当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL IMMUNOLOGY期刊下所有文献 > A search for circulating immune complex-like material during the course of autoimmune complex glomerulonephritis in Lewis and Brown Norway rats.

A search for circulating immune complex-like material during the course of autoimmune complex glomerulonephritis in Lewis and Brown Norway rats.

Abstract：

:Circulating immune complexes were repeatedly searched for using the C1q-binding assay and the Raji cell test in Lewis and BN rats immunized with the Fx1A fraction from convoluted proximal tubule or with kidney homogenate, mixed with various adjuvants. An autoimmune glomerulonephritis was easily induced in Lewis rats. A potent adjuvant and a booster injection were necessary to obtain such a glomerulonephritis in the BN strain which is reputedly resistant. No circulating immune complex-like material could be found in Lewis rats using the C1q-binding assay. A high C1q-binding activity was found in Bn rats including control rats. The Raji cell test was weakly positive in Lewis and BN rats including control rats. This study demonstrates that the classical resistance of BN rats can be overcome if a potent adjuvant is used. Our failure to demonstrate circulating immune complexes suggests that in situ formation of immune deposits, as recently demonstrated in passive Heymann's nephritis, may also be operative in autoimmune complex glomerulonephritis. Other factors than the antigen used can be responsible for positive C1q-binding or Raji cell tests.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Zanetti M,Bellon B,Verroust P,Druet P

subject

Has Abstract

pub_date

1980-10-01 00:00:00

pages

86-94

issue

1

eissn

0009-9104

issn

1365-2249

journal_volume

42

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL IMMUNOLOGY文献大全
  • The influence of diesel exhaust particles on mononuclear phagocytic cell-derived cytokines: IL-10, TGF-beta and IL-1 beta.

    abstract：:Diesel exhaust particles (DEP) are known to modulate the production of cytokines associated with acute and chronic respiratory symptoms and allergic respiratory disease. Tolerance is an important mechanism through which the immune system can maintain nonresponsiveness to common environmental antigens. We examined the ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2001.01698.x

    authors： Pacheco KA,Tarkowski M,Sterritt C,Negri J,Rosenwasser LJ,Borish L

    更新日期：2001-12-01 00:00:00

  • Epitope mapping of an HLA-B27 monoclonal antibody that also reacts with a 35-kD bacterial outer-membrane protein.

    abstract：:Ye-3 is an HLA-B27-specific murine monoclonal antibody recognizing the heat-modifiable protein of Enterobacteriaceae. Here we used recombinant hybrid molecules between the HLA-B7 and HLA-B27 antigens to delineate the epitope recognized by Ye-3. Results of these experiments indicated that the segment of HLA-B*2705 span...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1990.tb05397.x

    authors： Toubert A,Hamachi M,Raffoux C,Park MS,Yu DT

    更新日期：1990-10-01 00:00:00

  • IgA containing circulating immune complexes and IgA anti-single stranded DNA antibodies in patients with obstructive jaundice.

    abstract：:Elevated levels of IgA containing circulating immune complexes (IgA-CIC) and IgG containing (IgG-) CIC were detected in patients with obstructive jaundice due to biliary tract stones and/or tumour of biliary tract or pancreas. Levels of serum IgA were also elevated, and correlated with the levels of IgA-CIC. The level...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Ohshio G,Furukawa F,Sekita K,Manabe T,Tobe T,Hamashima Y

    更新日期：1985-02-01 00:00:00

  • Immune responses to fractionated cytomegalovirus (CMV) antigens after HIV infection. Loss of cellular and humoral reactivity to antigens recognized by HIV-, CMV+ individuals.

    abstract：:In order to delineate the molecular pathogenesis of the increased susceptibility to CMV disease in HIV infection, the patterns of antigen responsiveness in HIV-infected and non-infected individuals were investigated. CMV was fractionated by SDS-PAGE and electroblotted onto nitrocellulose. Lymphoproliferative responses...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1990.tb05490.x

    authors： Converse PJ,Fehniger TE,Ehrnst A,Strannegård O,Britton S

    更新日期：1990-12-01 00:00:00

  • Hybrids from normal, germ free, nude and neonatal mice produce monoclonal autoantibodies to eight different intracellular structures.

    abstract：:The supernatants of hybrids produced by fusion of splenocytes from normal, germ free, nude and neonatal BALB/c mice with mouse NS-1 myeloma cells were examined for immunofluorescence reactivity with viable and acetone fixed monolayers of syngeneic mouse fibroblasts and mouse 3T3 cells and with viable cell suspensions ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Underwood JR,Pedersen JS,Chalmers PJ,Toh BH

    更新日期：1985-05-01 00:00:00

  • Effects of oestradiol and raloxifene on the induction and effector phases of experimental postmenopausal arthritis and secondary osteoporosis.

    abstract：:Oestradiol and the selective oestrogen receptor modulator (SERM) raloxifene have been shown to ameliorate collagen-induced arthritis (CIA) in rats and in mice. One aim was to investigate if raloxifene exerts its anti-arthritic and anti-osteoporotic effects during the induction or effector phase of arthritis. A second ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2011.04397.x

    authors： Jochems C,Islander U,Erlandsson M,Engdahl C,Lagerquist M,Ohlsson C,Nandakumar KS,Holmdahl R,Carlsten H

    更新日期：2011-07-01 00:00:00

  • The potential role for infections in the pathogenesis of autoimmune Addison's disease.

    abstract：:Autoimmune Addison's disease (AAD), or primary adrenocortical insufficiency, is a classical organ-specific autoimmune disease with 160 years of history. AAD is remarkably homogeneous with one major dominant self-antigen, the cytochrome P450 21-hydroxylase enzyme, which is targeted by both autoantibodies and autoreacti...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：10.1111/cei.13207

    authors： Hellesen A,Bratland E

    更新日期：2019-01-01 00:00:00

  • Demonstration of two disease specific antigens in circulating immune complexes.

    abstract：:A method is described to assess antigenic cross-reactivity between soluble immune complexes precipitated from sera with polyethylene glycol. The precipitated complex from one serum was dissociated in acid and used to coat a plastic cup. Radioiodinated complexes from another serum were dissociated in the cup, neutraliz...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Dambuyant C,Burton-Kee J,Mowbray JF

    更新日期：1979-09-01 00:00:00

  • Polyclonal T cell elimination by prolonged immunostimulation in an experimental model.

    abstract：:An experimental model of immunological deficiency obtained by treating mice for 6 months with serum of human blood drawn from different healthy individuals has been studied. The results show that an alteration of a circulating lymphocyte population with alterations of the ratio CD4+/CD8+ appeared in mice stimulated fo...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1997.tb08315.x

    authors： Galdiero F,Galdiero M,Nuzzo I,Vitiello M,Bentivoglio C,Romano-Carratelli C

    更新日期：1997-11-01 00:00:00

  • Increased expression of class II antigens of the major histocompatibility complex on alveolar macrophages and alveolar type II cells and interleukin-1 (IL-1) secretion from alveolar macrophages in an animal model of silicosis.

    abstract：:Silicosis is a chronic progressive granulomatous and fibrotic lung disease caused by inhaled silica. Although the causative agent is known, the pathogenesis, especially the immunologic response, is not well understood. We examined two important components of cell-mediated immune responses in the lungs of rats with sil...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Struhar DJ,Harbeck RJ,Gegen N,Kawada H,Mason RJ

    更新日期：1989-08-01 00:00:00

  • Antisera to human IgE can also recognize IgA and IgM molecules as produced by selected B lymphoblastoid cell lines.

    abstract：:A series of polyclonal and monoclonal anti-human IgE sera reacted with a panel of 11 selected IgA and IgM producing B lymphoblastoid cell lines (BLCLs) in cytoplasmic fluorescence, ELISA and immunoprecipitation assays. The reactions were discordant between the BLCLs and the individual antisera. The panel of 11 BLCLs w...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Hendriks RW,Thompson A,Kraakman ME,Drayer AL,Schuurman RK

    更新日期：1988-11-01 00:00:00

  • Functional T lymphocytes infiltrate implanted polyvinyl alcohol foams during surgical wound closure therapy.

    abstract：:Vacuum-assisted closure involving the implantation of polyvinyl alcohol foam is a technique recently developed for the treatment of patients suffering from either wound infection or chronic wounds. This method has been shown to improve and accelerate wound healing. However, little is known about the cell populations t...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2001.01547.x

    authors： Gouttefangeas C,Eberle M,Ruck P,Stark M,Müller JE,Becker HD,Rammensee HG,Pinocy J

    更新日期：2001-06-01 00:00:00

  • Isolation of circulating immune complexes by conglutinin and separation of antigen from dissociated complexes by immobilized protein A.

    abstract：:A method for the isolation of complement-fixing immune complexes from human serum and the separation of antigen from antibody is described. In order to isolate the complexes, we used soluble bovine conglutinin in a three-step procedure: (1) serum containing immune complexes is reacted with conglutinin in the presence ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Gupta RC,Tan EM

    更新日期：1981-10-01 00:00:00

  • Engagement of Toll-like receptor 2 enhances interleukin (IL)-17(+) autoreactive T cell responses via p38 mitogen-activated protein kinase signalling in dendritic cells.

    abstract：:Functional analysis of single Toll-like receptors (TLRs) in vivo is necessary to understand how they shape the ocular inflammation involved in uveitis. In this study we explored the role and mechanisms of TLR-2 agonists on the autoreactive T helper type 17 (Th17) response in experimental autoimmune uveitis (EAU). Trea...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12405

    authors： Wei R,Dong L,Xiao Q,Sun D,Li X,Nian H

    更新日期：2014-11-01 00:00:00

  • Natural thymocytotoxic autoantibodies in non-obese diabetic (NOD) mice: characterization and fine specificity.

    abstract：:The NOD mouse is a model of human juvenile type I diabetes mellitus. As in humans and in the BB rat model, the development of diabetes in NOD mice is accompanied by evident manifestations of cell-mediated and humoral autoimmunity. Beside autoantibodies directed at putative islet cell antigens, NOD sera contain antibod...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1990.tb05347.x

    authors： Lehuen A,Altman J,Bach JF,Carnaud C

    更新日期：1990-09-01 00:00:00

  • Acute phase proteins and C9 in patients with Behcet's syndrome and aphthous ulcers.

    abstract：:Estimation of the concentration of C9, C-reactive protein (CRP) and alpha1-antitrypsin in forty sera from patients with Behcet's syndrome and recurrent oral ulcers showed significantly increased amounts of C9 and CRP in Behcet's syndrome. The concentration of C9 was also significantly raised in recurrent oral ulcerati...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Adinolfi M,Lehner T

    更新日期：1976-07-01 00:00:00

  • The effect of anti-neutrophil cytoplasm autoantibodies on the signal transduction in human neutrophils.

    abstract：:The effect of anti-neutrophil cytoplasm autoantibodies (ANCA) on neutrophil activation was studied by pre-incubating neutrophils with IgG and F(ab')2 prepared from ANCA patients with Wegener's granulomatosis or microscopic polyarteritis. We measured the generation of inositol triphosphate (IP3) (a product of hydrolysi...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1991.tb05738.x

    authors： Lai KN,Lockwood CM

    更新日期：1991-09-01 00:00:00

  • Rosette formation of human null lymphocytes with Rhesus monkey erythrocytes.

    abstract：:Human null lymphocytes which lack B- and T-lymphocyte markers were found to form spontaneous rosettes with uncoated Rhesus monkey erythrocytes. Rosette-forming null lymphocytes were determined in null lymphocyte-enriched preparations of healthy persons and of patients with lymphoproliferative diseases. Quantitative de...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Chiao JW,Dowling M,Good RA

    更新日期：1978-06-01 00:00:00

  • Lack of evidence of a specific role for C4A gene deficiency in determining disease susceptibility among C4-deficient patients with systemic lupus erythematosus (SLE).

    abstract：:The aim of the present study was to investigate the prevalence of C4 and C2 deficiencies and to characterize genomic alterations in C4 genes in a large cohort of 125 unselected patients with SLE. We determined the protein concentration and functional activity of C2 and C4, as well as the C4 phenotype. C4 genotyping in...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2001.01438.x

    authors： Dragon-Durey MA,Rougier N,Clauvel JP,Caillat-Zucman S,Remy P,Guillevin L,Liote F,Blouin J,Ariey F,Lambert BU,Kazatchkine MD,Weiss L

    更新日期：2001-01-01 00:00:00

  • Stimulation of antibody synthesis induced by surgical trauma in rats.

    abstract：:The effect of a standard laparatomy on antibody synthesis was studied in Wistar R/A rats recieving an intravenous injection of 10(9) sheep red blood cells (SRBC) during the surgical procedure. Anti-SRBC antibody titres were significantly higher in operated animals than in controls. When SRBC were given 2 hr after the ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Kinnaert P,Mahieu A,Van Geertruyden N

    更新日期：1978-05-01 00:00:00

  • Nasal tolerance in experimental autoimmune myasthenia gravis (EAMG): induction of protective tolerance in primed animals.

    abstract：:Nasal administration of microg doses of acetylcholine receptor (AChR) is effective in preventing the development of B cell-mediated EAMG in the Lewis rat, a model for human MG. In order to investigate whether nasal administration of AChR modulates ongoing EAMG, Lewis rats were treated nasally with AChR 2 weeks after i...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1998.00521.x

    authors： Shi FD,Bai XF,Li HL,Huang YM,Van der Meide PH,Link H

    更新日期：1998-03-01 00:00:00

  • Abnormalities of lymphocyte locomotion in immunodeficiency disease.

    abstract：:Lymphocyte and neutrophil locomotion were studied in 23 patients with well defined, primary immunodeficiencies. These included eight patients with common variable immune deficiency, three patients with X-linked agammaglobulinaemia, two patients with the Wiskott-Aldrich syndrome, three patients with ataxia telangiectas...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Van Epps DE,El-Naggar A,Ochs HD

    更新日期：1983-09-01 00:00:00

  • Identification of DNA-binding proteins on human umbilical vein endothelial cell plasma membrane.

    abstract：:The binding of anti-DNA antibodies to the endothelial cell is mediated through DNA, which forms a bridge between the immunoglobulin and the plasma membrane. We have shown that 32P-labelled DNA bound to the plasma membrane of human umbilical vein endothelial cells (HUVEC) by a saturable process, which could be competit...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1993.tb03363.x

    authors： Chan TM,Frampton G,Cameron JS

    更新日期：1993-01-01 00:00:00

  • Glucocorticoid-mediated immunomodulation: hydrocortisone enhances immunosuppressive endogenous retroviral protein (p15E) expression in mouse immune cells.

    abstract：:To define glucocorticoid (GC)-regulated genes contributing to the anti-inflammatory and immunosuppressive effects of GC, previous work from our laboratory revealed up-regulation of transcripts from endogenous type B mouse mammary tumour virus (Mtv) and type C murine leukaemia virus (Emv) loci by high dose GC treatment...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1995.tb08348.x

    authors： Fiegl M,Strasser-Wozak E,Geley S,Gsur A,Drach J,Kofler R

    更新日期：1995-08-01 00:00:00

  • Clinical significance of immunopathological findings in patients with post-pericardiotomy syndrome. II. The significance of serum inhibition and rosette inhibitory factors.

    abstract：:Serum inhibition factors (SIF) that suppress phytohaemagglutinin-induced blast transformation of normal lymphocytes, and lymphocyte E-rosette inhibitory factors (RIF) that inhibit the T cell-specific property of E-rosette formation were determined in sixty-five patients before and after cardiac surgery. SIF was found ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Maisch B,Schuff-Werner P,Berg PA,Kochsiek K

    更新日期：1979-11-01 00:00:00

  • NK cells, displaying early activation, cytotoxicity and adhesion molecules, are associated with mild dengue disease.

    abstract：:During the innate immune response against infections, Natural Killer (NK) cells are as important effector cells as are Cytotoxic T lymphocytes (CTL) generated after antigenic stimulation in the adaptative response. NK cells increase in numbers, after viral infection or vaccination. We investigated the NK cell and CD8 ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2006.02996.x

    authors： Azeredo EL,De Oliveira-Pinto LM,Zagne SM,Cerqueira DI,Nogueira RM,Kubelka CF

    更新日期：2006-02-01 00:00:00

  • A gp120 HIV peptide with high similarity to HLA class II beta chains enhances PPD-specific and autoreactive T cell activation.

    abstract：:The recent report that anti-gp120 antibodies can be induced by allogeneic stimuli in experimental animals in the absence of HIV, has focused attention on the structural similarities between gp120 and MHC. Here we report that some HIV+ individuals develop antibodies which similarly react with the gp120 HIV sequence (aa...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1992.tb07923.x

    authors： Pugliese O,Viora M,Camponeschi B,Cordiali Fei P,Caprilli F,Chersi A,Evangelista M,Di Massimo AM,Colizzi V

    更新日期：1992-11-01 00:00:00

  • Anti-pancreatic immunity. In vitro studies of cellular and humoral immune reactions directed toward pancreatic islets.

    abstract：:It has been suggested that the immune system may be responsible for the destruction of insulin secreting cells in some types of diabetes. In order to test this hypothesis, we studied the consequences of immune-mediated reactions on the function of pancreatic islet cells in vitro. A model was set up in vitro where mous...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Boitard C,Saï P,Debray-Sachs M,Assan R,Hamburger J

    更新日期：1984-03-01 00:00:00

  • T helper type-1 (Th1)/Th2 profiles of peripheral blood mononuclear cells (PBMC); responses to antigens of Chlamydia trachomatis in subjects with severe trachomatous scarring.

    abstract：:Increased stimulation of Th2 cytokines may contribute to the development of persistent ocular chlamydial infection, resulting in the blinding pathological changes of trachoma. Proliferation and cytokine production profiles of PBMC in response to stimulation with antigens of Chlamydia trachomatis were compared in 30 pa...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1996.d01-792.x

    authors： Holland MJ,Bailey RL,Conway DJ,Culley F,Miranpuri G,Byrne GI,Whittle HC,Mabey DC

    更新日期：1996-09-01 00:00:00

  • Opsonizing antibodies (IgG1) up-regulate monocyte proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and IL-6 but not anti-inflammatory cytokine IL-10 in mycobacterial antigen-stimulated monocytes-implications for pathogenesis.

    abstract：:Cachexia is one of the prominent features of advanced tuberculosis (TB) seen in association with increased expression of the monokine TNF-alpha. Several mycobacterial proteins, including PPD, stimulate TNF-alpha secretion from monocytes. Host factors that may play a role in cytokine expression from monocytes remain la...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2001.01439.x

    authors： Hussain R,Shiratsuchi H,Phillips M,Ellner J,Wallis RS

    更新日期：2001-02-01 00:00:00