Widespread IgE-mediated hypersensitivity in Northern Sudan to the chironomid Cladotanytarsus lewisi ('green nimitti').

Abstract:

:Hypersensitivity to Chironomidae (non-biting midges) has been a problem in Northern Sudan since about 1927 and is probably due to the working of dams which have produced lake-like conditions on parts of the Blue and main Niles where breeding has evidently increased. Studies were undertaken to determine whether this hypersensitivity is mediated by IgE. Sixteen Sudanese, with bronchial asthma associated with exposure to the chironomid, Cladotanytarsus lewisi ('green nimitti'), were investigated. All patients gave a positive immediate-type skin reaction to an extract of the midge and the majority had markedly elevated concentrations of circulating IgE. Serum from all patients passively sensitized human lung fragments in vitro for the release of histamine and slow-reacting substance of anaphylaxis by the 'nimitti' antigen. This tissue-sensitizing activity could be removed by immunoabsorption with an anti-IgE. These results indicate that this widespread and important hypersensitivity in the Sudan is IgE-mediated and thus may potentially be treated by desensitization.

journal_name

Clin Exp Immunol

authors

Kay AB,Gad El Rab MO,Stewart J,Erwa HH

subject

Has Abstract

pub_date

1978-10-01 00:00:00

pages

106-10

issue

1

eissn

0009-9104

issn

1365-2249

journal_volume

34

pub_type

杂志文章
  • Generation of activated lymphocytes. Analysis of giant SRBC rosettes.

    abstract::Giant SRBC rosette-forming cells were detected in samples of mitogen-stimulated human peripheral blood lymphocytes. When the concentrations of mitogens were varied, the amount of [3H]TdR incorporated by the lymphocytes also varied. In general, the higher the amount of [3H]TdR incorporated, the higher were the percenta...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Yu DT

    更新日期:1976-12-01 00:00:00

  • Increased killer B cells in chronic HCV infection may lead to autoimmunity and increased viral load.

    abstract::Regulatory B (Breg ) cells are characterized by various membrane markers and the secretion of different inhibitory cytokines. A new subset of Breg cells was identified as CD5hi Fas-ligand (FasL)hi . Their main reported role is to suppress anti-viral and anti-tumour immune responses, and, hence they have been dubbed 'k...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.13139

    authors: Eiza N,Zuckerman E,Carlebach M,Rainis T,Goldberg Y,Vadasz Z

    更新日期:2018-08-01 00:00:00

  • Specific activation of resting T cells against tumour cells by bispecific antibodies and CD28-mediated costimulation is accompanied by Th1 differentiation and recruitment of MHC-independent cytotoxicity.

    abstract::Specific activation of resting lymphocytes for tumour targeting can be achieved by bispecific monoclonal antibodies (bi-MoAbs) with specificity for tumour antigens and T cell-activating antigens in combination with a costimulatory anti-CD28 antibody. In this study we focus on the immunomodulatory function of an anti-C...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1997.3481245.x

    authors: Hombach A,Tillmann T,Jensen M,Heuser C,Sircar R,Diehl V,Kruis W,Pohl C

    更新日期:1997-05-01 00:00:00

  • Natural killer (NK) T cells are significantly decreased in the peripheral blood of patients with rheumatoid arthritis (RA).

    abstract::The number of NK T cells was measured in relation to the Th1/Th2 imbalance observed in RA. Peripheral blood samples of patients with RA (n = 60) and healthy controls (n = 36) were stained with anti-NK receptor 1A (anti-NKR-P1A), anti-CD56, and anti-CD3 MoAbs, and examined by three-colour flow cytometry. NK T (NKR-P1A+...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1999.01018.x

    authors: Yanagihara Y,Shiozawa K,Takai M,Kyogoku M,Shiozawa S

    更新日期:1999-10-01 00:00:00

  • Analysis of T cell subsets by monoclonal antibodies in patients with tuberculosis after in vitro stimulation with purified protein derivative of tuberculin.

    abstract::By using OKT monoclonal antibodies; OKT3(pan T), OKT4(inducer/helper), OKT8 (suppressor/cytotoxic) and OKIa1, T lymphocyte subsets were examined in lymphocytes of patients with tuberculosis both before and after in vitro stimulation with purified protein derivative of tuberculin (PPD). In freshly obtained lymphocytes ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Shiratsuchi H,Tsuyuguchi I

    更新日期:1984-08-01 00:00:00

  • Eosinophil involvement in rheumatoid arthritis as reflected by elevated serum levels of eosinophil cationic protein.

    abstract::Circulating levels of eosinophil cationic protein (ECP), an eosinophil specific granule protein, and numbers of peripheral eosinophils were determined in 42 patients with rheumatoid arthritis. At the time of the investigation the patients were without drug treatment. They had normal blood counts of eosinophils but on ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Hällgren R,Feltelius N,Svenson K,Venge P

    更新日期:1985-03-01 00:00:00

  • Prostaglandin E2 down-regulates viable Bacille Calmette-Guérin-induced macrophage cytotoxicity against murine bladder cancer cell MBT-2 in vitro.

    abstract::The regulatory effect of prostaglandin (PG) E2 and a cyclooxygenase (COX) inhibitor on Bacille Calmette-Guérin (BCG)-induced macrophage cytotoxicity in a bladder cancer cell, MBT-2, was studied in vitro. BCG stimulated thioglycollate-elicited murine peritoneal exudate cells (PEC) to induce cytotoxic activity and to pr...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2002.01686.x

    authors: Yamada H,Kuroda E,Matsumoto S,Matsumoto T,Yamada T,Yamashita U

    更新日期:2002-04-01 00:00:00

  • Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy.

    abstract::Antigen- and mitogen-stimulated cytokine production by peripheral blood mononuclear cells (PBMC) of 50 pregnant women and 31 age- and sex-matched non-pregnant controls were analysed to determine whether changes in cytokine production occur during normal and pathologic human gestation. The pregnant women, consecutively...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1996.d01-809.x

    authors: Marzi M,Vigano A,Trabattoni D,Villa ML,Salvaggio A,Clerici E,Clerici M

    更新日期:1996-10-01 00:00:00

  • Soluble complement receptor type 1 (sCR1) in chronic liver diseases: serum levels at different stages of liver diseases.

    abstract::Complement receptor type 1 (CR1) is an integral membrane protein of many haematopoietic cells and plays an important role in the clearance of complement-associated immune complexes, favouring their transport to liver and spleen macrophages. A small amount of soluble CR1 (sCR1) is also found in plasma and might origina...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1998.00707.x

    authors: Di Bona D,Montalto G,Clemenza L,Bascone F,Accardo P,Bellavia D,Craxì A,Brai M

    更新日期:1998-10-01 00:00:00

  • Monoclonal anti-poly(rA) hybridoma antibodies from an autoimmune MRL/MpJ-lpr/lpr mouse.

    abstract::Three B cell hybridomas were produced by the fusion of spleen cells from a 5 month old MRL/Mp-lpr/lpr mouse with the myeloma cell line, NS-1. By competitive inhibition, all three monoclonal antibodies (MoAb) were specific for poly(rA) and were inhibited to a lesser extent by dDNA, nDNA, poly(rI) and poly(rC). Moreover...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Dang H,Fischbach M,Erdos M,Talal N

    更新日期:1985-07-01 00:00:00

  • HIV isolation from pulmonary cells derived from bronchoalveolar lavage.

    abstract::In a study of 75 alveolar cell co-cultures from 55 HIV-seropositive subjects, p24 antigen production was identified by ELISA in 11 out of 26 (42%) of unseparated cell cultures, 15 out of 39 (38%) purified alveolar macrophage cultures and eight out of 10 purified alveolar lymphocyte samples. Positivity in unseparated c...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Jeffrey AA,Israël-Biet D,Andrieu JM,Even P,Venet A

    更新日期:1991-06-01 00:00:00

  • Lupus anticoagulant activities of murine monoclonal antibodies to liposomal phosphatidylinositol phosphate.

    abstract::Four murine monoclonal antibodies having high levels of activity against phosphatidyl-inositol phosphate (PIP) were tested for lupus anticoagulant activity. The antibodies showed different degrees of potency in a modified partial thromboplastin time test (APTT) that used dilutions of either bovine brain extract (Throm...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Alving BM,Banerji B,Fogler WE,Alving CR

    更新日期:1987-08-01 00:00:00

  • Suppression of IL-6 biological activities by activin A and implications for inflammatory arthropathies.

    abstract::Activin A is a cytokine whose multiple functions have yet to be fully determined. In this study, the role of proinflammatory cytokines in regulatory control of activin A production was shown in synoviocytes and chondrocytes. Additional facets of functional inflammation-related activities of activin A were also determi...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1998.00522.x

    authors: Yu EW,Dolter KE,Shao LE,Yu J

    更新日期:1998-04-01 00:00:00

  • Presence of antibodies to replication protein A in some patients with systemic lupus erythematosus (SLE).

    abstract::Presence of antibodies directed against replication protein A (RPA), a DNA binding protein complex composed of three subunits (RPA-70, RPA-32 and RPA-14) was investigated among patients with SLE and other autoimmune diseases using immunoblot analysis to RPA-70 and RPA-32 recombinant proteins. Anti-RPA antibodies were ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1996.00919.x

    authors: Garcia-Lozano R,Wichmann I,Garcia A,Sanchez-Roman J,Gonzalez-Escribano F,Nuñez-Roldan A

    更新日期:1996-01-01 00:00:00

  • Increased secretion of IL-18 in vitro by peripheral blood mononuclear cells of patients with bronchial asthma and atopic dermatitis.

    abstract::This study was performed to determine whether or not IL-18, formerly called IFN-gamma-inducing factor, is involved in the pathogeneses of allergic disorders. Peripheral blood mononuclear cells (PBMC) were obtained from patients with allergic bronchial asthma (BA), patients with atopic dermatitis (AD) and controls who ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2001.01664.x

    authors: El-Mezzein RE,Matsumoto T,Nomiyama H,Miike T

    更新日期:2001-11-01 00:00:00

  • Comparative analysis of mononuclear cells isolated from mucosal lymphoid follicles of the human ileum and colon.

    abstract::Studies of human mucosal lymphoid follicles are rare and have been limited to children's Peyer's patches, which are visible at endoscopy. We investigated lymphoid follicles in ileum biopsies of 87 patients and surgical colon specimens from 66 cancer patients, and examined phenotype and function of isolated follicular ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2009.03883.x

    authors: Junker Y,Bode H,Wahnschaffe U,Kroesen A,Loddenkemper C,Duchmann R,Zeitz M,Ullrich R

    更新日期:2009-05-01 00:00:00

  • Activation of human peripheral blood lymphocytes by a trypanosome-derived mitogen.

    abstract::Activation of human peripheral blood lymphocytes from unsensitized donors by fractions of T.b rhodesiense has been demonstrated in vitro. Both T and B cells were stimulated to differentiate into blast cells. Purified T cells failed to proliferate, but did so when mitomycin C-treated non-T cells were added. Non-T cell ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Selkirk ME,Ogilvie BM,Platts-Mills TA

    更新日期:1981-09-01 00:00:00

  • Immunofluorescence studies for immunoglobulins and complement C3 in synovial joint membranes in psoriatic arthritis.

    abstract::Synovial tissues from fifteen patients with psoriatic arthritis were investigated with direct immunofluorescence staining for immunoglobulins (IgG, IgA, and IgM) and from eigth patients for complement component C3. As control groups, there were synovial tissues from seven patients with seropositive rheumatoid arthriti...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Fyrand O,Mellbye OJ,Natvig JB

    更新日期:1977-09-01 00:00:00

  • Interleukin-2 activated peripheral blood lymphocytes and the correlation of lytic activity and peanut agglutinin receptor expression on malignant cells.

    abstract::The possibility that the peanut agglutinin (PNA) receptor and/or its co-ordinate structures on the surface of leukaemia cells might be recognized by lectin free crude interleukin-2 (IL-2) activated human peripheral blood lymphocytes (LAK) was investigated. Analysis was undertaken of the correlation between the sensiti...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Gotoh YI,Minegishi M,Yamaguchi Y,Konno T,Tada K

    更新日期:1984-09-01 00:00:00

  • Vitamin C and immunity: an assessment of the evidence.

    abstract::The high concentration of ascorbate in leucocytes and its rapid expenditure during infection and phagocytosis suggests a role for the vitamin in the immune process. Evidence published to date shows an involvement in the migration and phagocytosis by macrophages and leucocytes, as well as the induction and expression o...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审

    doi:

    authors: Thomas WR,Holt PG

    更新日期:1978-05-01 00:00:00

  • T cell clones from a Sjögren's syndrome salivary gland biopsy produce high levels of IL-10.

    abstract::Sjögren's syndrome (SS) is characterized by a focal periductal salivary gland infiltrate consisting mainly of T and B lymphocytes. Most of the T cells bear the memory CD4+ Th1-like phenotype and express high levels of class II, though CD8+ cells are also present. We have studied 17 labial salivary gland and 15 periphe...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1996.d01-623.x

    authors: Brookes SM,Cohen SB,Price EJ,Webb LM,Feldmann M,Maini RN,Venables PJ

    更新日期:1996-02-01 00:00:00

  • Isolation and characterization of dendritic cells from adenoids of children with otitis media with effusion.

    abstract::Dendritic cells were enriched from adenoids of children with otitis media with effusion (OME) by density gradient centrifugation and culture techniques. An enrichment of 40-140-fold was obtained for dendritic cells. These cells were identified using morphology, enzyme cytochemistry, immunocytochemistry and functional ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1992.tb03085.x

    authors: van Nieuwkerk EB,van der Baan S,Richters CD,Kamperdijk EW

    更新日期:1992-05-01 00:00:00

  • Inhibition of interferon-gamma-mediated activation in mouse macrophages treated with lipoarabinomannan.

    abstract::Lipoarabinomannan (LAM), purified from the cell walls of Mycobacterium leprae and M. tuberculosis, is a potent inhibitor of interferon-gamma (IFN-gamma) mediated activation of macrophages. The capability of LAM to inhibit IFN-gamma activation of macrophages in vitro was dose dependent and required a 24-h pre-exposure....

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1990.tb06454.x

    authors: Sibley LD,Adams LB,Krahenbuhl JL

    更新日期:1990-04-01 00:00:00

  • Asbestos related changes in pulmonary and systemic immune responses--early enhancement followed by inhibition.

    abstract::We recently developed an animal model in order to study the pulmonary and systemic reactions following exposure to environmental pollutants. In this model, conscious sheep received repeated intratracheal instillations of a suspension of 0 (controls), 2mg (low dose) or 128 mg (high dose) of chrysotile asbestos fibres o...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Rola-Pleszczynski M,Lemaire I,Sirois P,Massé S,Bégin R

    更新日期:1982-08-01 00:00:00

  • Cell-mediated immune response during experimental arthritis induced in rats with streptococcal cell walls.

    abstract::Chronic, remittent, erosive arthritis was produced in rats by a single intraperitoneal injection of an aqueous suspension of cell wall fragments isolated from group A streptococci. Arthritis could be induced in rats which had been immunologically compromised by neonatal thymectomy. Delayed hypersensitivity to cell wal...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Hunter N,Anderle SK,Brown RR,Dalldorf FG,Clark RL,Cromartie WJ,Schwab JH

    更新日期:1980-12-01 00:00:00

  • Low mannose-binding lectin (MBL) levels in neonates with pneumonia and sepsis.

    abstract::We investigated whether deficiency of mannose-binding lectin (MBL), a component of innate immunity, is associated with neonatal pneumonia and sepsis during the first 72 h, i.e. early onset, and during the first month after birth. In 88 neonatal intensive care patients (71 premature), MBL2 genotype and MBL plasma level...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2007.03479.x

    authors: Frakking FN,Brouwer N,van Eijkelenburg NK,Merkus MP,Kuijpers TW,Offringa M,Dolman KM

    更新日期:2007-11-01 00:00:00

  • Distribution of immunoglobulin G subclasses of anti-thyroid peroxidase antibody in sera from patients with Hashimoto's thyroiditis with different thyroid functional status.

    abstract::The mechanism of disease progression in Hashimoto's thyroiditis (HT) is still unclear. Anti-thyroid peroxidase antibody (TPOAb), a diagnostic hallmark of HT, is principally of the immunoglobulin G (IgG) isotype, and it appears to be a response to thyroid injury. The aim of our study was to evaluate the distribution of...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2008.03756.x

    authors: Xie LD,Gao Y,Li MR,Lu GZ,Guo XH

    更新日期:2008-11-01 00:00:00

  • Epigenetic alterations on C1-inhibitor expression may influence hereditary angioedema attack frequency and C4 levels: Comment on: Karagianni P, Goules AV, Tzioufas AG. Epigenetic alterations in Sjogren's syndrome patient saliva.

    abstract::Epigenetic studies reveal how our genes (nature) are influenced by environment (nurture) leading to wide variability in clinical presentations, especially in autoimmune diseases. Patients with C1-inhibitor deficiency, even within the same family, have diverse clinical presentations that may reflect epigenetic control ...

    journal_title:Clinical and experimental immunology

    pub_type: 评论,杂志文章

    doi:10.1111/cei.13516

    authors: Khan S,Longhurst H

    更新日期:2020-11-01 00:00:00

  • Human intestinal epithelial cell-derived interleukin (IL)-18, along with IL-2, IL-7 and IL-15, is a potent synergistic factor for the proliferation of intraepithelial lymphocytes.

    abstract::Intestinal epithelial cell (IEC)-derived cytokines, such as stem cell factor (SCF), interleukin (IL)-7 and IL-15 are known to be required for the development of intestinal intraepithelial lymphocytes (IELs). A newly described cytokine, IL-18, has also been shown to be produced by intestinal epithelial cells. To demons...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2004.02431.x

    authors: Okazawa A,Kanai T,Nakamaru K,Sato T,Inoue N,Ogata H,Iwao Y,Ikeda M,Kawamura T,Makita S,Uraushihara K,Okamoto R,Yamazaki M,Kurimoto M,Ishii H,Watanabe M,Hibi T

    更新日期:2004-05-01 00:00:00

  • Long term spectrotypic and idiotypic stability of thyroglobulin autoantibodies in patients with Hashimoto's thyroiditis.

    abstract::Isoelectric focusing of serial bleeds from patients with Hashimoto's thyroiditis was carried out and thyroglobulin (Tg) autoantibodies visualized using 125I-labelled Tg followed by autoradiography. Although the spectrotype of these antibodies was polyclonal and varied from patient to patient, each individual's spectro...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Delves PJ,Roitt IM

    更新日期:1988-03-01 00:00:00