Altered polyvinylpyrrolidone clearance and immune responsiveness caused by small dietary changes.

Abstract:

:The introduction of 25 mg of a new protein antigen into the diets of mice produced transient increases in PVP clearance which reached a maximum 60 hr after the change of diet and had disappeared by 4 days. At the same time the immune responsiveness to unrelated antigens given parenterally was also raised transiently, reaching a peak 5 days following the change and disappearing by 7 days. In contrast the responsiveness to the fed antigen was diminished.

journal_name

Clin Exp Immunol

authors

Newby TJ,Stokes CR,Bourne FJ

subject

Has Abstract

pub_date

1980-02-01 00:00:00

pages

349-54

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

39

pub_type

杂志文章
  • Tetrandrine, a plant alkaloid, inhibits the production of tumour necrosis factor-alpha (cachectin) hy human monocytes.

    abstract::Human mononuclear leucocytes (MNL) or the adherent fraction (monocytes) produced tumour necrosis factor-alpha (TNF-alpha) (by ELISA) in culture when stimulated with killed Staphylococcus aureus. The bisbenzylisoquinoline alkaloid, tetrandrine inhibited the capacity of MNL and monocytes to produce TNF-alpha at a concen...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1990.tb05239.x

    authors: Ferrante A,Seow WK,Rowan-Kelly B,Thong YH

    更新日期:1990-05-01 00:00:00

  • Mammalian Toll-like receptors: to immunity and beyond.

    abstract::Toll-like receptors (TLRs) constitute an archetypal pattern recognition system. Their sophisticated biology underpins the ability of innate immunity to discriminate between highly diverse microbial pathogens and self. However, the remarkable progress made in describing this biology has also revealed new immunological ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2249.2005.02801.x

    authors: Hopkins PA,Sriskandan S

    更新日期:2005-06-01 00:00:00

  • 5,7-dihydroxy-3,4,6-trimethoxyflavone inhibits the inflammatory effects induced by Bacteroides fragilis enterotoxin via dissociating the complex of heat shock protein 90 and I kappaB alpha and I kappaB kinase-gamma in intestinal epithelial cell culture.

    abstract::Enterotoxin produced by enterotoxigenic Bacteroides fragilis (BFT) has been associated with mucosal inflammation and diarrhoeal diseases. In this study, the anti-inflammatory molecular mechanism of 5,7-dihydroxy-3,4,6-trimethoxyflavone (eupatilin) was characterized in an HT-29 intestinal epithelial cell line stimulate...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2008.03849.x

    authors: Kim JM,Lee DH,Kim JS,Lee JY,Park HG,Kim YJ,Oh YK,Jung HC,Kim SI

    更新日期:2009-03-01 00:00:00

  • T cell subpopulations in CLL: methods of T cell enrichment artificially alter proportions of OKT4 and OKT8 positive cells.

    abstract::There is growing speculation about the meaning of reported imbalances in subpopulations of T lymphocytes in patients with chronic lymphocytic leukaemia (CLL). This study compared two techniques for producing T cell enriched subpopulations from both patients with CLL and normal individuals and the effects of these tech...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Dickinson AM,George S,Proctor SJ

    更新日期:1983-11-01 00:00:00

  • Activated inducible co-stimulator-positive programmed cell death 1-positive follicular helper T cells indicate disease activity and severity in ulcerative colitis patients.

    abstract::Inducible co-stimulator-positive (ICOS) and programmed cell death 1-positive (PD-1) are important markers for follicular helper T cells (Tfh); however, their roles and clinical values in ulcerative colitis (UC) remain unknown. In this study, we recruited 68 UC patients and 34 healthy controls. Circulating ICOS+ , PD-1...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.13485

    authors: Long Y,Zhao X,Liu C,Xia C,Liu C

    更新日期:2020-10-01 00:00:00

  • Activation of human complement by mouse and mouse/human chimeric monoclonal antibodies.

    abstract::The complement (C)-activating capabilities in human serum of 32 mouse and 10 mouse/human chimeric MoAbs of different isotypes, and their fragments, were tested in vitro. Activation of C via the classical pathway (CP) was performed in 1% factor D-deficient serum in gelatin containing Veronal buffer in the presence of c...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1993.tb03446.x

    authors: Seino J,Eveleigh P,Warnaar S,van Haarlem LJ,van Es LA,Daha MR

    更新日期:1993-11-01 00:00:00

  • Yes T cells, but three different T cells (alphabeta, gammadelta and NK T cells), and also B-1 cells mediate contact sensitivity.

    abstract::Transfer of contact sensitivity (CS) responses by immune lymphoid cells was the first finding that distinguished cellular from humoral immunity. CS has remained the most studied T cell reaction in vivo, and is the prototype for a variety of delayed-type hypersensitivity (DTH) responses. DTH in essence is the recruitme...

    journal_title:Clinical and experimental immunology

    pub_type: 评论,杂志文章,评审

    doi:10.1046/j.1365-2249.2001.01619.x

    authors: Askenase PW

    更新日期:2001-09-01 00:00:00

  • Interleukin-2 reverses deficient cell-mediated immune responses in rheumatoid arthritis.

    abstract::The depressed cell-mediated immunity in rheumatoid arthritis was investigated in vivo by cutaneous hypersensitivity responses to seven antigens including tuberculin PPD, and in vitro by lymphocyte transformation to the latter antigen. In vivo 40% of rheumatoid patients were anergic compared to 2% of controls (P less t...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Emery P,Panayi GS,Nouri AM

    更新日期:1984-07-01 00:00:00

  • Enhanced therapeutic effect of B cell-depleting anti-CD20 antibodies upon combination with in-situ dendritic cell vaccination in advanced lymphoma.

    abstract::The present standard of care for B cell non-Hodgkin's lymphoma includes the anti-CD20 monoclonal antibody rituximab. Although combination treatments with chemotherapy and rituximab improved the duration of remissions and overall survival in indolent B cell lymphoma, the disease is essentially incurable. Thus, new ther...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2012.04658.x

    authors: Manzur S,Cohen S,Haimovich J,Hollander N

    更新日期:2012-12-01 00:00:00

  • Study of antigenic sites on the asialoglycoprotein receptor recognized by autoantibodies.

    abstract::The aim of this study was to identify the epitopes recognized by antibodies to the asialoglycoprotein receptor, a specific hepatocyte protein, from sera of patients with autoimmune hepatitis. An ELISA test was used to detect anti-asialoglycoprotein receptor antibodies in the sera of patients with autoimmune hepatitis....

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1998.00673.x

    authors: Hajoui O,Martin S,Alvarez F

    更新日期:1998-09-01 00:00:00

  • Immunostimulating activities of the novel peptidomimetic L-glutamyl-histamine.

    abstract::An original representative of histamine-containing peptidomimetics L-glutamyl-histamine (L-Glu-Hist) was synthesized and characterized as a cytokine mimic leading to cellular responses of improved specificity. The energy-minimized 3-D conformations of L-Glu-Hist derived from its chemical structure resulted in stabiliz...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2004.02710.x

    authors: Babizhayev MA,Semiletov YA,Lul'kin YA,Sakina NL,Savel'yeva EL,Alimbarova LM,Barinskii IP

    更新日期:2005-03-01 00:00:00

  • Anti-tumour necrosis factor treatment increases circulating T helper type 17 cells similarly in different types of inflammatory arthritis.

    abstract::We investigated changes in circulating T helper type 17 (Th17) cells following anti-tumour necrosis factor (TNF) in rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients. Peripheral blood mononuclear cells (PBMC) were isolated from 25 RA, 15 AS and eight PsA patients at baseline...

    journal_title:Clinical and experimental immunology

    pub_type: 临床试验,杂志文章

    doi:10.1111/cei.12626

    authors: Hull DN,Williams RO,Pathan E,Alzabin S,Abraham S,Taylor PC

    更新日期:2015-09-01 00:00:00

  • Kinetic properties of 5' nucleotidase in blood lymphocytes from healthy subjects, immunodeficient patients and cord blood.

    abstract::The Km for AMP for 5' nucleotidase was increased in lymphocytes from patients with common variable (CVH) and sex linked (XLH) hypogammaglobulinaemia and from patients with chronic lymphatic leukaemia (CLL): the Vmax of the latter was low. The kinetic constants for cord blood lymphocytes are similar to adults and the K...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Shah T,Webster AD,Peters TJ

    更新日期:1984-07-01 00:00:00

  • Variability of sequential studies of lymphocyte blastogenesis in normal adults.

    abstract::Sixteen healthy adults had serial studies of delayed-type skin test reactivity and in vitro lymphocyte blastogenesis to several antigens over a period of 7 months. In many subjects blastogenesis varied broadly from month to month without apparent cause. Responses to all antigens usually increased or decreased together...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Graybill JR,Alford RH

    更新日期:1976-07-01 00:00:00

  • Self-reactive B lymphocytes detected in young adults, children and newborns after in vitro infection with Epstein-Barr virus.

    abstract::B-lymphocytes from healthy children and young adults who were seronegative for autoantibodies and B lymphocytes from umbilical cord blood of newborns were induced to secrete a variety of autoantibodies upon infection with Epstein-Barr virus. Such autoantibody-secreting clones were obtained from different lymphoid tiss...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Uhlig H,Rutter G,Dernick R

    更新日期:1985-10-01 00:00:00

  • Both Th1- and Th2-derived cytokines in serum are elevated in Graves' ophthalmopathy.

    abstract::Increased serum cytokine levels have been reported in patients with autoimmune thyroid disease, but less is known about their levels in patients with Graves' ophthalmopathy (GO). It is not known whether GO is a cell-mediated or humoral autoimmune disease. We investigated whether serum cytokines are elevated in GO pati...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2000.01335.x

    authors: Wakelkamp IM,Gerding MN,Van Der Meer JW,Prummel MF,Wiersinga WM

    更新日期:2000-09-01 00:00:00

  • Circulating immune complexes in old people and in diabetics: correlation with autoantibodies.

    abstract::Circulating immune complexes (CIC) were detected by a solid-phase radioassay in 34% of fifty-three insulin-dependent diabetics (IDD) as compared to 18% of forty-five non-insulin-dependent diabetics (NIDD) and 14% of 173 control subjects. In control subjects, the prevalence of CIC increased with age and was higher in m...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Delespesse G,Gausset P,Sarfati M,Dubi-Rucquoy M,Debisschop MJ,van Haelst L

    更新日期:1980-04-01 00:00:00

  • Highly active anti-retroviral therapy (HAART) is associated with a lower level of CD4+ T cell apoptosis in HIV-infected patients.

    abstract::HAART may increase CD4+ T cell counts despite a persistently detectable HIV load. The impact of HAART on apoptosis, which may play a role in the disease process in HIV-infected patients, has not been extensively studied. We performed a study to compare the level of spontaneous T cell apoptosis and anti-retroviral trea...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1999.01076.x

    authors: Roger PM,Breittmayer JP,Arlotto C,Pugliese P,Pradier C,Bernard-Pomier G,Dellamonica P,Bernard A

    更新日期:1999-12-01 00:00:00

  • Lymphocyte expression of a 90 kD brush border antigen.

    abstract::This study analyses the expression by rat lymphocytes of six renal brush border (BB) antigens defined by a set of monoclonal antibodies and demonstrates that a 90 kD protein (gp 90), synthesized by BB and glomeruli is found on the surface of T and B cells. The other antigens, including the 330 kD protein involved in H...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Van Leer EH,Moullier P,Ronco P,Verroust P

    更新日期:1987-03-01 00:00:00

  • The effect of protamine sulfate on the course of immune complex glomerulonephritis in the rat.

    abstract::In vivo studies in rats demonstrated that the binding of a highly cationic antigen (cationized human IgG, pI greater than 9.5) to glomerular polyanion could be significantly reduced by prior application of a small polycation, protamine sulfate. The degree of inhibition was dose dependent and the highest dose used, 4 m...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Oite T,Shimizu F,Batsford SR,Vogt A

    更新日期:1986-05-01 00:00:00

  • IgG-mediated anaphylaxis via Fc gamma receptor in CD40-deficient mice.

    abstract::Anaphylaxis denotes an immediate hypersensitivity reaction to allergen, exclusively mediated by IgE antibodies. However, IgE antibodies do not explain all the syndromes that are encountered. We investigated potent IgG-mediated anaphylaxis in CD40-deficient mice that lack the immunoglobulin class switching for T cell-d...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1998.00717.x

    authors: Wakayama H,Hasegawa Y,Kawabe T,Saito H,Kikutani H,Shimokata K

    更新日期:1998-11-01 00:00:00

  • Characteristics of splenic CD8+ T cell exhaustion in patients with hepatitis C.

    abstract::There is increasing interest in the role of T cell exhaustion and it is well known that the natural history of chronic hepatitis C virus infection (HCV) is modulated by CD8(+) T cell immunobiology. There are many pathways that alter the presence of exhaustive T cells and, in particular, they are functionally impaired ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12158

    authors: Sumida K,Shimoda S,Iwasaka S,Hisamoto S,Kawanaka H,Akahoshi T,Ikegami T,Shirabe K,Shimono N,Maehara Y,Selmi C,Gershwin ME,Akashi K

    更新日期:2013-10-01 00:00:00

  • Specific activation of CD4- CD8- double-negative T cells by Trypanosoma cruzi-derived glycolipids induces a proinflammatory profile associated with cardiomyopathy in Chagas patients.

    abstract::Cardiomyopathy is the most severe outcome of Chagas disease, causing more than 12 000 deaths/year. Immune cells participate in cardiomyopathy development either by direct tissue destruction, or by driving inflammation. We have shown that CD4- CD8- [double-negative (DN)] T cells are major sources of inflammatory and an...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12992

    authors: Passos LSA,Magalhães LMD,Soares RP,Marques AF,Nunes MDCP,Gollob KJ,Dutra WO

    更新日期:2017-10-01 00:00:00

  • Identification of Goodpasture antigens in human alveolar basement membrane.

    abstract::Goodpasture (GP) antigens, protein components reactive with human autoantibodies against glomerular basement membrane (GBM), were identified in human alveolar basement membrane (ABM) using an enzyme-linked immunoassay (ELISA), Western blotting and immunoprecipitation. All six anti-GBM antisera studied, three obtained ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Yoshioka K,Iseki T,Okada M,Morimoto Y,Eryu N,Maki S

    更新日期:1988-12-01 00:00:00

  • Recognition of Epstein-Barr virus (EBV)-infected cells by T cell colonies from a human chimera: restriction by allogeneic determinants.

    abstract::The anti-EBV T cell response was studied in a severe combined immunodeficiency patient (PS) who received two transplants of fetal liver cells. His peripheral blood mononuclear cells (PBMC) were incubated with EBV and cultured during 15 days. Eleven colonies were derived from the T lymphocytes causing the regression of...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Plotnicky H,Touraine JL

    更新日期:1993-12-01 00:00:00

  • IgA and temperature dependent IgG complex formation in a patient with Waldenström's hypergammaglobulinaemic purpura.

    abstract::We describe a patient with hypergammaglobulinaemic purpura and show that the serum contains IgG and IgA immune complexes sedimenting between IgM and IgG on ultracentrifugation. The complexes containing IgG were markedly temperature dependent. A drop in temperature from 37 degrees C to 28 degrees C gave a seventeen-fol...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Roberts-Thomson PJ,Kemp AS

    更新日期:1980-01-01 00:00:00

  • A minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical disease.

    abstract::Reduced B cell numbers and a mutation in Btk are considered sufficient to make the diagnosis of X-linked agammaglobulinaemia. In the process of conducting family studies, we identified a 58-year-old healthy man with an amino acid substitution, Y418H, in the adenosine-5'-triphosphate binding site of Btk. Immunofluoresc...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2008.03593.x

    authors: Conley ME,Farmer DM,Dobbs AK,Howard V,Aiba Y,Shurtleff SA,Kurosaki T

    更新日期:2008-04-01 00:00:00

  • Immunoglobulin abnormalities in Paget's disease of bone.

    abstract::Several patients with Paget's disease have been reported to have monoclonal IgM proteins in their serum. We have systematically studied 26 patients with Paget's disease severe enough to require diphosphonate therapy. Five of these patients were found to have isolated elevations of serum IgM which were well outside the...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Buxbaum JN,Kammerman S

    更新日期:1984-04-01 00:00:00

  • Effects of activin A on IgE synthesis and cytokine production by human peripheral mononuclear cells.

    abstract::Activin A not only stimulates the synthesis and release of pituitary follicle-stimulating hormone, but exerts various effects on haematopoietic cells, embryos, and fibroblasts. In the present study we have examined effects of activin A on IgE synthesis and cytokine production by peripheral blood mononuclear cells (PBM...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1993.tb06003.x

    authors: Yamashita N,Nakajima T,Takahashi H,Kaneoka H,Mizushima Y,Sakane T

    更新日期:1993-10-01 00:00:00

  • Chemokines and common variable immunodeficiency; possible contribution of CCL19, CCL21 and CCR7 to immune dysregulation.

    abstract::Common variable immunodeficiency (CVID) is a heterogeneous syndrome characterized by defective immunoglobulin production and high frequency of bacterial infections, autoimmunity and manifestations of chronic inflammation. The homeostatic chemokines CCL19 and CCL21 and their receptor CCR7 are associated with modulation...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2009.04013.x

    authors: Fevang B,Yndestad A,Damås JK,Halvorsen B,Holm AM,Beiske K,Aukrust P,Frøland SS

    更新日期:2009-11-01 00:00:00