The distribution of a specific HLA-B27-associated cell surface component on the tissues of patients with ankylosing spondylitis.

abstract：:We analysed the proportions of different microparticles (MPs) in plasma from patients with rheumatoid arthritis (RA), and assessed their relationship with disease activity/therapy and their in-vitro effect on proinflammatory cytokine release. Blood and urine samples were obtained from 55 patients with RA (24 untreated...

journal_title：Clinical and experimental immunology

authors： Viñuela-Berni V,Doníz-Padilla L,Figueroa-Vega N,Portillo-Salazar H,Abud-Mendoza C,Baranda L,González-Amaro R

更新日期：2015-06-01 00:00:00

abstract：:An immunoglobulin phage display library constructed from a tumour-associated pericolic lymph node was panned against the extracellular domain of the oncoprotein c-erbB-2. Sixteen independent clones were confirmed as positive binders based on ELISA analysis of soluble Fabs. Nucleotide sequencing demonstrated that the V...

journal_title：Clinical and experimental immunology

authors： Clark MA,Hawkins NJ,Papaioannou A,Fiddes RJ,Ward RL

更新日期：1997-07-01 00:00:00

abstract：:beta7 Integrins have been shown to have an important role in the localization of T cells to the intestine. Utilizing two different experimental mouse models of inflammatory bowel disease (IBD), this study was undertaken to determine if beta7 integrin expression is critical for T cell localization to the intestine and ...

journal_title：Clinical and experimental immunology

authors： Sydora BC,Wagner N,Lohler J,Yakoub G,Kronenberg M,Muller W,Aranda R

更新日期：2002-07-01 00:00:00

abstract：:The possible role of cytokines in leprosy reactions was investigated by analysing the levels of tumour necrosis factor (TNF) and interleukin-1 (IL-1) in serum samples from 39 leprosy patients, 22 of them presenting either type I (upgrading) or type II (ENL) reactions. Fifty per cent of the patients showed elevated con...

journal_title：Clinical and experimental immunology

authors： Sarno EN,Grau GE,Vieira LM,Nery JA

更新日期：1991-04-01 00:00:00

abstract：:The human immune response to the 10-kD M. tuberculosis protein was studied by a competition ELISA using monoclonal antibody (MoAb) SA-12. Twenty-five per cent of the sera from 20 patients with tuberculosis and none from 21 control subjects inhibited binding of SA-12 to the 10-kD antigen. To characterize the antigenic ...

journal_title：Clinical and experimental immunology

authors： Verbon A,Hartskeerl RA,Kolk AH

更新日期：1991-10-01 00:00:00

abstract：:Endothelial cells (ECs) are a target in inflammation, and the death of EC is regulated by various factors. Although intravenous immunoglobulin (IVIG) preparations are known to be beneficial therapeutic agents for the treatment of autoimmune diseases and systemic inflammatory disorders, their mechanism of action have n...

journal_title：Clinical and experimental immunology

authors： Nakatani K,Takeshita S,Tsujimoto H,Sekine I

更新日期：2002-03-01 00:00:00

abstract：:To investigate the possible role of IL-6 in the activation of the autoimmune process in systemic lupus erythematosus (SLE), we serially measured concentrations of IL-6, IgG, and anti-dsDNA antibodies before and during exacerbations in patients with SLE. In addition, we serially related the IL-6 response to the generat...

journal_title：Clinical and experimental immunology

authors： Spronk PE,ter Borg EJ,Limburg PC,Kallenberg CG

更新日期：1992-10-01 00:00:00

abstract：:Fifty sera which gave ring-like nuclear staining in immunofluorescence on rat liver tissue sections were characterized. Using immunoprecipitation and Western blotting we showed that 10 of the sera contained antibodies to 200 kD polypeptide(s) of nuclear envelope. Clinical and biological data were available for nine of...

journal_title：Clinical and experimental immunology

authors： Lassoued K,Guilly MN,Andre C,Paintrand M,Dhumeaux D,Danon F,Brouet JC,Courvalin JC

更新日期：1988-11-01 00:00:00

abstract：:Two cationic proteins, a neutral phosphatase (NP-tase) and a 70-kD protein (p70) were isolated from Staphylococcus aureus by ion exchange chromatography. We compared their properties to those of the well established B cell mitogen of whole, fixed Staph. aureus strain Cowan I cells (SAC). Both purified proteins were ab...

journal_title：Clinical and experimental immunology

authors： Jahreis A,Yousif Y,Rump JA,Dräger R,Vogt A,Peter HH,Schlesier M

更新日期：1995-06-01 00:00:00

abstract：:Immunoenzymatic assays were developed for the measurement of antibodies against mycobacterial lipoarabinomannan (LAM), a cell-free proteic extract (CFX) of Mycobacterium leprae, and the 38-kD protein antigen of M. tuberculosis. Sera from 108 leprosy patients, belonging to all clinical-immunological forms of the spectr...

journal_title：Clinical and experimental immunology

authors： Sousa AO,Henry S,Marója FM,Lee FK,Brum L,Singh M,Lagrange PH,Aucouturier P

更新日期：1998-01-01 00:00:00

abstract：:Uveitis (intraocular inflammation) is a leading cause of loss of vision. Although its aetiology is largely speculative, it is thought to arise from complex genetic-environmental interactions that break immune tolerance to generate eye-specific autoreactive T cells. Experimental autoimmune uveitis (EAU), induced by imm...

journal_title：Clinical and experimental immunology

authors： Brown BR,Lee EJ,Snow PE,Vance EE,Iwakura Y,Ohno N,Miura N,Lin X,Brown GD,Wells CA,Smith JR,Caspi RR,Rosenzweig HL

更新日期：2017-12-01 00:00:00

abstract：:We report the immunological studies on three transplantable lymphoma lines that developed when CAF1 mice were injected with busulfan and chloramphenicol. The lymphoma cells displayed Thy-1.2, brain associated antigen, and H-2d alloantigen. They were negative for surface IgM and Ia antigens. Expression of T cell differ...

journal_title：Clinical and experimental immunology

authors： Bhoopalam N,Price K,Norgello H,Barone-Varelas J,Fried W

更新日期：1986-06-01 00:00:00

abstract：:Protection against intracellular pathogens such as Mycobacterium leprae is critically dependent on the function of NK cells at early stages of the immune response and on Th1 cells at later stages. In the present report we evaluated the role of IL-18 and IL-13, two cytokines that can influence NK cell activity, in the ...

journal_title：Clinical and experimental immunology

authors： de la Barrera S,Finiasz M,Fink S,Ilarregui J,Aleman M,Olivares L,Franco MC,Pizzariello G,del Carmen Sasiain M

更新日期：2004-01-01 00:00:00

abstract：:Parasite antigens released from Trypanosoma cruzi-infected cells were adsorbed to infected and uninfected mammalian cells thus rendering them susceptible to immune lysis by antibody and cell-mediated immunity directed against the parasite. BALB/c mice infected with T. cruzi for 15 days developed cytotoxic T lymphocyte...

journal_title：Clinical and experimental immunology

authors： Ribeiro Dos Santos R,Hudson L

更新日期：1980-04-01 00:00:00

abstract：:Myasthenia gravis (MG) is a debilitating and potentially fatal neuromuscular disease characterized by the generation of autoantibodies reactive with nicotinic acetylcholine receptors (AChR) that cause loss of AChR from the neuromuscular endplate with resultant failure of neuromuscular transmission. A role for compleme...

journal_title：Clinical and experimental immunology

authors： Chamberlain-Banoub J,Neal JW,Mizuno M,Harris CL,Morgan BP

更新日期：2006-11-01 00:00:00

abstract：:Regulatory T cells (T(regs)) may inhibit immunity against cancer. Induction and expansion of T(regs) in the immunosuppressive microenvironment created by a growing tumour appear to be one of the mechanisms by which it can evade host defence. We studied the impact of CD25+ T(regs) in a B cell lymphoma model in which Ra...

journal_title：Clinical and experimental immunology

authors： Heier I,Hofgaard PO,Brandtzaeg P,Jahnsen FL,Karlsson M

更新日期：2008-05-01 00:00:00

abstract：:The HLA phenotype of fifty-four patients with myasthenia gravis (MG) was compared to that of 600 controls. When male and female patients were compared separately with the control group, HLA-B12 was increased in MG males (P less than 0-023) and HLA-A1, B8 in MG females (P less than 0-023). In addition, HLA-A1, B8 was c...

journal_title：Clinical and experimental immunology

authors： Gross WL,Krüger J,Gröschel-Stewart U,Friedrich H,Kunze K

更新日期：1977-01-01 00:00:00

abstract：:To investigate the binding properties of dendritic cells (DC) to vascular endothelium, a comparative analysis was undertaken of DC, monocytes and lymphocytes isolated from the blood of 25 healthy subjects using monolayers of human umbilical vein endothelial cells as the adherence substrate. More blood DC (mean 24% adh...

journal_title：Clinical and experimental immunology

authors： Brown KA,Bedford P,Macey M,McCarthy DA,Leroy F,Vora AJ,Stagg AJ,Dumonde DC,Knight SC

更新日期：1997-03-01 00:00:00

abstract：:It has previously been shown that murine sarcoma cells express high-affinity IL-4 receptors (IL-4R) which are internalized after binding to the ligand (Puri et al., Cancer Res 1991; 51:3011-7). We have also reported that human renal cell carcinoma cells express high-affinity IL-4R, and IL-4 inhibits tumour growth in v...

journal_title：Clinical and experimental immunology

authors： Obiri NI,Siegel JP,Varricchio F,Puri RK

更新日期：1994-01-01 00:00:00

abstract：:Measles-specific IgA antibody titres were determined by radioimmunoassay (RIA) for serial serum, saliva and tear samples obtained from 21 children with measles infection, from onset of rash until up to 14 months later. Serum IgA titres rose rapidly after onset of illness and remained detectable throughout the follow-u...

journal_title：Clinical and experimental immunology

authors： Friedman MG,Phillip M,Dagan R

更新日期：1989-01-01 00:00:00

abstract：:There is increasing interest in the role of T cell exhaustion and it is well known that the natural history of chronic hepatitis C virus infection (HCV) is modulated by CD8(+) T cell immunobiology. There are many pathways that alter the presence of exhaustive T cells and, in particular, they are functionally impaired ...

journal_title：Clinical and experimental immunology

authors： Sumida K,Shimoda S,Iwasaka S,Hisamoto S,Kawanaka H,Akahoshi T,Ikegami T,Shirabe K,Shimono N,Maehara Y,Selmi C,Gershwin ME,Akashi K

更新日期：2013-10-01 00:00:00

abstract：:Heymann nephritis of the rat has several similarities to human idiopathic membranous glomerulo-nephropathy, and therefore serves as an animal model for study of the human disease. The disease process in the rat is initiated by autoantibodies forming in situ immune deposits on the surface of the glomerular epithelial c...

journal_title：Clinical and experimental immunology

authors： Singh AK,Kasinath BS

更新日期：1993-12-01 00:00:00

abstract：:Complement C6 has a common charge polymorphism designated A and B with gene frequencies of 0.65 and 0.35. The probable molecular basis for this is a Glu (C6A) for Ala (C6B) substitution at amino acid position 98, and is detected by digestion with the restriction enzyme Dde I of a polymerase chain reaction (PCR)-amplif...

journal_title：Clinical and experimental immunology

authors： Fernie BA,Hobart MJ,Delbridge G,Potter PC,Orren A,Lachmann PJ

更新日期：1994-02-01 00:00:00

abstract：:Mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway (BN) rats is a highly polarized polyclonal Th2-driven autoimmune response with increased IgE production, lymphoproliferation, vasculitis and proteinuria. The increase in serum IgE concentration is clearly measurable by day 4 after the first HgCl2 injection...

journal_title：Clinical and experimental immunology

authors： Macphee IA,Turner DR,Yagita H,Oliveira DB

更新日期：2002-09-01 00:00:00

abstract：:In normal subjects, factor B and C3b inactivator (KAF) levels were linearly related (r = 0-71); factor B levels in subjects with low normal levels of KAF were significantly lower than in those with high normal levels of KAF. This relationship is postulated to be the result of modulation by the level of KAF of the avai...

journal_title：Clinical and experimental immunology

authors： Forristal J,Iitaka K,Vallota EH,West CD

更新日期：1977-04-01 00:00:00

abstract：:Both viral effect and immune-mediated mechanism are involved in the pathogenesis of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection. In this study, we showed that in SARS patient sera there were autoantibodies (autoAbs) that reacted with A549 cells, the type-2 pneumocytes, and that these ...

journal_title：Clinical and experimental immunology

authors： Lin YS,Lin CF,Fang YT,Kuo YM,Liao PC,Yeh TM,Hwa KY,Shieh CC,Yen JH,Wang HJ,Su IJ,Lei HY

更新日期：2005-09-01 00:00:00

abstract：:The immunoregulatory role of histamine is presumably mediated by specific receptors on the plasma membrane of lymphocytes. However, using murine spleen cells and a whole cell assay commonly applied in hormone receptor studies, specific histamine receptors with an affinity higher than that of non-specific binding could...

journal_title：Clinical and experimental immunology

authors： Wang Y,Kristensen F,Joncourt F,Slauson DO,De Weck AL

更新日期：1983-11-01 00:00:00

abstract：:We report a case of a combined immunodeficiency (CID) in a child affected by trichothiodystrophy (TTD) characterized by an altered response to ultraviolet (UV) light due to a defect in the XPD gene. The XPD gene encodes a subunit of the transcription factor II H (TFIIH), a complex involved in nucleotide-excision repai...

journal_title：Clinical and experimental immunology

authors： Racioppi L,Cancrini C,Romiti ML,Angelini F,Di Cesare S,Bertini E,Livadiotti S,Gambarara MG,Matarese G,Lago Paz F,Stefanini M,Rossi P

更新日期：2001-12-01 00:00:00

abstract：:Individuals with type 1 diabetes (T1D) are at increased risk of coeliac disease (CD), autoimmune thyroiditis and autoimmune gastritis, but the absolute risks are unclear. The aim of this study was to investigate the prevalence of autoantibodies to tissue transglutaminase (TGA), thyroid peroxidase (TPOA) and gastric H+...

journal_title：Clinical and experimental immunology

authors： Kozhakhmetova A,Wyatt RC,Caygill C,Williams C,Long AE,Chandler K,Aitken RJ,Wenzlau JM,Davidson HW,Gillespie KM,Williams AJK

更新日期：2018-06-01 00:00:00

abstract：:IgE rheumatoid factor activity was found to be significantly elevated (P less than 0.01) using an ELISA assay when paired synovial fluid and sera from 13 patients with active RA were compared to ten control samples. Synovial fluid IgE RF activity was higher than predicted by diffusion alone in 7/11 (64%) of the RA syn...

journal_title：Clinical and experimental immunology

authors： Gruber B,Ballan D,Gorevic PD

更新日期：1988-02-01 00:00:00