T- and B-lymphocyte subpopulations following radiotherapy for invasive squamous cell carcinoma of the uterine cervix.

abstract：:Reduced B cell numbers and a mutation in Btk are considered sufficient to make the diagnosis of X-linked agammaglobulinaemia. In the process of conducting family studies, we identified a 58-year-old healthy man with an amino acid substitution, Y418H, in the adenosine-5'-triphosphate binding site of Btk. Immunofluoresc...

journal_title：Clinical and experimental immunology

authors： Conley ME,Farmer DM,Dobbs AK,Howard V,Aiba Y,Shurtleff SA,Kurosaki T

更新日期：2008-04-01 00:00:00

abstract：:Autoantibodies characteristic for anti-phospholipid syndrome (APS) and systemic lupus erythematosus (SLE) are anti-β2 -glycoprotein I (β2 GPI) antibodies and anti-DNA antibodies, respectively, and almost half of APS cases occur in SLE. Anti-β2 GPI antibodies are recognized to play a pivotal role in inducing a prothrom...

journal_title：Clinical and experimental immunology

authors： Virachith S,Saito M,Watanabe Y,Inoue K,Hoshi O,Kubota T

更新日期：2019-02-01 00:00:00

abstract：:Thymoma is known to contain CD4+CD8+ T cells, indicating that neoplastic epithelial cells of thymoma have a function as thymic cortical epithelium. However, it has been shown that there is an impairment of CD4+ T cell development in thymoma and that IFN-gamma-induced HLA-DR expression on cultured thymic epithelial cel...

journal_title：Clinical and experimental immunology

authors： Kadota Y,Okumura M,Miyoshi S,Kitagawa-Sakakida S,Inoue M,Shiono H,Maeda Y,Kinoshita T,Shirakura R,Matsuda H

更新日期：2000-07-01 00:00:00

abstract：:Monocyte and macrophage dysfunction may be important for both immunopathogenesis and clinical manifestations in subgroups of patients with primary hypogammaglobulinaemia. In the present study we examined the ability to generate reactive oxygen species (ROS) in isolated monocytes from these patients by two different me...

journal_title：Clinical and experimental immunology

authors： Aukrust P,Müller F,Frøland SS

更新日期：1994-08-01 00:00:00

abstract：:Antigens present in the products released by the larval stage of schistosome (SRP-A) were shown to induce a strong cytotoxic and protective IgE response both in the rat and the monkey. T cell lines and clones specific for SRP-A or 26 kD antigens which are the main target of the cytotoxic IgE have been derived. The pas...

journal_title：Clinical and experimental immunology

authors： Damonneville M,Velge F,Verwaerde C,Pestel J,Auriault C,Capron A

更新日期：1987-08-01 00:00:00

abstract：:For 'the total population of patients with sepsis, sepsis syndrome or SIRS', the question of whether intravenous immune globulin (IVIG) reduces mortality is neither proved nor disproved. For the sepsis subgroups 'postoperative sepsis with a sepsis score more than 19' and 'endotoxaemic, early septic shock', a significa...

journal_title：Clinical and experimental immunology

authors： Werdan K,Pilz G

更新日期：1996-05-01 00:00:00

abstract：:Measles-specific IgA antibody titres were determined by radioimmunoassay (RIA) for serial serum, saliva and tear samples obtained from 21 children with measles infection, from onset of rash until up to 14 months later. Serum IgA titres rose rapidly after onset of illness and remained detectable throughout the follow-u...

journal_title：Clinical and experimental immunology

authors： Friedman MG,Phillip M,Dagan R

更新日期：1989-01-01 00:00:00

abstract：:The ability of lymphocytes from a patient suffering from the acquired immune deficiency syndrome (AIDS) to produce interleukin-2 (IL-2) was found to be comparable to that of his healthy sex partner and to that of a normal control. Addition of exogenous IL-2 to lymphocyte cultures did not improve the poor mitogen respo...

journal_title：Clinical and experimental immunology

authors： Hauser GJ,Bino T,Rosenberg H,Zakuth V,Geller E,Spirer Z

更新日期：1984-04-01 00:00:00

abstract：:Vacuum-assisted closure involving the implantation of polyvinyl alcohol foam is a technique recently developed for the treatment of patients suffering from either wound infection or chronic wounds. This method has been shown to improve and accelerate wound healing. However, little is known about the cell populations t...

journal_title：Clinical and experimental immunology

authors： Gouttefangeas C,Eberle M,Ruck P,Stark M,Müller JE,Becker HD,Rammensee HG,Pinocy J

更新日期：2001-06-01 00:00:00

abstract：:The secondary antibody response to 5.0 microgram flagellin was studied by haemagglutination in 132 healthy or convalescent subjects given a primary challenge with 5.0 microgram flagellin from 1 to 44 months previously. The peak titre, expressed as total antibody, occurred at 2 weeks and was mainly immunoglobulin (Ig)G...

journal_title：Clinical and experimental immunology

authors： Whittingham S,Buckley JD,Mackay IR

更新日期：1978-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a persistent virus with oncogenic capacity that has been implicated in the development of aggressive B cell lymphomas, primarily in immunosuppressed individuals, although it can be present in immunocompetent individuals. Changes in the function and clonal diversity of T lymphocytes might be...

journal_title：Clinical and experimental immunology

authors： Cárdenas D,Vélez G,Orfao A,Herrera MV,Solano J,Olaya M,Uribe AM,Saavedra C,Duarte M,Rodríguez M,López M,Fiorentino S,Quijano S

更新日期：2015-11-01 00:00:00

abstract：:Natural killer (NK) cell adoptive transfer is a promising approach for cancer immunotherapy; however, its development has been hindered by the lack of efficient methods to produce large numbers of functional NK cells. In this study, we engineered the leukaemia cell line K562 to express CD137 ligand (CD137L) and membra...

journal_title：Clinical and experimental immunology

authors： Wang X,Lee DA,Wang Y,Wang L,Yao Y,Lin Z,Cheng J,Zhu S

更新日期：2013-04-01 00:00:00

abstract：:The CXC chemokines, monokine induced by interferon (IFN)-gamma (MIG) (CXCL9), IFN-gamma-induced protein 10 (IP-10) (CXCL10) and IFN-inducible T cell alpha chemoattractant (I-TAC) (CXCL11), are known to attract CXCR3- (CXCR3A and CXCR3B) T lymphocytes. We investigated MIG, IP-10 and I-TAC mRNAs expression by semi-quant...

journal_title：Clinical and experimental immunology

authors： Manousou P,Kolios G,Drygiannakis I,Koulentaki M,Pyrovolaki K,Voumvouraki A,Notas G,Bourikas L,Papadaki HA,Kouroumalis E

更新日期：2013-04-01 00:00:00

abstract：:It has been postulated that autoantibody formation occurs as a consequence of a depression of function of certain thymus-derived lymphocytes (T cells). We have examined cell-mediated immunity, a T-cell function, in infectious mononucleosis, a condition in which autoantibodies are known to develop. We have shown some e...

journal_title：Clinical and experimental immunology

authors： Russell AS,Percy JS,Grace M

更新日期：1975-04-01 00:00:00

abstract：:Lysinuric protein intolerance (LPI) is characterized by defective cellular transport of the dibasic amino acids, secondary dysfunction of the urea cycle, aversion to dietary protein, failure to thrive, hepatosplenomegaly and osteoporosis. Because several patients have suffered from recurrent respiratory infections and...

journal_title：Clinical and experimental immunology

authors： Lukkarinen M,Parto K,Ruuskanen O,Vainio O,Käyhty H,Olander RM,Simell O

更新日期：1999-06-01 00:00:00

abstract：:In susceptible mice, the heavy metal ion mercury is able to induce a strong immune activation, which resembles a T helper 2 (Th2) type of immune response and is characterized by a polyclonal B cell activation, formation of high levels of IgG1 and IgE antibodies, production of autoantibodies of different specificities ...

journal_title：Clinical and experimental immunology

authors： Brenden N,Rabbani H,Abedi-Valugerdi M

更新日期：2001-08-01 00:00:00

abstract：:After 3-4 weeks culture of human bone marrow cells in medium supplemented with IL-3, macrophage- (M-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF), the firmly adherent cells exhibited the morphologic features of mononuclear phagocytes and were strongly esterase-positive. Flow cytometric analysis r...

journal_title：Clinical and experimental immunology

authors： Keller R,Keist R,Joller P,Groscurth P

更新日期：1993-01-01 00:00:00

abstract：:The NOD mouse is a model of human juvenile type I diabetes mellitus. As in humans and in the BB rat model, the development of diabetes in NOD mice is accompanied by evident manifestations of cell-mediated and humoral autoimmunity. Beside autoantibodies directed at putative islet cell antigens, NOD sera contain antibod...

journal_title：Clinical and experimental immunology

authors： Lehuen A,Altman J,Bach JF,Carnaud C

更新日期：1990-09-01 00:00:00

abstract：:Lymphocytes and plasma cells in the peripheral blood and bone marrow of patients with multiple myeloma, benign monoclonal gammopathy and Waldenström's macroglobulinaemia were investigated for their cytoplasmic immunoglobulin distribution. Anti-idiotypic sera were used as markers for monoclonality. Double-wavelength fl...

journal_title：Clinical and experimental immunology

authors： Van Camp B,Reynaert P,Broodtaerts L

更新日期：1981-04-01 00:00:00

abstract：:In a study of thirty-nine children with recurrent infections, circulating antigens, either free or in the form of immune complexes, were detected in thirty. The ability of sera to inhibit the agglutination of latex by rheumatoid factor or the C1q component of complement was used as a test for the presence of immune co...

journal_title：Clinical and experimental immunology

authors： Delire M,Masson PL

更新日期：1977-09-01 00:00:00

abstract：:As Q fever is associated with an inflammatory syndrome, we determined circulating levels of inflammatory cytokines, cytokine antagonists, and activation markers of leucocytes in patients with acute Q fever and Q fever endocarditis. Tumour necrosis factor (TNF) and IL-6, but not IL-1beta, were markedly increased compar...

journal_title：Clinical and experimental immunology

authors： Capo C,Amirayan N,Ghigo E,Raoult D,Mege J

更新日期：1999-01-01 00:00:00

abstract：:Immunoblotting of platelets that have been subjected to SDS-PAGE has revealed that sera from normal individuals contain IgG which binds to many platelet components. This binding was seen with autologous and heterologous platelets using serum of males and of nulliparous females who had not received blood transfusions. ...

journal_title：Clinical and experimental immunology

authors： Pfueller SL,Logan D,Tran TT,Bilston RA

更新日期：1990-03-01 00:00:00

abstract：:Antibody response and antigen specific suppression to bovine serum albumin (BSA) in uremic rats have been investigated. Primary immune response was found to be significantly reduced independent of the route of administration or adjuvant while secondary response was affected only in animals in which a weak adjuvant suc...

journal_title：Clinical and experimental immunology

authors： Mezzano S,Pesce A,Peters T Jr,Pollak VE,Reed R,Michael G

更新日期：1982-04-01 00:00:00

abstract：:The high affinity form of the human IL-2 receptor (IL-2R) has two known components, the IL-2R alpha (p55) and the IL-2R beta chain (p75). We have previously shown that recombinant IL-2 (rIL-2) could induce the expression of the alpha-chain (p55) on T cells and thymocytes, and increase this expression following subopti...

journal_title：Clinical and experimental immunology

authors： Reem GH,Han X,Marcelli A

更新日期：1992-01-01 00:00:00

abstract：:Lymphocyte transformation test has often been used as an in vitro test for nickel allergy. We have previously demonstrated the presence of nickel-reactive T cells in individuals with no history of allergic disease and with a negative patch test towards NiSO4. In this study, we show that this proliferative response was...

journal_title：Clinical and experimental immunology

authors： Lisby S,Hansen LH,Menn T,Baadsgaard O

更新日期：1999-08-01 00:00:00

abstract：:Specific antibody deficiency (SAD) to unconjugated pneumococcal vaccine (PPV) is an established primary B cell immunodeficiency. The occurrence and natural history of SAD in children is unclear. We conducted an observational study to identify SAD in children with recurrent respiratory infections. Ninety-nine children,...

journal_title：Clinical and experimental immunology

authors： Ruuskanen O,Nurkka A,Helminen M,Viljanen MK,Käyhty H,Kainulainen L

更新日期：2013-05-01 00:00:00

abstract：:Peripheral blood leucocytes from multiple sclerosis (MS) patients and from normal individuals were tested for their interferon (IFN) producing capacity after stimulation in vitro with various lectins and viruses. The lectins, Con A, PHA and PWM, induced IFN-gamma. In a kinetic study, the response to Con A revealed its...

journal_title：Clinical and experimental immunology

authors： Vervliet G,Carton H,Meulepas E,Billiau A

更新日期：1984-10-01 00:00:00

abstract：:Gambian children with past or present Plasmodium falciparum malaria were investigated for the incidence of Coombs positivity using monospecific antisera. Approximately 50% were positive and the most frequent form of erythrocyte sensitization was with C3d. Other specificities, EIgG, EIgGC3d and EIgGC4bC3d were less com...

journal_title：Clinical and experimental immunology

authors： Facer CA,Bray RS,Brown J

更新日期：1979-01-01 00:00:00

abstract：:Glutamic acid decarboxylase (GAD) is a major autoantigen in insulin-dependent diabetes mellitus (IDDM). This was initially identified as a 64-65 kD molecule according to migration in gels after immunoprecipitation from pancreatic islets. We studied the antigenicity of two different radiolabelled preparations of GAD, d...

journal_title：Clinical and experimental immunology

authors： Rowley MJ,Chen QY,Teoh KL,Zimmet PZ,Tuomi T,Knowles WJ,Mackay IR

更新日期：1996-11-01 00:00:00

abstract：:Binding of lymphocytes to human umbilical vein endothelial cells (EC) was quantitated by measuring adhesion of 51Cr labelled lymphocytes to endothelial cell monolayers and rosette formation between lymphocytes and EC in suspension. Mitogen stimulated human peripheral blood mononuclear cell culture supernatants and mix...

journal_title：Clinical and experimental immunology

authors： Yu CL,Haskard DO,Cavender D,Johnson AR,Ziff M

更新日期：1985-12-01 00:00:00