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Effects of recombinant granulocyte-colony stimulating factor administration during Mycobacterium avium infection in mice.

Abstract：

:Granulocyte colony-stimulating factor (G-CSF) administration in vivo has been shown to improve the defence mechanisms against infection by different microbes. Here we evaluated a possible protective role of this molecule in a mouse model of mycobacterial infection. The administration of recombinant G-CSF promoted an extensive blood neutrophilia but failed to improve the course of Mycobacterium avium infection in C57Bl/6 or beige mice. G-CSF administration also failed to improve the efficacy of a triple chemotherapeutic regimen (clarithromycin + ethambutol + rifabutin). G-CSF treatment did not protect interleukin-10 gene disrupted mice infected with M. avium. Spleen cells from infected mice treated with G-CSF had a decreased priming for antigen-specific production of interferon gamma compared to control infected mice. Our data do not substantiate previous reports on the protective activity of G-CSF in antimycobacterial immunity using mouse models.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Gonçalves AS,Appelberg R

doi

10.1046/j.1365-2249.2001.01552.x

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

239-47

issue

2

eissn

0009-9104

issn

1365-2249

pii

cei1552

journal_volume

124

pub_type

杂志文章

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