After chemotherapy, functional humoral response capacity is restored before complete restoration of lymphoid compartments.

Abstract:

:Chemotherapy has, besides the beneficial effects, several adverse effects. Suppression of the immune system is one of the most important problems. Infections caused by encapsulated bacteria like Streptococcus pneumoniae are responsible for a major part of infectious problems during and after treatment. The splenic marginal zone is essential in the initiation of an immune response to encapsulated bacteria. In this study, we analysed the effects of three different cytostatic agents on humoral immune responses. We found a reduced, but detectable immune response capacity at two days after treatment although the marginal zone B cell population is severely reduced at this time point. Twenty-four days after cessation of treatment, the immune response capacity was largely restored although lymphoid compartments were still not completely restored at that time point. Apparently, the presence of only few marginal zone B cells is sufficient to evoke a rise in antibody titres and although antibody titre increases are low, even small rises are most likely clinically relevant.

journal_name

Clin Exp Immunol

authors

Zandvoort A,Lodewijk ME,Klok PA,Breukels MA,Rijkers GT,Timens W

doi

10.1046/j.1365-2249.2003.02044.x

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

8-16

issue

1

eissn

0009-9104

issn

1365-2249

pii

2044

journal_volume

131

pub_type

杂志文章
  • Analysis of CD4-positive T cell subpopulation in sarcoidosis.

    abstract::Double-labelling immunofluorescence analysis within the CD4+ cell subset was carried out in 27 bronchoalveolar lavage fluids and 11 peripheral blood samples of sarcoidosis patients with anti-TQ1, anti-2H4 and anti-4B4 monoclonal antibodies. Helper/inducer CD4+TQ1-/4B4+ cells were strongly increased in the lung and sli...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Gerli R,Darwish S,Broccucci L,Minotti V,Spinozzi F,Cernetti C,Bertotto A,Rambotti P

    更新日期:1988-08-01 00:00:00

  • Protein biochip array technology to monitor rituximab in rheumatoid arthritis.

    abstract::In rheumatoid arthritis (RA) there are currently no good indicators to predict a clinical response to rituximab. The purpose of this study was to monitor and determine the role of peripheral blood cytokine profiling in differentiating between a good versus poor response to rituximab in RA. Blood samples were collected...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2008.03804.x

    authors: Fabre S,Guisset C,Tatem L,Dossat N,Dupuy AM,Cohen JD,Cristol JP,Daures JP,Jorgensen C

    更新日期:2009-03-01 00:00:00

  • Anti-atherogenic peptide Ep1.B derived from apolipoprotein E induces tolerogenic plasmacytoid dendritic cells.

    abstract::Tolerogenic dendritic cells (DCs) play a critical role in the induction of regulatory T cells (Tregs ), which in turn suppress effector T cell responses. We have previously shown the induction of DCs from human and mouse monocytic cell lines, mouse splenocytes and human peripheral blood monocytes by a novel apolipopro...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12370

    authors: Bellemore SM,Nikoopour E,Au BC,Krougly O,Lee-Chan E,Haeryfar SM,Singh B

    更新日期:2014-09-01 00:00:00

  • Metabolic and cytoskeletal modulation of transferrin receptor mobility in mitogen-activated human lymphocytes.

    abstract::The transferrin receptors which appear on mitogen-activated human peripheral blood lymphocytes were found by the use of immunofluorescence techniques to display temperature-dependent patching and capping reactions upon binding of transferrin. Lateral mobility of ligand-occupied membrane sites was accompanied by both s...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Galbraith GM,Galbraith RM

    更新日期:1980-11-01 00:00:00

  • Kinetics of interaction of immune complexes with complement receptors on human blood cells: modification of complexes during interaction with red cells.

    abstract::Antigen-antibody complexes, composed of 125I-BSA and guinea-pig or rabbit antibody, were incubated at 37 degrees C with human blood cells suspended in autologous serum and kinetics of binding analysed. When purified polymorphonuclear (PMN) or mononuclear cells (MNC) were studied, maximum binding was observed within 8 ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Medof ME,Prince GM,Oger JJ

    更新日期:1982-06-01 00:00:00

  • A combination of a transforming growth factor-beta antagonist and an inhibitor of cyclooxygenase is an effective treatment for murine pulmonary tuberculosis.

    abstract::Transforming growth factor-beta (TGF-beta) and prostaglandins (PG) regulate the cell-mediated immune response, so it has been proposed that they affect the progression of pulmonary tuberculosis. Here we report that the administration of soluble betaglycan, a potent TGF-beta antagonist, and niflumic acid, a PG synthesi...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2006.03049.x

    authors: Hernández-Pando R,Orozco-Esteves H,Maldonado HA,Aguilar-León D,Vilchis-Landeros MM,Mata-Espinosa DA,Mendoza V,López-Casillas F

    更新日期:2006-05-01 00:00:00

  • Specificities of antibody to acetylcholine receptor in rabbits with experimental myasthenia gravis.

    abstract::The injection of acetylcholine receptor (AChR) purified from Narke electroplax japonica induced 'experimental autoimmune myasthenia gravis' (EAMG) in rabbits. Serial measurements of anti-AChR antibody titre using Narke AChR and rabbit AChR as antigen revealed that the intensity of myasthenia had a rather closer correl...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Ueno S,Kang J,Takeuchi H,Takahashi M,Tarui S

    更新日期:1980-07-01 00:00:00

  • CARD11 blockade suppresses murine collagen-induced arthritis via inhibiting CARD11/Bcl10 assembly and T helper type 17 response.

    abstract::The scaffold protein caspase recruitment domain-containing protein 11 (CARD11) is implicated in the regulation of inflammation and autoimmunity. The present study aimed to explore the role of CARD11 in the pathogenesis of rheumatoid arthritis (RA). Mice with collagen-induced arthritis (CIA) were treated with either CA...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12275

    authors: Wang H,Zhao J,Zhang H,Huang Y,Wang S,Tu Q,Yang N

    更新日期:2014-05-01 00:00:00

  • Augmented production of chemokines (monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1alpha (MIP-1alpha) and MIP-1beta) in patients with systemic sclerosis: MCP-1 and MIP-1alpha may be involved in the development of pulmonary fibros

    abstract::To determine the role of chemokines in the pathogenesis of systemic sclerosis (SSc), we examined serum levels, spontaneous production by peripheral blood mononuclear cells (PBMC), and histological distribution in the affected skin, of MCP-1, MIP-1alpha and MIP-1beta in SSc patients. Serum levels of these chemokines we...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1999.00929.x

    authors: Hasegawa M,Sato S,Takehara K

    更新日期:1999-07-01 00:00:00

  • Antibody-dependent cellular cytotoxicity in recurrent aphthous ulceration.

    abstract::Antibody-dependent cellular cytotoxicity (ADCC) was investigated as s possible mechanism of pathogenesis in recurrent aphthous ulceration (RAU). ADCC induced by mononuclear cells from patients at various stages of RAU was compared with ADCC induced by mononuclear cells from paired controls. Chicken red blood cells (Ch...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Greenspan JS,Gadol N,Olson JA,Talal N

    更新日期:1981-06-01 00:00:00

  • Human bronchoalveolar macrophage heterogeneity demonstrated by histochemistry, surface markers and phagocytosis.

    abstract::Human alveolar macrophages (AM) were obtained by bronchoalveolar lavage from 18 patients with a variety of conditions. For each patient the percentages of AM showing the following properties were determined: (1) staining for the enzymes non-specific esterase (NSE) and acid phosphatase (ACP); (2) in vitro phagocytosis ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Gant VA,Hamblin AS

    更新日期:1985-06-01 00:00:00

  • Defective yeast opsonization and C2 deficiency in atopic patients.

    abstract::Twenty-seven per cent of atopic patients initially presenting with infantile eczema or hay fever were defective for yeast opsonization and 18% had low levels of C2; these deficiencies were mutually exclusive, suggesting that they are primary. Both defects were associated with each of four different atopic syndromes, s...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Turner MW,Mowbray JF,Harvey BA,Brostoff J,Wells RS,Soothill JF

    更新日期:1978-11-01 00:00:00

  • Study on the nature of the Goodpasture antigen using a basement membrane-producing mouse tumour.

    abstract::Autoantibodies in the sera of patients with Goodpasture's syndrome showed a strong reaction in indirect immunofluorescence tests on unfixed, frozen sections of a mouse tumour (EHS sarcoma), previously shown to produce extracellular basement membrane. Anti-basement membrane antibodies from patients with bullous pemphig...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Wick G,Timpl R

    更新日期:1980-03-01 00:00:00

  • Depletion of CD4+ CD25+ regulatory T cells inhibits local tumour growth in a mouse model of B cell lymphoma.

    abstract::Regulatory T cells (T(regs)) may inhibit immunity against cancer. Induction and expansion of T(regs) in the immunosuppressive microenvironment created by a growing tumour appear to be one of the mechanisms by which it can evade host defence. We studied the impact of CD25+ T(regs) in a B cell lymphoma model in which Ra...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2008.03642.x

    authors: Heier I,Hofgaard PO,Brandtzaeg P,Jahnsen FL,Karlsson M

    更新日期:2008-05-01 00:00:00

  • Activation of liver macrophages in murine malaria is enhanced by vaccination.

    abstract::During blood-stage infection of mice with a lethal variant of Plasmodium yoelii, cells in both spleen and liver became activated to reach a peak at day 5. In mice protected by vaccination, activation was accelerated after infection. The most striking difference observed was in the 10-fold greater yield of infiltrating...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Taverne J,Rahman D,Dockrell HM,Alavi A,Leveton C,Playfair JH

    更新日期:1987-12-01 00:00:00

  • Neutrophil phagocytosis and killing in insulin-dependent diabetes.

    abstract::Neutrophil phagocytosis and killing of Candida albicans were examined using a radiometric assay in 25 patients with insulin-dependent diabetes and 17 controls under various in vitro metabolic conditions. Glucose was present at 5, 10 and 50 mM, beta-hydroxybutyrate at 1, 5 and 20 mM and glucose with beta-hydroxybutyrat...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Wilson RM,Reeves WG

    更新日期:1986-02-01 00:00:00

  • Decrease of peripheral large granular lymphocytes in Graves' disease.

    abstract::Peripheral large granular lymphocytes (LGL) were enumerated in normal subjects and patients with autoimmune thyroid diseases. In normal subjects, the percentage of LGL was significantly lower in women (mean +/- s.d., 17.0 +/- 3.6%; n = 35; P less than 0.05) than in men (19.5 +/- 5.3%; n = 20). In untreated patients wi...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Iwatani Y,Amino N,Kabutomori O,Mori H,Tamaki H,Motoi S,Izumiguchi Y,Miyai K

    更新日期:1984-01-01 00:00:00

  • Thymoma and hypogammaglobulinaemia with and without T suppressor cells.

    abstract::Patients with acquired hypogammaglobulinaemia usually have near normal numbers of B cells and normal T cell function. When hypogammaglobulinaemia occurs in association with thymoma, then B cell numbers have been reported as low, and distinctive T cells are present which inhibit immunoglobulin production by normal cell...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Brenner MK,Reittie JG,Chadda HR,Pollock A,Asherson GL

    更新日期:1984-12-01 00:00:00

  • IL-2 production by intestinal lamina propria cells in normal inflamed and cancer-bearing colons.

    abstract::Biologically significant levels of IL-2 activity were produced by isolated lamina propria mononuclear cells (LPMC) from normal intestine (n = 12), cancer-bearing colons (n = 35) and inflammatory bowel disease (IBD) affected tissue (n = 12). The levels of IL-2 produced were similar for all three sources of LPMC (normal...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1992.tb03052.x

    authors: Pullman WE,Doe WF

    更新日期:1992-04-01 00:00:00

  • Immune responses to fractionated cytomegalovirus (CMV) antigens after HIV infection. Loss of cellular and humoral reactivity to antigens recognized by HIV-, CMV+ individuals.

    abstract::In order to delineate the molecular pathogenesis of the increased susceptibility to CMV disease in HIV infection, the patterns of antigen responsiveness in HIV-infected and non-infected individuals were investigated. CMV was fractionated by SDS-PAGE and electroblotted onto nitrocellulose. Lymphoproliferative responses...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1990.tb05490.x

    authors: Converse PJ,Fehniger TE,Ehrnst A,Strannegård O,Britton S

    更新日期:1990-12-01 00:00:00

  • Monocytes show immunoregulatory capacity on CD4+ T cells in a human in-vitro model of extracorporeal photopheresis.

    abstract::Extracorporeal photopheresis (ECP) is a widely used immunomodulatory therapy for the treatment of various T cell-mediated disorders such as cutaneous T cell lymphoma (CTCL), graft-versus-host disease (GvHD) or systemic sclerosis. Although clinical benefits of ECP are already well described, the underlying mechanism of...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.13232

    authors: Wiese F,Reinhardt-Heller K,Volz M,Gille C,Köstlin N,Billing H,Handgretinger R,Holzer U

    更新日期:2019-03-01 00:00:00

  • Macrophage migration inhibitory factor contributes to the development of acute dextran sulphate sodium-induced colitis in Toll-like receptor 4 knockout mice.

    abstract::Toll-like receptor 4 (TLR4), which recognizes lipopolysaccharides, plays an important role in the innate immune response. In this study, we investigated the role of TLR4 in the development of experimental colitis with regard to the biological actions of macrophage migration inhibitory factor (MIF) using TLR4 null ((-/...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2005.02877.x

    authors: Ohkawara T,Takeda H,Nishihira J,Miyashita K,Nihiwaki M,Ishiguro Y,Takeda K,Akira S,Iwanaga T,Sugiyama T,Asaka M

    更新日期:2005-09-01 00:00:00

  • Abundance of intraepithelial gamma delta T cells in hypertrophic obstructive but not in chronically infected adenoids.

    abstract::Using quantitative morphometric analysis of immunohistochemically stained tissue sections we compared hypertrophic obstructive adenoids (HOA, n = 10) from children without middle ear disease with chronically infected adenoids (CIA, n = 10) from children with middle ear disease. gamma delta T cell receptor (TCR)+ cells...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1996.d01-825.x

    authors: Olofsson K,Hellström S,Hammarström ML

    更新日期:1996-11-01 00:00:00

  • Renal-infiltrating CD11c+ cells are pathogenic in murine lupus nephritis through promoting CD4+ T cell responses.

    abstract::Lupus nephritis (LN) is a major manifestation of systemic lupus erythematosus (SLE), causing morbidity and mortality in 40-60% of SLE patients. The pathogenic mechanisms of LN are not completely understood. Recent studies have demonstrated the presence of various immune cell populations in lupus nephritic kidneys of b...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.13017

    authors: Liao X,Ren J,Reihl A,Pirapakaran T,Sreekumar B,Cecere TE,Reilly CM,Luo XM

    更新日期:2017-11-01 00:00:00

  • Increased peripheral blood Ia positive T cells and their effect on autologous mixed lymphocyte reaction in chronic active liver disease.

    abstract::We measured Ia antigen bearing peripheral blood T cells, as an index of immunological stimulation, of patients with chronic active liver diseases (CALD) by the rosette assay method. We also examined the role of Ia antigen which represents the products of the genes of the major histocompatibility complex on the autolog...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Fukui K,Kakumu S,Murakami H,Kuriki J,Yoshioka K,Sakamoto N

    更新日期:1984-10-01 00:00:00

  • Detection of immune complexes by a new assay, the polyethylene glycol precipitation-complement consumption test (PEG-CC).

    abstract::A new assay for the detection of circulating immune complexes, the polyethylene glycol precipitation-complement consumption assay (PEG-CC), is described. The test is both simple and sensitive, and exhibits a high degree of specificity. Immune complexes are first isolated from serum by precipitation in 2.5% polyethylen...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Harkiss GD,Brown DL

    更新日期:1979-04-01 00:00:00

  • Accessory cell function of a human colonic epithelial cell line HT-29 for bacterial superantigens.

    abstract::The expression and up-regulation of cell adhesion molecules on a human colonic epithelial cell line HT-29, and the peripheral blood T lymphocyte proliferation responses to bacterial superantigens presented by this cell line were investigated, compared with peripheral blood monocytes. In HT-29 cells, there was constitu...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1997.3961293.x

    authors: Liu ZX,Sugawara S,Hiwatashi N,Noguchi M,Rikiishi H,Kumagai K,Toyota T

    更新日期:1997-06-01 00:00:00

  • Cytotoxic T lymphocyte and natural killer cell responses to non-typeable Haemophilus influenzae.

    abstract::Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells have a key role in host defence against infectious pathogens, but their response to bacteria is not well characterized. Non-typeable Haemophilus influenzae is a major cause of respiratory tract infection including otitis media, sinusitis, tonsillitis and chro...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2008.03667.x

    authors: King PT,Ngui J,Farmer MW,Hutchinson P,Holmes PW,Holdsworth SR

    更新日期:2008-06-01 00:00:00

  • Characterization of immunological depression in mice exposed to normobaric oxygen.

    abstract::Immunological cell functions were evaluated during 24, 48 and 96 h O2 exposure in C57Bl/6 mice. A normobaric O2 exposure resulted in depression of delayed type hypersensitivity (DTH) to oxazolone and Staphylococcus aureus antigens. This effect was proportional to the duration of O2 exposure. The antibody response of s...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Levacher-Place M,Gougerot-Pocidalo MA,Rouveix B,Kraus L,Pocidalo JJ

    更新日期:1983-11-01 00:00:00

  • Activation of the lectin pathway of complement by cardiopulmonary bypass contributes to the development of systemic inflammatory response syndrome after paediatric cardiac surgery.

    abstract::The systemic inflammatory response is a challenge in the management of paediatric patients undergoing cardiac surgery. Although multi-factorial, a contribution by the lectin pathway of complement activation has been postulated. We therefore investigated the changes in serum levels of mannose binding lectin (MBL) and a...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12763

    authors: Pągowska-Klimek I,Świerzko AS,Michalski M,Głowacka E,Szala-Poździej A,Sokołowska A,Moll M,Krajewski WR,Romak J,Cedzyński M

    更新日期:2016-05-01 00:00:00