Abstract:
:Patients with acquired hypogammaglobulinaemia usually have near normal numbers of B cells and normal T cell function. When hypogammaglobulinaemia occurs in association with thymoma, then B cell numbers have been reported as low, and distinctive T cells are present which inhibit immunoglobulin production by normal cells. It has been suggested that these T cells are responsible for the observed hypogammaglobulinaemia. We report a patient with thymoma and hypogammaglobulinaemia who lacks these distinctive suppressor cells and has normal B cell numbers. It is therefore incorrect to propose a single pathogenic mechanism for hypogammaglobulinaemia in association with thymoma.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Brenner MK,Reittie JG,Chadda HR,Pollock A,Asherson GLsubject
Has Abstractpub_date
1984-12-01 00:00:00pages
619-24issue
3eissn
0009-9104issn
1365-2249journal_volume
58pub_type
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