Immunological effects of insulin-like growth factor-I--enhancement of immunoglobulin synthesis.

abstract：:Common variable immunodeficiency (CVID) is a heterogeneous syndrome characterized by defective immunoglobulin production and high frequency of bacterial infections, autoimmunity and manifestations of chronic inflammation. The homeostatic chemokines CCL19 and CCL21 and their receptor CCR7 are associated with modulation...

journal_title：Clinical and experimental immunology

authors： Fevang B,Yndestad A,Damås JK,Halvorsen B,Holm AM,Beiske K,Aukrust P,Frøland SS

更新日期：2009-11-01 00:00:00

abstract：:T cells are thought to play an important regulatory role in atopic asthma. We hypothesized that human blood and BAL T cell subsets bearing various TCR-Vbeta genes might show selective differences in their cytokine profile. Peripheral blood (PB) and bronchoalveolar lavage (BAL) T cells from seven atopic asthmatic and s...

journal_title：Clinical and experimental immunology

authors： Bakakos P,Pickard C,Smith JL,Frew AJ

更新日期：2002-05-01 00:00:00

abstract：:Previous studies have indicated phenotypical differences in glutamic acid decarboxylase 65 autoantibodies (GADA) found in type 1 diabetes (T1D) patients, individuals at risk of developing T1D and stiff-person syndrome (SPS) patients. In a Phase II trial using aluminium-formulated GAD(65) (GAD-alum) as an immunomodula...

journal_title：Clinical and experimental immunology

authors： Chéramy M,Hampe CS,Ludvigsson J,Casas R

更新日期：2013-03-01 00:00:00

abstract：:Benznidazole (BZL) is a nitroheterocyclic drug employed in the chemotherapy of Chagas' disease, a protozoan disease caused by Trypanosoma cruzi. Because this parasite mostly replicates in macrophages, we investigated whether BZL was likely to modify the synthesis of macrophage mediators such as nitrite, tumour necrosi...

journal_title：Clinical and experimental immunology

authors： Revelli S,Le Page C,Piaggio E,Wietzerbin J,Bottasso O

更新日期：1999-11-01 00:00:00

abstract：:Antibody-dependent cellular cytotoxicity (ADCC) was investigated as s possible mechanism of pathogenesis in recurrent aphthous ulceration (RAU). ADCC induced by mononuclear cells from patients at various stages of RAU was compared with ADCC induced by mononuclear cells from paired controls. Chicken red blood cells (Ch...

journal_title：Clinical and experimental immunology

authors： Greenspan JS,Gadol N,Olson JA,Talal N

更新日期：1981-06-01 00:00:00

abstract：:Patients with acquired hypogammaglobulinaemia usually have near normal numbers of B cells and normal T cell function. When hypogammaglobulinaemia occurs in association with thymoma, then B cell numbers have been reported as low, and distinctive T cells are present which inhibit immunoglobulin production by normal cell...

journal_title：Clinical and experimental immunology

authors： Brenner MK,Reittie JG,Chadda HR,Pollock A,Asherson GL

更新日期：1984-12-01 00:00:00

abstract：:After 3-4 weeks culture of human bone marrow cells in medium supplemented with IL-3, macrophage- (M-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF), the firmly adherent cells exhibited the morphologic features of mononuclear phagocytes and were strongly esterase-positive. Flow cytometric analysis r...

journal_title：Clinical and experimental immunology

authors： Keller R,Keist R,Joller P,Groscurth P

更新日期：1993-01-01 00:00:00

abstract：:Ageing is a very complex process, the result of the dysregulation of multiple systems interacting in many ways. A prominent change occurring with ageing is related to the architecture and functioning of the immune system, viewed commonly as detrimental and termed 'immunosenescence'. However, age-associated changes may...

journal_title：Clinical and experimental immunology

authors： Fulop T,Witkowski JM,Le Page A,Fortin C,Pawelec G,Larbi A

更新日期：2017-01-01 00:00:00

abstract：:Solubilization of an immune precipitate by serum is a complement function mediated by the alternative pathway and enhanced by the classical pathway--it therefore provides the basis of a simple quantitative assessment of the integrity of complement function. Using a preformed radiolabelled precipitate of BSA-alpha BSA ...

journal_title：Clinical and experimental immunology

authors： Schifferli JA,Morris SM,Dash A,Peters DK

更新日期：1981-12-01 00:00:00

abstract：:Rheumatoid arthritis (RA), seronegative spondyloarthropathy (SA) and osteoarthritis (OA) patients receiving no steroid or disease-modifying therapy have been monitored, along with healthy controls, for their prevailing level of Epstein-Barr virus (EBV) infection using four independent indices of the EBV-host balance, ...

journal_title：Clinical and experimental immunology

authors： Yao QY,Rickinson AB,Gaston JS,Epstein MA

更新日期：1986-05-01 00:00:00

abstract：:Multiple halothane exposures in rabbits generate modified liver proteins or antigens that appear to incorporate the metabolic intermediate of halothane, trifluoroacetyl halide (TFA), as identified by specific anti-TFA antibody. These halothane-induced antigens are most prevalent throughout the second to fourth days fo...

journal_title：Clinical and experimental immunology

authors： Roth TP,Hubbard AK,Gandolfi AJ,Brown BR

更新日期：1988-05-01 00:00:00

abstract：:The mechanism of disease progression in Hashimoto's thyroiditis (HT) is still unclear. Thyroglobulin antibody (TgAb) is a diagnostic hallmark of HT. The aim of our study was to evaluate the avidity of TgAb in sera from HT patients with different thyroid functional status. Sera from 50 patients with newly diagnosed HT ...

journal_title：Clinical and experimental immunology

authors： Zhang Y,Gao Y,Li M,Xie L,Huang Y,Gao Y,Guo X

更新日期：2010-07-01 00:00:00

abstract：:Lung cancer is strongly associated with cigarette smoking. More than 20 lung carcinogens have been identified in cigarette smoke and one of the most abundant is 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). We hypothesized that NNK modulates alveolar macrophage (AM) mediator production, thus contributing to ca...

journal_title：Clinical and experimental immunology

authors： Therriault MJ,Proulx LI,Castonguay A,Bissonnette EY

更新日期：2003-05-01 00:00:00

abstract：:Heymann nephritis of the rat has several similarities to human idiopathic membranous glomerulo-nephropathy, and therefore serves as an animal model for study of the human disease. The disease process in the rat is initiated by autoantibodies forming in situ immune deposits on the surface of the glomerular epithelial c...

journal_title：Clinical and experimental immunology

authors： Singh AK,Kasinath BS

更新日期：1993-12-01 00:00:00

abstract：:Regulatory T cells seem to play a central role in maintaining immune tolerance in the gut mucosa. Previously we have shown that interleukin (IL)-10 is produced at high levels in the inflamed colonic tissue of ulcerative colitis (UC) patients. The cellular source was CD4+ T cells, suggesting local activation of regulat...

journal_title：Clinical and experimental immunology

authors： Sitohy B,Hammarström S,Danielsson A,Hammarström ML

更新日期：2008-02-01 00:00:00

abstract：:Intravenous injection of t-butyl hydroperoxide rapidly killed Plasmodium vinckei in mice, and caused haemolysis. The same dose seemed harmless to unparasitized mice. Many parasites disintegrated inside circulating erythrocytes, so parasite death was not simply a passive consequence of haemolysis. Injection of desferri...

journal_title：Clinical and experimental immunology

authors： Clark IA,Hunt NH,Cowden WB,Maxwell LE,Mackie EJ

更新日期：1984-06-01 00:00:00

abstract：:The aim of the present study was to investigate the prevalence of C4 and C2 deficiencies and to characterize genomic alterations in C4 genes in a large cohort of 125 unselected patients with SLE. We determined the protein concentration and functional activity of C2 and C4, as well as the C4 phenotype. C4 genotyping in...

journal_title：Clinical and experimental immunology

authors： Dragon-Durey MA,Rougier N,Clauvel JP,Caillat-Zucman S,Remy P,Guillevin L,Liote F,Blouin J,Ariey F,Lambert BU,Kazatchkine MD,Weiss L

更新日期：2001-01-01 00:00:00

abstract：:Two patients with severe combined immunodeficiency disease (SCID) having variable B-cell development have been shown to have marrow precursors of lymphoid cells which can be induced in vitro by thymic factors to express certain T-cell surface characteristics (HTLA+ phenotypes). Their marrow cells could not, however, b...

journal_title：Clinical and experimental immunology

authors： Incefy GS,Grimes E,Kagan WA,Goldstein G,Smithwick E,O'Reilly R,Good RA

更新日期：1976-09-01 00:00:00

abstract：:Using in situ hybridization, we analysed the immunoglobulin repertoire expressed by the B cells present in myasthenia gravis thymuses from four patients. B cells, mostly in activated state, were clustered in germinal centres, in which multiple isotypes were identified. A majority of cells expressed IgG as compared wit...

journal_title：Clinical and experimental immunology

authors： Guigou V,Emilie D,Berrih-Aknin S,Fumoux F,Fougereau M,Schiff C

更新日期：1991-02-01 00:00:00

abstract：:Commensal enteric bacteria stimulate innate immune cells and increase numbers of lamina propria and mesenteric lymph node (MLN) T and B lymphocytes. However, the influence of luminal bacteria on acquired immune function is not understood fully. We investigated the effects of intestinal bacterial colonization on T cell...

journal_title：Clinical and experimental immunology

authors： Walton KL,Galanko JA,Balfour Sartor R,Fisher NC

更新日期：2006-03-01 00:00:00

abstract：:Using the natural killer (NK) sensitive K562 cell line, enhanced NK cell cytotoxicity was demonstrable early in the course of acute hepatitis B while normal values were obtained in patients studied during convalescence. No evidence of enhanced NK activity was instead obtained in the course of acute non-A, non-B hepati...

journal_title：Clinical and experimental immunology

authors： Chemello L,Mondelli M,Bortolotti F,Schiavon E,Pontisso P,Alberti A,Rondanelli EG,Realdi G

更新日期：1986-04-01 00:00:00

abstract：:The family of Toll-like receptors (TLRs) initiates innate immune responses, and Toll-like receptor 4 (TLR4) was considered to be an important player in the initiation and progression of atherosclerotic disease. The aim of the study was to investigate the expression of TLR4 on peripheral-blood mononuclear cells (PBMCs)...

journal_title：Clinical and experimental immunology

authors： Geng HL,Lu HQ,Zhang LZ,Zhang H,Zhou L,Wang H,Zhong RQ

更新日期：2006-02-01 00:00:00

abstract：:The systemic inflammatory response is a challenge in the management of paediatric patients undergoing cardiac surgery. Although multi-factorial, a contribution by the lectin pathway of complement activation has been postulated. We therefore investigated the changes in serum levels of mannose binding lectin (MBL) and a...

journal_title：Clinical and experimental immunology

authors： Pągowska-Klimek I,Świerzko AS,Michalski M,Głowacka E,Szala-Poździej A,Sokołowska A,Moll M,Krajewski WR,Romak J,Cedzyński M

更新日期：2016-05-01 00:00:00

abstract：:We have previously reported the finding of circulating antibodies recognizing two proteins of 100 and 120 kD (PO100 and PO120) from Pityrosporum ovale in patients with psoriasis. These antibodies were specific, since they were not detected in normal sera nor in other diseases linked to P. ovale such as seborrhoeic der...

journal_title：Clinical and experimental immunology

authors： Mathov I,Plotkin L,Abatangelo C,Galimberti R,Squiquera L,Leoni J

更新日期：1996-07-01 00:00:00

abstract：:A rabbit antiserum has been prepared using peripheral mononuclear cells from a patient with common variable hypogammaglobulinaemia (CVH) who had demonstrable suppressor cells in vitro. This antiserum (anti-Ck), after absorption with pooled normal glass-non-adherent cells and platelets, showed selective reactivity with...

journal_title：Clinical and experimental immunology

authors： Rizzoli AJ,Bankhurst AD

更新日期：1981-12-01 00:00:00

abstract：:Proliferation of mesangial cells is a hallmark of glomerular disease, and understanding the regulatory mechanisms is critically important. The purpose of this study was to examine the relationship between mesangial cell proliferation and phosphorylated signal transducer and activator of transcription (STAT) 3 and to d...

journal_title：Clinical and experimental immunology

authors： Hirai T,Masaki T,Kuratsune M,Yorioka N,Kohno N

更新日期：2006-05-01 00:00:00

abstract：:The effector arm of the mucosal immune system comprises lymphocytes scattered at intraepithelial and lamina propria levels. Intraepithelial lymphocytes (IEL) are a large population of oligoclonal resting cells which exhibit phenotypic and functional characteristics of cytolytic T cells when activated. Several mechanis...

journal_title：Clinical and experimental immunology

authors： Ciccocioppo R,Di Sabatino A,Parroni R,D'alò S,Pistoia MA,Doglioni C,Cifone MG,Corazza GR

更新日期：2000-05-01 00:00:00

abstract：:Circulating immune complexes have been investigated in jirds (Meriones unguiculatus) infected with the filarial nematode Brugia pahangi. Two-month-old male jirds were inoculated with seventy-five B. pahangi infective larvae into the left groin. At 8 months post-infection, sera of individual animals from a group of sev...

journal_title：Clinical and experimental immunology

authors： Karavodin LM,Ash LR

更新日期：1980-05-01 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease caused by the T cell-mediated destruction of the pancreatic insulin-producing beta cells. Currently there are no widely accepted and standardized assays available to analyse the function of autoreactive T cells involved in T1D. The development of such an assay would great...

journal_title：Clinical and experimental immunology

authors： Mannering SI,Wong FS,Durinovic-Belló I,Brooks-Worrell B,Tree TI,Cilio CM,Schloot NC,Mallone R,Immunology of Diabetes Society T-Cell Workshop Committee.

更新日期：2010-11-01 00:00:00

abstract：:In this study we demonstrate that IgG present in the sera of patients with primary Sjögren's syndrome (PSS) could bind and activate muscarinic acetylcholine receptors (mAChRs) of rat parotid gland. These antibodies were able to inhibit in a non-competitive manner the binding of 3H-quinuclidinyl benzilate (QNB) to mACh...

journal_title：Clinical and experimental immunology

authors： Bacman S,Sterin-Borda L,Camusso JJ,Arana R,Hubscher O,Borda E

更新日期：1996-06-01 00:00:00