chu FL,Jin L,Li YG,Zhang Z,Xu D,Shi M,Wu H,Moulds JM

doi

10.1111/j.1365-2249.2005.02681.x

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

112-9

issue

1

eissn

0009-9104

issn

1365-2249

pii

CEI2681

journal_volume

139

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL IMMUNOLOGY文献大全
  • Levels of soluble Fc gammaRIII correlate with disease severity in sepsis.

    abstract：:Neutrophil activation is thought to play a crucial role in the pathogenesis of sepsis. During activation, neutrophils adhere to and migrate through the endothelium. Therefore, the amount of circulating neutrophils does not adequately reflect the total amount of neutrophils that are involved in the pathophysiologic pro...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1998.00727.x

    authors： Muller Kobold AC,Zijlstra JG,Koene HR,de Haas M,Kallenberg CG,Tervaert JW

    更新日期：1998-11-01 00:00:00

  • Functional deficiency of complement factor D in a monozygous twin.

    abstract：:An adult twin with recurrent bacterial infections was found to have a partial functional deficiency of complement factor D. Full restoration of alternative pathway activity and zymosan- or cobra venom factor-induced consumption of C3 and B was found after reconstitution of patient's serum with purified D. Family studi...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Kluin-Nelemans HC,van Velzen-Blad H,van Helden HP,Daha MR

    更新日期：1984-12-01 00:00:00

  • Tissue distribution of brain-thymus shared antigens recognized by anti-brain xenosera in the rat, dog and man.

    abstract：:A comparative and quantitative study of the tissue distribution of brain-thymus shared antigens was carried out using rabbit antisera to rat, dog and human brain homogenates, assayed on rat, dog and human thymus cells, respectively. Quantitative absorption analyses with eleven different tissues showed that the tissue ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Dalchau R,Fabre JW

    更新日期：1979-03-01 00:00:00

  • Characteristics of in-vitro phenotypes of glutamic acid decarboxylase 65 autoantibodies in high-titre individuals.

    abstract：:Previous studies have indicated phenotypical differences in glutamic acid decarboxylase 65 autoantibodies (GADA) found in type 1 diabetes (T1D) patients, individuals at risk of developing T1D and stiff-person syndrome (SPS) patients. In a Phase II trial using aluminium-formulated GAD(65) (GAD-alum) as an immunomodula...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12026

    authors： Chéramy M,Hampe CS,Ludvigsson J,Casas R

    更新日期：2013-03-01 00:00:00

  • A minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical disease.

    abstract：:Reduced B cell numbers and a mutation in Btk are considered sufficient to make the diagnosis of X-linked agammaglobulinaemia. In the process of conducting family studies, we identified a 58-year-old healthy man with an amino acid substitution, Y418H, in the adenosine-5'-triphosphate binding site of Btk. Immunofluoresc...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2008.03593.x

    authors： Conley ME,Farmer DM,Dobbs AK,Howard V,Aiba Y,Shurtleff SA,Kurosaki T

    更新日期：2008-04-01 00:00:00

  • Is ageing associated with a shift in the balance between Type 1 and Type 2 cytokines in humans?

    abstract：:The balance between Type 1 and Type 2 cytokines is important for the outcome of several infectious diseases. As elderly humans show increased morbidity and mortality from infectious diseases, this study tests if ageing is associated with a change towards Type 2 dominance in T cells. Expression of IFN-gamma, and IL-4 w...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2002.01736.x

    authors： Sandmand M,Bruunsgaard H,Kemp K,Andersen-Ranberg K,Pedersen AN,Skinhøj P,Pedersen BK

    更新日期：2002-01-01 00:00:00

  • In the rat, citrullinated autologous fibrinogen is immunogenic but the induced autoimmune response is not arthritogenic.

    abstract：:Conversion of arginyl to citrullyl residues (citrullination) is essential for the formation of the epitopes recognized by rheumatoid arthritis (RA)-associated autoantibodies to citrullinated proteins (ACPA). ACPA are secreted by plasma cells of the rheumatoid synovial tissue where their major target, citrullinated fib...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2006.03168.x

    authors： Duplan V,Foulquier C,Clavel C,Al Badine R,Serre G,Saoudi A,Sebbag M

    更新日期：2006-09-01 00:00:00

  • Spontaneous autoimmune thyroiditis in the rat accelerated by thymectomy and low doses of irradiation: mechanisms implicated in the pathogenesis.

    abstract：:Factors involved in the production of autoimmune thyroiditis in thymectomized and sublethally irradiated rats were investigated. The study suggested that a gene linked to RT1 of the rat major histocompatibility complex (MHC), a selective depletion of suppressor T cells and high radiosensitivity of the thyroid gland we...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Kotani T,Komuro K,Yoshiki T,Itoh T,Aizawa M

    更新日期：1981-08-01 00:00:00

  • Factors associated with CD4 lymphocyte counts in HIV-negative Senegalese individuals.

    abstract：:CD4+ lymphocytes are a primary target of the human immunodeficiency virus (HIV), and CD4 counts are one of the factors used to measure disease progression in HIV-positive individuals. CD4 counts vary in uninfected individuals and across populations due to a variety of demographic, environmental, immunological and gene...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1365-2249.2007.03573.x

    authors： Mair C,Hawes SE,Agne HD,Sow PS,N'doye I,Manhart LE,Fu PL,Gottlieb GS,Kiviat NB

    更新日期：2008-03-01 00:00:00

  • Cell-mediated immunity in patients with chronic fatigue syndrome, healthy control subjects and patients with major depression.

    abstract：:The chronic fatigue syndrome (CFS) is characterized by severe persistent fatigue and neuropsychiatric symptoms. It has been proposed that the abnormalities in cell-mediated immunity which have been documented in patients with CFS may be attributable to a clinical depression, prevalent in patients with this disorder. C...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1992.tb06416.x

    authors： Lloyd A,Hickie I,Hickie C,Dwyer J,Wakefield D

    更新日期：1992-01-01 00:00:00

  • Mercury exposure as a model for deviation of cytokine responses in experimental Lyme arthritis: HgCl2 treatment decreases T helper cell type 1-like responses and arthritis severity but delays eradication of Borrelia burgdorferi in C3H/HeN mice.

    abstract：:Lyme borreliosis is a complex infection, where some individuals develop so-called 'chronic borreliosis'. The pathogenetic mechanisms are unknown, but the type of immune response is probably important for healing. A strong T helper cell type 1 (Th1)-like response has been suggested as crucial for eradication of Borreli...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2007.03474.x

    authors： Ekerfelt C,Andersson M,Olausson A,Bergström S,Hultman P

    更新日期：2007-10-01 00:00:00

  • Langerhans cells from human oral epithelium are more effective at stimulating allogeneic T cells in vitro than Langerhans cells from skin.

    abstract：:This report is focused on the functional capacity of Langerhans cells (LC) in the epithelium of skin and oral mucosa, which both meet different antigenic challenges. The capacity of LC from human oral and skin epithelium to provide co-stimulatory signals to T cells in vitro was compared. LC in a crude suspension of or...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2004.02469.x

    authors： Hasséus B,Jontell M,Bergenholtz G,Dahlgren UI

    更新日期：2004-06-01 00:00:00

  • Thymoma and hypogammaglobulinaemia with and without T suppressor cells.

    abstract：:Patients with acquired hypogammaglobulinaemia usually have near normal numbers of B cells and normal T cell function. When hypogammaglobulinaemia occurs in association with thymoma, then B cell numbers have been reported as low, and distinctive T cells are present which inhibit immunoglobulin production by normal cell...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Brenner MK,Reittie JG,Chadda HR,Pollock A,Asherson GL

    更新日期：1984-12-01 00:00:00

  • Immunoglobulin (Ig)M antibodies against oxidized cardiolipin but not native cardiolipin are novel biomarkers in haemodialysis patients, associated negatively with mortality.

    abstract：:The risk of premature death is high in haemodialysis (HD) patients. Antibodies against cardiolipin (anti-CL) are thrombogenic in diseases such as systemic lupus erythematosus (SLE). CL is easily oxidized (Ox) and plays a role in apoptosis. In this work we studied immunoglobulin (Ig)M anti-CL and anti-OxCL in HD-patien...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12181

    authors： Frostegård AG,Hua X,Su J,Carrero JJ,Heimbürger O,Bárány P,Stenvinkel P,Frostegård J

    更新日期：2013-12-01 00:00:00

  • Mutations in CHD7 in patients with CHARGE syndrome cause T-B + natural killer cell + severe combined immune deficiency and may cause Omenn-like syndrome.

    abstract：:More than 11 genetic causes of severe combined immunodeficiency (SCID) have been identified, affecting development and/or function of T lymphocytes, and sometimes B lymphocytes and natural killer (NK) cells. Deletion of 22q11.2 is associated with immunodeficiency, although less than 1% of cases are associated with T-B...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2008.03681.x

    authors： Gennery AR,Slatter MA,Rice J,Hoefsloot LH,Barge D,McLean-Tooke A,Montgomery T,Goodship JA,Burt AD,Flood TJ,Abinun M,Cant AJ,Johnson D

    更新日期：2008-07-01 00:00:00

  • Stimulation by means of dendritic cells followed by Epstein-Barr virus-transformed B cells as antigen-presenting cells is more efficient than dendritic cells alone in inducing Aspergillus f16-specific cytotoxic T cell responses.

    abstract：:Adoptive immunotherapy with in vitro expanded antigen-specific cytotoxic T lymphocytes (CTLs) may be an effective approach to prevent, or even treat, Aspergillus (Asp) infections. Such lines can be generated using monocyte-derived dendritic cells (DC) as antigen-presenting cells (APC) but requires a relatively high vo...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2007.03544.x

    authors： Zhu F,Ramadan G,Davies B,Margolis DA,Keever-Taylor CA

    更新日期：2008-02-01 00:00:00

  • The role of neutrophil activation in determining the outcome of pregnancy and modulation by hormones and/or cytokines.

    abstract：:Neutrophils are often exclusively considered as a first-line innate immune defence, able to rapidly kill or trap pathogens and causing in case of over-activation tissue damage. In the female reproductive tract, however, the presence and activity of neutrophils seems to be tightly regulated. Major players in orchestrat...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：10.1111/cei.13278

    authors： Hahn S,Hasler P,Vokalova L,van Breda SV,Lapaire O,Than NG,Hoesli I,Rossi SW

    更新日期：2019-10-01 00:00:00

  • Renal-infiltrating CD11c+ cells are pathogenic in murine lupus nephritis through promoting CD4+ T cell responses.

    abstract：:Lupus nephritis (LN) is a major manifestation of systemic lupus erythematosus (SLE), causing morbidity and mortality in 40-60% of SLE patients. The pathogenic mechanisms of LN are not completely understood. Recent studies have demonstrated the presence of various immune cell populations in lupus nephritic kidneys of b...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.13017

    authors： Liao X,Ren J,Reihl A,Pirapakaran T,Sreekumar B,Cecere TE,Reilly CM,Luo XM

    更新日期：2017-11-01 00:00:00

  • Autoantibodies in recent onset type-1 diabetic patients to a Mr 60K microsomal hepatic protein: new evidence for autoantibodies to the type-2 glucose transporter.

    abstract：:Here we describe the presence of IgG antibodies, in the sera of patients presenting with insulin-dependent diabetes mellitus (IDDM), that react in Western blots with a 60-kD protein (Mr 60K) from rat hepatic microsomal extracts. Sera from 60 IDDM patients were screened and 31.6% were positive for the Mr 60K band. This...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2000.01366.x

    authors： Pehuet-Figoni M,Alvarez F,Bach JF,Chatenoud L

    更新日期：2000-11-01 00:00:00

  • The relative roles of genetic and environmental factors in the regulation of erythrocyte C3b receptor (ECR1) numbers in normal individuals.

    abstract：:Erythrocyte C3b receptors (ECR1) have been measured in 122 pairs of twins (60 monozygotic, 62 dizygotic) using an [125I]-labelled monoclonal antibody (E11). The range of ECR1 numbers was wide, 99-4179 sites/cell, with a log-normal distribution around a geometric mean of 837 sites/cell. The intra-pair variance in dizyg...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Fyfe A,Holme ER,McKay IC,Zoma A,Hunter J,Lucie NP,Whaley K

    更新日期：1987-10-01 00:00:00

  • T cell activation by antigen-presenting cells from lung tissue digests: suppression by endogenous macrophages.

    abstract：:Parechymal cells (PC) were prepared by digestion of perfused, lavaged rat lung in a mixture of collagenase and DNase, and harvested on a discontinuous percoll gradient. The process yielded on average 1.0 X 10(8) viable cells/gram tissue. PC were pulsed with soluble antigen, and tested for their capacity to trigger ant...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Holt PG,Degebrodt A,O'Leary C,Krska K,Plozza T

    更新日期：1985-12-01 00:00:00

  • Effects of ultraviolet B irradiation on cell-cell interaction; implication of morphological changes and actin filaments in irradiated cells.

    abstract：:We studied the effects of ultraviolet B (UV-B) irradiation on cell-cell interactions using mouse lymphoma RMA cells and T cell hybridoma HTB-176.10. RMA cells act as stimulators by presenting H-2Kb surface antigens to HTB-176.10 cells, inducing IL-2 production in HTB-176.10 cells. Irradiating RMA cells with 1000J/m2 U...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1996.d01-760.x

    authors： Maekawa TL,Takahashi TA,Fujihara M,Akasaka J,Fujikawa S,Minami M,Sekiguchi S

    更新日期：1996-08-01 00:00:00

  • After chemotherapy, functional humoral response capacity is restored before complete restoration of lymphoid compartments.

    abstract：:Chemotherapy has, besides the beneficial effects, several adverse effects. Suppression of the immune system is one of the most important problems. Infections caused by encapsulated bacteria like Streptococcus pneumoniae are responsible for a major part of infectious problems during and after treatment. The splenic mar...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2003.02044.x

    authors： Zandvoort A,Lodewijk ME,Klok PA,Breukels MA,Rijkers GT,Timens W

    更新日期：2003-01-01 00:00:00

  • Cellular autoreactivity against heat shock protein 60 in renal transplant patients: peripheral and graft-infiltrating responses.

    abstract：:Autoreactivity to heat shock protein 60 (Hsp60) has been implicated in the pathogenesis and regulation of chronic inflammation, especially in autoimmune diseases. In transplantation, there is a lack of information regarding the cytokine profile and specificity of cells that recognize self-Hsp60 as well as the kinetics...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2006.03195.x

    authors： Caldas C,Luna E,Spadafora-Ferreira M,Porto G,Iwai LK,Oshiro SE,Monteiro SM,Fonseca JA,Lemos F,Hammer J,Ho PL,Kalil J,Coelho V

    更新日期：2006-10-01 00:00:00

  • Hypogalactosylation of serum IgG in patients with coeliac disease.

    abstract：:Coeliac disease (CD) is described as an autoimmune enteropathy associated with the presence of IgG and IgA antigliadin and antitransglutaminase autoantibodies. While of diagnostic significance, the role of these autoantibodies in the immunopathogenesis of CD is elucidated. An inappropriate T cell immune response to gl...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2003.02220.x

    authors： Cremata JA,Sorell L,Montesino R,Garcia R,Mata M,Cabrera G,Galvan JA,Garcia G,Valdes R,Garrote JA

    更新日期：2003-09-01 00:00:00

  • Studies of human myeloid antigens using monoclonal antibodies and variant lines from the promyeloid cell line HL60.

    abstract：:Monoclonal antibodies were produced using mice immunized with the human promyeloid cell line HL60. Two antibodies are described which identify antigens selectively expressed by myeloid cells. Studies using normal bone marrow and myeloid leukaemia cells demonstrated that one of these antibodies (AGF4.48) identifies an ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Fisher AG,Bunce CM,Toksoz D,Stone PC,Brown G

    更新日期：1982-11-01 00:00:00

  • Analysis of gamma delta V region usage in normal and diseased human intestinal biopsies and peripheral blood by polymerase chain reaction (PCR) and flow cytometry.

    abstract：:The intestinal population of gamma delta T cell receptor (TCR)-bearing cells was characterized with regard to V delta and V gamma subtype expression. For this purpose, we utilized V gene-specific PCR of mRNA prepared from intestinal biopsies. Predominant expression of the V delta 1 subtype was demonstrated in the smal...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1995.tb03472.x

    authors： Bucht A,Söderström K,Esin S,Grunewald J,Hagelberg S,Magnusson I,Wigzell H,Grönberg A,Kiessling R

    更新日期：1995-01-01 00:00:00

  • Increased intracellular T helper 1 proinflammatory cytokine production in peripheral blood, bronchoalveolar lavage and intraepithelial T cells of COPD subjects.

    abstract：:The role of T cells in the pathophysiology of chronic obstructive pulmonary disease (COPD) is not yet certain, although varying reports have shown increases in T helper 1 (Th1) and/or Th2 cytokines in peripheral blood and bronchoalveolar lavage (BAL). No studies have examined cytokine production by intraepithelial T c...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2007.03451.x

    authors： Hodge G,Nairn J,Holmes M,Reynolds PN,Hodge S

    更新日期：2007-10-01 00:00:00

  • Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells.

    abstract：:The mechanism of action of methotrexate (MTX) in autoimmune diseases (AID) is unclear. A pro-apoptotic effect has been demonstrated in mitogen-stimulated peripheral blood mononuclear cells (PBMC), but studies employing conventional antigens have disputed a pro-apoptotic effect. CD4+ T helper (Th) cells play a signific...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2007.03335.x

    authors： Nielsen CH,Albertsen L,Bendtzen K,Baslund B

    更新日期：2007-05-01 00:00:00

  • Expression of types I, III and IV collagen genes in fibrotic skin and nerve lesions of toxic oil syndrome patients.

    abstract：:We have studied the skin and nerve fibrosis in toxic oil syndrome by in situ hybridization using specific cDNA probes for types I, III, and IV collagens. Fibroblasts with high levels of type I and III collagen mRNA were observed in biopsies from fibrotic skin areas. Similarly, type IV collagen mRNA was abundant in cel...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1993.tb06504.x

    authors： Gomez-Reino JJ,Sandberg M,Carreira PE,Vuorio E

    更新日期：1993-07-01 00:00:00