Abstract:
:The failure of B cells from CVI patients to secrete normal amounts of antibodies has been attributed either to an intrinsic B cell defect or to a lack of cooperation from T cells. In an attempt to improve the definition of the origin of this defect in one of the main cellular compartments, we studied the ability of helper CD4 cells and their CD4 CD45RO subpopulation from CVI patients to secrete interleukins (IL-2 and IL-4) in response to mitogen stimulation. We found that CD4 and CD4 CD45RO cells from some patients secrete abnormal amounts of interleukins (in general low levels of IL-2 and high levels of IL-4) upon stimulation with pokeweed mitogen (PWM). These irregularities may contribute to the defective differentiation of B cells in these patients.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Ferrer JM,Iglesias J,Hernández M,Matamoros Ndoi
10.1111/j.1365-2249.1995.tb03779.xsubject
Has Abstractpub_date
1995-11-01 00:00:00pages
286-9issue
2eissn
0009-9104issn
1365-2249journal_volume
102pub_type
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