Altered CD45 isoform expression in C77G carriers influences cytokine responsiveness and adhesion properties of T cells.

abstract：:PHA activated human peripheral blood mononuclear cells (MNC) were incubated with human interleukin 2 (IL-2) in the absence or in the presence of 10(-6)-10(-9) M hydrocortisone (HC). HC suppressed the proliferative response of the activated MNC to highly purified human leucocyte IL-2 in a dose dependent manner. This su...

journal_title：Clinical and experimental immunology

authors： Horst HJ,Flad HD

更新日期：1987-04-01 00:00:00

abstract：:Peripheral T lymphocytes from asymptomatic HBsAg carriers and hepatitis B (HB) immune (naturally acquired or vaccine induced) donors were induced into interleukin-2 (IL-2) secretion by plasma-derived HBsAg and the translational products of the S- and pre-S2+S gene of HB virus (HBV) in vitro. Biphasic time courses of I...

journal_title：Clinical and experimental immunology

authors： Sylvan SP,Hekkström UB

更新日期：1989-11-01 00:00:00

abstract：:Bone marrow (BM) lymphocytes were obtained by sucrose density gradient centrifugation of the nucleated cells from adult human BM. BM was obtained from rib sections removed routinely during thoracotomy from thirteen patients with a localized lung tumour and from two other patients without tumour (mean age 47 years). Th...

journal_title：Clinical and experimental immunology

authors： De Gast GC,Platts-Mills TA

更新日期：1979-10-01 00:00:00

abstract：:Bovine type II collagen administered to non-pregnant female DBA/1 mice caused arthritis in 55% of animals with a mean onset time of 70 days following immunization. Of collagen-treated females subsequently becoming syngeneically pregnant before the onset of arthritis, all developed the disease within 10 days of parturi...

journal_title：Clinical and experimental immunology

authors： Waites GT,Whyte A

更新日期：1987-03-01 00:00:00

abstract：:Extracorporeal photopheresis (ECP) is a widely used immunomodulatory therapy for the treatment of various T cell-mediated disorders such as cutaneous T cell lymphoma (CTCL), graft-versus-host disease (GvHD) or systemic sclerosis. Although clinical benefits of ECP are already well described, the underlying mechanism of...

journal_title：Clinical and experimental immunology

authors： Wiese F,Reinhardt-Heller K,Volz M,Gille C,Köstlin N,Billing H,Handgretinger R,Holzer U

更新日期：2019-03-01 00:00:00

abstract：:Activation of human umbilical vein endothelial (HUVE) cells with the inflammatory mediators tumour necrosis factor-alpha (TNF), interleukin-1 (IL-1), lipopolysaccharide (LPS) and phorbol esters enhanced their adhesiveness for leucocytes. The appearance of an activation antigen ELAM-1, recognized by a monoclonal antibo...

journal_title：Clinical and experimental immunology

authors： Leeuwenberg JF,Jeunhomme GM,Buurman WA

更新日期：1990-09-01 00:00:00

abstract：:A previously unrecognized autoantibody, detected by immunofluorescence, reacted with all human organs but gave negative results on tissues from rat, mouse, rabbit, guinea-pig, calf and chicken. From its predilection for mitochondria-rich cells (oncocytes) and its selective absorption with human but not animal mitochon...

journal_title：Clinical and experimental immunology

authors： Swana GT,Swana MR,Bottazzo GF,Doniach D

更新日期：1977-06-01 00:00:00

abstract：:To determine the role of chemokines in the pathogenesis of systemic sclerosis (SSc), we examined serum levels, spontaneous production by peripheral blood mononuclear cells (PBMC), and histological distribution in the affected skin, of MCP-1, MIP-1alpha and MIP-1beta in SSc patients. Serum levels of these chemokines we...

journal_title：Clinical and experimental immunology

authors： Hasegawa M,Sato S,Takehara K

更新日期：1999-07-01 00:00:00

abstract：:Spleens of BALB/c mice with plasmacytoma contain macrophages (M phi) which were found to suppress the in vitro immune function of normal splenic cells through a diffusible factor. The suppressor activity of these macrophages was reversibly inhibited by ligands specific for the corresponding PC globulin, but not by ant...

journal_title：Clinical and experimental immunology

authors： Chen YH,Heller P

更新日期：1982-11-01 00:00:00

abstract：:Morbidity and mortality in cystic fibrosis (CF) is predominantly due to destruction of pulmonary tissue. The host immune response may, in part, play a pathogenic role in pulmonary destruction in these patients. To further understand host immune response in CF, we examined the state of activation of peripheral blood mo...

journal_title：Clinical and experimental immunology

authors： Jones MM,Seilheimer DK,Pier GB,Rossen RD

更新日期：1990-06-01 00:00:00

abstract：:The transferrin receptors which appear on mitogen-activated human peripheral blood lymphocytes were found by the use of immunofluorescence techniques to display temperature-dependent patching and capping reactions upon binding of transferrin. Lateral mobility of ligand-occupied membrane sites was accompanied by both s...

journal_title：Clinical and experimental immunology

authors： Galbraith GM,Galbraith RM

更新日期：1980-11-01 00:00:00

abstract：:Eight genetically different strains of mice were compared regarding the dissemination of Paracoccidioides brasiliensis to the lungs, liver and omentum/pancreas, DTH responses and specific antibody production at 16 weeks after intraperitoneal infection with Pb18, a virulent P. brasiliensis isolate. The degree of dissem...

journal_title：Clinical and experimental immunology

authors： Singer-Vermes LM,Sakamoto TN,Vaz CA,Calich VL

更新日期：1995-07-01 00:00:00

abstract：:Human thymic stromal lymphopoietin (TSLP) promotes CD4(+) T-cell proliferation both directly and indirectly through dendritic cell (DC) activation. Although human TSLP-activated DCs induce CD8(+) T-cell proliferation, it is not clear whether TSLP acts directly on CD8(+) T cells. In this study, we show that human CD8(+...

journal_title：Clinical and experimental immunology

authors： Akamatsu T,Watanabe N,Kido M,Saga K,Tanaka J,Kuzushima K,Nishio A,Chiba T

更新日期：2008-10-01 00:00:00

abstract：:Podocytes, the main target of immune complex, participate actively in the development of glomerular injury as immune cells. Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is an innate immune molecular that has an immune recognition function, and is involved in mediation of ce...

journal_title：Clinical and experimental immunology

authors： Cai M,Zhou T,Wang X,Shang M,Zhang Y,Luo M,Xu C,Yuan W

更新日期：2016-03-01 00:00:00

abstract：:YKL-40 is secreted by macrophages and neutrophils and patients with bacterial infections have elevated circulating YKL-40. The aim was to evaluate changes in plasma YKL-40 (determined by enzyme-linked immunosorbent assay (ELISA) at 0, 2, 4, 8, 24 and 32 h) in eight healthy volunteers after injection with Esherichia co...

journal_title：Clinical and experimental immunology

authors： Johansen JS,Krabbe KS,Møller K,Pedersen BK

更新日期：2005-05-01 00:00:00

abstract：:Immunopathological mechanisms are speculated to underlie haemorrhagic fever with renal syndrome (HFRS) caused by Hantaviruses. CD4+CD25+ T regulatory cells (T(regs)), a subset of CD4+ T cells, expressed high levels of CD25 and the forkhead box transcription factor P3 (FoxP3), plays an important role in the down-regula...

journal_title：Clinical and experimental immunology

authors： Zhu LY,Chi LJ,Wang X,Zhou H

更新日期：2009-04-01 00:00:00

abstract：:Antigenic diversity in field populations of Plasmodium falciparum parasites may delay the acquisition of protective immunity to malaria, the development of which may thus require repeated exposure to infection over a prolonged period of time. In this study we show that P. falciparum parasites may vary in their sensiti...

journal_title：Clinical and experimental immunology

authors： Flyg BW,Perlmann H,Perlmann P,Esposito F,Berzins K

更新日期：1997-02-01 00:00:00

abstract：:Hybridomas producing monoclonal antibodies that bind to determinants on myelogenous leukaemia blast cells were developed using fresh leukaemia blasts as immunogens. These monoclonal antibodies were used to quantitate the amount of a variety of antigens on both leukaemia and normal blood cells in a radioimmunoassay. Th...

journal_title：Clinical and experimental immunology

authors： Ball ED,Fanger MW

更新日期：1982-06-01 00:00:00

abstract：:Glomerulonephritis with organized microtubular monoclonal immunoglobulin deposits (GOMMID) and glomerulonephritis related to type I cryoglobulin are well-known but rare complications of B cell derived chronic lymphocytic leukaemia. In these disorders, monoclonal Ig have never been studied at the molecular level. We co...

journal_title：Clinical and experimental immunology

authors： Galea HR,Bridoux F,Aldigier JC,Paraf F,Bordessoule D,Touchard G,Cogné M

更新日期：2002-07-01 00:00:00

abstract：:Complement induces mixed aggregation of murine spleen cells bearing C3 receptors. In the present studies, we show with immunofluorescent techniques that these aggregates are formed by T and B lymphocytes and myeloid cells, B cells constituting the predominant component in normal mice. There are striking changes in the...

journal_title：Clinical and experimental immunology

authors： Arnaiz-Villena A,Roitt IM

更新日期：1975-07-01 00:00:00

abstract：:Five out of 51 sera (10%) from patients with progressive systemic sclerosis reacted by immunoblotting with tissue concanavalin A binding glycoproteins of 50 kD and 45 kD Mr, whereas only one out of 133 control sera gave the same reaction (P less than 0.001). The antigens were localized to the microsomal fractions of t...

journal_title：Clinical and experimental immunology

authors： Alderuccio F,Witherden D,Toh BH,Barnett A

更新日期：1989-10-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are of crucial importance in immune regulation and response to microbial factors. In multiple sclerosis (MS), pDCs from peripheral blood showed an immature phenotype, but its role in susceptibility to MS is not determined. Because infectious diseases are established triggers of exac...

journal_title：Clinical and experimental immunology

authors： Bayas A,Stasiolek M,Kruse N,Toyka KV,Selmaj K,Gold R

更新日期：2009-09-01 00:00:00

abstract：:The synthesis of some class 1 acute-phase proteins (APP), including C-reactive protein (CRP) and serum amyloid A (SAA) protein is completely blocked by the IL-1 receptor antagonist (IL-1Ra), whereas the production of fibrinogen, a class 2 APP, is increased by IL-1Ra in hepatoma cells, but this has never been tested in...

journal_title：Clinical and experimental immunology

authors： Gabay C,Genin B,Mentha G,Iynedjian PB,Roux-Lombard P,Guerne PA

更新日期：1995-05-01 00:00:00

abstract：:The humoral immune response, especially IgG and IgA, is considered to be protective in the pathogenesis of periodontal disease, but the precise mechanisms are still unknown. Immunoglobulins arriving at the periodontal lesion are from both systemic and local tissue sources. In order to understand better the local immun...

journal_title：Clinical and experimental immunology

authors： Kinane DF,Lappin DF,Koulouri O,Buckley A

更新日期：1999-03-01 00:00:00

abstract：:Erythrocyte autoantibodies in NZB mice react by hemagglutination methods with exposed and hidden red cell antigens. The hidden antigens can be exposed by treatment with proteolytic enzymes. By indirect immunofluorescence one antibody population can be shown to react with modified red cells. In the present study the lo...

journal_title：Clinical and experimental immunology

authors： Linder E

更新日期：1977-03-01 00:00:00

abstract：:Antibody-dependent cellular cytotoxicity (ADCC) was investigated as s possible mechanism of pathogenesis in recurrent aphthous ulceration (RAU). ADCC induced by mononuclear cells from patients at various stages of RAU was compared with ADCC induced by mononuclear cells from paired controls. Chicken red blood cells (Ch...

journal_title：Clinical and experimental immunology

authors： Greenspan JS,Gadol N,Olson JA,Talal N

更新日期：1981-06-01 00:00:00

abstract：:The capacity of microbial products to inhibit allergic inflammation make them logical candidates for novel therapies in allergic diseases such as atopic dermatitis. To assess the effects of intradermal Mycobacterium vaccae derivative on allergen-specific immune responses in children with moderate to severe atopic derm...

journal_title：Clinical and experimental immunology

authors： Dunstan JA,Brothers S,Bauer J,Hodder M,Jaksic MM,Asher MI,Prescott SL

更新日期：2011-06-01 00:00:00

abstract：:While most of our understanding of immune dysfunction in dialysis patients involves alterations in CD28-CD80/86 signalling, nothing is known of CD46-mediated co-stimulation of T cells in these patients. Because C3b/C4b bind to CD46 and complement activation occurs during haemodialysis (HD), we addressed whether CD46-m...

journal_title：Clinical and experimental immunology

authors： Brinkkoetter PT,Marinaki S,Gottmann U,Fleckenstein S,Stump C,Van Der Woude FJ,Braun C,Yard BA

更新日期：2005-03-01 00:00:00

abstract：:Sixteen healthy adults had serial studies of delayed-type skin test reactivity and in vitro lymphocyte blastogenesis to several antigens over a period of 7 months. In many subjects blastogenesis varied broadly from month to month without apparent cause. Responses to all antigens usually increased or decreased together...

journal_title：Clinical and experimental immunology

authors： Graybill JR,Alford RH

更新日期：1976-07-01 00:00:00

abstract：:Recent evidence has shown that microRNA-126 (miR-126) has been involved in the development and function of immune cells, which contributed to the pathogenesis of related clinical diseases. However, the potential role of miR-126 in the development and function of CD4+ T cells remains largely unknown. Here we first foun...

journal_title：Clinical and experimental immunology

authors： Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L

更新日期：2018-02-01 00:00:00