A monoclonal DNA-binding autoantibody causes a deterioration in renal function in MRL mice with lupus disease.


:Two DNA-binding monoclonal antibodies (MoAb) derived from lupus mice were examined for their effects on kidney function. Antibody IV-228, reactive with single-stranded DNA (ssDNA) but not double-stranded DNA (dsDNA) significantly altered kidney function in some MRL/Mp-lpr/lpr (MRL/lpr) mice with lupus glomerulonephritis. Antibody II-410, preferentially reactive with dsDNA, did not modify kidney function in MRL/lpr mice. Neither antibody affected normal healthy MRL/Mp- +/+ (MRL/n) mice. Not all MRL/lpr mice were equally affected by IV-228 and in some animals with clinical disease it was without effect even when high circulating antibody levels were maintained by five sequential daily injections. Its affects upon kidney function appeared to be related to its ability to localize in vivo in glomeruli. It is assumed that epitopes on trapped immune complexes are immunologically available to circulating antibodies, and in those animals where injected antibody is not captured this is because the antigen epitope is either absent or is masked by the animals' own auto-antibodies. We conclude that antibodies which bind to ssDNA contribute to lupus nephritis; that individual mice make DNA-binding antibodies of different fine specificity; and that kidney disease is not always due to the same balance of antibodies in members of a genetically homogeneous stock.


Clin Exp Immunol


Lake RA,Staines NA


Has Abstract


1988-07-01 00:00:00












  • Measles antibodies and autoantibodies in autoimmune disorders.

    abstract::Measles CF antibodies have been examined in the sera of patients with a variety of clinical disorders associated with the production of autoantibodies. Previous reports of high-titre reactions in DLE and chronic active hepatitis have been confirmed, the titres in the latter disorder being particularly elevated. Mean a...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Triger DR,Gamlen TR,Paraskevas E,Lloyd RS,Wright R

    更新日期:1976-06-01 00:00:00

  • Thymic hormone containing cells. II. Evolution of cells containing the serum thymic factor (FTS or thymulin) in normal and autoimmune mice, as revealed by anti-FTS monoclonal antibodies. Relationship with Ia bearing cells.

    abstract::The number of thymic epithelial cells containing the serum thymic factor (FTS or thymulin), assessed by indirect immunofluorescence using an anti-FTS monoclonal antibody, was studied in the thymus of normal and autoimmune mice as a function of age. In normal mice the number of FTS+ cells was constant until the age of ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Savino W,Dardenne M,Bach JF

    更新日期:1983-04-01 00:00:00

  • 2-Chlorodeoxyadenosine (cladribine) induces apoptosis in human monocyte-derived dendritic cells.

    abstract::2-Chlorodeoxyadenosine (cladribine, CdA) is an immunosuppressive drug that is licensed to treat hairy cell leukaemia, and has been shown recently to have beneficial effects in patients with multiple sclerosis (MS). The therapeutic effects of CdA have been suggested to be mediated partly through its potent toxicity tow...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Singh V,Prajeeth CK,Gudi V,Bénardais K,Voss EV,Stangel M

    更新日期:2013-08-01 00:00:00

  • Molecular studies and NK cell function of a new case of TAP2 homozygous human deficiency.

    abstract::In this paper we describe the clinical and molecular features of a new case (GOR) of homozygous human TAP2 deficiency, analysing the phenotype and function of NK cells. The patient presented from infancy with recurrent sinopulmonary infections; a selective IgG2 deficiency, negative antibody response to polysaccharide ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Matamoros N,Milà J,Llano M,Balas A,Vicario JL,Pons J,Crespí C,Martinez N,Iglesias-Alzueta J,López-Botet M

    更新日期:2001-08-01 00:00:00

  • Self-reactive B lymphocytes detected in young adults, children and newborns after in vitro infection with Epstein-Barr virus.

    abstract::B-lymphocytes from healthy children and young adults who were seronegative for autoantibodies and B lymphocytes from umbilical cord blood of newborns were induced to secrete a variety of autoantibodies upon infection with Epstein-Barr virus. Such autoantibody-secreting clones were obtained from different lymphoid tiss...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Uhlig H,Rutter G,Dernick R

    更新日期:1985-10-01 00:00:00

  • Gliadin and tissue transglutaminase complexes in normal and coeliac duodenal mucosa.

    abstract::Tissue transglutaminase (tTG) seems to be the target self-antigen for endomysial antibodies in coeliac disease (CD) and to catalyse the critical deamidation of gliadin which strengthens its recognition by HLA-restricted gut-derived T cells. To date, it has not been demonstrated whether gliadin is cross-linked to tTG w...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Ciccocioppo R,Di Sabatino A,Ara C,Biagi F,Perilli M,Amicosante G,Cifone MG,Corazza GR

    更新日期:2003-12-01 00:00:00

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    abstract::A solid-phase radioimmunoassay was developed to detect antibodies to liver membrane antigens in sera of patients with HBsAg-negative and -positive liver diseases and primary non-hepatic autoimmune diseases. Ten of fourteen patients with HBsAg-negative CAH had autoantibodies detected by RIA; negative results were obtai...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Manns M,Meyer zum Büschenfelde KH,Hütteroth TH,Hess G

    更新日期:1980-11-01 00:00:00

  • Bispecific anti-human red blood Rhesus-D antigen x anti Fc gamma RI targeted antibody-dependent cell-mediated cytotoxicity and phagocytosis by mononuclear leucocytes.

    abstract::The Fc receptor mediated antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis induced by bispecific antibody (BsAb) to the high-affinity Fc receptor for IgG (Fc gamma RI) and to human red blood group antigen RhD were studied in vitro, using human mononuclear leucocytes as effector cells. The results w...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Deramoudt EX,Gilard C,Lepine N,Alonso JM,Romet-Lemonne JL

    更新日期:1992-08-01 00:00:00

  • B7/BB1 provides an important costimulatory signal for CD3-mediated T lymphocyte proliferation in patients with systemic lupus erythematosus (SLE).

    abstract::Successful T cell activation via the T cell receptor (TCR)/CD3 complex requires at least one contact-dependent second signal delivered by costimulatory molecules, including the B7/BB1 molecule, that are present on antigen-presenting cells (APC). SLE is characterized by multiple complex lymphocyte abnormalities of unde...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Sfikakis PP,Oglesby R,Sfikakis P,Tsokos GC

    更新日期:1994-04-01 00:00:00

  • Altered balance between self-reactive T helper (Th)17 cells and Th10 cells and between full-length forkhead box protein 3 (FoxP3) and FoxP3 splice variants in Hashimoto's thyroiditis.

    abstract::T helper type 17 (Th17) cells play a pathogenic role in autoimmune disease, while interleukin (IL)-10-producing Th10 cells serve a protective role. The balance between the two subsets is regulated by the local cytokine milieu and by the relative expression of intact forkhead box protein 3 (FoxP3) compared to FoxP3Δ2, ...

    journal_title:Clinical and experimental immunology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Kristensen B,Hegedüs L,Madsen HO,Smith TJ,Nielsen CH

    更新日期:2015-04-01 00:00:00

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Alexander K,Edwards C,Misko IS,Geczy AF,Bashir HV,Edmonds JP

    更新日期:1981-07-01 00:00:00

  • Phenotypic analysis of cells in bronchoalveolar lavage fluid and peripheral blood of maedi visna-infected sheep.

    abstract::A phenotypic analysis of bronchoalveolar lavage fluid (BALF) and peripheral blood (PB) cells in maedi visna virus (MVV)-infected sheep has been performed. The differential cell count in BALF from MVV-infected animals was characterized by a significant increase (P < 0.05) in lymphocytes and neutrophils. Lymphocyte phen...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Luján L,Begara I,Collie DD,Watt NJ

    更新日期:1993-02-01 00:00:00

  • Natural thymocytotoxic autoantibodies in non-obese diabetic (NOD) mice: characterization and fine specificity.

    abstract::The NOD mouse is a model of human juvenile type I diabetes mellitus. As in humans and in the BB rat model, the development of diabetes in NOD mice is accompanied by evident manifestations of cell-mediated and humoral autoimmunity. Beside autoantibodies directed at putative islet cell antigens, NOD sera contain antibod...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Lehuen A,Altman J,Bach JF,Carnaud C

    更新日期:1990-09-01 00:00:00

  • Immune-bone interplay in the structural damage in rheumatoid arthritis.

    abstract::The immune and bone systems maintain homeostasis by interacting closely with each other. Rheumatoid arthritis is a pathological consequence of their interplay, as activated T cell immune responses result in osteoclast-mediated bone erosion. An imbalance between forkhead box protein 3 (Foxp3)+ regulatory T (Treg ) cell...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审


    authors: Komatsu N,Takayanagi H

    更新日期:2018-10-01 00:00:00

  • T cell clones from a non-leprosy exposed subject recognize the Mycobacterium leprae 18-kD protein.

    abstract::Although Mycobacterium leprae shares many protein antigens with other mycobacterial species, there is a degree of specificity in the T cell response to the organism. This is evident in the failure of cross-protection between mycobacterial species and the specific unresponsiveness to M. leprae in lepromatous leprosy pa...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Adams E,Basten A,Prestidge R,Britton WJ

    更新日期:1995-10-01 00:00:00

  • A syngeneic monoclonal anti-idiotype antibody against HNK-1: characterization and cytotoxic activity in vitro.

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Schluep M,Page N,Burger D,Steck AJ

    更新日期:1989-02-01 00:00:00

  • After chemotherapy, functional humoral response capacity is restored before complete restoration of lymphoid compartments.

    abstract::Chemotherapy has, besides the beneficial effects, several adverse effects. Suppression of the immune system is one of the most important problems. Infections caused by encapsulated bacteria like Streptococcus pneumoniae are responsible for a major part of infectious problems during and after treatment. The splenic mar...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Zandvoort A,Lodewijk ME,Klok PA,Breukels MA,Rijkers GT,Timens W

    更新日期:2003-01-01 00:00:00

  • Dynamics of M1 macrophages in oral mucosal lesions during the development of acute graft-versus-host disease in rats.

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Seno K,Yasunaga M,Kajiya H,Izaki-Hagio K,Morita H,Yoneda M,Hirofuji T,Ohno J

    更新日期:2017-12-01 00:00:00

  • MicroRNA-155 may be involved in the pathogenesis of atopic dermatitis by modulating the differentiation and function of T helper type 17 (Th17) cells.

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Ma L,Xue HB,Wang F,Shu CM,Zhang JH

    更新日期:2015-07-01 00:00:00

  • Syncytial cell formation in vivo by type C retroviral particles in the systemic lupus erythematosus (SLE) lung.

    abstract::Significant numbers of syncytial cells were observed in the bronchoalveolar lavage fluid (BALF) of a 42-year-old patient who had SLE with interstitial pneumonia. Electron microscopic study of the BALF cells and positive reverse transcriptase activity in the supernatant of the cultured cells revealed unknown retroviral...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Tamura N,Sekigawa I,Hashimoto H,Yamamoto N,Kira S

    更新日期:1997-03-01 00:00:00

  • Correlations among cutaneous reactivity to DNCB, PHA-induced lymphocyte blastogenesis and peripheral blood E rosettes.

    abstract::Comparisons of the results obtained in a study of fifty-two patients with genitourinary malignancies using three assays to monitor the thymus-dependent immune system (delayed cutaneous hypersensitivity to DNCB, PHA-induced lymphocyte blastogenesis, and peripheral blood E rosette-forming lymphocyte counts) yielded stat...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Catalona WJ,Tarpley JL,Potvin C,Chretien PB

    更新日期:1975-02-01 00:00:00

  • Neopterin release from human endothelial cells is triggered by interferon-gamma.

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Andert SE,Griesmacher A,Zuckermann A,Müller MM

    更新日期:1992-06-01 00:00:00

  • Cytokine responses to the native and recombinant forms of the major surface glycoprotein of Pneumocystis carinii.

    abstract::Pneumocystis carinii is a major opportunistic pathogen and leading cause of morbidity in patients with AIDS. The major surface glycoprotein (MSG) of P. carinii, represented by a family of related proteins encoded by unique genes, is highly immunogenic and contains T cell-protective epitopes. We undertook the present s...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Theus SA,Smulian AG,Sullivan DW,Walzer PD

    更新日期:1997-08-01 00:00:00

  • Increased sensitivity to natural killing in Raji cells is due to effector recognition of molecules appearing on target cell membranes following EBV cycle induction.

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Blazar BA,Fitzgerald J,Sutton L,Strome M

    更新日期:1983-10-01 00:00:00

  • Epitope shift of proteinase-3 anti-neutrophil cytoplasmic antibodies in patients with small vessel vasculitis.

    abstract::Anti-neutrophil cytoplasmic antibodies against proteinase 3 (PR3-ANCA) are used as diagnostic tools for patients with small vessel vasculitis (AASV). We have produced chimeric mouse/human PR3 molecules and investigate changes in reactivity over time and the possible relationship between epitope specificity and clinica...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,多中心研究


    authors: Selga D,Segelmark M,Gunnarsson L,Hellmark T

    更新日期:2010-06-01 00:00:00

  • Expression of high-affinity IL-4 receptors on human melanoma, ovarian and breast carcinoma cells.

    abstract::It has previously been shown that murine sarcoma cells express high-affinity IL-4 receptors (IL-4R) which are internalized after binding to the ligand (Puri et al., Cancer Res 1991; 51:3011-7). We have also reported that human renal cell carcinoma cells express high-affinity IL-4R, and IL-4 inhibits tumour growth in v...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Obiri NI,Siegel JP,Varricchio F,Puri RK

    更新日期:1994-01-01 00:00:00

  • Nifurtimox-induced alterations in the cell-mediated immune response to PPD tin guinea-pigs.

    abstract::Positive skin reactions to PPD in guinea-pigs immunized with Freund's complete adjuvant (FCA) were reversed after treatment with 10 mg/kg/day nifurtimox for 12 days. The in vitro migration of peripheral blood leucocytes from FCA-immunized guinea-pigs was inhibited with PPD, but it returned to normal values after nifur...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Lelchuk R,Cardoni RL,Levis S

    更新日期:1977-12-01 00:00:00

  • Thymic stromal lymphopoietin expression is increased in the horny layer of patients with atopic dermatitis.

    abstract::Thymic stromal lymphopoietin (TSLP) is known for its capacity to induce CD11c(+) myeloid dendritic cells to promote T helper type 2 (Th2)-skewed inflammatory responses. Although increased expression of TSLP was reported in the lesional skin of limited numbers of patients with atopic dermatitis (AD), the relationships...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Sano Y,Masuda K,Tamagawa-Mineoka R,Matsunaka H,Murakami Y,Yamashita R,Morita E,Katoh N

    更新日期:2013-03-01 00:00:00

  • High levels of glucocorticoid receptors in patients with active Crohn's disease may predict steroid resistance.

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Towers R,Naftali T,Gabay G,Carlebach M,Klein A,Novis B

    更新日期:2005-08-01 00:00:00

  • Multi-component meningococcal serogroup B (MenB)-4C vaccine induces effective opsonophagocytic killing in children with a complement deficiency.

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    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: van den Broek B,van Els CACM,Kuipers B,van Aerde K,Henriet SS,de Groot R,de Jonge MI,Langereis JD,van der Flier M

    更新日期:2019-12-01 00:00:00