Prolonged circulation of immune complexes due to various altered immune functions contributes to nephritis in MRL/lpr mice.

abstract：:Peripheral blood mononuclear cells from 14 healthy donors and 22 allergic patients were incubated with 51Cr-labelled chicken erythrocytes coated with an IgE myeloma protein or rabbit IgG antibodies. Mononuclear cells from patients with severe atopic disorders released a significantly greater percentage of 51Cr (P less...

journal_title：Clinical and experimental immunology

authors： Melewicz FM,Zeiger RS,Mellon MH,O'Connor RD,Spiegelberg HL

更新日期：1981-03-01 00:00:00

abstract：:Progressive immunodeficiency in HIV infection is paralleled by a decrease in IL-12 production, a cytokine crucial for cellular immune function. Here we examine the molecular mechanisms by which HIV infection suppresses IL-12 p40 expression. HIV infection of THP-1 myeloid cells resulted in decreased LPS-induced nuclear...

journal_title：Clinical and experimental immunology

authors： Chambers KA,Parks RJ,Angel JB

更新日期：2004-08-01 00:00:00

abstract：:A complete functional deficiency of C1q is described in a patient suffering from SLE. From reduced plasma C1 activity of the parents a hereditary trait was assumed. The defective C1q molecule was haemolytically inactive, did not bind to immune complexes, and was not recognized by the monocyte C1q receptor. C1 activity...

journal_title：Clinical and experimental immunology

authors： Kirschfink M,Petry F,Khirwadkar K,Wigand R,Kaltwasser JP,Loos M

更新日期：1993-11-01 00:00:00

abstract：:There are lines of evidence that natural killer (NK) cells are sensitive to physical and psychological stress. Alterations in the immune system including NK cells are known to differ among tissues and organs. The effect of stress on the lung immune system, however, has not been well documented in spite of the fact tha...

journal_title：Clinical and experimental immunology

authors： Kanemi O,Zhang X,Sakamoto Y,Ebina M,Nagatomi R

更新日期：2005-01-01 00:00:00

abstract：:Patients with functional deficiency of C1-inhibitor (C1-INH) suffer from recurrent acute attacks (AA) of localized oedema associated with activation of the contact system, complement and fibrinolysis. To unravel further the role of coagulation and fibrinolysis in the pathophysiology of C1-INH deficiency, we performed ...

journal_title：Clinical and experimental immunology

authors： van Geffen M,Cugno M,Lap P,Loof A,Cicardi M,van Heerde W

更新日期：2012-03-01 00:00:00

abstract：:Staphyllococcus aureus-induced infections often result in high mortality and permanent joint destruction, despite treatment with antibiotics. IL-10 is typically regarded as an anti-inflammatory cytokine because it promotes a T helper cell type 2 response, and subsequently down-regulates cell mediated immune functions....

journal_title：Clinical and experimental immunology

authors： Gjertsson I,Hultgren OH,Tarkowski A

更新日期：2002-12-01 00:00:00

abstract：:The aim of this study was to investigate the diagnostic value of using the copy number of propionibacterial rRNA as a biomarker for sarcoidosis. Ribosomal RNA of Propionibacterium acnes and P. granulosum was measured by real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) using formalin-fixe...

journal_title：Clinical and experimental immunology

authors： Zhou Y,Wei YR,Zhang Y,Du SS,Baughman RP,Li HP

更新日期：2015-09-01 00:00:00

abstract：:Serum cytokine levels and peripheral T cell subpopulations of HIV-1-infected patients before, during and after active visceral leishmaniasis (VL) were analysed and compared with appropriate controls. At VL diagnosis, co-infected patients showed higher serum levels of interferon-gamma (IFN-gamma) than matched HIV-1 con...

journal_title：Clinical and experimental immunology

authors： Medrano FJ,Rey C,Leal M,Cañavate C,Rubio A,Sánchez-Quijano A,Alvar J,Lissen E

更新日期：1998-12-01 00:00:00

abstract：:In this study, we hypothesized that the granulomatous disorder sarcoidosis is not caused by a single pathogen, but rather results from abnormal responses of Toll-like receptors (TLRs) to conserved bacterial elements. Unsorted bronchoalveolar lavage (BAL) cells from patients with suspected pulmonary sarcoidosis and hea...

journal_title：Clinical and experimental immunology

authors： Gabrilovich MI,Walrath J,van Lunteren J,Nethery D,Seifu M,Kern JA,Harding CV,Tuscano L,Lee H,Williams SD,Mackay W,Tomashefski JF Jr,Silver RF

更新日期：2013-09-01 00:00:00

abstract：:Eighteen patients showing hypersensitivity to nitrofurantoin with symptoms like sudden fever, malaise, cough, pleuritis, leucocytosis and sometimes eosinophilia were analysed for immune reactions, i.e. lymphocyte transformation and specific antibodies. In addition, thirty-three individuals treated with the drug but wi...

journal_title：Clinical and experimental immunology

authors： Bäck O,Lidén S,Ahlstedt S

更新日期：1977-06-01 00:00:00

abstract：:Interleukin-18 (IL-18) has been demonstrated to synergize with BCG for induction of a T-helper-type 1 (Th1) immune response. Since successful treatment of superficial bladder cancer with BCG requires proper induction of Th1 immunity, we have developed a recombinant (r) BCG strain that functionally secretes mouse (m) I...

journal_title：Clinical and experimental immunology

authors： Luo Y,Yamada H,Chen X,Ryan AA,Evanoff DP,Triccas JA,O'Donnell MA

更新日期：2004-07-01 00:00:00

abstract：:CFA is an inflammatory condition of the lungs resulting in scarring, pulmonary failure and death. The etiology of the disease is unknown, but the pathogenesis is believed to involve a persistent immunological reaction to unidentified antigen in the lung resulting in tissue damage. Recent advances in our understanding ...

journal_title：Clinical and experimental immunology

authors： Wallace WA,Ramage EA,Lamb D,Howie SE

更新日期：1995-09-01 00:00:00

abstract：:Interleukin-6 (IL-6, BSF-2 or IFN-beta 2) is thought to be the major regulator of the acute-phase protein response that follows tissue injury and inflammation, with interleukin-1 (IL-1), tumour necrosis factor and more recently, LIF or HSF III, slightly stimulatory on only certain acute phase proteins. The synthesis o...

journal_title：Clinical and experimental immunology

authors： Raynes JG,Eagling S,McAdam KP

更新日期：1991-03-01 00:00:00

abstract：:We have previously found that isolated B-CLL cells from progressive disease produce less interleukin-1 beta (IL-1 beta) as compared with cells from patients with indolent disease. Here we extend that finding to include measurements of IL-1 beta mRNA and secretion of IL-1 alpha and interleukin-6 (IL-6). As before, a lo...

journal_title：Clinical and experimental immunology

authors： Aguilar-Santelises M,Magnusson R,Svenson SB,Loftenius A,Andersson B,Mellstedt H,Jondal M

更新日期：1991-06-01 00:00:00

abstract：:In humans and in laboratory animals, administration of a single does of glucocorticosteroids induces a rapid and transient decrease in the numbers of peripheral blood lymphocytes through a redistribution of circulating lymphocytes. This lymphocytopenic effect is an important factor in the immunosuppressive capacity of...

journal_title：Clinical and experimental immunology

authors： Bloemena E,Weinreich S,Schellekens PT

更新日期：1990-06-01 00:00:00

abstract：:Amino acid residues involved in the peptide binding groove of HLA-DRB1 alleles were examined in three Nigerian ethnic groups with leprosy (n = 287) and 170 controls to determine the role of DRB1 alleles in disease outcome with Mycobacterium leprae. Nine positively charged motifs and two others with neutral charge to t...

journal_title：Clinical and experimental immunology

authors： Uko GP,Lu LY,Asuquo MA,Fici D,Mahan S,Awdeh Z,Udim ER,Ding W,Umana U,Adewole T,Fraser PA

更新日期：1999-10-01 00:00:00

abstract：:Recent evidence suggests that T cell apoptosis could be involved in the pathogenesis of HIV-1 infection. As the progression of HIV-2 associated disease appears to be slower than that of HIV-1, we investigated whether there were differences in the degree of T cell death and apoptosis in peripheral blood mononuclear cel...

journal_title：Clinical and experimental immunology

authors： Jaleco AC,Covas MJ,Victorino RM

更新日期：1994-11-01 00:00:00

abstract：:Kawasaki disease (KD) is an acute febrile illness of early childhood, in which the activation of monocytes/macrophages plays a central role in the development of vasculitis during the acute stage of disease. In this study we investigated peripheral blood T cells of 10 patients with KD, focusing on the Th1 and Th2 imba...

journal_title：Clinical and experimental immunology

authors： Matsubara T,Katayama K,Matsuoka T,Fujiwara M,Koga M,Furukawa S

更新日期：1999-06-01 00:00:00

abstract：:An immunoglobulin phage display library constructed from a tumour-associated pericolic lymph node was panned against the extracellular domain of the oncoprotein c-erbB-2. Sixteen independent clones were confirmed as positive binders based on ELISA analysis of soluble Fabs. Nucleotide sequencing demonstrated that the V...

journal_title：Clinical and experimental immunology

authors： Clark MA,Hawkins NJ,Papaioannou A,Fiddes RJ,Ward RL

更新日期：1997-07-01 00:00:00

abstract：:Two-stage stimulation of SK activity of normal human peripheral blood lymphocytes by soluble factors was demonstrated. The first stage was initiated by factors present in supernatant derived from normal B-LCL cultures. Only cell lines which could induce SK activity in culture in an MLR-type reaction had the capacity t...

journal_title：Clinical and experimental immunology

authors： Hofman FM,Spina CA

更新日期：1980-12-01 00:00:00

abstract：:A rabbit antiserum has been prepared using peripheral mononuclear cells from a patient with common variable hypogammaglobulinaemia (CVH) who had demonstrable suppressor cells in vitro. This antiserum (anti-Ck), after absorption with pooled normal glass-non-adherent cells and platelets, showed selective reactivity with...

journal_title：Clinical and experimental immunology

authors： Rizzoli AJ,Bankhurst AD

更新日期：1981-12-01 00:00:00

abstract：:IgM-rheumatoid factor (RF) interference in the determination of total serum IgE and IgE-containing circulating immune complexes (IgE-CIC) was studied by inhibition experiments in vitro comparing a new ELISA technique free of IgM-RF interference with more widely used RIA methods. It was shown that a considerable overes...

journal_title：Clinical and experimental immunology

authors： De Clerck LS,Gigase PL,Bridts CH,Stevens WJ

更新日期：1988-04-01 00:00:00

abstract：:Pneumocystis carinii is a major opportunistic pathogen and leading cause of morbidity in patients with AIDS. The major surface glycoprotein (MSG) of P. carinii, represented by a family of related proteins encoded by unique genes, is highly immunogenic and contains T cell-protective epitopes. We undertook the present s...

journal_title：Clinical and experimental immunology

authors： Theus SA,Smulian AG,Sullivan DW,Walzer PD

更新日期：1997-08-01 00:00:00

abstract：:The search for novel chemical classes of anti-malarial compounds to cope with the current state of chemoresistance of malaria parasites has led to the identification of Plasmodium falciparum aminopeptidase 1 (PfA-M1) as a new therapeutic target. PfA-M1, known to be involved in the hemoglobin digestion cascade which he...

journal_title：Clinical and experimental immunology

authors： Oyegue-Liabagui SL,Imboumy-Limoukou RK,Kouna CL,Bangueboussa F,Schmitt M,Florent I,Lekana-Douki JB

更新日期：2020-06-01 00:00:00

abstract：:Current therapies for inflammatory bowel diseases (IBD) are aimed at controlling the exacerbated response in the gut, but no treatment is fully effective for many refractory patients. Mesenchymal stromal cells (MSC) are multi-potent cells with regulatory immunosuppressive activity that may control inflammatory disease...

journal_title：Clinical and experimental immunology

authors： Alves VBF,de Sousa BC,Fonseca MTC,Ogata H,Caliári-Oliveira C,Yaochite JNU,Rodrigues Júnior V,Chica JEL,da Silva JS,Malmegrim KCR,Pernomian L,Cardoso CR

更新日期：2019-05-01 00:00:00

abstract：:In vitro delayed hypersensitivity was studied in patients with either the chronic or the indeterminate phase of Chagas' disease. Normal healthy individuals were used as controls. The leucocyte migration inhibition test was applied using an antigen an extract of culture forms of T. cruzi or an extract of normal rat hea...

journal_title：Clinical and experimental immunology

authors： Toledo Barros MA,Amato Neto V,Mendes E,Mota I

更新日期：1979-11-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial fibroblast hyperplasia and bone erosion. Fibroblast-like synoviocytes (FLS) play a pivotal role in RA pathogenesis through aggressive migration and matrix invasion, and certain proinflammatory cytokines may affect synoviocyte invasio...

journal_title：Clinical and experimental immunology

authors： Xing R,Jin Y,Sun L,Yang L,Li C,Li Z,Liu X,Zhao J

更新日期：2016-05-01 00:00:00

abstract：:In Helicobacter pylori gastritis gastric epithelium plays a central role in the innate immunity to H. pylori. However, epithelial receptors interacting with H. pylori have been poorly characterized so far. Recently a new triggering receptor expressed on myeloid cells-1 (TREM-1) has been identified on human neutrophils...

journal_title：Clinical and experimental immunology

authors： Schmausser B,Endrich S,Beier D,Moran AP,Burek CJ,Rosenwald A,Rieckmann P,Müller-Hermelink HK,Eck M

更新日期：2008-04-01 00:00:00

abstract：:In addition to its activity as a metabolic hormone and a regulator of somatic growth, insulin-like growth factor-I (IGF-I) has cytokine-like activities on lymphoid cells. A 14-day infusion of recombinant human (rh)IGF-I increased lymphocyte numbers in all the peripheral lymphoid organs examined. This increase was appa...

journal_title：Clinical and experimental immunology

authors： Robbins K,McCabe S,Scheiner T,Strasser J,Clark R,Jardieu P

更新日期：1994-02-01 00:00:00

abstract：:Anti-phospholipid syndrome (APS) is characterized by arterial and/or venous thrombosis and pregnancy morbidity. It is well known that in these patients thrombosis may be the result of a hypercoagulable state related to anti-β2-glycoprotein I (β2-GPI) antibodies. Moreover, platelets may play a role in thrombotic manife...

journal_title：Clinical and experimental immunology

authors： Capozzi A,Manganelli V,Riitano G,Recalchi S,Truglia S,Alessandri C,Longo A,Garofalo T,Misasi R,Valesini G,Conti F,Sorice M

更新日期：2019-04-01 00:00:00