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Glycosylphosphatidylinositol (GPI)-anchored surface antigens in the allogeneic activation of T cells.

Abstract：

:GPI-linked surface molecules have recently been described as structures with an activation potential for human T lymphocytes. To study the role of these molecules in T cell activation we analysed GPI-deficient or normal T cells from patients with paroxysmal nocturnal haemoglobinuria (PNH). On activation with allogeneic Epstein-Barr virus (EBV)-transformed B cell lines GPI-deficient freshly separated T cells or continuously growing T cell lines exhibited a significantly lower proliferation or cytokine production compared with their normal counterparts. In contrast, stimulation via the T cell receptor-associated CD3 structure resulted in a comparable response. There was no difference in activation of normal T lymphocytes when GPI-deficient B cells were used as stimulators compared with normal B cells obtained from the same PNH patient. We conclude from these data that GPI deficiency in PNH leads to a functional deficiency of GPI-deficient T cells. In contrast, no difference in activation of T lymphocytes for GPI-deficient cells on the stimulator cell level was observed.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Schubert J,Stroehmann A,Scholz C,Schmidt RE

doi

10.1111/j.1365-2249.1995.tb06656.x

subject

Has Abstract

pub_date

1995-10-01 00:00:00

pages

199-203

issue

1

eissn

0009-9104

issn

1365-2249

journal_volume

102

pub_type

杂志文章

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