The detection of circulating immune complexes in children with recurrent infections and their treatment with human immunoglobulins.

abstract：:The C77G polymorphism in exon A of the human CD45 gene occurs with low frequency in healthy individuals. An enhanced frequency of C77G individuals has been reported in cohorts of patients suffering from multiple sclerosis, systemic sclerosis, autoimmune hepatitis, hepatitis C and human immunodeficiency virus (HIV)-1. ...

journal_title：Clinical and experimental immunology

authors： Windhagen A,Sönmez D,Hornig-Do HT,Kalinowsky A,Schwinzer R

更新日期：2007-12-01 00:00:00

abstract：:The expression in tissue and serum of a panel of murine and human common DNA antibody idiotypes (Ids) (BEG 2, PR 4, F-423, I-402, II-28, IV-228, V-88) has been investigated. The murine V-88 Id was detected in eight out of 10 and the human BEG 2 Id in five out of 10 labial biopsies from patients with Sjögren's syndrome...

journal_title：Clinical and experimental immunology

authors： Watts RA,Ravirajan CT,Wilkinson LS,Williams W,Griffiths M,Butcher D,Horsfall AT,Staines NA,Isenberg DA

更新日期：1991-02-01 00:00:00

abstract：:Asthma is a chronic inflammatory disease affecting the airways. Increased levels of T cells are found in the lungs after the induction of an allergic-like inflammation in rats, and flow cytometry studies have shown that these levels are reduced in CD26-deficient rats. However, the precise anatomical sites where these ...

journal_title：Clinical and experimental immunology

authors： Schade J,Schmiedl A,Kehlen A,Veres TZ,Stephan M,Pabst R,von Hörsten S

更新日期：2009-10-01 00:00:00

abstract：:The expression of melanocortin MC(1) receptors on human peripheral lymphocyte subsets was analysed by flow cytometry using rabbit antibodies selective for the human MC(1) receptor and a panel of monoclonal antibodies against lymphocyte differentiation markers. The MC(1) receptor was found to be constitutively expresse...

journal_title：Clinical and experimental immunology

authors： Neumann Andersen G,Nagaeva O,Mandrika I,Petrovska R,Muceniece R,Mincheva-Nilsson L,Wikberg JE

更新日期：2001-12-01 00:00:00

abstract：:We assessed whether complement and its factor C4 or abnormal immunoglobulin levels are associated with chronic or recurrent rhinosinusitis. We used multiple patient and control groups to obtain clinically meaningful data. Adult chronic or recurrent rhinosinusitis and acute purulent rhinosinusitis patients were compare...

journal_title：Clinical and experimental immunology

authors： Seppänen M,Suvilehto J,Lokki ML,Notkola IL,Järvinen A,Jarva H,Seppälä I,Tahkokallio O,Malmberg H,Meri S,Valtonen V

更新日期：2006-08-01 00:00:00

abstract：:Dendritic cells (DC) are the most professional antigen-presenting cells of the immune system and are capable of initiating immune responses in vitro and in vivo. One of the great challenges in immunotherapy protocols is to introduce relevant antigens into DC for stimulation of major histocompatibility complex (MHC) cl...

journal_title：Clinical and experimental immunology

authors： Ponsaerts P,Van Tendeloo VF,Berneman ZN

更新日期：2003-12-01 00:00:00

abstract：:This longitudinal study investigates the change of erythrocyte complement receptor (E-CR1) expression in patients with severe acute respiratory syndrome (SARS). Circulating E-CR1 expression was semiquantified by flow cytometric analyses in 54 SARS patients and in 212 healthy individuals as a control. Since E-CR1 expre...

journal_title：Clinical and experimental immunology

authors： Wang FS,Chu FL,Jin L,Li YG,Zhang Z,Xu D,Shi M,Wu H,Moulds JM

更新日期：2005-01-01 00:00:00

abstract：:Oxazolone-induced colitis in mice has become a recognized model to study the efficacy of therapeutics targeting the immunological response underlying the development of inflammatory bowel disease. However, this model cannot be used when therapeutics designed to address human targets do not interact with the respective...

journal_title：Clinical and experimental immunology

authors： Nolte T,Zadeh-Khorasani M,Safarov O,Rueff F,Gülberg V,Herbach N,Wollenberg A,Mueller T,Siebeck M,Wolf E,Gropp R

更新日期：2013-05-01 00:00:00

abstract：:Complement activation may play an important role in renal injury associated with glomerular deposition of IgA immune complexes. The ability of naturally occurring human IgA immune complexes (IgA-IC) and covalently cross-linked human IgA oligomers (X-IgA) to activate complement were examined in vitro and in vivo. Large...

journal_title：Clinical and experimental immunology

authors： Imai H,Chen A,Wyatt RJ,Rifai A

更新日期：1988-09-01 00:00:00

abstract：:The proinflammatory cytokines play a central role in mediating cellular and physiological responses, and levels may reflect immune system effectiveness. In this study, the effect of ageing on the inflammatory response was examined using a novel method to detect production of the proinflammatory cytokines, i.e. tumour ...

journal_title：Clinical and experimental immunology

authors： O'Mahony L,Holland J,Jackson J,Feighery C,Hennessy TP,Mealy K

更新日期：1998-08-01 00:00:00

abstract：:Recent evidence has shown that microRNA-126 (miR-126) has been involved in the development and function of immune cells, which contributed to the pathogenesis of related clinical diseases. However, the potential role of miR-126 in the development and function of CD4+ T cells remains largely unknown. Here we first foun...

journal_title：Clinical and experimental immunology

authors： Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L

更新日期：2018-02-01 00:00:00

abstract：:It is well known that monocytes may play an active role in thrombogenesis, since they may express on their surface tissue factor, the major initiator of the clotting cascade. The results of this investigation demonstrate beta-2-glycoprotein I (beta2-GPI) mRNA expression by human peripheral blood monocytes, indicating ...

journal_title：Clinical and experimental immunology

authors： Conti F,Sorice M,Circella A,Alessandri C,Pittoni V,Caronti B,Calderaro C,Griggi T,Misasi R,Valesini G

更新日期：2003-06-01 00:00:00

abstract：:Clearance rates in the guinea pig were determined for intact guinea pig and human C1 inhibitor, the complexes of both inhibitors with human Cls, beta factor XIIa and kallikrein, and for each inhibitor cleaved at its reactive centre with trypsin. Intact human and guinea pig C1 inhibitor were cleared from the circulatio...

journal_title：Clinical and experimental immunology

authors： Malek R,Aulak KS,Davis AE 3rd

更新日期：1996-07-01 00:00:00

abstract：:Activation of human natural killer (NK) cells is associated with the cleavage of CD16 from the cell surface, a process mediated by matrix metalloproteinases (MMPs). In this report, we examined whether inhibition of MMPs would lead to improved NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) function. Using...

journal_title：Clinical and experimental immunology

authors： Zhou Q,Gil-Krzewska A,Peruzzi G,Borrego F

更新日期：2013-07-01 00:00:00

abstract：:Immunotherapy of murine autoimmune and allergic diseases by administration of peptides corresponding to the dominant T cell epitope is a reality. However, problems remain in applying this therapy to reduce antibody responses in humans. To overcome these difficulties, a preclinical system was developed to test the effe...

journal_title：Clinical and experimental immunology

authors： Jackson DJ,Elson CJ,Kumpel BM

更新日期：2004-08-01 00:00:00

abstract：:Human neutrophils, added to fibronectin (FN)-coated polystyrene wells and exposed to tumour necrosis factor-alpha (TNF-alpha), were found to exhibit a prolonged production of superoxide anion (O2-) after a lag period of approx 30 min. The O2- production, but not the cell adherence to FN, was completely inhibited by tw...

journal_title：Clinical and experimental immunology

authors： Dapino P,Dallegri F,Ottonello L,Sacchetti C

更新日期：1993-12-01 00:00:00

abstract：:Hybridomas producing monoclonal antibodies that bind to determinants on myelogenous leukaemia blast cells were developed using fresh leukaemia blasts as immunogens. These monoclonal antibodies were used to quantitate the amount of a variety of antigens on both leukaemia and normal blood cells in a radioimmunoassay. Th...

journal_title：Clinical and experimental immunology

authors： Ball ED,Fanger MW

更新日期：1982-06-01 00:00:00

abstract：:Sixteen healthy adults had serial studies of delayed-type skin test reactivity and in vitro lymphocyte blastogenesis to several antigens over a period of 7 months. In many subjects blastogenesis varied broadly from month to month without apparent cause. Responses to all antigens usually increased or decreased together...

journal_title：Clinical and experimental immunology

authors： Graybill JR,Alford RH

更新日期：1976-07-01 00:00:00

abstract：:Young rats were not able to expel adult N. brasiliensis infections even when the worms were damaged by antibodies and the young rats were given all the cellular components (sensitized lymphocytes and bone marrow cells) shown to be necessary for the expulsion of antibody-damaged worms from adult rats. In contrast, most...

journal_title：Clinical and experimental immunology

authors： Love RJ,Ogilvie BM

更新日期：1975-07-01 00:00:00

abstract：:Adult-onset Still's disease (AOSD) patients may show an evanescent salmon-pink erythema appearing during febrile attacks and reducing without fever. Some patients may experience this eruption for many weeks. During AOSD, exceptionally high serum levels of ferritin may be observed; it is an iron storage protein compose...

journal_title：Clinical and experimental immunology

authors： Ruscitti P,Cipriani P,Ciccia F,Di Benedetto P,Liakouli V,Berardicurti O,Carubbi F,Guggino G,Di Bartolomeo S,Triolo G,Giacomelli R

更新日期：2016-10-01 00:00:00

abstract：:A monoclonal IgM smooth muscle antibody secreted by a hybrid (MMI-1) of mouse plasmacytoma NS-1 with spleen cells from mouse immunized with Treponema pallidum was detected by indirect immunofluorescence tests on frozen tissue sections and on acetone fixed monolayers of rat and human fibroblasts. The antibody did not r...

journal_title：Clinical and experimental immunology

authors： Strugnell RA,Underwood JR,Clarke FM,Pedersen JS,Chalmers PJ,Faine S,Toh BH

更新日期：1983-06-01 00:00:00

abstract：:Traumatic injury and sepsis reduce HLA-DR expression on monocytes. This study assessed the effect of interferon-gamma (IFN-gamma) on the expression of HLA-DR on monocytes taken from severely injured patients. The mononuclear layer of each blood sample was incubated with either 500 units IFN-gamma or control media. The...

journal_title：Clinical and experimental immunology

authors： Hershman MJ,Appel SH,Wellhausen SR,Sonnenfeld G,Polk HC Jr

更新日期：1989-07-01 00:00:00

abstract：:Pre-eclampsia is an endothelial disorder and TNF-alpha has fundamental effects on endothelial cells by several means, including altering the balance between oxidant and anti-oxidant, changing the pattern of prostaglandin production and affecting expression of several cell surface components. To determine whether TNF-a...

journal_title：Clinical and experimental immunology

authors： Chen G,R Wilson,Wang SH,Zheng HZ,Walker JJ,McKillop JH

更新日期：1996-04-01 00:00:00

abstract：:It has been postulated that autoantibody formation occurs as a consequence of a depression of function of certain thymus-derived lymphocytes (T cells). We have examined cell-mediated immunity, a T-cell function, in infectious mononucleosis, a condition in which autoantibodies are known to develop. We have shown some e...

journal_title：Clinical and experimental immunology

authors： Russell AS,Percy JS,Grace M

更新日期：1975-04-01 00:00:00

abstract：:Previous studies of an experimental human immunoglobulin preparation for intravenous use, containing normal pooled IgM (IVIgM), have shown its beneficial therapeutic effect in experimental autoimmune diseases. The mechanisms of its immunomodulatory activity remain however, poorly understood. In the experiments reporte...

journal_title：Clinical and experimental immunology

authors： Vassilev T,Mihaylova N,Voynova E,Nikolova M,Kazatchkine M,Kaveri S

更新日期：2006-07-01 00:00:00

abstract：:The prevalence of atopic diseases in children has increased during the last decades. Atopic symptoms usually appear early in life. This implies an early priming for atopic disease, possibly even at the fetal level. We therefore compared the presence and production of IgE in the local in utero environment during pregna...

journal_title：Clinical and experimental immunology

authors： Sverremark Ekstrom E,Nilsson C,Holmlund U,van der Ploeg I,Sandstedt B,Lilja G,Scheynius A

更新日期：2002-02-01 00:00:00

abstract：:Complement activation with formation of biologically potent mediators like C5a and the terminal C5b-9 complex (TCC) contributes essentially to development of inflammation and tissue damage in a number of autoimmune and inflammatory conditions. A particular role for complement in the ischaemia/reperfusion injury of the...

journal_title：Clinical and experimental immunology

authors： Harboe M,Ulvund G,Vien L,Fung M,Mollnes TE

更新日期：2004-12-01 00:00:00

abstract：:Neutrophils are often exclusively considered as a first-line innate immune defence, able to rapidly kill or trap pathogens and causing in case of over-activation tissue damage. In the female reproductive tract, however, the presence and activity of neutrophils seems to be tightly regulated. Major players in orchestrat...

journal_title：Clinical and experimental immunology

authors： Hahn S,Hasler P,Vokalova L,van Breda SV,Lapaire O,Than NG,Hoesli I,Rossi SW

更新日期：2019-10-01 00:00:00

abstract：:One hundred and seventy-five sera from thirty-three patients with acute myeloid leukaemia, forty-two patients with chronic myeloid leukaemia and twelve patients with acute lymphatic leukaemia were examined by a radioimmunological technique for the presence of antibodies against single-stranded and double-stranded DNA....

journal_title：Clinical and experimental immunology

authors： Izui S,Lambert PH,Carpentier N,Miescher PA

更新日期：1976-06-01 00:00:00

abstract：:Two colour fluorescent staining using anti-Leu-1 and anti-B1 monoclonal antibodies has been combined with continuous flow microfluorimetry to analyse and isolate the T and B cell populations in B cell chronic lymphocytic leukaemia (B-CLL) patients. In Rai stage 0 patients two distinct B1 positive populations were dete...

journal_title：Clinical and experimental immunology

authors： Murphy JJ,Tooze J,Millard RE,Hudson L

更新日期：1987-06-01 00:00:00