H-ferritin and CD68(+) /H-ferritin(+) monocytes/macrophages are increased in the skin of adult-onset Still's disease patients and correlate with the multi-visceral involvement of the disease.

abstract：:Kawasaki disease (KD) is an immune-mediated vasculitis with symptoms that mimic febrile illness; the immune origin has been suggested but never proved. First, cell chip technology was used to screen immune targets cells. With the indirect immunofluorescence assay we found that the HeLa cell chip could be recognized by...

journal_title：Clinical and experimental immunology

authors： Cui J,Zhou Y,Hu H,Zhao L,Du Z,Du H

更新日期：2018-12-01 00:00:00

abstract：:We have studied the skin and nerve fibrosis in toxic oil syndrome by in situ hybridization using specific cDNA probes for types I, III, and IV collagens. Fibroblasts with high levels of type I and III collagen mRNA were observed in biopsies from fibrotic skin areas. Similarly, type IV collagen mRNA was abundant in cel...

journal_title：Clinical and experimental immunology

authors： Gomez-Reino JJ,Sandberg M,Carreira PE,Vuorio E

更新日期：1993-07-01 00:00:00

abstract：:The objective of the study was to determine the diagnostic value for rheumatoid arthritis (RA) of anti-filaggrin autoantibodies (autoAb) recognizing citrullinated recombinant rat filaggrin (ACRF) in community cases of very early arthritis. To evaluate the diagnostic value of ACRF, were studied sera from patients with ...

journal_title：Clinical and experimental immunology

authors： Vittecoq O,Incaurgarat B,Jouen-Beades F,Legoedec J,Letourneur O,Rolland D,Gervasi G,Ménard JF,Gayet A,Fardellone P,Daragon A,Jolivet M,le Loët X,Tron F

更新日期：2004-01-01 00:00:00

abstract：:The number of thymic epithelial cells containing the serum thymic factor (FTS or thymulin), assessed by indirect immunofluorescence using an anti-FTS monoclonal antibody, was studied in the thymus of normal and autoimmune mice as a function of age. In normal mice the number of FTS+ cells was constant until the age of ...

journal_title：Clinical and experimental immunology

authors： Savino W,Dardenne M,Bach JF

更新日期：1983-04-01 00:00:00

abstract：:Nickel (Ni), the main cause of contact allergy to metals, induces in vitro production of both Th1- and Th2-type cytokines in peripheral blood mononuclear cells (PBMC) from allergic subjects. Because the knowledge of the cellular immune response to other metals involved in contact allergy has been limited, we investiga...

journal_title：Clinical and experimental immunology

authors： Minang JT,Areström I,Troye-Blomberg M,Lundeberg L,Ahlborg N

更新日期：2006-12-01 00:00:00

abstract：:Immunotherapy of murine autoimmune and allergic diseases by administration of peptides corresponding to the dominant T cell epitope is a reality. However, problems remain in applying this therapy to reduce antibody responses in humans. To overcome these difficulties, a preclinical system was developed to test the effe...

journal_title：Clinical and experimental immunology

authors： Jackson DJ,Elson CJ,Kumpel BM

更新日期：2004-08-01 00:00:00

abstract：:Transmembrane activator and calcium modulator and cyclophilin ligand interactor-immunoglobulin (TACI-Ig) is a human fusion protein that binds and neutralizes both B lymphocyte stimulator (BLyS), a cytokine shown to be a key regulator of B cell maturation, proliferation and survival, and a proliferation-inducing ligand...

journal_title：Clinical and experimental immunology

authors： Wang D,Chang Y,Wu Y,Zhang L,Yan S,Xie G,Qin Q,Jin J,Wang W,Fang J,Wei W

更新日期：2011-02-01 00:00:00

abstract：:Antibody response and antigen specific suppression to bovine serum albumin (BSA) in uremic rats have been investigated. Primary immune response was found to be significantly reduced independent of the route of administration or adjuvant while secondary response was affected only in animals in which a weak adjuvant suc...

journal_title：Clinical and experimental immunology

authors： Mezzano S,Pesce A,Peters T Jr,Pollak VE,Reed R,Michael G

更新日期：1982-04-01 00:00:00

abstract：:Activation of human natural killer (NK) cells is associated with the cleavage of CD16 from the cell surface, a process mediated by matrix metalloproteinases (MMPs). In this report, we examined whether inhibition of MMPs would lead to improved NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) function. Using...

journal_title：Clinical and experimental immunology

authors： Zhou Q,Gil-Krzewska A,Peruzzi G,Borrego F

更新日期：2013-07-01 00:00:00

abstract：:Neutrophil phagocytosis and killing of Candida albicans were examined using a radiometric assay in 25 patients with insulin-dependent diabetes and 17 controls under various in vitro metabolic conditions. Glucose was present at 5, 10 and 50 mM, beta-hydroxybutyrate at 1, 5 and 20 mM and glucose with beta-hydroxybutyrat...

journal_title：Clinical and experimental immunology

authors： Wilson RM,Reeves WG

更新日期：1986-02-01 00:00:00

abstract：:We describe two brothers with marked leucopenia, lymphopenia, no immunologicl response to infections (no Ig production, negative PHA response and very low number of T and B lymphocytes in peripheral blood) and hypocellular marrow. They died at 12 and 8 days of life with infection (E. coli and Klebsiella, respectively)...

journal_title：Clinical and experimental immunology

authors： Español T,Compte J,Alvarez C,Tallada N,Laverde R,Peguero G

更新日期：1979-12-01 00:00:00

abstract：:In order to study T-cell function related to the production of autoimmune nephropathy, we immunized random-bred mice, homozygous athymic nude (nu/nu) mice and heterozygous hairy (nu/+) mice with human glomeruli contained in Freund's complete adjuvant. The random-bred and heterozygous hairy mice developed circulating a...

journal_title：Clinical and experimental immunology

authors： Bolton WK,Benton FR,Lobo PI

更新日期：1978-09-01 00:00:00

abstract：:Hepatitis B (HB) vaccine is very promising for the prevention of HB infection. There exist, however, some non-responders to current vaccination trials. In this study, taurine, parotin and lithium were selected as adjuvants which can be administered orally. The mechanisms of these three materials as adjuvants and their...

journal_title：Clinical and experimental immunology

authors： Kuriyama S,Tsujii T,Ishizaka S,Kikuchi E,Kinoshita K,Nishimura K,Kitagami K,Yoshikawa M,Matsumoto M

更新日期：1988-06-01 00:00:00

abstract：:It is unclear how breakdown in immune tolerance to the ubiquitous self-antigen pyruvate dehydrogenase complex (PDC), seen in the autoimmune liver disease PBC, gives rise to tissue damage with such a limited distribution (restricted to the liver and salivary and lachrymal glands). One property shared by these tissues i...

journal_title：Clinical and experimental immunology

authors： Palmer JM,Doshi M,Kirby JA,Yeaman SJ,Bassendine MF,Jones DE

更新日期：2000-12-01 00:00:00

abstract：:Tertiary lymphoid structure (TLS) provides a local and critical microenvironment for both cellular and humoral immunity and supports effective antigen presentation and lymphocyte activation. However, the gene expression profile and prognostic significance of TLS in oral cancer remain largely unrevealed. In this study,...

journal_title：Clinical and experimental immunology

authors： Li K,Guo Q,Zhang X,Dong X,Liu W,Zhang A,Li Y,Yan J,Jia G,Zheng Z,Tang W,Pan L,An M,Zhang B,Liu S,Fu B

更新日期：2020-02-01 00:00:00

abstract：:The serum levels of TGF-beta1, measured by solid-phase ELISA, were determined to be significantly augmented in patients with both relapsing remitting (RR) and secondary chronic progressive (CP) MS compared with sex- and age-matched healthy controls. Moreover, in RR MS patients, the blood levels of the cytokine were fu...

journal_title：Clinical and experimental immunology

authors： Nicoletti F,Di Marco R,Patti F,Reggio E,Nicoletti A,Zaccone P,Stivala F,Meroni PL,Reggio A

更新日期：1998-07-01 00:00:00

abstract：:Antibody responses in immunoglobulin G1, G2, G3, G4, A (IgA1) and M isotypes were studied in 10 patients with an acute influenza A and in another 10 patients with a parainfluenza type 1 virus infection using radioimmunoassay with standardized monoclonal anti-immunoglobulins. A four-fold or greater increase of antibody...

journal_title：Clinical and experimental immunology

authors： Julkunen I,Hovi T,Seppälä I,Mäkelä O

更新日期：1985-04-01 00:00:00

abstract：:Complement receptor 2 (CR2, CD21), the receptor for both the C3d,g portion of human complement component C3 and the Epstein-Barr virus, has been recently described on peripheral T cells. By using dual stain flow cytometric analysis, we have also observed that a peripheral T lymphocyte subpopulation of normal healthy d...

journal_title：Clinical and experimental immunology

authors： Levy E,Ambrus J,Kahl L,Molina H,Tung K,Holers VM

更新日期：1992-11-01 00:00:00

abstract：:Pre-eclampsia is an endothelial disorder and TNF-alpha has fundamental effects on endothelial cells by several means, including altering the balance between oxidant and anti-oxidant, changing the pattern of prostaglandin production and affecting expression of several cell surface components. To determine whether TNF-a...

journal_title：Clinical and experimental immunology

authors： Chen G,R Wilson,Wang SH,Zheng HZ,Walker JJ,McKillop JH

更新日期：1996-04-01 00:00:00

abstract：:Recent evidence suggests that T cell apoptosis could be involved in the pathogenesis of HIV-1 infection. As the progression of HIV-2 associated disease appears to be slower than that of HIV-1, we investigated whether there were differences in the degree of T cell death and apoptosis in peripheral blood mononuclear cel...

journal_title：Clinical and experimental immunology

authors： Jaleco AC,Covas MJ,Victorino RM

更新日期：1994-11-01 00:00:00

abstract：:Skin nuclear speckled IgG deposition was noted in seven patients. The patients' clinical courses satisfied at least four of the preliminary criteria of the American Rheumatism Association for the diagnosis of systemic lupus erthematosus (SLE). Examination of approximately 700 additional biopsies from patiets with SLE,...

journal_title：Clinical and experimental immunology

authors： Shu S,Provost T,Croxdale MB,Reichlin M,Beutner EH

更新日期：1977-02-01 00:00:00

abstract：:This study presents data on more than 300 RA and allergic patients analysed for their serum levels of anti-immunoglobulin isotype autoantibodies and IgE. We observed high levels of IgE in sera of RA and allergic patients. Interestingly, we measured significantly higher specific IgE levels against Alternaria but not ag...

journal_title：Clinical and experimental immunology

authors： Millauer N,Zuercher AW,Miescher SM,Gerber HA,Seitz M,Stadler BM

更新日期：1999-01-01 00:00:00

abstract：:We serially monitored cell surface antigen expression on mononuclear cells in peripheral blood isolated from patients with Kawasaki disease (KD), and found, for the first time, that a markedly increased number of CD4+CD8+ T lymphocytes was present in some of the patients (11 of the 24 cases). The cases of five of thes...

journal_title：Clinical and experimental immunology

authors： Hirao J,Sugita K

更新日期：1998-02-01 00:00:00

abstract：:People receiving therapy with either 8-methoxypsoralen plus long wavelength ultraviolet radiation (PUVA) or medium wavelength ultraviolet radiation (UVB) have been studied to see whether their unresponsiveness to the contact sensitizer dinitrochlorobenzene (DNCB) is a form of immunological tolerance. It was confirmed ...

journal_title：Clinical and experimental immunology

authors： Friedmann PS,White SI,Parker S,Moss C,Matthews JN

更新日期：1989-04-01 00:00:00

abstract：:We used three-colour cytometry to analyse intracellular cytokine production in activated whole blood cultures derived from patients with HIV-1 infection. We assessed mitogen-induced IL-2, IL-4 and IFN-gamma production from T cells as possible markers of immune dysfunction. The percentages of T cells staining for IL-2 ...

journal_title：Clinical and experimental immunology

authors： Westby M,Marriott JB,Guckian M,Cookson S,Hay P,Dalgleish AG

更新日期：1998-02-01 00:00:00

abstract：:We investigated whether deficiency of mannose-binding lectin (MBL), a component of innate immunity, is associated with neonatal pneumonia and sepsis during the first 72 h, i.e. early onset, and during the first month after birth. In 88 neonatal intensive care patients (71 premature), MBL2 genotype and MBL plasma level...

journal_title：Clinical and experimental immunology

authors： Frakking FN,Brouwer N,van Eijkelenburg NK,Merkus MP,Kuijpers TW,Offringa M,Dolman KM

更新日期：2007-11-01 00:00:00

abstract：:Frozen sections of control and coeliac jejunal mucosa were examined for HLA-DR staining. In general the staining pattern in the controls and treated coeliac patients was a patchy subapical pattern on villous tips. Untreated coeliac patients gave a different pattern with staining extending to the crypt enterocytes. Glu...

journal_title：Clinical and experimental immunology

authors： Ciclitira PJ,Nelufer JM,Ellis HJ,Evans DJ

更新日期：1986-01-01 00:00:00

abstract：:Recently we have observed that the CD4+ T cell response of peripheral blood mononuclear cells (PBMC) to soluble antigens is the first to be lost in the course of HIV-1 infection followed by the loss of response to HLA alloantigens. In this study we compared serum neopterin concentrations of individuals with early stag...

journal_title：Clinical and experimental immunology

authors： Fuchs D,Shearer GM,Boswell RN,Clerici M,Reibnegger G,Werner ER,Zajac RA,Wachter H

更新日期：1990-04-01 00:00:00

abstract：:The controlled induction of haemoxygenase-1 (HO-1), an enzyme that catabolizes haem, has been shown to reduce haem, preventing pathologies associated with haem toxicity. The hemoglobin genotype HbAS confers reduced susceptibility to severe complications of malaria by a mechanism that is not well understood. Using a lo...

journal_title：Clinical and experimental immunology

authors： Ademolue TW,Amodu OK,Awandare GA

更新日期：2017-05-01 00:00:00

abstract：:Native human CRP in solution formed complexes with the abnormal lipoprotein beta-VLDL in serum of patients with type III hyperlipoproteinaemia. CRP also formed complexes in sera from individuals with type IV and type V hyperlipoproteinaemia. The binding was calcium-dependent and inhibitable by free phosphoryl choline....

journal_title：Clinical and experimental immunology

authors： Rowe IF,Soutar AK,Trayner IM,Thompson GR,Pepys MB

更新日期：1984-10-01 00:00:00