Clonal B cell expansions in patients with essential mixed cryoglobulinaemia.

abstract：:Native human CRP in solution formed complexes with the abnormal lipoprotein beta-VLDL in serum of patients with type III hyperlipoproteinaemia. CRP also formed complexes in sera from individuals with type IV and type V hyperlipoproteinaemia. The binding was calcium-dependent and inhibitable by free phosphoryl choline....

journal_title：Clinical and experimental immunology

authors： Rowe IF,Soutar AK,Trayner IM,Thompson GR,Pepys MB

更新日期：1984-10-01 00:00:00

abstract：:A complete functional deficiency of C1q is described in a patient suffering from SLE. From reduced plasma C1 activity of the parents a hereditary trait was assumed. The defective C1q molecule was haemolytically inactive, did not bind to immune complexes, and was not recognized by the monocyte C1q receptor. C1 activity...

journal_title：Clinical and experimental immunology

authors： Kirschfink M,Petry F,Khirwadkar K,Wigand R,Kaltwasser JP,Loos M

更新日期：1993-11-01 00:00:00

abstract：:The pattern of T cell receptor V gene expression by lymphocytes from rheumatoid synovial fluid and paired peripheral blood samples was compared using a polymerase chain reaction (PCR)-based assay. Eight rheumatoid arthritis (RA) patients who had varying durations of disease (from 2 to 20 years) were studied. In all pa...

journal_title：Clinical and experimental immunology

authors： Lunardi C,Marguerie C,So AK

更新日期：1992-12-01 00:00:00

abstract：:The influx of monocytes and neutrophils into the inflamed tissue could be an important aspect in the pathogenesis of inflammatory bowel disease (IBD). A membrane protein involved in the monocyte/neutrophil adherence to endothelium is CD11b/CD18 or alpha M beta 2 (complement receptor type 3 = CR3). In the present study...

journal_title：Clinical and experimental immunology

authors： Palmen MJ,Dijkstra CD,van der Ende MB,Peña AS,van Rees EP

更新日期：1995-08-01 00:00:00

abstract：:In this study which included 16 patients with inflammatory or non-inflammatory arthropathies, human granulocyte-macrophage colony-stimulating activity was detected in synovial fluid. This was attributable to the presence of colony-stimulating factor(s) (CSF), as a direct action on human bone marrow progenitor cells wa...

journal_title：Clinical and experimental immunology

authors： Williamson DJ,Begley CG,Vadas MA,Metcalf D

更新日期：1988-04-01 00:00:00

abstract：:Human thyroid epithelial cells (thyrocytes) express HLA Class II molecules in autoimmune thyroid diseases (ATD). Normal thyrocytes do not express Class II, but can be induced to do so by culture with interferon-gamma (gamma-IFN). We have examined HLA-D subregion expression in sections and monolayers of thyroid by indi...

journal_title：Clinical and experimental immunology

authors： Todd I,Pujol-Borrell R,Abdul-Karim BA,Hammond LJ,Feldmann M,Bottazzo GF

更新日期：1987-09-01 00:00:00

abstract：:It has been postulated that autoantibody formation occurs as a consequence of a depression of function of certain thymus-derived lymphocytes (T cells). We have examined cell-mediated immunity, a T-cell function, in infectious mononucleosis, a condition in which autoantibodies are known to develop. We have shown some e...

journal_title：Clinical and experimental immunology

authors： Russell AS,Percy JS,Grace M

更新日期：1975-04-01 00:00:00

abstract：:The emerging role of interleukin (IL)-17 as a hallmark proinflammatory cytokine of the adaptive immune system, produced primarily by a new T helper cell subset termed 'Th17', has received considerable attention. Differentiation of Th17 cells is driven by the simultaneous presence of transforming growth factor-beta and...

journal_title：Clinical and experimental immunology

authors： Nalbandian A,Crispín JC,Tsokos GC

更新日期：2009-08-01 00:00:00

abstract：:A highly concentrated (20%) immunoglobulin (Ig)G preparation for subcutaneous administration (IGSC 20%), would offer a new option for antibody replacement therapy in patients with primary immunodeficiency diseases (PIDD). The efficacy, safety, tolerability and pharmacokinetics of IGSC 20% were evaluated in a prospecti...

journal_title：Clinical and experimental immunology

authors： Borte M,Kriván G,Derfalvi B,Maródi L,Harrer T,Jolles S,Bourgeois C,Engl W,Leibl H,McCoy B,Gelmont D,Yel L

更新日期：2017-01-01 00:00:00

abstract：:An injection of human renal tubular fraction, Fx1A, with Freund's complete adjuvant in rats induces Heymann nephritis (HN) with clinical and morphological features similar to rat Fx1A-induced HN. The present study was undertaken to characterize antibody specificities and the corresponding antigen involved in human Fx1...

journal_title：Clinical and experimental immunology

authors： Natori Y,Hayakawa I,Shibata S

更新日期：1987-07-01 00:00:00

abstract：:It has earlier been reported that the human monoclonal antibody (MoAb 33G2) and polyclonal antibodies reactive with Pf332 may interfere in vitro with the erythrocytic cycle of Plasmodium falciparum at two potential target sites for protective antibodies, indicating that the antigen may constitute an important target f...

journal_title：Clinical and experimental immunology

authors： Iqbal J,Perlmann P,Greenwood BM,Berzins K

更新日期：1993-10-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) administration in vivo has been shown to improve the defence mechanisms against infection by different microbes. Here we evaluated a possible protective role of this molecule in a mouse model of mycobacterial infection. The administration of recombinant G-CSF promoted an e...

journal_title：Clinical and experimental immunology

authors： Gonçalves AS,Appelberg R

更新日期：2001-05-01 00:00:00

abstract：:Factor H and the FHL-1/reconectin protein are two human plasma proteins that act as important regulators of the alternative complement pathway. Each protein is encoded by a unique transcript, but both mRNAs are derived from the factor H gene by means of alternative processing. In order to address potential functional ...

journal_title：Clinical and experimental immunology

authors： Friese MA,Hellwage J,Jokiranta TS,Meri S,Müller-Quernheim HJ,Peter HH,Eibel H,Zipfel PF

更新日期：2000-08-01 00:00:00

abstract：:PHA activated human peripheral blood mononuclear cells (MNC) were incubated with human interleukin 2 (IL-2) in the absence or in the presence of 10(-6)-10(-9) M hydrocortisone (HC). HC suppressed the proliferative response of the activated MNC to highly purified human leucocyte IL-2 in a dose dependent manner. This su...

journal_title：Clinical and experimental immunology

authors： Horst HJ,Flad HD

更新日期：1987-04-01 00:00:00

abstract：:Cyclosporin A (Cy A) enhances immunoglobulin (Ig) production by EB virus stimulated peripheral blood lymphocytes from normal subjects with prior immunity to EB virus. In 11 normal adults, this enhancement of Ig production correlated with T cell-mediated cytotoxic regression. Cultures from normal healthy adults without...

journal_title：Clinical and experimental immunology

authors： Pereira RS,Gear AJ,Doré CJ,Webster AD

更新日期：1983-07-01 00:00:00

abstract：:Recurrent respiratory papillomatosis (RRP) is characterized by benign exophytic lesions of the respiratory tract caused by the human papillomavirus (HPV), in particular low-risk HPV6 and HPV11. Aggressiveness varies greatly among patients. Surgical excision is the current standard of care for RRP, with adjuvant therap...

journal_title：Clinical and experimental immunology

authors： Ivancic R,Iqbal H,deSilva B,Pan Q,Matrka L

更新日期：2020-02-01 00:00:00

abstract：:Dysfunction of cytotoxic activity of T and natural killer (NK) lymphocytes is a main immunological feature in patients with AIDS, but its basis are not well understood. It has been recently described that T and NK cell-mediated cytotoxicity can be regulated by HLA killer inhibitory receptors (KIR). In this work, we ha...

journal_title：Clinical and experimental immunology

authors： Galiani MD,Aguado E,Tarazona R,Romero P,Molina I,Santamaria M,Solana R,Peña J

更新日期：1999-03-01 00:00:00

abstract：:By immunological screening of a cDNA library derived from protoscoleces of Echinococcus granulosus with IgE from patients with cystic echinococcosis (CE) and allergic manifestations, we isolated a protein identical to E. granulosus cyclophilin. The protein, named EA21, has close homology with Malassezia furfur cycloph...

journal_title：Clinical and experimental immunology

authors： Ortona E,Vaccari S,Margutti P,Delunardo F,Rigano R,Profumo E,Buttari B,Rasool O,Teggi A,Siracusano A

更新日期：2002-04-01 00:00:00

abstract：:Human mononuclear leucocytes (MNL) or the adherent fraction (monocytes) produced tumour necrosis factor-alpha (TNF-alpha) (by ELISA) in culture when stimulated with killed Staphylococcus aureus. The bisbenzylisoquinoline alkaloid, tetrandrine inhibited the capacity of MNL and monocytes to produce TNF-alpha at a concen...

journal_title：Clinical and experimental immunology

authors： Ferrante A,Seow WK,Rowan-Kelly B,Thong YH

更新日期：1990-05-01 00:00:00

abstract：:During 25 years of research since HIV-1 was first identified in Paris, there have been great advances in our understanding of the virus and of the immune system. Practical advances include the early development of diagnostic tests of infection that made blood donation safe, and since 1996, combination anti-retroviral ...

journal_title：Clinical and experimental immunology

authors： Weiss RA

更新日期：2008-05-01 00:00:00

abstract：:A soluble form of CD23 (sCD23) was found in the urine from 12 normal individuals but was not present in 20 normal sera, suggesting that sCD23 produced by cells in tissues is eliminated in the urine. The sCD23 from urine differed in physicochemical properties from the sCD23 found in supernates from B-lymphoblastoid cel...

journal_title：Clinical and experimental immunology

authors： Ling NR,Stevenson FK,Brown B

更新日期：1991-12-01 00:00:00

abstract：:The objective of this study was to evaluate prospectively the relationship between Yersinia enterocolitica (YE) infection and the development of overt autoimmune hypo- or hyperthyroidism (study A) and the de novo occurrence of thyroid antibodies (study B). This was a prospective cohort study of 790 euthyroid women who...

journal_title：Clinical and experimental immunology

authors： Effraimidis G,Tijssen JG,Strieder TG,Wiersinga WM

更新日期：2011-07-01 00:00:00

abstract：:Primary immunodeficiencies (PIDs) are uncommon, chronic and severe disorders of the immune system in which patients cannot mount a sufficiently protective immune response, leading to an increased susceptibility to infections. The treatment of choice for PID patients with predominant antibody deficiency is intravenous ...

journal_title：Clinical and experimental immunology

authors： Ballow M,Notarangelo L,Grimbacher B,Cunningham-Rundles C,Stein M,Helbert M,Gathmann B,Kindle G,Knight AK,Ochs HD,Sullivan K,Franco JL

更新日期：2009-12-01 00:00:00

abstract：:Autoantibodies to the intermediate filament proteins vimentin and keratin were studied in sera of 50 Caribbean patients with Schistosoma mansoni infection and 50 control subjects. Autoantibodies were detected by indirect immunofluorescence on HEp-2 cells pretreated with colchicine. The incidence of anti-vimentin antib...

journal_title：Clinical and experimental immunology

authors： Boehme MW,Kataaha PK,Holborow EJ

更新日期：1989-08-01 00:00:00

abstract：:Summary The interaction between stroma and blood cells in the human spleen has received little attention, despite their well-defined roles during blood cell development in bone marrow. We have reported previously that human spleen-derived fibroblasts display a differentiated myofibroblast phenotype and constitutively ...

journal_title：Clinical and experimental immunology

authors： Briard D,Azzarone B,Brouty-Boyé D

更新日期：2005-05-01 00:00:00

abstract：:CBA/KlJms-lprcg/lprcg mice with a novel mutation producing systemic lymphoproliferation were investigated for their serological and histological characteristics. The mutant mice showed elevated levels of serum immunoglobulin, C1q-binding immune complexes and antibodies to nuclear antigens such as dsDNA and ssDNA and p...

journal_title：Clinical and experimental immunology

authors： Kimura M,Mohri H,Shimada K,Wakabayashi T,Kanai Y,Matsuzawa A

更新日期：1990-01-01 00:00:00

abstract：:Intestinal epithelial cell (IEC)-derived cytokines, such as stem cell factor (SCF), interleukin (IL)-7 and IL-15 are known to be required for the development of intestinal intraepithelial lymphocytes (IELs). A newly described cytokine, IL-18, has also been shown to be produced by intestinal epithelial cells. To demons...

journal_title：Clinical and experimental immunology

authors： Okazawa A,Kanai T,Nakamaru K,Sato T,Inoue N,Ogata H,Iwao Y,Ikeda M,Kawamura T,Makita S,Uraushihara K,Okamoto R,Yamazaki M,Kurimoto M,Ishii H,Watanabe M,Hibi T

更新日期：2004-05-01 00:00:00

abstract：:The era prior to 1990 was a time of careful observation of disease presentation, course, outcomes and meticulous pathology studies. These mainly single-centre studies introduced new life-saving therapies for drugs still used effectively today. In the 1970-1980s, cyclophosphamide (CyP) added to glucocorticosteroids (GC...

journal_title：Clinical and experimental immunology

authors： Hoffman GS

更新日期：2011-05-01 00:00:00

abstract：:Specific assays for 5'-nucleotidase, adenosine diphosphatase (ADPase) and Mg2+-dependent adenosine triphosphatase (Mg2+-ATPase) have been optimized for human lymphocytes and their subcellular localizations determined by sucrose density gradient centrifugation. 5'-Nucleotidase was localized solely to the plasma membran...

journal_title：Clinical and experimental immunology

authors： Smith GP,Shah T,Webster AD,Peters TJ

更新日期：1982-08-01 00:00:00

abstract：:Amyloid obtained from the myocardium of a patient (Han) with familial amyloid cardiomyopathy of Danish origin was studied. Gel filtration and electrophoresis of purified and denatured amyloid fibrils Han revealed various fractions ranging in mol. wt from 40,000 to 8,000 daltons. Amyloid Han and fractions reacted with ...

journal_title：Clinical and experimental immunology

authors： Husby G,Ranløv PJ,Sletten K,Marhaug G

更新日期：1985-04-01 00:00:00