In vitro production of IgE by human peripheral blood mononuclear cells. IV. Modulation by allergen of the spontaneous IgE antibody biosynthesis.

abstract：:Soluble histocompatibility antigens of the class II region have been detected in synovial fluids obtained from patients with rheumatoid arthritis. A capture immunoassay involving two monoclonal antibodies was used; interference by rheumatoid factor, which is a feature of such assays, was overcome by mild pretreatment ...

journal_title：Clinical and experimental immunology

authors： Stevenson FK,Douglass WA,Spellerberg MB,Walters MT,Cawley MI

更新日期：1990-04-01 00:00:00

abstract：:To elucidate the mechanisms of anti-DNA production, we assessed the binding of sera of normal human subjects (NHS) and patients with SLE to a panel of bacterial and mammalian DNA. Using single-stranded DNA as antigens in an ELISA, NHS showed significant binding to some but not all bacterial DNA, while lacking reactivi...

journal_title：Clinical and experimental immunology

authors： Wu ZQ,Drayton D,Pisetsky DS

更新日期：1997-07-01 00:00:00

abstract：:In a study of thirty-nine children with recurrent infections, circulating antigens, either free or in the form of immune complexes, were detected in thirty. The ability of sera to inhibit the agglutination of latex by rheumatoid factor or the C1q component of complement was used as a test for the presence of immune co...

journal_title：Clinical and experimental immunology

authors： Delire M,Masson PL

更新日期：1977-09-01 00:00:00

abstract：:A better understanding about the mechanisms involved in the pathogenesis of type 2 diabetes mellitus (T2D) showed that inflammatory cytokines such as tumour necrosis factor (TNF) and interleukin (IL)-1β play a pivotal role, mirroring data largely reported in rheumatoid arthritis (RA). IL-1β is produced mainly by monoc...

journal_title：Clinical and experimental immunology

authors： Ruscitti P,Cipriani P,Di Benedetto P,Liakouli V,Berardicurti O,Carubbi F,Ciccia F,Alvaro S,Triolo G,Giacomelli R

更新日期：2015-10-01 00:00:00

abstract：:The capacity of microbial products to inhibit allergic inflammation make them logical candidates for novel therapies in allergic diseases such as atopic dermatitis. To assess the effects of intradermal Mycobacterium vaccae derivative on allergen-specific immune responses in children with moderate to severe atopic derm...

journal_title：Clinical and experimental immunology

authors： Dunstan JA,Brothers S,Bauer J,Hodder M,Jaksic MM,Asher MI,Prescott SL

更新日期：2011-06-01 00:00:00

abstract：:In this study the antigen-presenting capacity of human peritoneal cells and the influence of continuous ambulant peritoneal dialysis (CAPD) were studied. On average 6% of the peritoneal cells were dendritic cells (DC), with no difference between CAPD and control peritoneal cells. DC were enriched by selecting for non-...

journal_title：Clinical and experimental immunology

authors： Betjes MG,Tuk CW,Struijk DG,Krediet RT,Arisz L,Beelen RH

更新日期：1993-11-01 00:00:00

abstract：:Merozoite surface protein 2 (MSP2) expressed by Plasmodium falciparum asexual blood stages has been identified as a promising vaccine candidate. In order to explore allelic family-specific humoral responses which may be responsible for parasite neutralization during natural infections, isolates from individuals with e...

journal_title：Clinical and experimental immunology

authors： Ekala MT,Jouin H,Lekoulou F,Mercereau-Puijalon O,Ntoumi F

更新日期：2002-08-01 00:00:00

abstract：:The spot-ELISA technique has been used to enumerate the frequency of cells secreting tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), isolated from biopsies of normal intestine and from biopsies of children with inflammatory bowel disease. TNF-alpha production was undetectable in six out of 12...

journal_title：Clinical and experimental immunology

authors： MacDonald TT,Hutchings P,Choy MY,Murch S,Cooke A

更新日期：1990-08-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by extensive immune response, including over-activation of T and B cell development of pathogenic autoantibodies, organ damage induced by the formation and deposition of immune complex and the abnormal elevation of type I interferon. Semaphorin5...

journal_title：Clinical and experimental immunology

authors： Du Y,Wu X,Chen M,Wang W,Xv W,Ye L,Wu D,Xue J,Sun W,Luo J,Wu H

更新日期：2017-05-01 00:00:00

abstract：:Bronchiolitis obliterans syndrome (BOS) is characterized by persistent alloreactive, infective and non-specific epithelial injury, loss of epithelial integrity and dysregulated repair. We have reported increased apoptosis of epithelial cells collected from the large airway in lung transplant recipients. As part of the...

journal_title：Clinical and experimental immunology

authors： Hodge S,Hodge G,Ahern J,Liew CL,Hopkins P,Chambers DC,Reynolds PN,Holmes M

更新日期：2009-11-01 00:00:00

abstract：:Delayed-type hypersensitivity (DTH) to a soluble Mycobacterium leprae skin test antigen (SML) was successfully induced in healthy volunteers following immunization with 2 X 10(8) killed armadillo-derived M. leprae. No better sensitization was obtained by a mixture of live BCG and killed M. leprae. The relative specifi...

journal_title：Clinical and experimental immunology

authors： Smelt AH,Rees RJ,Liew FY

更新日期：1981-06-01 00:00:00

abstract：:The capacity of human T cell subsets, CD4+ or CD8+ T cells, to produce tumour necrosis factors (TNF-alpha and TNF-beta) upon stimulation with toxic shock syndrome toxin-1 (TSST-1) and the requirement for MHC class II molecules on accessory cells (AC) in the response were investigated. The capacity of CD4+ T cells was ...

journal_title：Clinical and experimental immunology

authors： Akatsuka H,Imanishi K,Inada K,Yamashita H,Yoshida M,Uchiyama T

更新日期：1994-06-01 00:00:00

abstract：:By immunological screening of a cDNA library derived from protoscoleces of Echinococcus granulosus with IgE from patients with cystic echinococcosis (CE) and allergic manifestations, we isolated a protein identical to E. granulosus cyclophilin. The protein, named EA21, has close homology with Malassezia furfur cycloph...

journal_title：Clinical and experimental immunology

authors： Ortona E,Vaccari S,Margutti P,Delunardo F,Rigano R,Profumo E,Buttari B,Rasool O,Teggi A,Siracusano A

更新日期：2002-04-01 00:00:00

abstract：:Tuberculosis (TB) enhances human immunodeficiency virus-1 (HIV-1) activity in patients with dual HIV-1/TB infection. Therapies that control augmentations of HIV-1 activity at sites of Mycobacterium tuberculosis (MTB) infection may be useful in inhibition of viral expansion. Regulated upon activation, normal T-cell exp...

journal_title：Clinical and experimental immunology

authors： Toossi Z,Mayanja-Kizza H,Baseke J,Peters P,Wu M,Abraha A,Aung H,Okwera A,Hirsch C,Arts E

更新日期：2005-11-01 00:00:00

abstract：:Statins reduce plasma cholesterol, but clinical trials and in vitro studies indicate that they might also possess anti-inflammatory properties. The effect of simvastatin on circulating cytokines and leucocytes was evaluated in a human in vivo model of low-grade inflammation. Thirty young healthy male participants rece...

journal_title：Clinical and experimental immunology

authors： Erikstrup C,Ullum H,Pedersen BK

更新日期：2006-04-01 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis. Historically believed to be a relatively rare human disease in tropical countries, a recent study estimated that, worldwide, there are approximately 165 000 human melioidosis cases per year, more than half of whom die. The bacterium is inherently resista...

journal_title：Clinical and experimental immunology

authors： Morici L,Torres AG,Titball RW

更新日期：2019-05-01 00:00:00

abstract：:The emerging role of interleukin (IL)-17 as a hallmark proinflammatory cytokine of the adaptive immune system, produced primarily by a new T helper cell subset termed 'Th17', has received considerable attention. Differentiation of Th17 cells is driven by the simultaneous presence of transforming growth factor-beta and...

journal_title：Clinical and experimental immunology

authors： Nalbandian A,Crispín JC,Tsokos GC

更新日期：2009-08-01 00:00:00

abstract：:Antibody-dependent cellular cytotoxicity (ADCC) was investigated as s possible mechanism of pathogenesis in recurrent aphthous ulceration (RAU). ADCC induced by mononuclear cells from patients at various stages of RAU was compared with ADCC induced by mononuclear cells from paired controls. Chicken red blood cells (Ch...

journal_title：Clinical and experimental immunology

authors： Greenspan JS,Gadol N,Olson JA,Talal N

更新日期：1981-06-01 00:00:00

abstract：:The IgG and IgA subclass distribution of specific antibodies as well as the distribution of total and specific IgE in 15 patients with schistosomiasis was determined in consecutive samples before and after initiation of treatment. An adult worm antigen preparation and a soluble egg antigen preparation were used as ant...

journal_title：Clinical and experimental immunology

authors： Evengård B,Hammarström L,Smith CI,Johansson SG,Linder E

更新日期：1988-09-01 00:00:00

abstract：:The high incidence of infections characteristic of impaired cell-mediated immunity in patients with hairy cell leukemia led us to study T lymphocyte function in sixteen patients with the lymphocyte transformation test. All patients showed imparied responses to mitogens, attributable to one or more of the following cau...

journal_title：Clinical and experimental immunology

authors： Sabbe LJ,Meijer CJ,Jansen J

更新日期：1980-11-01 00:00:00

abstract：:New antibodies against a U3 snRNP, which were named anti-Myo 22/25 antibodies, were detected in four (8%) of 53 serum samples from patients with polymyositis/dermatomyositis (PM/DM) by RNA immunoprecipitation. In the protein immunoprecipitation analysis, all four serum samples precipitated 22 kDa and 25 kDa proteins, ...

journal_title：Clinical and experimental immunology

authors： Kubo M,Ihn H,Kuwana M,Yamane K,Yazawa N,Tamaki K

更新日期：2001-11-01 00:00:00

abstract：:A solid-phase platelet membrane enzyme linked immunosorbent assay (ELISA) was developed for the detection of circulating platelet binding IgG in serum. 18 out of 28 (64%) sera from patients with chronic idiopathic thrombocytopenic purpura (ITP) and 10 out of 21 (48%) sera from patients with acute ITP contained more pl...

journal_title：Clinical and experimental immunology

authors： Winiarski J,Ekelund E

更新日期：1986-02-01 00:00:00

abstract：:By using OKT monoclonal antibodies; OKT3(pan T), OKT4(inducer/helper), OKT8 (suppressor/cytotoxic) and OKIa1, T lymphocyte subsets were examined in lymphocytes of patients with tuberculosis both before and after in vitro stimulation with purified protein derivative of tuberculin (PPD). In freshly obtained lymphocytes ...

journal_title：Clinical and experimental immunology

authors： Shiratsuchi H,Tsuyuguchi I

更新日期：1984-08-01 00:00:00

abstract：:This longitudinal study investigates the change of erythrocyte complement receptor (E-CR1) expression in patients with severe acute respiratory syndrome (SARS). Circulating E-CR1 expression was semiquantified by flow cytometric analyses in 54 SARS patients and in 212 healthy individuals as a control. Since E-CR1 expre...

journal_title：Clinical and experimental immunology

authors： Wang FS,Chu FL,Jin L,Li YG,Zhang Z,Xu D,Shi M,Wu H,Moulds JM

更新日期：2005-01-01 00:00:00

abstract：:Exposure to intratracheal immunization and aerosolization with soluble antigen plus murmayl-dipeptide (MDP) induces the development of plaque-forming cells in the pulmonary draining lymph nodes of two of three inbred mouse strains. Splenectomy before immunization led to a heightened plaque-forming cell response in the...

journal_title：Clinical and experimental immunology

authors： Allen EM,Abramoff P,Fink JN,Calvanico NJ

更新日期：1987-08-01 00:00:00

abstract：:The skin is a major target organ in human graft-versus-host disease (GVHD) after bone-marrow transplantation. GVHD can be induced in mice by i.v. injection of T cells into unirradiated semi-allogeneic or lethally irradiated allogeneic recipients. However, in the murine systemic GVHD model, cutaneous lesions occur only...

journal_title：Clinical and experimental immunology

authors： Kawai K,Matsumoto Y,Watanabe H,Ito M,Fujiwara M

更新日期：1991-05-01 00:00:00

abstract：:Renal allograft survival is related directly to cell senescence. In the transplantation scenario many cellular events - participating as immunological and non-immunological factors - could contribute to accelerate this biological process, responsible for the ultimate fate of the graft. Mechanisms concerned in toleranc...

journal_title：Clinical and experimental immunology

authors： Furuzawa-Carballeda J,Lima G,Alberú J,Palafox D,Uribe-Uribe N,Morales-Buenrostro LE,Reyes Acevedo R,Mondragón G,Chevaile A,Llorente L

更新日期：2012-02-01 00:00:00

abstract：:Immunohistological analysis of the cellular composition of the small intestinal mucosa in a group of untreated and treated coeliac patients and non-coeliac control subjects was performed using monoclonal antibodies and an immunoperoxidase technique. A characteristic cellular distribution was observed within the normal...

journal_title：Clinical and experimental immunology

authors： Kelly J,O'Farrelly C,O'Mahony C,Weir DG,Feighery C

更新日期：1987-04-01 00:00:00

abstract：:Mixed leucocyte culture blocking factor activity (MLC-BFA) in the plasma of haemodialysis patients appears as a result of recent blood transfusions and is concentrated in IgG fractions of the blocking serum. Four patients neither developed lymphocytotoxins nor MLC-BFA in spite of having received multiple blood transfu...

journal_title：Clinical and experimental immunology

authors： Sengar DP,Rashid A,Perelmutter L,Harris JE

更新日期：1975-05-01 00:00:00

abstract：:CD4+ lymphocytes are a primary target of the human immunodeficiency virus (HIV), and CD4 counts are one of the factors used to measure disease progression in HIV-positive individuals. CD4 counts vary in uninfected individuals and across populations due to a variety of demographic, environmental, immunological and gene...

journal_title：Clinical and experimental immunology

authors： Mair C,Hawes SE,Agne HD,Sow PS,N'doye I,Manhart LE,Fu PL,Gottlieb GS,Kiviat NB

更新日期：2008-03-01 00:00:00