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Antibody production and antigenic specific suppression to bovine serum albumin in uremic rats.

Abstract：

:Antibody response and antigen specific suppression to bovine serum albumin (BSA) in uremic rats have been investigated. Primary immune response was found to be significantly reduced independent of the route of administration or adjuvant while secondary response was affected only in animals in which a weak adjuvant such as Al(OH)3 was used. Antigen specific suppression of uremic rats was achieved by intravenous pretreatment with BSA or a C terminal fragment (505-582) of BSA. Secondary response in sham operated controls was suppressed by BSA but not by the fragment. There was about five-fold greater retention of the fragments in the uremic rats than in sham-operated controls at a 6 hr or later after i.v. administration.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Mezzano S,Pesce A,Peters T Jr,Pollak VE,Reed R,Michael G

subject

Has Abstract

pub_date

1982-04-01 00:00:00

pages

111-7

issue

1

eissn

0009-9104

issn

1365-2249

journal_volume

48

pub_type

杂志文章

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