Abstract:
:Chemotherapy has, besides the beneficial effects, several adverse effects. Suppression of the immune system is one of the most important problems. Infections caused by encapsulated bacteria like Streptococcus pneumoniae are responsible for a major part of infectious problems during and after treatment. The splenic marginal zone is essential in the initiation of an immune response to encapsulated bacteria. In this study, we analysed the effects of three different cytostatic agents on humoral immune responses. We found a reduced, but detectable immune response capacity at two days after treatment although the marginal zone B cell population is severely reduced at this time point. Twenty-four days after cessation of treatment, the immune response capacity was largely restored although lymphoid compartments were still not completely restored at that time point. Apparently, the presence of only few marginal zone B cells is sufficient to evoke a rise in antibody titres and although antibody titre increases are low, even small rises are most likely clinically relevant.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Zandvoort A,Lodewijk ME,Klok PA,Breukels MA,Rijkers GT,Timens Wdoi
10.1046/j.1365-2249.2003.02044.xsubject
Has Abstractpub_date
2003-01-01 00:00:00pages
8-16issue
1eissn
0009-9104issn
1365-2249pii
2044journal_volume
131pub_type
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