T lymphocyte function in hairy cell leukaemia.

abstract：:Inflammation is an unstable state; it either resolves or persists. Inflammatory reactions often have a propensity for specific anatomical sites. Why inflammation persists with specific tissue tropism remains obscure. Increasing evidence suggests that stromal cells which define tissue architecture are the key cells inv...

journal_title：Clinical and experimental immunology

authors： Naylor AJ,Filer A,Buckley CD

更新日期：2013-01-01 00:00:00

abstract：:Previous studies in this laboratory have shown that efficient activation of complement (C) on HIV isolates and HIV-infected cells requires the binding of specific anti-HIV antibodies, while other investigators have observed 'antibody-independent' C activation. In an attempt to clarify these disparate findings, we inve...

journal_title：Clinical and experimental immunology

authors： Saarloos MN,Lint TF,Spear GT

更新日期：1995-02-01 00:00:00

abstract：:Intraepithelial lymphocytes (IELs) can be identified among epithelial cells in systemic mucosal tissues. Although intestinal IELs play a crucial role in mucosal immunity, their bronchial counterparts have not been well studied. The purpose of this study was to determine the immunological functions of human bronchial I...

journal_title：Clinical and experimental immunology

authors： Hirosako S,Goto E,Fujii K,Tsumori K,Hirata N,Tsumura S,Kamohara H,Kohrogi H

更新日期：2009-02-01 00:00:00

abstract：:A solid-phase radioimmunoassay was developed to detect antibodies to liver membrane antigens in sera of patients with HBsAg-negative and -positive liver diseases and primary non-hepatic autoimmune diseases. Ten of fourteen patients with HBsAg-negative CAH had autoantibodies detected by RIA; negative results were obtai...

journal_title：Clinical and experimental immunology

authors： Manns M,Meyer zum Büschenfelde KH,Hütteroth TH,Hess G

更新日期：1980-11-01 00:00:00

abstract：:Haematopoietic stem cell transplantation (HSCT) is an immunological treatment that has been used for more than 40 years to cure a variety of diseases. The procedure is associated with serious side effects, due to the severe impairment of the immune system induced by the treatment. After a conditioning regimen with hig...

journal_title：Clinical and experimental immunology

authors： Bemark M,Holmqvist J,Abrahamsson J,Mellgren K

更新日期：2012-01-01 00:00:00

abstract：:Complement C5a is aetiologically linked to inflammatory tissue damage in conditions like septicaemia, immune complex diseases and ischaemia-reperfusion injury. We here describe a monoclonal antibody (mAb), 137-26, that binds to the C5a moiety of human C5 and neutralizes the effects of C5a without interfering with C5 c...

journal_title：Clinical and experimental immunology

authors： Fung M,Lu M,Fure H,Sun W,Sun C,Shi NY,Dou Y,Su J,Swanson X,Mollnes TE

更新日期：2003-08-01 00:00:00

abstract：:The contribution of circulating anti-La(SS-B) antibody to the hypergammaglobulinaemia seen in primary Sjögren's syndrome is unknown. In this study levels of anti-La(SS-B) antibody directed against three immunodominant epitopes of the anti-La(SS-B) autoantigen were measured by ELISA in 84 anti-La(SS-B)+ sera using puri...

journal_title：Clinical and experimental immunology

authors： Gordon TP,Greer M,Reynolds P,Guidolin A,McNeilage LJ

更新日期：1991-09-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) administration in vivo has been shown to improve the defence mechanisms against infection by different microbes. Here we evaluated a possible protective role of this molecule in a mouse model of mycobacterial infection. The administration of recombinant G-CSF promoted an e...

journal_title：Clinical and experimental immunology

authors： Gonçalves AS,Appelberg R

更新日期：2001-05-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) and prostaglandins (PG) regulate the cell-mediated immune response, so it has been proposed that they affect the progression of pulmonary tuberculosis. Here we report that the administration of soluble betaglycan, a potent TGF-beta antagonist, and niflumic acid, a PG synthesi...

journal_title：Clinical and experimental immunology

authors： Hernández-Pando R,Orozco-Esteves H,Maldonado HA,Aguilar-León D,Vilchis-Landeros MM,Mata-Espinosa DA,Mendoza V,López-Casillas F

更新日期：2006-05-01 00:00:00

abstract：:Mutations in the Bruton's tyrosine kinase (BTK) gene result in XLA. Despite the large numbers of BTK mutations reported, no correlation can be made between the clinical phenotype and the gene defects. Analysis of Btk protein expression and activity in individuals with XLA was performed to characterize the relationship...

journal_title：Clinical and experimental immunology

authors： Gaspar HB,Lester T,Levinsky RJ,Kinnon C

更新日期：1998-02-01 00:00:00

abstract：:HAART may increase CD4+ T cell counts despite a persistently detectable HIV load. The impact of HAART on apoptosis, which may play a role in the disease process in HIV-infected patients, has not been extensively studied. We performed a study to compare the level of spontaneous T cell apoptosis and anti-retroviral trea...

journal_title：Clinical and experimental immunology

authors： Roger PM,Breittmayer JP,Arlotto C,Pugliese P,Pradier C,Bernard-Pomier G,Dellamonica P,Bernard A

更新日期：1999-12-01 00:00:00

abstract：:The role of complement has been studied in the autologous phase of nephrotoxic nephritis (NTN) in rabbits. No reduction in glomerular fibrin deposition, crescent formation or protection from renal failure was observed in either the standard model of NTN when decomplementing doses of cobra venom factor (CVF) were given...

journal_title：Clinical and experimental immunology

authors： Thomson NM,Naish PF,Simpson IJ,Peters DK

更新日期：1976-06-01 00:00:00

abstract：:Lymphocyte subpopulations in patients with cervical carcinoma were studied before and after radiotherapy. T lymphocytes were recognized by their ability to form spontaneous rosettes with sheep erythrocytes (E rosettes). Two surface marker characteristics were used to detect B lymphocytes: receptors for activated compl...

journal_title：Clinical and experimental immunology

authors： Rand RJ,Jenkins DM,Bulmer R

更新日期：1978-07-01 00:00:00

abstract：:Hyperlipidaemia accompanies chronic renal disease either as a consequence of the renal dysfunction or as part of generalized metabolic derangements. Under both situations, the lipid profile is characterized by accumulation of triglyceride-rich lipoproteins (TGRLs). This lipid profile is recognized as a risk factor for...

journal_title：Clinical and experimental immunology

authors： Saja MF,Cook HT,Ruseva MM,Szajna M,Pickering MC,Woollard KJ,Botto M

更新日期：2018-06-01 00:00:00

abstract：:There is a link between increased allergy and a reduction of some infections in western countries. Epidemiological data also show that respiratory allergy is less frequent in people exposed to orofaecal and foodborne microbes such as Toxoplasma gondii. Infection with T. gondii induces a strong cell-mediated immunity w...

journal_title：Clinical and experimental immunology

authors： Fenoy I,Giovannoni M,Batalla E,Martin V,Frank FM,Piazzon I,Goldman A

更新日期：2009-02-01 00:00:00

abstract：:We previously demonstrated that high levels of IL-6/sIL-6R complexes are present in sera of patients with systemic juvenile idiopathic arthritis (s-JIA) and that the amount of IL-6 estimated in the IL-6/sIL-6R complexes is markedly higher than that measured by the B9 assay. Here, we show that two additional bioassays,...

journal_title：Clinical and experimental immunology

authors： Pignatti P,Ciapponi L,Galle P,Hansen MB,Massa M,Meazza C,Paonessa G,Novick D,Ciliberto G,Martini A,De Benedetti F

更新日期：2003-02-01 00:00:00

abstract：:It is unclear how breakdown in immune tolerance to the ubiquitous self-antigen pyruvate dehydrogenase complex (PDC), seen in the autoimmune liver disease PBC, gives rise to tissue damage with such a limited distribution (restricted to the liver and salivary and lachrymal glands). One property shared by these tissues i...

journal_title：Clinical and experimental immunology

authors： Palmer JM,Doshi M,Kirby JA,Yeaman SJ,Bassendine MF,Jones DE

更新日期：2000-12-01 00:00:00

abstract：:Reduced microbial exposure in early life may contribute to the increase of atopic diseases in 'westernized' societies but the underlying mechanisms remain elusive. The objective of this study was to examine how exposure to bacterial lipopolysaccharide (LPS) during early antigen encounter might influence the maturation...

journal_title：Clinical and experimental immunology

authors： Haddeland U,Sletten GB,Brandtzaeg P,Nakstad B

更新日期：2005-02-01 00:00:00

abstract：:Eosinophils from the peritoneal washings of normal rats adhered to live or formalin-fixed schistosomula of Schistosoma mansoni in vitro, in the presence of heat-inactivated serum from infected rats. Eosinophil adherence caused permeability changes in the schistosomula as revealed by 51Cr release and methylene blue upt...

journal_title：Clinical and experimental immunology

authors： Mackenzie CD,Ramalho-Pinto FJ,McLaren DJ,Smithers SR

更新日期：1977-10-01 00:00:00

abstract：:The effects of various cytokines on synthesis and microheterogeneity of carbohydrate structure of alpha 1-proteinase inhibitor (PI) and alpha-fetoprotein (AFP) in the human hepatoma cell lines Hep 3B and Hep G2 were studied. In both lines, crude cytokine preparations from LPS-activated human monocytes (CM) and several...

journal_title：Clinical and experimental immunology

authors： Mackiewicz A,Schultz D,Mathison J,Ganapathi M,Kushner I

更新日期：1989-01-01 00:00:00

abstract：:Thirty-four out of fifty-two vasectomized men studied previously were studied again about 5 years after vasectomy for sperm-agglutinating and sperm-immoblizing antibodies, and for antibodies to human protamine. Only one man lost his already weak antibody activity, whilst one out of eight men, negative at 1 year, appea...

journal_title：Clinical and experimental immunology

authors： Hellema HW,Samuel T,Rumke P

更新日期：1979-10-01 00:00:00

abstract：:Recent advances in immunological and genetic research in coeliac disease provide new and complementary insights into the immune response driving this chronic intestinal inflammatory disorder. Both approaches confirm the central importance of T cell-mediated immune responses to disease pathogenesis and have further beg...

journal_title：Clinical and experimental immunology

authors： Dubois PC,van Heel DA

更新日期：2008-08-01 00:00:00

abstract：:More than 11 genetic causes of severe combined immunodeficiency (SCID) have been identified, affecting development and/or function of T lymphocytes, and sometimes B lymphocytes and natural killer (NK) cells. Deletion of 22q11.2 is associated with immunodeficiency, although less than 1% of cases are associated with T-B...

journal_title：Clinical and experimental immunology

authors： Gennery AR,Slatter MA,Rice J,Hoefsloot LH,Barge D,McLean-Tooke A,Montgomery T,Goodship JA,Burt AD,Flood TJ,Abinun M,Cant AJ,Johnson D

更新日期：2008-07-01 00:00:00

abstract：:Clinically, corticosteroids (CS) are among the first line drugs in the therapy of autoimmune and allergic diseases and potently inhibit the activation of immune cells. However, due to their pleiotropic mode of action, the prolonged use of CS is generally associated with a range of undesirable side-effects. In this stu...

journal_title：Clinical and experimental immunology

authors： Kalthoff FS,Chung J,Musser P,Stuetz A

更新日期：2003-09-01 00:00:00

abstract：:Monocytes (MO) migrating into normal, non-inflamed intestinal mucosa undergo a specific differentiation resulting in a non-reactive, tolerogenic intestinal macrophage (IMAC). Recently we demonstrated the differentiation of MO into an intestinal-like macrophage (MAC) phenotype in vitro in a three-dimensional cell cultu...

journal_title：Clinical and experimental immunology

authors： Spoettl T,Hausmann M,Herlyn M,Gunckel M,Dirmeier A,Falk W,Herfarth H,Schoelmerich J,Rogler G

更新日期：2006-07-01 00:00:00

abstract：:Monoclonal antibodies reacting with thyroid microsomes have been described. In this report, we present evidence that some of these monoclonal antibodies (MoAb) MAH C3 and perhaps MAH C6 are directed towards the thyroid microsomal antigen towards which microsomal autoantibodies from Hashimoto patients are directed. Imm...

journal_title：Clinical and experimental immunology

authors： Banga JP,Mirakian R,Hammond L,Pryce G,Bidey S,Bottazzo F,Weetman AP,McGregor AM,Roitt IM

更新日期：1986-06-01 00:00:00

abstract：:In the present study we describe the in vitro transcription-translation of human melanocyte-specific protein Pmel17 cDNA and subsequent use of the resulting 35S-labelled Pmel17 in an RIA to analyse vitiligo sera for the presence of Pmel17 antibodies. Of 53 vitiligo sera examined in the assay, three (5.9%) were found t...

journal_title：Clinical and experimental immunology

authors： Kemp EH,Gawkrodger DJ,Watson PF,Weetman AP

更新日期：1998-12-01 00:00:00

abstract：:We have investigated the T-cell antigen receptor constant beta and alpha chain genes (TCR-C beta, -C alpha) and the immunoglobulin (Ig) heavy chain switch regions of patients with Graves' disease (GD) using restriction fragment length polymorphism (RFLP) analysis. No significant associations were found with RFLPs of e...

journal_title：Clinical and experimental immunology

authors： Demaine AG,Ratanachaiyavong S,Pope R,Ewins D,Millward BA,McGregor AM

更新日期：1989-07-01 00:00:00

abstract：:Ribonucleic acid extracts (RNA) obtained from the lymph nodes and spleens of guinea pigs, which were immunized with testicular antigen emulsified in Freund's complete adjuvant (FCA), were injected intraperitoneally into normal guinea pigs. The transferred guinea pigs developed a delayed hypersensitivity to sperm antig...

journal_title：Clinical and experimental immunology

authors： Fainboim L,Sztein MB,Serrate S,Mancini RE

更新日期：1978-10-01 00:00:00

abstract：:Aspergillus fumigatus, a ubiquitous fungus, is implicated in the pathogenesis of a number of clinically different allergic diseases in man, including allergic bronchopulmonary aspergillosis. Peptide-based immunotherapy may offer an alternative treatment strategy for the management of allergic disease. The objective of...

journal_title：Clinical and experimental immunology

authors： Svirshchevskaya EV,Alekseeva L,Marchenko A,Viskova N,Andronova TM,Benevolenskii SV,Kurup VP

更新日期：2002-02-01 00:00:00