Up-regulation of the tumour-associated marker CD44V6 in experimental kidney disease.

abstract：:IFN-gamma is known to be a major inhibitor of IgE synthesis in vitro. Recent studies demonstrating reduced production of IFN-gamma in children and adults with atopic dermatitis and elevated serum IgE suggest a similar role for this cytokine in vivo. The reasons for this reduced IFN-gamma production are not known. One ...

journal_title：Clinical and experimental immunology

authors： Tang M,Kemp A

更新日期：1994-01-01 00:00:00

abstract：:The effects of cyclophosphamide an antinuclear antibody levels, immune complex deposition in renal glomeruli, glomerular cell proliferation and glomerulosclerosis in the (NZB x NZW)F1 hybrid mouse have been investigated in order to better understand the mechanism of action of this drug on nephritis. Five groups of mic...

journal_title：Clinical and experimental immunology

authors： Hurd ER,Ziff M

更新日期：1977-07-01 00:00:00

abstract：:An experimental model of immunological deficiency obtained by treating mice for 6 months with serum of human blood drawn from different healthy individuals has been studied. The results show that an alteration of a circulating lymphocyte population with alterations of the ratio CD4+/CD8+ appeared in mice stimulated fo...

journal_title：Clinical and experimental immunology

authors： Galdiero F,Galdiero M,Nuzzo I,Vitiello M,Bentivoglio C,Romano-Carratelli C

更新日期：1997-11-01 00:00:00

abstract：:The lectin pathway of complement activation is used by a collectin, mannan-binding lectin (MBL), and two ficolins, L-ficolin and H-ficolin, to opsonize microorganisms for phagocytosis. We published evidence recently that MBL insufficiency is associated with recurrent respiratory infections in childhood. We have now me...

journal_title：Clinical and experimental immunology

authors： Atkinson AP,Cedzynski M,Szemraj J,St Swierzko A,Bak-Romaniszyn L,Banasik M,Zeman K,Matsushita M,Turner ML,Kilpatrick DC

更新日期：2004-12-01 00:00:00

abstract：:Groups of subjects during acute (0-3 days) and convalescent (2-3 weeks) phase of recurrent herpes labialis (RHL), and other subjects seropositive or seronegative for herpes simplex virus type 1 (HSV-1) antibody without any history of RHL, were tested for the appearance of cell-mediated cytotoxic responses by stimulati...

journal_title：Clinical and experimental immunology

authors： Tsutsumi H,Bernstein JM,Riepenhoff-Talty M,Cohen E,Orsini F,Ogra PL

更新日期：1986-12-01 00:00:00

abstract：:Circulating immune complexes have been investigated in jirds (Meriones unguiculatus) infected with the filarial nematode Brugia pahangi. Two-month-old male jirds were inoculated with seventy-five B. pahangi infective larvae into the left groin. At 8 months post-infection, sera of individual animals from a group of sev...

journal_title：Clinical and experimental immunology

authors： Karavodin LM,Ash LR

更新日期：1980-05-01 00:00:00

abstract：:The effect of cyclosporin A (CyA) immunosuppression on the murine thymic microenvironment and T lymphocyte development has been analysed using monoclonal antibodies to epithelial and lymphocyte subpopulations, macrophages and major histocompatibility complex (MHC) class II antigens in immunohistochemistry and flow cyt...

journal_title：Clinical and experimental immunology

authors： Kanariou M,Huby R,Ladyman H,Colic M,Sivolapenko G,Lampert I,Ritter M

更新日期：1989-11-01 00:00:00

abstract：:Summary The interaction between stroma and blood cells in the human spleen has received little attention, despite their well-defined roles during blood cell development in bone marrow. We have reported previously that human spleen-derived fibroblasts display a differentiated myofibroblast phenotype and constitutively ...

journal_title：Clinical and experimental immunology

authors： Briard D,Azzarone B,Brouty-Boyé D

更新日期：2005-05-01 00:00:00

abstract：:Quantification of human peripheral blood NK subsets has been made in a group of Kenyan adults and children with acute P. falciparum malaria. Results were compared with data obtained from three age- and sex-matched control cohorts: parasitaemic but asymptomatic children; aparasitaemic children and adults; and adult Cau...

journal_title：Clinical and experimental immunology

authors： Orago AS,Facer CA

更新日期：1991-10-01 00:00:00

abstract：:Recent evidence has suggested that IgA1-containing macromolecules and the glycosylation of IgA1 in sera from patients with IgAN might involve the pathogenesis of IgAN. However, whether the different histological phenotypes can be attributed or not to the aberrant glycosylation of macromolecular IgA1 has not yet been e...

journal_title：Clinical and experimental immunology

authors： Xu LX,Yan Y,Zhang JJ,Zhang Y,Zhao MH

更新日期：2005-12-01 00:00:00

abstract：:Elevated numbers of peripheral T cells expressing the activation associated antigen T9 are found in patients with active Crohn's disease. Expression of T9 is found to be correlated to the activity of the disease. However the presence of activated peripheral T cells is not restricted to Crohn's disease, but could also ...

journal_title：Clinical and experimental immunology

authors： Raedler A,Fraenkel S,Klose G,Thiele HG

更新日期：1985-06-01 00:00:00

abstract：:In addition to its activity as a metabolic hormone and a regulator of somatic growth, insulin-like growth factor-I (IGF-I) has cytokine-like activities on lymphoid cells. A 14-day infusion of recombinant human (rh)IGF-I increased lymphocyte numbers in all the peripheral lymphoid organs examined. This increase was appa...

journal_title：Clinical and experimental immunology

authors： Robbins K,McCabe S,Scheiner T,Strasser J,Clark R,Jardieu P

更新日期：1994-02-01 00:00:00

abstract：:In autoimmune diseases, mitogen-induced IL-2 production in vitro is generally considered to be diminished despite evidence of lymphoid hyperactivity in vivo. HgCl2 is known to cause T-dependent polyclonal B cell activation in Brown-Norway (BN) rats, resulting in autoimmune disease. We show here that the IL-2 producing...

journal_title：Clinical and experimental immunology

authors： Baran D,Lantz O,Dosquet P,Sfaksi A,Druet P

更新日期：1988-09-01 00:00:00

abstract：:Peripheral blood lymphocytes (PBL) from a proportion of grass-sensitive patients, studied during or immediately after the grass pollination period, showed spontaneous production in vitro of grass-specific IgE antibody, whereas PBL from atopic patients sensitive to allergens other than grass pollens or non-atopic indiv...

journal_title：Clinical and experimental immunology

authors： Romagnani S,Maggi E,Del Prete GF,Almerigogna F,Biagiotti R,Giudizi MG,Ricci M

更新日期：1982-07-01 00:00:00

abstract：:Dysregulation of apoptosis, particularly in the Fas/Fas ligand (FasL) pathway, is considered to be involved in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE). Recently, a soluble decoy receptor, termed decoy receptor 3 (DcR3), that binds FasL and inhibits FasL-induced apoptosis, has...

journal_title：Clinical and experimental immunology

authors： Otsuki T,Tomokuni A,Sakaguchi H,Aikoh T,Matsuki T,Isozaki Y,Hyodoh F,Ueki H,Kusaka M,Kita S,Ueki A

更新日期：2000-02-01 00:00:00

abstract：:The sera of patients with histologically proven carcinomata of the gastrointestinal tract were fractionated by gel filtration and the fractions assayed for the presence of free carcinoembryonic antigen (CEA) binding immunoglobulins and CEA immune complexes by radioimmuno-double-diffusion, using 125I-CEA as a marker. I...

journal_title：Clinical and experimental immunology

authors： Kapsopoulou-Dominos K,Anderer FA

更新日期：1979-02-01 00:00:00

abstract：:The mechanism of action of methotrexate (MTX) in autoimmune diseases (AID) is unclear. A pro-apoptotic effect has been demonstrated in mitogen-stimulated peripheral blood mononuclear cells (PBMC), but studies employing conventional antigens have disputed a pro-apoptotic effect. CD4+ T helper (Th) cells play a signific...

journal_title：Clinical and experimental immunology

authors： Nielsen CH,Albertsen L,Bendtzen K,Baslund B

更新日期：2007-05-01 00:00:00

abstract：:This study examined the expression of the inhibitory receptor, leucocyte-associated immunoglobulin (Ig)-like receptor-1 (LAIR-1) in fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) patients to investigate its potential role in the modulation of inflammatory cytokines, matrix metalloproteinases (MMPs) an...

journal_title：Clinical and experimental immunology

authors： Zhang Y,Wang S,Dong H,Yi X,Zhang J,Liu X,Zhuang R,Ding Y

更新日期：2018-05-01 00:00:00

abstract：:In vitro lymphocyte function of 13 patients with selective IgA deficiency was studied. IgG, IgA and IgM secretion by pokeweed mitogen-stimulated peripheral blood lymphocytes from normal donors and IgA deficient patients was measured by an enzyme-linked immunosorbent assay. Addition of concanavalin A or hydrocortisone ...

journal_title：Clinical and experimental immunology

authors： De la Concha EG,Subiza JL,Fontán G,Pascual-Salcedo D,Sequí J,Bootello A

更新日期：1982-08-01 00:00:00

abstract：:We recently separated a PG1828-encoded triacylated lipoprotein (Pg-LP), composed of two palmitoyl and one pentadecanoyl groups at the N-terminal of glycerocysteine from Porphyromonas gingivalis, a periodontopathic bacteria, and found that Pg-LP exhibited definite biological activities through Toll-like receptor (TLR) ...

journal_title：Clinical and experimental immunology

authors： Makimura Y,Asai Y,Taiji Y,Sugiyama A,Tamai R,Ogawa T

更新日期：2006-10-01 00:00:00

abstract：:Lymphocyte and neutrophil locomotion were studied in 23 patients with well defined, primary immunodeficiencies. These included eight patients with common variable immune deficiency, three patients with X-linked agammaglobulinaemia, two patients with the Wiskott-Aldrich syndrome, three patients with ataxia telangiectas...

journal_title：Clinical and experimental immunology

authors： Van Epps DE,El-Naggar A,Ochs HD

更新日期：1983-09-01 00:00:00

abstract：:Depression of one or more parameters of cellular and/or humoral immune responses was found in 60% of general hospital patients treated with phenytoin and 47% of patients treated with carbamazepine. Phenytoin-treated patients failed to manifest delayed hypersensitivity (DHS) reactions to common antigens, and to make an...

journal_title：Clinical and experimental immunology

authors： Sorrell TC,Forbes IJ

更新日期：1975-05-01 00:00:00

abstract：:We have investigated the expression of chemokines and their receptors in leprosy skin lesions using immunohistochemistry. Skin biopsies from 25 leprosy patients across the leprosy spectrum, 11 patients undergoing type I reversal reactions and four normal donors were immunostained by ABC peroxidase method using antibod...

journal_title：Clinical and experimental immunology

authors： Kirkaldy AA,Musonda AC,Khanolkhar-Young S,Suneetha S,Lockwood DN

更新日期：2003-12-01 00:00:00

abstract：:Activin A is a multi-functional cytokine with a potent stimulation on erythroid cell differentiation in the bone marrow. The actions of activin A are determined by a balance of the levels of activin A and its inhibitor, follistatin (FS). However, the regulation of its actions in the bone marrow has been unclear. Here ...

journal_title：Clinical and experimental immunology

authors： Abe M,Shintani Y,Eto Y,Harada K,Fujinaka Y,Kosaka M,Matsumoto T

更新日期：2001-10-01 00:00:00

abstract：:Dendritic cells were enriched from adenoids of children with otitis media with effusion (OME) by density gradient centrifugation and culture techniques. An enrichment of 40-140-fold was obtained for dendritic cells. These cells were identified using morphology, enzyme cytochemistry, immunocytochemistry and functional ...

journal_title：Clinical and experimental immunology

authors： van Nieuwkerk EB,van der Baan S,Richters CD,Kamperdijk EW

更新日期：1992-05-01 00:00:00

abstract：:Dysregulation of IL-6 synthesis is thought to play a role in the development of a number of age-related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis, Alzheimer's disease and B cell malignancies. Recently it has been suggested that the production of IL-6 is influenced by the adrenal hormone d...

journal_title：Clinical and experimental immunology

authors： Young DG,Skibinski G,Mason JI,James K

更新日期：1999-09-01 00:00:00

abstract：:We have recently demonstrated that peripheral blood monocytes from patients with multiple sclerosis (MS) have a defect in stimulating autologous and allogeneic T lymphocytes. This defect was found to correlate with disease activity. In this report we demonstrate that prothymosin alpha (ProT alpha), a rat thymus fracti...

journal_title：Clinical and experimental immunology

authors： Reclos GJ,Baxevanis CN,Sfagos C,Papageorgiou C,Tsokos GC,Papamichail M

更新日期：1987-11-01 00:00:00

abstract：:Myeloid and plasmacytoid dendritic cells (DC) are present in cerebrospinal fluid (CSF) in non-inflammatory neurological diseases (NIND) and elevated in clinically definite multiple sclerosis (MS) and in early MS - acute monosymptomatic optic neuritis (ON). Here, we show that expression of CCR5, a chemokine receptor fo...

journal_title：Clinical and experimental immunology

authors： Pashenkov M,Teleshova N,Kouwenhoven M,Kostulas V,Huang YM,Soderstrom M,Link H

更新日期：2002-03-01 00:00:00

abstract：:We have previously demonstrated enhanced synovial fluid (SF) antigen-presenting cell (APC) function in inflammatory arthritis patients selected on the basis of marked SF mononuclear cell (MNC) responsiveness to reactive arthritis-associated bacteria (Clin Exp Immunol 1990; 79:189-94). In this study we have assessed wh...

journal_title：Clinical and experimental immunology

authors： Viner NJ,Gaston JS,Bacon PA

更新日期：1993-05-01 00:00:00

abstract：:The effect of IL-4 and transforming growth factor-beta (TGF-beta) on immunoglobulin secretion in vitro by peripheral blood mononuclear cells (PBMC) or purified B cells activated with murine EL4 thymoma cells and phorbol myristate acetate (PMA) was investigated. As previously reported, IL-4 induced IgE and IgG4 secreti...

journal_title：Clinical and experimental immunology

authors： Ninomiya C,Spiegelberg HL

更新日期：1992-08-01 00:00:00