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Functional T lymphocytes infiltrate implanted polyvinyl alcohol foams during surgical wound closure therapy.

Abstract：

:Vacuum-assisted closure involving the implantation of polyvinyl alcohol foam is a technique recently developed for the treatment of patients suffering from either wound infection or chronic wounds. This method has been shown to improve and accelerate wound healing. However, little is known about the cell populations that infiltrate the foam, and their potential role in resolving the infection and promoting granulation tissue formation. Our study demonstrates that wound-implanted foams are mainly infiltrated with granulocytes, but that mononuclear cells, including macrophages and minor populations of T, B and natural killer lymphocytes, are also present. We show that foam-infiltrating T cells, especially CD4(+) T cells, constitute a phenotypically and functionally heterogeneous population influenced by wound-infecting bacteria. Thus, T lymphocytes could play a role in wound cleansing. In addition, our data indicate that implanted polyvinyl alcohol foams might be suitable microenvironments for manipulating T cell-mediated immune responses in patients.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Gouttefangeas C,Eberle M,Ruck P,Stark M,Müller JE,Becker HD,Rammensee HG,Pinocy J

doi

10.1046/j.1365-2249.2001.01547.x

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

398-405

issue

3

eissn

0009-9104

issn

1365-2249

pii

cei1547

journal_volume

124

pub_type

杂志文章

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