Abstract:
:Complement receptor type 1 (CR1) is an integral membrane protein of many haematopoietic cells and plays an important role in the clearance of complement-associated immune complexes, favouring their transport to liver and spleen macrophages. A small amount of soluble CR1 (sCR1) is also found in plasma and might originate directly from release of leucocytes and other circulating cells. In previous studies, an increase in serum sCR1 level has been observed in liver cirrhosis and end-stage renal failure. High levels have also been found in patients with some haematologic malignancies. sCR1 serum levels were measured using a specific double sandwich ELISA assay. The present study demonstrates the correlation between mean serum sCR1 concentrations and disease severity in patients with chronic liver disease. In patients with liver cirrhosis, grouped according to the Child-Pugh classification, sCR1 rose as liver function decreased. The presence of neoplastic growth in the liver apparently does not play a role in the increase of sCR1. Serum sCR1 was not elevated in other solid malignancies. Since sCR1 accumulates in liver diseases, evaluation of its serum levels could be useful as a liver function test.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Di Bona D,Montalto G,Clemenza L,Bascone F,Accardo P,Bellavia D,Craxì A,Brai Mdoi
10.1046/j.1365-2249.1998.00707.xsubject
Has Abstractpub_date
1998-10-01 00:00:00pages
102-5issue
1eissn
0009-9104issn
1365-2249journal_volume
114pub_type
杂志文章abstract::Functional impairments of polymorphonuclear granulocytes (PMN) are believed to contribute to hampered inflammation and host defence in alcoholics. We studied effects of i.v. ethanol administration on PMN responses in rabbits during induction of a knee-joint synovitis. The synovitis conferred systemic effects, since ch...
journal_title:Clinical and experimental immunology
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journal_title:Clinical and experimental immunology
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pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
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journal_title:Clinical and experimental immunology
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