A monoclonal IgM smooth muscle antibody reactive with fibroblast stress fibres produced by immunization with Treponema pallidum.

abstract：:Twenty-seven per cent of atopic patients initially presenting with infantile eczema or hay fever were defective for yeast opsonization and 18% had low levels of C2; these deficiencies were mutually exclusive, suggesting that they are primary. Both defects were associated with each of four different atopic syndromes, s...

journal_title：Clinical and experimental immunology

authors： Turner MW,Mowbray JF,Harvey BA,Brostoff J,Wells RS,Soothill JF

更新日期：1978-11-01 00:00:00

abstract：:The humoral immune response, especially IgG and IgA, is considered to be protective in the pathogenesis of periodontal disease, but the precise mechanisms are still unknown. Immunoglobulins arriving at the periodontal lesion are from both systemic and local tissue sources. In order to understand better the local immun...

journal_title：Clinical and experimental immunology

authors： Kinane DF,Lappin DF,Koulouri O,Buckley A

更新日期：1999-03-01 00:00:00

abstract：:Autoimmune T cell responses directed against insulin-producing β cells are central to the pathogenesis of type 1 diabetes (T1D). Detection of such responses is therefore critical to provide novel biomarkers for T1D 'immune staging' and to understand the mechanisms underlying the disease. While different T cell assays ...

journal_title：Clinical and experimental immunology

authors： Mallone R,Mannering SI,Brooks-Worrell BM,Durinovic-Belló I,Cilio CM,Wong FS,Schloot NC,T-Cell Workshop Committee, Immunology of Diabetes Society.

更新日期：2011-01-01 00:00:00

abstract：:Transmembrane activator and calcium modulator and cyclophilin ligand interactor-immunoglobulin (TACI-Ig) is a human fusion protein that binds and neutralizes both B lymphocyte stimulator (BLyS), a cytokine shown to be a key regulator of B cell maturation, proliferation and survival, and a proliferation-inducing ligand...

journal_title：Clinical and experimental immunology

authors： Wang D,Chang Y,Wu Y,Zhang L,Yan S,Xie G,Qin Q,Jin J,Wang W,Fang J,Wei W

更新日期：2011-02-01 00:00:00

abstract：:Cytokines have been extensively studied in coeliac disease, but cytokine release related to exposure to gluten and associated symptoms has only recently been described. Prominent, early elevations in serum interleukin (IL)-2 after gluten support a central role for T cell activation in the clinical reactions to gluten ...

journal_title：Clinical and experimental immunology

authors： Goel G,Daveson AJM,Hooi CE,Tye-Din JA,Wang S,Szymczak E,Williams LJ,Dzuris JL,Neff KM,Truitt KE,Anderson RP

更新日期：2020-01-01 00:00:00

abstract：:Two DNA-binding monoclonal antibodies (MoAb) derived from lupus mice were examined for their effects on kidney function. Antibody IV-228, reactive with single-stranded DNA (ssDNA) but not double-stranded DNA (dsDNA) significantly altered kidney function in some MRL/Mp-lpr/lpr (MRL/lpr) mice with lupus glomerulonephrit...

journal_title：Clinical and experimental immunology

authors： Lake RA,Staines NA

更新日期：1988-07-01 00:00:00

abstract：:We have investigated TNF-alpha secretory response of peripheral blood mononuclear cells (PBMC) from 13 uraemic patients undergoing regular haemodialysis with cuprophane membrane (CM). Sixteen healthy subjects and five uraemic patients under conservative therapy were also studied as controls. Cells of haemodialysis pat...

journal_title：Clinical and experimental immunology

authors： Annenkov AY,Strokov AG,Baranova FS

更新日期：1992-10-01 00:00:00

abstract：:The present report concerns the site of synthesis of alpha 1-anti-trypsin (alpha 1 AT). In this study circulating cells and tissue fragments were incubated with radioactive amino acids to be incorporated during protein synthesis. The de novo synthesis of proteins was demonstrated by autoradiography of the immunoelectr...

journal_title：Clinical and experimental immunology

authors： van Furth R,Kramps JA,Diesselhof-den Dulk MM

更新日期：1983-03-01 00:00:00

abstract：:Immunofluorescence (IF) to detect HCV antigens and non-isotopic in situ hybridization (NISH) to detect HCV RNA genome were carried out on bone marrow (BM) and peripheral blood (PB) mononuclear cells (MC) of 11 chronically HCV-infected patients. In four patients (36.4%) HCV antigens were detected in monocytes/macrophag...

journal_title：Clinical and experimental immunology

authors： Sansonno D,Iacobelli AR,Cornacchiulo V,Iodice G,Dammacco F

更新日期：1996-03-01 00:00:00

abstract：:Amyloid A (AA) amyloidosis is characterized by extracellular pathogenic deposition of insoluble fibril protein in various body organs. Deposited amyloid generally remains in a variety of organs for long periods, but its disappearance has been reported after the precursor protein is diminished. The kinetics of AA depos...

journal_title：Clinical and experimental immunology

authors： Muhammad N,Murakami T,Inoshima Y,Ishiguro N

更新日期：2015-07-01 00:00:00

abstract：:The influx of monocytes and neutrophils into the inflamed tissue could be an important aspect in the pathogenesis of inflammatory bowel disease (IBD). A membrane protein involved in the monocyte/neutrophil adherence to endothelium is CD11b/CD18 or alpha M beta 2 (complement receptor type 3 = CR3). In the present study...

journal_title：Clinical and experimental immunology

authors： Palmen MJ,Dijkstra CD,van der Ende MB,Peña AS,van Rees EP

更新日期：1995-08-01 00:00:00

abstract：:Autoantibodies directed against the Sm proteins of the spliceosome complex are found in approximately 25% of systemic lupus erythematosus (SLE) patients sera. To determine which regions of the Sm D polypeptide are involved in the lupus autoimmune response, binding to overlapping octapeptides of Sm D has been evaluated...

journal_title：Clinical and experimental immunology

authors： James JA,Mamula MJ,Harley JB

更新日期：1994-12-01 00:00:00

abstract：:In reactive arthritis (ReA) there is specific proliferation of synovial fluid (SF) mononuclear cells (MNC) to the triggering bacterial antigen; comparatively little or no response is seen in peripheral blood (PB). To investigate the mechanism of this elevated local immune response, we examined patients with typical Re...

journal_title：Clinical and experimental immunology

authors： Sieper J,Braun J,Wu P,Kingsley G

更新日期：1993-01-01 00:00:00

abstract：:IgG2 deficiency has been recently associated with the appearance of vasculitis. None of the 42 patients with IgG2 deficiency whom we studied has a history of vasculitis. We have also studied 56 patients with vasculitis, and found four of them with IgG2 levels below the normal range for their age. As a group, the vascu...

journal_title：Clinical and experimental immunology

authors： Jiménez A,López-Trascasa M,Fontán G

更新日期：1989-11-01 00:00:00

abstract：:By using a flow cytometric technique which allows direct identification of proliferating cells within mixed cell populations, we have previously described that soluble extracts obtained from Mycobacterium tuberculosis or M. avium represent strong stimuli for human gammadelta+ T cells. In the present study, we demonstr...

journal_title：Clinical and experimental immunology

authors： Batoni G,Esin S,Harris RA,Källenius G,Svenson SB,Andersson R,Campa M,Wigzell H

更新日期：1998-04-01 00:00:00

abstract：:Previous studies have shown that rabbit anti-mouse immunoglobulin sera (anti-Ig) which kill non-activated B lymphocytes in the presence of complement, are incapable of doing so when the cells are activated by antigen or mitogen into mitosis. Results reported here indicate that the resistance is not dependent on either...

journal_title：Clinical and experimental immunology

authors： Kerbel RS,Birbeck MS,Robertson D,Cartwright P

更新日期：1975-04-01 00:00:00

abstract：:Ox-LDL is thought to play a major role in atherogenesis. The mechanisms mediating the deleterious influences of Ox-LDL include foam cell formation and cell cytotoxicity. The production of anti-Ox-LDL antibodies results in the formation of immune complexes which are taken up at enhanced rate by macrophages, leading to ...

journal_title：Clinical and experimental immunology

authors： George J,Blank M,Hojnik M,Bar-Meir E,Koike T,Matsuura E,Lorber M,Aviram M,Shoenfeld Y

更新日期：1997-05-01 00:00:00

abstract：:Analysis of the VH gene repertoire of the J558 family was done in lipopolysaccharide (LPS)-stimulated resting cells and in vivo activated cells derived from C57Bl/6-lpr mice (IghCb). Using a restriction fragment length polymorphism (RFLP) based on digestion with the restriction enzyme Pstl, the expression of the subfa...

journal_title：Clinical and experimental immunology

authors： Alarcón-Riquelme ME,Fernández C

更新日期：1995-02-01 00:00:00

abstract：:This study was performed to determine whether or not IL-18, formerly called IFN-gamma-inducing factor, is involved in the pathogeneses of allergic disorders. Peripheral blood mononuclear cells (PBMC) were obtained from patients with allergic bronchial asthma (BA), patients with atopic dermatitis (AD) and controls who ...

journal_title：Clinical and experimental immunology

authors： El-Mezzein RE,Matsumoto T,Nomiyama H,Miike T

更新日期：2001-11-01 00:00:00

abstract：:Ten out of 20 (50%) 17-week-old female NOD/WEHI mice developed an acute form of autoimmune diabetes when injected with two large doses of cyclophosphamide (CY), given at 14-day intervals. If these mice were treated under a prophylactic regimen with 2.5 mg/kg body weight per day of the novel immunosuppressant deoxysper...

journal_title：Clinical and experimental immunology

authors： Nicoletti F,Borghi MO,Meroni PL,Barcellini W,Fain C,Di Marco R,Menta R,Schorlemmer HU,Bruno G,Magro G

更新日期：1993-02-01 00:00:00

abstract：:Endothelial cells (ECs) are a target in inflammation, and the death of EC is regulated by various factors. Although intravenous immunoglobulin (IVIG) preparations are known to be beneficial therapeutic agents for the treatment of autoimmune diseases and systemic inflammatory disorders, their mechanism of action have n...

journal_title：Clinical and experimental immunology

authors： Nakatani K,Takeshita S,Tsujimoto H,Sekine I

更新日期：2002-03-01 00:00:00

abstract：:Epstein-Barr (EB) virus serology was correlated with the results of immunological investigations of three inherited immunodeficiency diseases, in an attempt to understand the immune mechanisms controlling EB virus infection. In nine patients with Wiskott-Aldrich syndrome (WAS), the constant lack of anti-EB virus assoc...

journal_title：Clinical and experimental immunology

authors： Vilmer E,Lenoir GM,Virelizier JL,Griscelli C

更新日期：1984-02-01 00:00:00

abstract：:We report a study on immunoregulation of in vitro antibody to hepatitis B surface antigen (anti-HBs) synthesis induced by pokeweed mitogen (PWM) from peripheral blood mononuclear cells (PBMC) in chronic hepatitis B surface antigen (HBsAg) carriers and in 'high responders', (anti-HBs RIA ratio greater than or equal to ...

journal_title：Clinical and experimental immunology

authors： Barnaba V,Valesini G,Levrero M,Zaccari C,Van Dyke A,Falco M,Musca A,Balsano F

更新日期：1985-05-01 00:00:00

abstract：:Serum activity of the adenosine deaminase (ADA) isozyme, ADA2, has been reported to be elevated during various disease states. Macrophages have been suggested as the cellular source of extracellular ADA activity because they are one of the only cell types in which intracellular ADA2 activity has been measured, but ext...

journal_title：Clinical and experimental immunology

authors： Conlon BA,Law WR

更新日期：2004-10-01 00:00:00

abstract：:Goodpasture (GP) antigens, protein components reactive with human autoantibodies against glomerular basement membrane (GBM), were identified in human alveolar basement membrane (ABM) using an enzyme-linked immunoassay (ELISA), Western blotting and immunoprecipitation. All six anti-GBM antisera studied, three obtained ...

journal_title：Clinical and experimental immunology

authors： Yoshioka K,Iseki T,Okada M,Morimoto Y,Eryu N,Maki S

更新日期：1988-12-01 00:00:00

abstract：:We investigated changes in circulating T helper type 17 (Th17) cells following anti-tumour necrosis factor (TNF) in rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients. Peripheral blood mononuclear cells (PBMC) were isolated from 25 RA, 15 AS and eight PsA patients at baseline...

journal_title：Clinical and experimental immunology

authors： Hull DN,Williams RO,Pathan E,Alzabin S,Abraham S,Taylor PC

更新日期：2015-09-01 00:00:00

abstract：:This study analyses the expression by rat lymphocytes of six renal brush border (BB) antigens defined by a set of monoclonal antibodies and demonstrates that a 90 kD protein (gp 90), synthesized by BB and glomeruli is found on the surface of T and B cells. The other antigens, including the 330 kD protein involved in H...

journal_title：Clinical and experimental immunology

authors： Van Leer EH,Moullier P,Ronco P,Verroust P

更新日期：1987-03-01 00:00:00

abstract：:Regulatory T cells seem to play a central role in maintaining immune tolerance in the gut mucosa. Previously we have shown that interleukin (IL)-10 is produced at high levels in the inflamed colonic tissue of ulcerative colitis (UC) patients. The cellular source was CD4+ T cells, suggesting local activation of regulat...

journal_title：Clinical and experimental immunology

authors： Sitohy B,Hammarström S,Danielsson A,Hammarström ML

更新日期：2008-02-01 00:00:00

abstract：:Human gut-associated immunoregulatory events were studied in a pokeweed mitogen (PWM)-stimulated culture system using lymphocytes obtained from the mesenteric lymph nodes (MLN) of female subjects undergoing gastroplasty for obesity. Compared with peripheral blood lymphocytes, lymphocytes obtained from MLN secreted IgG...

journal_title：Clinical and experimental immunology

authors： Pang G,Yeung S,Clancy RL,Cripps AW,Hennessy EJ,Santhanam AN

更新日期：1986-04-01 00:00:00

abstract：:A study was conducted to quantify soluble IL-2 receptor (sIL-2R) levels in sera of 57 chronic plaque psoriasis patients and correlate these measurements with disease activity and the number of IL-2R-positive (CD25+) lymphocytes in lesional biopsies of 11 cyclosporin A (CsA) and 13 psoralen plus ultraviolet radiation (...

journal_title：Clinical and experimental immunology

authors： Duncan JI,Horrocks C,Ormerod AD,Powles AV,Whiting PH,Fry L,Thomson AW

更新日期：1991-08-01 00:00:00