Studies of human myeloid antigens using monoclonal antibodies and variant lines from the promyeloid cell line HL60.

abstract：:Granulocyte colony-stimulating factor (G-CSF) administration in vivo has been shown to improve the defence mechanisms against infection by different microbes. Here we evaluated a possible protective role of this molecule in a mouse model of mycobacterial infection. The administration of recombinant G-CSF promoted an e...

journal_title：Clinical and experimental immunology

authors： Gonçalves AS,Appelberg R

更新日期：2001-05-01 00:00:00

abstract：:Tumour-infiltrating lymphocytes (TIL) have been isolated from early primary melanoma (Clark level III) and expanded in vitro using culture conditions with low concentrations of IL-2 (50 U/ml). Immediately after isolation TIL consisted of mainly CD3+ T cells, and the portion of CD56+ natural killer (NK) cells was below...

journal_title：Clinical and experimental immunology

authors： Becker JC,Schwinn A,Dummer R,Burg G,Bröcker EB

更新日期：1993-01-01 00:00:00

abstract：:Endogenous retrovirus-3 (ERV-3) is an endogenous retrovirus encoding an open reading frame for an envelope protein expressed in placenta. In this study we also found high levels of expression in fetal heart, with peak expression occurring between 11 and 17 weeks of gestation. Antibodies to a peptide corresponding to a...

journal_title：Clinical and experimental immunology

authors： Li JM,Fan WS,Horsfall AC,Anderson AC,Rigby S,Larsson E,Venables PJ

更新日期：1996-06-01 00:00:00

abstract：:Sjögren's syndrome (SS) is a chronic autoimmune disease that mainly damages the salivary and lacrimal glands. Immune complex (IC) formation triggers local inflammation through IC deposition and decreased antigen function. Some ICs can leak from the lesion and into the saliva but no salivary ICs have been reported to d...

journal_title：Clinical and experimental immunology

authors： Yamane K,Nakamura H,Hamasaki M,Minei Y,Aibara N,Shimizu T,Kawakami A,Nakashima M,Kuroda N,Ohyama K

更新日期：2021-01-12 00:00:00

abstract：:CSF-1 plays an important role in female reproduction and normal embryo development. To understand further CSF-1 function in normal and, especially, in compromised pregnancy, we studied the pattern of its mRNA expression as well as expression of its receptor (c-fms) in the uteroplacental units of mice with induced (cyc...

journal_title：Clinical and experimental immunology

authors： Gorivodsky M,Torchinsky A,Shepshelovich J,Savion S,Fein A,Carp H,Toder V

更新日期：1999-09-01 00:00:00

abstract：:The present report concerns the site of synthesis of alpha 1-anti-trypsin (alpha 1 AT). In this study circulating cells and tissue fragments were incubated with radioactive amino acids to be incorporated during protein synthesis. The de novo synthesis of proteins was demonstrated by autoradiography of the immunoelectr...

journal_title：Clinical and experimental immunology

authors： van Furth R,Kramps JA,Diesselhof-den Dulk MM

更新日期：1983-03-01 00:00:00

abstract：:Clinically, corticosteroids (CS) are among the first line drugs in the therapy of autoimmune and allergic diseases and potently inhibit the activation of immune cells. However, due to their pleiotropic mode of action, the prolonged use of CS is generally associated with a range of undesirable side-effects. In this stu...

journal_title：Clinical and experimental immunology

authors： Kalthoff FS,Chung J,Musser P,Stuetz A

更新日期：2003-09-01 00:00:00

abstract：:Binding of lymphocytes to human umbilical vein endothelial cells (EC) was quantitated by measuring adhesion of 51Cr labelled lymphocytes to endothelial cell monolayers and rosette formation between lymphocytes and EC in suspension. Mitogen stimulated human peripheral blood mononuclear cell culture supernatants and mix...

journal_title：Clinical and experimental immunology

authors： Yu CL,Haskard DO,Cavender D,Johnson AR,Ziff M

更新日期：1985-12-01 00:00:00

abstract：:Epstein-Barr (EB) virus serology was correlated with the results of immunological investigations of three inherited immunodeficiency diseases, in an attempt to understand the immune mechanisms controlling EB virus infection. In nine patients with Wiskott-Aldrich syndrome (WAS), the constant lack of anti-EB virus assoc...

journal_title：Clinical and experimental immunology

authors： Vilmer E,Lenoir GM,Virelizier JL,Griscelli C

更新日期：1984-02-01 00:00:00

abstract：:The open reading frame of human proteinase 3 (PR3) without the prepro-peptide was cloned and expressed in Escherichia coli (rcPR3) and in Pichia pastoris (rpPR3). The 6-histidine tagged rpPR3 was efficiently secreted into culture supernatant from which it could be purified by immobilized metal chelate chromatography. ...

journal_title：Clinical and experimental immunology

authors： Harmsen MC,Heeringa P,van der Geld YM,Huitema MG,Klimp A,Tiran A,Kallenberg CG

更新日期：1997-11-01 00:00:00

abstract：:Cell-mediated cytotoxicity was examined in thirty-seven patients with systemic sclerosis using both whole blood and purified peripheral blood mononuclear cells (PBM) to measure antibody-dependent (ADCC) and phytohaemagglutinin (PHA) induced lymphocyte cytotoxicity to 51Cr-labelled Chang liver cells. In twenty-three mi...

journal_title：Clinical and experimental immunology

authors： Wright JK,Hughes P,Rowell NR,Sneddon IB

更新日期：1979-04-01 00:00:00

abstract：:This longitudinal study investigates the change of erythrocyte complement receptor (E-CR1) expression in patients with severe acute respiratory syndrome (SARS). Circulating E-CR1 expression was semiquantified by flow cytometric analyses in 54 SARS patients and in 212 healthy individuals as a control. Since E-CR1 expre...

journal_title：Clinical and experimental immunology

authors： Wang FS,Chu FL,Jin L,Li YG,Zhang Z,Xu D,Shi M,Wu H,Moulds JM

更新日期：2005-01-01 00:00:00

abstract：:We examined the effect of IL-6 on the development of autoimmune diseases (primary biliary cirrhosis, Sjögren's syndrome) employing murine graft-versus-host reaction (GVHR) model with MHC class II disparity. For this purpose, we used IL-6 transgenic (B6.6) mice in which a high level of IL-6 was detected. C57Bl/6 (B6) s...

journal_title：Clinical and experimental immunology

authors： Kimura T,Suzuki K,Inada S,Hayashi A,Saito H,Miyai T,Ohsugi Y,Matsuzaki Y,Tanaka N,Osuga T

更新日期：1994-03-01 00:00:00

abstract：:Acute coronary syndromes (ACS) are associated with inflammation resulting from monocyte activation. We sought for differences in the production of pro- and anti-inflammatory cytokines by monocytes from patients with ACS. C-reactive protein (CRP) and neopterin were measured in 22 patients with acute coronary syndromes,...

journal_title：Clinical and experimental immunology

authors： van Haelst PL,Tervaert JW,Bijzet J,Baljé-Volkers C,May JF,Langeveld B,Gans RO

更新日期：2004-11-01 00:00:00

abstract：:The Km for AMP for 5' nucleotidase was increased in lymphocytes from patients with common variable (CVH) and sex linked (XLH) hypogammaglobulinaemia and from patients with chronic lymphatic leukaemia (CLL): the Vmax of the latter was low. The kinetic constants for cord blood lymphocytes are similar to adults and the K...

journal_title：Clinical and experimental immunology

authors： Shah T,Webster AD,Peters TJ

更新日期：1984-07-01 00:00:00

abstract：:Antibody response and antigen specific suppression to bovine serum albumin (BSA) in uremic rats have been investigated. Primary immune response was found to be significantly reduced independent of the route of administration or adjuvant while secondary response was affected only in animals in which a weak adjuvant suc...

journal_title：Clinical and experimental immunology

authors： Mezzano S,Pesce A,Peters T Jr,Pollak VE,Reed R,Michael G

更新日期：1982-04-01 00:00:00

abstract：:Four human B cell lines with a mature phenotype (immunoglobulin secretion and expression of membrane markers associated with maturation) were cultured in the presence of phorbol ester (PMA), dimethyl sulphoxide (DMSO) and two conditioned media. PMA and DMSO led to changes in phenotype which suggested the cells were be...

journal_title：Clinical and experimental immunology

authors： Zola H,Griffith V,Hunter I,Koh L,Bradley J

更新日期：1986-11-01 00:00:00

abstract：:Here we describe the presence of IgG antibodies, in the sera of patients presenting with insulin-dependent diabetes mellitus (IDDM), that react in Western blots with a 60-kD protein (Mr 60K) from rat hepatic microsomal extracts. Sera from 60 IDDM patients were screened and 31.6% were positive for the Mr 60K band. This...

journal_title：Clinical and experimental immunology

authors： Pehuet-Figoni M,Alvarez F,Bach JF,Chatenoud L

更新日期：2000-11-01 00:00:00

abstract：:Anti-phospholipid syndrome (APS) is characterized by arterial and/or venous thrombosis and pregnancy morbidity. It is well known that in these patients thrombosis may be the result of a hypercoagulable state related to anti-β2-glycoprotein I (β2-GPI) antibodies. Moreover, platelets may play a role in thrombotic manife...

journal_title：Clinical and experimental immunology

authors： Capozzi A,Manganelli V,Riitano G,Recalchi S,Truglia S,Alessandri C,Longo A,Garofalo T,Misasi R,Valesini G,Conti F,Sorice M

更新日期：2019-04-01 00:00:00

abstract：:The most likely source of autoantigens in systemic lupus erythematosus (SLE) is apoptotic material. Because increased levels of circulating apoptotic cells are found in SLE we wanted to investigate the capacity of serum from patients with SLE or other autoimmune or infectious diseases and normal healthy donors (NHD) t...

journal_title：Clinical and experimental immunology

authors： Bengtsson AA,Sturfelt G,Gullstrand B,Truedsson L

更新日期：2004-03-01 00:00:00

abstract：:C4BP has a central role in regulating the classical complement (C') pathway, but it is still uncertain whether or not it is consumed during in vivo complement activation. Attempts to demonstrate changes in C4BP plasma levels in systemic lupus erythematosus and essential mixed cryoglobulinaemia have failed, probably du...

journal_title：Clinical and experimental immunology

authors： Bergamaschini L,Miedico A,Cicardi M,Coppola R,Faioni EN,Agostoni A

更新日期：1999-05-01 00:00:00

abstract：:In essential mixed, type II, cryoglobulinaemia (EMC) monoclonal autoantibodies with rheumatoid factor activity are synthesized at an accelerated rate by non-malignant B lymphocytes. In order to determine if the high cryoglobulin production rate is related to a clonal B cell expansion, cell surface markers of periphera...

journal_title：Clinical and experimental immunology

authors： Perl A,Gorevic PD,Ryan DH,Condemi JJ,Ruszkowski RJ,Abraham GN

更新日期：1989-04-01 00:00:00

abstract：:Incubation with thymosin fraction 5, (TMS F5 at 300 micrograms/ml) a partially purified thymic factor, reduced the steroid binding activity of human infant thymocytes from 9.6 +/- 2.1 fmole/ml to 5.0 +/- 2.0 fmole/ml. The glucocorticoid receptor activity in normal infant thymocytes was found to be 2,146 +/- 726 (s.d.)...

journal_title：Clinical and experimental immunology

authors： Ma DD,Ho AH,Hoffbrand AV

更新日期：1984-02-01 00:00:00

abstract：:We report a study on immunoregulation of in vitro antibody to hepatitis B surface antigen (anti-HBs) synthesis induced by pokeweed mitogen (PWM) from peripheral blood mononuclear cells (PBMC) in chronic hepatitis B surface antigen (HBsAg) carriers and in 'high responders', (anti-HBs RIA ratio greater than or equal to ...

journal_title：Clinical and experimental immunology

authors： Barnaba V,Valesini G,Levrero M,Zaccari C,Van Dyke A,Falco M,Musca A,Balsano F

更新日期：1985-05-01 00:00:00

abstract：:We investigated whether deficiency of mannose-binding lectin (MBL), a component of innate immunity, is associated with neonatal pneumonia and sepsis during the first 72 h, i.e. early onset, and during the first month after birth. In 88 neonatal intensive care patients (71 premature), MBL2 genotype and MBL plasma level...

journal_title：Clinical and experimental immunology

authors： Frakking FN,Brouwer N,van Eijkelenburg NK,Merkus MP,Kuijpers TW,Offringa M,Dolman KM

更新日期：2007-11-01 00:00:00

abstract：:Complement receptor type 1 (CR1) is an integral membrane protein of many haematopoietic cells and plays an important role in the clearance of complement-associated immune complexes, favouring their transport to liver and spleen macrophages. A small amount of soluble CR1 (sCR1) is also found in plasma and might origina...

journal_title：Clinical and experimental immunology

authors： Di Bona D,Montalto G,Clemenza L,Bascone F,Accardo P,Bellavia D,Craxì A,Brai M

更新日期：1998-10-01 00:00:00

abstract：:Antibody-dependent cellular cytotoxicity (ADCC) of peripheral blood lymphocytes against chicken red blood cells (ChRBC) in the presence of specific antiserum has been studied in normal subjects and in patients with acute hepatitis B and with chronic active hepatitis (CAH). ADCC was significantly reduced in patients wi...

journal_title：Clinical and experimental immunology

authors： Bortolotti F,Realdi G,Diodati G,Fattovich G

更新日期：1978-08-01 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis. Historically believed to be a relatively rare human disease in tropical countries, a recent study estimated that, worldwide, there are approximately 165 000 human melioidosis cases per year, more than half of whom die. The bacterium is inherently resista...

journal_title：Clinical and experimental immunology

authors： Morici L,Torres AG,Titball RW

更新日期：2019-05-01 00:00:00

abstract：:Interferon-gamma (IFN-gamma) has been recognized to possess diverse non-immunological effects on epithelial cells such as cellular growth and differentiation. We have previously demonstrated that IFN-gamma suppressed thyroid-stimulating hormone (TSH)-stimulated thyroglobulin (TG) synthesis in human thyrocytes through ...

journal_title：Clinical and experimental immunology

authors： Kung AW,Ma L,Lau KS

更新日期：1992-02-01 00:00:00

abstract：:L-selectin in one of the key members of the selectin family of adhesion molecules and initiates leucocyte attachment to specialized high endothelial venules. The shed form, which retains functional activity, can be detected in biological fluids and is increased in diseases of many kinds. In the present study, we inves...

journal_title：Clinical and experimental immunology

authors： Zhang JG,Morgan L,Spickett GP

更新日期：1996-05-01 00:00:00