Abstract:
:Staphyllococcus aureus-induced infections often result in high mortality and permanent joint destruction, despite treatment with antibiotics. IL-10 is typically regarded as an anti-inflammatory cytokine because it promotes a T helper cell type 2 response, and subsequently down-regulates cell mediated immune functions. To investigate the role of IL-10 in S. aureus-induced arthritis and sepsis, Balb/c mice, intact or defective with respect to IL-10 gene were intravenously inoculated with bacteria. IL-10-/- mice develop a more frequent and destructive arthritis compared to their congeneic controls. The mechanisms regulating such outcome may be due not only to the anti-inflammatory properties of IL-10 but also, directly or indirectly, to antibacterial features of this molecule. Indeed, inoculation of staphylococci to IL-10-/- mice resulted in higher bacterial load in blood and kidneys compared to congeneic controls. Altogether our data indicate that IL-10 is essential for efficient elimination of bacteria and thereby for protection against septic arthritis.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Gjertsson I,Hultgren OH,Tarkowski Adoi
10.1046/j.1365-2249.2002.01999.xsubject
Has Abstractpub_date
2002-12-01 00:00:00pages
409-14issue
3eissn
0009-9104issn
1365-2249pii
1999journal_volume
130pub_type
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