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Expression of killer inhibitory receptors on cytotoxic cells from HIV-1-infected individuals.

Abstract：

:Dysfunction of cytotoxic activity of T and natural killer (NK) lymphocytes is a main immunological feature in patients with AIDS, but its basis are not well understood. It has been recently described that T and NK cell-mediated cytotoxicity can be regulated by HLA killer inhibitory receptors (KIR). In this work, we have determined on cytotoxic T cells and NK cells from HIV-1-infected individuals the expression of the following KIR molecules: p58, p70, and ILT2 (immunoglobulin-like family KIR) as well as CD94 and NKG2A (C-lectin-type family KIR). With some exceptions, no significant changes were found on the expression of immunoglobulin-like KIR in either CD8+ or CD56+ cells. Interestingly, the percentages of CD8+ and CD56+ cells expressing CD94 were significantly increased in these individuals. We also show that, in vitro, IL-10 up-regulates CD94 expression on CD8+ and CD56+ cells obtained from normal individuals, suggesting that the augmented expression observed in HIV-infected individuals could be related to the high levels of IL-10 previously described in HIV-1-infected individuals.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Galiani MD,Aguado E,Tarazona R,Romero P,Molina I,Santamaria M,Solana R,Peña J

doi

10.1046/j.1365-2249.1999.00833.x

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

472-6

issue

3

eissn

0009-9104

issn

1365-2249

journal_volume

115

pub_type

杂志文章

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