Experimental autoimmune uveoretinitis (EAU) versus experimental allergic encephalomyelitis (EAE): a comparison of T cell-mediated mechanisms.

abstract：:Previous findings have indicated that the major surface molecule of Leishmania, lipophosphoglycan (LPG), could abrogate HIV-1-induced syncytium formation and virus replication. In the present work, we were interested in characterizing this inhibitory process. Data from a new luciferase-based semiquantitative assay for...

journal_title：Clinical and experimental immunology

authors： Genois N,Barbeau B,Olivier M,Tremblay MJ

更新日期：2001-04-01 00:00:00

abstract：:A comparative and quantitative study of the tissue distribution of brain-thymus shared antigens was carried out using rabbit antisera to rat, dog and human brain homogenates, assayed on rat, dog and human thymus cells, respectively. Quantitative absorption analyses with eleven different tissues showed that the tissue ...

journal_title：Clinical and experimental immunology

authors： Dalchau R,Fabre JW

更新日期：1979-03-01 00:00:00

abstract：:We have studied both the humoral and cell mediated immune systems of 23 children with beta-thalassaemia major. In children who had not been splenectomized, a 3-fold expansion in the number of circulating B cells and a modest polyclonal gammopathy was present. Of these patients 70% had decreased numbers of circulating ...

journal_title：Clinical and experimental immunology

authors： Dwyer J,Wood C,McNamara J,Williams A,Andiman W,Rink L,O'Connor T,Pearson H

更新日期：1987-06-01 00:00:00

abstract：:To investigate the binding properties of dendritic cells (DC) to vascular endothelium, a comparative analysis was undertaken of DC, monocytes and lymphocytes isolated from the blood of 25 healthy subjects using monolayers of human umbilical vein endothelial cells as the adherence substrate. More blood DC (mean 24% adh...

journal_title：Clinical and experimental immunology

authors： Brown KA,Bedford P,Macey M,McCarthy DA,Leroy F,Vora AJ,Stagg AJ,Dumonde DC,Knight SC

更新日期：1997-03-01 00:00:00

abstract：:We have isolated tumour-infiltrating lymphocytes (TIL) clones from a patient with renal cell cancer. The cloning frequency and the effector function were measured. No difference in cloning frequency (r2 = 0.97, frequency = 1:13) was observed between TIL expanded with allogeneic versus autologous feeder cells. Sixty-fo...

journal_title：Clinical and experimental immunology

authors： Gorter A,Krüse KM,Schrier PI,Fleuren GJ,van de Griend RJ

更新日期：1992-01-01 00:00:00

abstract：:New antibodies against a U3 snRNP, which were named anti-Myo 22/25 antibodies, were detected in four (8%) of 53 serum samples from patients with polymyositis/dermatomyositis (PM/DM) by RNA immunoprecipitation. In the protein immunoprecipitation analysis, all four serum samples precipitated 22 kDa and 25 kDa proteins, ...

journal_title：Clinical and experimental immunology

authors： Kubo M,Ihn H,Kuwana M,Yamane K,Yazawa N,Tamaki K

更新日期：2001-11-01 00:00:00

abstract：:Antibodies recognizing infliximab (IFX) may develop in a proportion of treated patients, leading to loss of response or hypersensitivity reactions (HRs). T cell response to IFX has been poorly investigated. This paper was addressed to detect IFX-specific T cells in treated patients with inflammatory diseases developin...

journal_title：Clinical and experimental immunology

authors： Vultaggio A,Petroni G,Pratesi S,Nencini F,Cammelli D,Milla M,Prignano F,Annese V,Romagnani S,Maggi E,Matucci A,ABIRISK Consortium.

更新日期：2016-12-01 00:00:00

abstract：:Peripheral leucocytes and platelets from twenty healthy volunteers were incubated in vitro with radiographic contrast media (diatrizoate-Hypaque, iothalamate-Conray and iodipamide-Cholografin) under varying conditions. All radiographic contrast media (RCM) were able to induce histamine release from peripheral leucocyt...

journal_title：Clinical and experimental immunology

authors： Ring J,Arroyave CM,Frizler MJ,Tan EM

更新日期：1978-04-01 00:00:00

abstract：:Current therapies for inflammatory bowel diseases (IBD) are aimed at controlling the exacerbated response in the gut, but no treatment is fully effective for many refractory patients. Mesenchymal stromal cells (MSC) are multi-potent cells with regulatory immunosuppressive activity that may control inflammatory disease...

journal_title：Clinical and experimental immunology

authors： Alves VBF,de Sousa BC,Fonseca MTC,Ogata H,Caliári-Oliveira C,Yaochite JNU,Rodrigues Júnior V,Chica JEL,da Silva JS,Malmegrim KCR,Pernomian L,Cardoso CR

更新日期：2019-05-01 00:00:00

abstract：:Enterotoxin produced by enterotoxigenic Bacteroides fragilis (BFT) has been associated with mucosal inflammation and diarrhoeal diseases. In this study, the anti-inflammatory molecular mechanism of 5,7-dihydroxy-3,4,6-trimethoxyflavone (eupatilin) was characterized in an HT-29 intestinal epithelial cell line stimulate...

journal_title：Clinical and experimental immunology

authors： Kim JM,Lee DH,Kim JS,Lee JY,Park HG,Kim YJ,Oh YK,Jung HC,Kim SI

更新日期：2009-03-01 00:00:00

abstract：:We set out to examine the effect of gold treatment on the Th2-dependent antibodies IgG4 and IgE in relation to other IgG subclasses in patients with rheumatoid arthritis (RA). Eighty-five gold-treated RA patients and 82 RA controls were studied. Serum IgG subclass concentrations were measured by ELISA, IgE was measure...

journal_title：Clinical and experimental immunology

authors： Kiely PD,Helbert MR,Miles J,Oliveira DB

更新日期：2000-05-01 00:00:00

abstract：:The present study demonstrates that tumour necrosis factor (TNF) and FMLP, but not IL-1 or IL-8, enhanced the adherence of polymorphonuclear neutrophil (PMN) to fibronectin, an extracellular matrix protein. The adherence induced by FMLP was very rapid, within 5 min while the induction of adherence by TNF was much slow...

journal_title：Clinical and experimental immunology

authors： Thompson HL,Matsushima K

更新日期：1992-11-01 00:00:00

abstract：:CD3- CD56(+dim) natural killer (NK) cells, which are cytotoxic against virally infected cells, may be important in hepatitis C virus (HCV)-infected patients who are successfully treated with pegylated interferon (PEG-IFN)-alpha. We used flow cytometry to enumerate activated (CD69+) and apoptotic (annexin-V+) dim (CD3-...

journal_title：Clinical and experimental immunology

authors： Lin AW,Gonzalez SA,Cunningham-Rundles S,Dorante G,Marshall S,Tignor A,Ha C,Jacobson IM,Talal AH

更新日期：2004-08-01 00:00:00

abstract：:In fifty-seven healthy individuals a significant correlation ( r = 0.3, P < 0.05) has been found between responses of their lymphocytes to stimulation by PHA and by pooled lymphocytes in MLC. It is suggested that these tests quantitate the general status of T cell reactivity of individuals, and may be used in conjunct...

journal_title：Clinical and experimental immunology

authors： Nanra SK,Boettcher B

更新日期：1980-07-01 00:00:00

abstract：:We examined the effect of IL-6 on the development of autoimmune diseases (primary biliary cirrhosis, Sjögren's syndrome) employing murine graft-versus-host reaction (GVHR) model with MHC class II disparity. For this purpose, we used IL-6 transgenic (B6.6) mice in which a high level of IL-6 was detected. C57Bl/6 (B6) s...

journal_title：Clinical and experimental immunology

authors： Kimura T,Suzuki K,Inada S,Hayashi A,Saito H,Miyai T,Ohsugi Y,Matsuzaki Y,Tanaka N,Osuga T

更新日期：1994-03-01 00:00:00

abstract：:The induction of immunoregulatory cytokines IL-1 beta, IL-6, IL-12, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) was studied with neonatal (cord blood) monocyte-derived macrophages (MDM) after in vitro infection with respiratory syncytial virus (RSV). The expression of mRNAs for these cyto...

journal_title：Clinical and experimental immunology

authors： Tsutsumi H,Matsuda K,Sone S,Takeuchi R,Chiba S

更新日期：1996-12-01 00:00:00

abstract：:Here we describe the presence of IgG antibodies, in the sera of patients presenting with insulin-dependent diabetes mellitus (IDDM), that react in Western blots with a 60-kD protein (Mr 60K) from rat hepatic microsomal extracts. Sera from 60 IDDM patients were screened and 31.6% were positive for the Mr 60K band. This...

journal_title：Clinical and experimental immunology

authors： Pehuet-Figoni M,Alvarez F,Bach JF,Chatenoud L

更新日期：2000-11-01 00:00:00

abstract：:The tryptic FAD-peptide carrying the flavin in 8alpha-(N3)histidyl linkage as natural hapten was isolated by HPLC from the bacterial enzyme 6-hydroxy-d-nicotine oxidase. The same flavin protein linkage is found in the mitochondrial succinate dehydrogenase flavoprotein subunit, the predominant flavoprotein with covalen...

journal_title：Clinical and experimental immunology

authors： Cicek G,Schiltz E,Staiger J,Neumann FJ,Melchers I,Brandsch R

更新日期：2003-05-01 00:00:00

abstract：:The levels of soluble IL-2Ralpha (sIL-2Ralpha) in serum were measured in HTLV-1 carriers and ATL patients in order to evaluate their possible correlation with clinical status. Mean sIL-2R levels in ATL patients were found to be 9704 U/ml for the acute/lymphoma type, 1961 U/ml for the chronic type and 788 U/ml for the ...

journal_title：Clinical and experimental immunology

authors： Araki K,Harada K,Nakamoto K,Shiroma M,Miyakuni T

更新日期：2000-02-01 00:00:00

abstract：:Pneumocystis carinii is a major opportunistic pathogen and leading cause of morbidity in patients with AIDS. The major surface glycoprotein (MSG) of P. carinii, represented by a family of related proteins encoded by unique genes, is highly immunogenic and contains T cell-protective epitopes. We undertook the present s...

journal_title：Clinical and experimental immunology

authors： Theus SA,Smulian AG,Sullivan DW,Walzer PD

更新日期：1997-08-01 00:00:00

abstract：:In essential mixed, type II, cryoglobulinaemia (EMC) monoclonal autoantibodies with rheumatoid factor activity are synthesized at an accelerated rate by non-malignant B lymphocytes. In order to determine if the high cryoglobulin production rate is related to a clonal B cell expansion, cell surface markers of periphera...

journal_title：Clinical and experimental immunology

authors： Perl A,Gorevic PD,Ryan DH,Condemi JJ,Ruszkowski RJ,Abraham GN

更新日期：1989-04-01 00:00:00

abstract：:By using a flow cytometric technique which allows direct identification of proliferating cells within mixed cell populations, we have previously described that soluble extracts obtained from Mycobacterium tuberculosis or M. avium represent strong stimuli for human gammadelta+ T cells. In the present study, we demonstr...

journal_title：Clinical and experimental immunology

authors： Batoni G,Esin S,Harris RA,Källenius G,Svenson SB,Andersson R,Campa M,Wigzell H

更新日期：1998-04-01 00:00:00

abstract：:B-lymphocytes from healthy children and young adults who were seronegative for autoantibodies and B lymphocytes from umbilical cord blood of newborns were induced to secrete a variety of autoantibodies upon infection with Epstein-Barr virus. Such autoantibody-secreting clones were obtained from different lymphoid tiss...

journal_title：Clinical and experimental immunology

authors： Uhlig H,Rutter G,Dernick R

更新日期：1985-10-01 00:00:00

abstract：:Leucocyte adhesion deficiency type 1 (LAD-1) is characterized by the incapacity of leucocytes to carry out their adhesion functions via their CD11/CD18 antigens, which are also referred to as the leucocyte integrins. The patients generally suffer from poor wound healing and recurrent bacterial and fungal infections. I...

journal_title：Clinical and experimental immunology

authors： Mathew EC,Shaw JM,Bonilla FA,Law SK,Wright DA

更新日期：2000-07-01 00:00:00

abstract：:Antibody reactivity against the 'mitochondrial M2 antigen' was determined in sera from 10 patients with primary biliary cirrhosis (PBC), using Western blotting after SDS-PAGE separation of rat liver mitochondria (RLM) and plasma membrane proteins. The molecular weights of the major M2 antigens in rat liver mitochondri...

journal_title：Clinical and experimental immunology

authors： Sundin U,Sundqvist KG

更新日期：1991-03-01 00:00:00

abstract：:The presence of antibodies reactive to a recently cloned host-derived antigen GOR is highly correlated with the presence of antibodies to the hepatitis C virus (HCV). We explored the molecular basis for this observation, and address the following question: are antibodies reactive with GOR19-27 (QKAKSNPNR) a result of ...

journal_title：Clinical and experimental immunology

authors： Zhang ZX,Chen M,Wallhagen K,Trojnar J,Magnius LO,Wahren B,Sällberg M

更新日期：1994-06-01 00:00:00

abstract：:Kawasaki disease (KD) is an immune-mediated vasculitis with symptoms that mimic febrile illness; the immune origin has been suggested but never proved. First, cell chip technology was used to screen immune targets cells. With the indirect immunofluorescence assay we found that the HeLa cell chip could be recognized by...

journal_title：Clinical and experimental immunology

authors： Cui J,Zhou Y,Hu H,Zhao L,Du Z,Du H

更新日期：2018-12-01 00:00:00

abstract：:Peripheral blood natural killer (NK) activity was analysed from 32 asthma patients and 13 control donors. Male patients and female patients with atopic asthma had significantly stronger NK activity against the leukaemic cell line K-562. Fractionation of patient mononuclear cells by discontinuous density gradient centr...

journal_title：Clinical and experimental immunology

authors： Timonen T,Stenius-Aarniala B

更新日期：1985-01-01 00:00:00

abstract：:A method is described for culturing intact human thyroid follicles, based on the study of 40 thyroidectomy specimens from normal (n = 18) and diseased glands (n = 22). Reversal of the normal polarity of thyrocytes, whereby the microvilli move from the colloid edge to the vascular pole of the cells, occurs gradually wh...

journal_title：Clinical and experimental immunology

authors： Hanafusa T,Pujol-Borrell R,Chiovato L,Doniach D,Bottazzo GF

更新日期：1984-09-01 00:00:00

abstract：:The aetiology of sarcoidosis, an inflammatory granulomatous multi-system disorder, is unclear. It is thought to be the product of an unknown exogenous antigenic stimulus and an endogenous genetic susceptibility. Toll-like receptors (TLR) are signal molecules essential for the cellular response to bacterial cell wall c...

journal_title：Clinical and experimental immunology

authors： Pabst S,Baumgarten G,Stremmel A,Lennarz M,Knüfermann P,Gillissen A,Vetter H,Grohé C

更新日期：2006-03-01 00:00:00