Circulating cytokine balance and activation markers of leucocytes in Q fever.

Abstract:

:As Q fever is associated with an inflammatory syndrome, we determined circulating levels of inflammatory cytokines, cytokine antagonists, and activation markers of leucocytes in patients with acute Q fever and Q fever endocarditis. Tumour necrosis factor (TNF) and IL-6, but not IL-1beta, were markedly increased compared with controls. Cytokine antagonists and activation markers of leucocytes were profoundly different in acute and chronic Q fever. IL-1 receptor antagonist and TNF receptor type II were significantly increased in patients with acute Q fever, suggesting a shift of cytokine balance towards cytokine antagonists. The activation marker of B cells, sCD23, was significantly increased in Q fever endocarditis compared with controls and patients with acute Q fever. In a 2-year follow-up study of patients with Q fever endocarditis, sCD23 and specific IgG levels slowly decreased in patients whose symptoms resolved, but remained high in those who required prolonged treatment.

journal_name

Clin Exp Immunol

authors

Capo C,Amirayan N,Ghigo E,Raoult D,Mege J

doi

10.1046/j.1365-2249.1999.00786.x

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

120-3

issue

1

eissn

0009-9104

issn

1365-2249

journal_volume

115

pub_type

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