A novel method for direct measurement of complement convertases activity in human serum.

abstract：:IL-1 acts on many cells as an inflammatory mediator. Its two forms, IL-1 alpha and IL-1 beta, are regulated differentially within hyperproliferative inflammatory skin conditions, such as psoriasis. While IL-1 alpha is down-regulated within psoriatic lesions, the levels of IL-1 beta are increased. However, some investi...

journal_title：Clinical and experimental immunology

authors： Schön M,Behmenburg C,Denzer D,Schön MP

更新日期：2001-03-01 00:00:00

abstract：:Myeloid and plasmacytoid dendritic cells (DC) are present in cerebrospinal fluid (CSF) in non-inflammatory neurological diseases (NIND) and elevated in clinically definite multiple sclerosis (MS) and in early MS - acute monosymptomatic optic neuritis (ON). Here, we show that expression of CCR5, a chemokine receptor fo...

journal_title：Clinical and experimental immunology

authors： Pashenkov M,Teleshova N,Kouwenhoven M,Kostulas V,Huang YM,Soderstrom M,Link H

更新日期：2002-03-01 00:00:00

abstract：:Functional analysis of single Toll-like receptors (TLRs) in vivo is necessary to understand how they shape the ocular inflammation involved in uveitis. In this study we explored the role and mechanisms of TLR-2 agonists on the autoreactive T helper type 17 (Th17) response in experimental autoimmune uveitis (EAU). Trea...

journal_title：Clinical and experimental immunology

authors： Wei R,Dong L,Xiao Q,Sun D,Li X,Nian H

更新日期：2014-11-01 00:00:00

abstract：:IL-4 synergizes with signals delivered through CD40 both for the induction of CD23/Fc epsilon RII expression and for IgE synthesis. Moreover, engagement of CD40 on the B cell surface by MoAb overcomes the ability of interferons, transforming growth factor-beta, or anti-CD19 to inhibit IL-4-dependent change. We now rep...

journal_title：Clinical and experimental immunology

authors： Katira A,Knox KA,Finney M,Michell RH,Wakelam M,Gordon J

更新日期：1993-05-01 00:00:00

abstract：:We have previously used the antibody-mediated binding of bacteria to identify Ig-bearing cells and the natural binding of bacteria to identify several lymphocyte subpopulations. By using bacteria this identification can be carried out in conventional blood smears since bacteria are small and easily distinguished from ...

journal_title：Clinical and experimental immunology

authors： Bratescu A,Mayer E,Teodorescu M

更新日期：1980-09-01 00:00:00

abstract：:The possibility that the peanut agglutinin (PNA) receptor and/or its co-ordinate structures on the surface of leukaemia cells might be recognized by lectin free crude interleukin-2 (IL-2) activated human peripheral blood lymphocytes (LAK) was investigated. Analysis was undertaken of the correlation between the sensiti...

journal_title：Clinical and experimental immunology

authors： Gotoh YI,Minegishi M,Yamaguchi Y,Konno T,Tada K

更新日期：1984-09-01 00:00:00

abstract：:Myotonic dystrophy (MyD), an autosomal dominant neuromuscular disease with multisystem abnormalities, is associated with hypercatabolism of IgG. The hypercatabolism is not related to structural abnormalities of the IgG molecule in MyD but appears to be due to a derangement of the serum IgG concentration-fractional cat...

journal_title：Clinical and experimental immunology

authors： Banerjee D,McClintock J,Silver MM,Hudson AJ

更新日期：1982-12-01 00:00:00

abstract：:The recommended control option against onchocerciasis is repeated ivermectin treatment, which will need to be implemented for decades, and it remains unknown how repeated ivermectin therapy might affect immunity against Onchocerca volvulus in the long term. O. volvulus-specific antibody reactivity and cellular cytokin...

journal_title：Clinical and experimental immunology

authors： Mai CS,Hamm DM,Banla M,Agossou A,Schulz-Key H,Heuschkel C,Soboslay PT

更新日期：2007-03-01 00:00:00

abstract：:An expanded T cell subpopulation (CD8+ Leu-7+) has previously been reported in the peripheral blood of patients with Crohn's disease. This subpopulation of T cells was associated with a 'covert suppressor' function, particularly in patients with mild/early Crohn's disease, suppressing immunoglobulin production in vitr...

journal_title：Clinical and experimental immunology

authors： Deem RL,Targan SR,Niederlehner A,Shanahan F

更新日期：1990-06-01 00:00:00

abstract：:Intraepithelial lymphocytes (IELs) can be identified among epithelial cells in systemic mucosal tissues. Although intestinal IELs play a crucial role in mucosal immunity, their bronchial counterparts have not been well studied. The purpose of this study was to determine the immunological functions of human bronchial I...

journal_title：Clinical and experimental immunology

authors： Hirosako S,Goto E,Fujii K,Tsumori K,Hirata N,Tsumura S,Kamohara H,Kohrogi H

更新日期：2009-02-01 00:00:00

abstract：:In inflammatory bowel disease (IBD), inflammation is sustained by an exaggerated response of lymphocytes. This results from enhanced expression of anti-apoptotic B cell lymphoma (BCL-2) and BCL-XL associated with a diminished turnover. Azathioprine (AZA) directly targets BCL-2 family-mediated apoptosis. We investigate...

journal_title：Clinical and experimental immunology

authors： Weder B,Mozaffari M,Biedermann L,Mamie C,Moncsek A,Wang L,Clarke SH,Rogler G,McRae BL,Graff CL,Ruiz PA,Hausmann M

更新日期：2018-09-01 00:00:00

abstract：:Recent evidence has shown that microRNA-126 (miR-126) has been involved in the development and function of immune cells, which contributed to the pathogenesis of related clinical diseases. However, the potential role of miR-126 in the development and function of CD4+ T cells remains largely unknown. Here we first foun...

journal_title：Clinical and experimental immunology

authors： Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L

更新日期：2018-02-01 00:00:00

abstract：:This report is focused on the functional capacity of Langerhans cells (LC) in the epithelium of skin and oral mucosa, which both meet different antigenic challenges. The capacity of LC from human oral and skin epithelium to provide co-stimulatory signals to T cells in vitro was compared. LC in a crude suspension of or...

journal_title：Clinical and experimental immunology

authors： Hasséus B,Jontell M,Bergenholtz G,Dahlgren UI

更新日期：2004-06-01 00:00:00

abstract：:Several patients with Paget's disease have been reported to have monoclonal IgM proteins in their serum. We have systematically studied 26 patients with Paget's disease severe enough to require diphosphonate therapy. Five of these patients were found to have isolated elevations of serum IgM which were well outside the...

journal_title：Clinical and experimental immunology

authors： Buxbaum JN,Kammerman S

更新日期：1984-04-01 00:00:00

abstract：:Specific antibody deficiency (SAD) to unconjugated pneumococcal vaccine (PPV) is an established primary B cell immunodeficiency. The occurrence and natural history of SAD in children is unclear. We conducted an observational study to identify SAD in children with recurrent respiratory infections. Ninety-nine children,...

journal_title：Clinical and experimental immunology

authors： Ruuskanen O,Nurkka A,Helminen M,Viljanen MK,Käyhty H,Kainulainen L

更新日期：2013-05-01 00:00:00

abstract：:The effect of IL-4 and transforming growth factor-beta (TGF-beta) on immunoglobulin secretion in vitro by peripheral blood mononuclear cells (PBMC) or purified B cells activated with murine EL4 thymoma cells and phorbol myristate acetate (PMA) was investigated. As previously reported, IL-4 induced IgE and IgG4 secreti...

journal_title：Clinical and experimental immunology

authors： Ninomiya C,Spiegelberg HL

更新日期：1992-08-01 00:00:00

abstract：:Anti-proteinase 3 antibodies are a subgroup of anti-neutrophil cytoplasmic antibodies (ANCA), and we have established an ELISA for their detection using high performance liquid chromatography (HPLC)-purified protein. This assay is sensitive and specific: inhibition studies have shown that despite the homology between ...

journal_title：Clinical and experimental immunology

authors： Jennings JG,Chang L,Savige JA

更新日期：1994-02-01 00:00:00

abstract：:Reduced B cell numbers and a mutation in Btk are considered sufficient to make the diagnosis of X-linked agammaglobulinaemia. In the process of conducting family studies, we identified a 58-year-old healthy man with an amino acid substitution, Y418H, in the adenosine-5'-triphosphate binding site of Btk. Immunofluoresc...

journal_title：Clinical and experimental immunology

authors： Conley ME,Farmer DM,Dobbs AK,Howard V,Aiba Y,Shurtleff SA,Kurosaki T

更新日期：2008-04-01 00:00:00

abstract：:CVID is a primary immune disorder in which hypogammaglobulinaemia may be associated with a number of T cell defects including lymphopenia, anergy, impaired lymphocyte proliferation and deficient cytokine secretion. In this study we show that T cells of CVID subjects, in comparison with control T cells, undergo spontan...

journal_title：Clinical and experimental immunology

authors： Di Renzo M,Zhou Z,George I,Becker K,Cunningham-Rundles C

更新日期：2000-06-01 00:00:00

abstract：:Antibody-dependent cellular cytotoxicity (ADCC) of peripheral blood lymphocytes against chicken red blood cells (ChRBC) in the presence of specific antiserum has been studied in normal subjects and in patients with acute hepatitis B and with chronic active hepatitis (CAH). ADCC was significantly reduced in patients wi...

journal_title：Clinical and experimental immunology

authors： Bortolotti F,Realdi G,Diodati G,Fattovich G

更新日期：1978-08-01 00:00:00

abstract：:Macaques provide important animal models in biomedical research into infectious and chronic inflammatory disease. Therefore, a proper understanding of the similarities and differences in immune function between macaques and humans is needed for adequate interpretation of the data and translation to the human situation...

journal_title：Clinical and experimental immunology

authors： Koopman G,Beenhakker N,Burm S,Bouwhuis O,Bajramovic J,Sommandas V,Mudde G,Mooij P,'t Hart BA,Bogers WM

更新日期：2013-10-01 00:00:00

abstract：:Significant numbers of syncytial cells were observed in the bronchoalveolar lavage fluid (BALF) of a 42-year-old patient who had SLE with interstitial pneumonia. Electron microscopic study of the BALF cells and positive reverse transcriptase activity in the supernatant of the cultured cells revealed unknown retroviral...

journal_title：Clinical and experimental immunology

authors： Tamura N,Sekigawa I,Hashimoto H,Yamamoto N,Kira S

更新日期：1997-03-01 00:00:00

abstract：:Extracorporeal photopheresis (ECP) has been used as a prophylactic and therapeutic option to avoid and treat rejection after heart transplantation (HTx). Tolerance-inducing effects of ECP such as up-regulation of regulatory T cells (T(regs)) are known, but specific effects of ECP on regulatory T cell (T(reg)) subsets ...

journal_title：Clinical and experimental immunology

authors： Dieterlen MT,Bittner HB,Pierzchalski A,Dhein S,Mohr FW,Barten MJ

更新日期：2014-04-01 00:00:00

abstract：:IgG2 deficiency has been recently associated with the appearance of vasculitis. None of the 42 patients with IgG2 deficiency whom we studied has a history of vasculitis. We have also studied 56 patients with vasculitis, and found four of them with IgG2 levels below the normal range for their age. As a group, the vascu...

journal_title：Clinical and experimental immunology

authors： Jiménez A,López-Trascasa M,Fontán G

更新日期：1989-11-01 00:00:00

abstract：:Activin A is a multi-functional cytokine with a potent stimulation on erythroid cell differentiation in the bone marrow. The actions of activin A are determined by a balance of the levels of activin A and its inhibitor, follistatin (FS). However, the regulation of its actions in the bone marrow has been unclear. Here ...

journal_title：Clinical and experimental immunology

authors： Abe M,Shintani Y,Eto Y,Harada K,Fujinaka Y,Kosaka M,Matsumoto T

更新日期：2001-10-01 00:00:00

abstract：:We report a study on immunoregulation of in vitro antibody to hepatitis B surface antigen (anti-HBs) synthesis induced by pokeweed mitogen (PWM) from peripheral blood mononuclear cells (PBMC) in chronic hepatitis B surface antigen (HBsAg) carriers and in 'high responders', (anti-HBs RIA ratio greater than or equal to ...

journal_title：Clinical and experimental immunology

authors： Barnaba V,Valesini G,Levrero M,Zaccari C,Van Dyke A,Falco M,Musca A,Balsano F

更新日期：1985-05-01 00:00:00

abstract：:The scaffold protein caspase recruitment domain-containing protein 11 (CARD11) is implicated in the regulation of inflammation and autoimmunity. The present study aimed to explore the role of CARD11 in the pathogenesis of rheumatoid arthritis (RA). Mice with collagen-induced arthritis (CIA) were treated with either CA...

journal_title：Clinical and experimental immunology

authors： Wang H,Zhao J,Zhang H,Huang Y,Wang S,Tu Q,Yang N

更新日期：2014-05-01 00:00:00

abstract：:Endothelial cells (ECs) are a target in inflammation, and the death of EC is regulated by various factors. Although intravenous immunoglobulin (IVIG) preparations are known to be beneficial therapeutic agents for the treatment of autoimmune diseases and systemic inflammatory disorders, their mechanism of action have n...

journal_title：Clinical and experimental immunology

authors： Nakatani K,Takeshita S,Tsujimoto H,Sekine I

更新日期：2002-03-01 00:00:00

abstract：:Anti-endothelial cell antibodies (AECA) have been frequently detected in systemic vasculitis, which affects blood vessels of various sizes. To understand the pathogenic roles of AECA in systemic vasculitis, we attempted to identify target antigens for AECA comprehensively by a proteomic approach. Proteins extracted fr...

journal_title：Clinical and experimental immunology

authors： Karasawa R,Kurokawa MS,Yudoh K,Masuko K,Ozaki S,Kato T

更新日期：2010-09-01 00:00:00

abstract：:A large series of leukaemias (1,512 cases) and leukaemic cell lines (40) have been tested for selective expression of a monomorphic HLR-DR determinant using a monoclonal antibody (DA2). Relatively mature myeloid leukaemias (APML, CGL) and erythroid leukemias are DR-, in contrast to most (72% leukaemias of myeloid prec...

journal_title：Clinical and experimental immunology

authors： Newman RA,Greaves MF

更新日期：1982-10-01 00:00:00