当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL IMMUNOLOGY期刊下所有文献 > Suppression of autologous peripheral blood mononuclear cell proliferation by alveolar macrophages from young infants.

Suppression of autologous peripheral blood mononuclear cell proliferation by alveolar macrophages from young infants.

Abstract：

:Maintenance of lung homeostasis involves a complex interaction between T lymphocytes and alveolar macrophages (AM), in which AM suppress pulmonary T cell proliferation to antigenic stimuli. To assess whether AM-mediated suppression is attenuated in healthy young infants, AM and peripheral blood mononuclear cells (PBMC) were sampled prior to elective surgery. Children were divided into <4 months of age (Group I) and >4 months (Group II). Autologous PBMC and AM were co-cultured in vitro with phytohaemaglutinin (PHA) at AM : PBMC ratios ranging from 2:1 to 1 : 5. Methyl-tritiated thymidine was added after 48 h and uptake determined at 72 h. Percentage suppression or enhancement of PBMC proliferation by AM was determined relative to proliferation of PBMC with PHA. To determine the role of soluble factors of suppression, cell-free supernatants from paediatric AM and PBMC co-cultures were added to PHA-stimulated adult PBMC. The median age was 3 months for Group I (n = 9) and 7 years 2 months (n = 13) for Group II. Percentage suppression of PBMC proliferation was attenuated in Group I (versus Group II) at AM : PBMC ratios of 2:1 (median 78 versus 92, P< 0 x 05) and 1 : 1 (45 versus 87, P< 0 x 01). Cell-free supernatants from Groups I and II suppressed proliferation of adult PBMC, but there was no difference in suppression between the age groups. We conclude that suppression of autologous PHA-stimulated PBMC proliferation by AM is attenuated in young infants, and this immaturity is not explained by reduced release of soluble factors.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Bunn HJ,Hewitt CR,Grigg J

doi

10.1046/j.1365-2249.2002.01848.x

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

313-7

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

128

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL IMMUNOLOGY文献大全
  • Elevated semaphorin5A in systemic lupus erythematosus is in association with disease activity and lupus nephritis.

    abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by extensive immune response, including over-activation of T and B cell development of pathogenic autoantibodies, organ damage induced by the formation and deposition of immune complex and the abnormal elevation of type I interferon. Semaphorin5...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12924

    authors： Du Y,Wu X,Chen M,Wang W,Xv W,Ye L,Wu D,Xue J,Sun W,Luo J,Wu H

    更新日期：2017-05-01 00:00:00

  • Analysis of the major antigenic determinants of the characteristic phenolic glycolipid from Mycobacterium leprae.

    abstract：:Antibodies to the major phenolic glycolipid purified from Mycobacterium leprae have been demonstrated previously in sera of leprosy but not tuberculosis patients using an ELISA. The major antigenic determinants on this molecule were investigated using antisera raised in rabbits to the purified glycolipid and with a po...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Brett SJ,Payne SN,Draper P,Gigg R

    更新日期：1984-04-01 00:00:00

  • The death-promoting molecule tumour necrosis factor-related apoptosis inducing ligand (TRAIL) is not required for the development of peripheral lymphopenia or granuloma necrosis during infection with virulent Mycobacterium avium.

    abstract：:Disseminated infection with virulent Mycobacterium avium in C57Bl/6 (B6) mice leads to severe lymphocyte depletion in secondary lymphoid organs. In this study, we found an up-regulation of caspase-8 activity in spleen cell extracts from M. avium 25291-infected B6 mice compared to non-infected mice. The activation of t...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2011.04385.x

    authors： Borges M,Rosa GT,Appelberg R

    更新日期：2011-06-01 00:00:00

  • Localization of 20-kD homologous restriction factor (HRF20) in diseased human glomeruli. An immunofluorescence study.

    abstract：:The 20-kD homologous restriction factor (HRF20), which is identical to CD59, is a membrane-associated protein which inhibits the reaction of C9 to form membrane attack complex (MAC) of homologous complements. In various human glomerular diseases deposition of complement components is frequently seen and MAC is reporte...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1991.tb08158.x

    authors： Tamai H,Matsuo S,Fukatsu A,Nishikawa K,Sakamoto N,Yoshioka K,Okada N,Okada H

    更新日期：1991-05-01 00:00:00

  • Immune complexes with antiglobulin activity in sera of Moloney sarcoma-bearing rats.

    abstract：:Immune complexes (IC) were detected and isolated from the serum of Brown Norway (BN), (Lewis x BN)F1, and Lewis rats bearing a Moloney sarcoma (MST). IC were isolated from the serum of individual rats employing a system of G-200 chromatography and passage through a heavy chain specific anti-rat IgG Immunoadsorbent. Ig...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Balint JR

    更新日期：1982-04-01 00:00:00

  • Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H.

    abstract：:Factor H is an abundant plasma glycoprotein that plays a critical role in the regulation of the complement system in plasma and in the protection of host cells and tissues from damage by complement activation. Several recent studies have described the association of genetic variations of the complement factor H gene (...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2249.2007.03552.x

    authors： de Córdoba SR,de Jorge EG

    更新日期：2008-01-01 00:00:00

  • Cytotoxic T lymphocyte and natural killer cell responses to non-typeable Haemophilus influenzae.

    abstract：:Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells have a key role in host defence against infectious pathogens, but their response to bacteria is not well characterized. Non-typeable Haemophilus influenzae is a major cause of respiratory tract infection including otitis media, sinusitis, tonsillitis and chro...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2008.03667.x

    authors： King PT,Ngui J,Farmer MW,Hutchinson P,Holmes PW,Holdsworth SR

    更新日期：2008-06-01 00:00:00

  • Microbial interactions in the atopic march.

    abstract：:The human body is populated by a large number of microorganisms and exist in symbiosis with these immensely diverse communities, which are suggested to influence health and disease. The microbiota plays an essential role in the maturation and function of the immune system. The prevalence of atopic diseases has increas...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：10.1111/cei.13398

    authors： Nibbering B,Ubags NDJ

    更新日期：2020-01-01 00:00:00

  • Wild isolates of Plasmodium falciparum malaria show decreased sensitivity to in vitro inhibition of parasite growth mediated by autologous host antibodies.

    abstract：:Antigenic diversity in field populations of Plasmodium falciparum parasites may delay the acquisition of protective immunity to malaria, the development of which may thus require repeated exposure to infection over a prolonged period of time. In this study we show that P. falciparum parasites may vary in their sensiti...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1997.273-ce1163.x

    authors： Flyg BW,Perlmann H,Perlmann P,Esposito F,Berzins K

    更新日期：1997-02-01 00:00:00

  • Antibody-dependent cellular cytotoxicity in recurrent aphthous ulceration.

    abstract：:Antibody-dependent cellular cytotoxicity (ADCC) was investigated as s possible mechanism of pathogenesis in recurrent aphthous ulceration (RAU). ADCC induced by mononuclear cells from patients at various stages of RAU was compared with ADCC induced by mononuclear cells from paired controls. Chicken red blood cells (Ch...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Greenspan JS,Gadol N,Olson JA,Talal N

    更新日期：1981-06-01 00:00:00

  • Invasive amoebiasis is associated with the development of anti-neutrophil cytoplasmic antibody.

    abstract：:Features of tissue damage in invasive amoebiasis, in particular polymorphonuclear neutrophil (PMN) degranulation and vasculitis, bear resemblance to that seen in Wegener's granulomatosis, the latter being associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA). We therefore tested sera from patie...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1994.tb06578.x

    authors： Pudifin DJ,Duursma J,Gathiram V,Jackson TF

    更新日期：1994-07-01 00:00:00

  • Membrane phenotype and functional behaviour of T lymphocytes in multiple myeloma: correlation with clinical stages of the disease.

    abstract：:The distribution of T lymphocyte subsets was assessed using monoclonal antibodies (MoAbs) in 44 untreated patients with multiple myeloma (MM) subdivided according to the clinical stage of the disease. A significant reduction (P less than 0.001) of T lymphocytes was observed only in stage II and III patients. The propo...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Lauria F,Foa R,Cavo M,Gobbi M,Raspadori D,Giubellino MC,Tazzari PL,Tura S

    更新日期：1984-06-01 00:00:00

  • A serologic study of cultured breast cancer cell lines: lack of antibody response to tumour specific membrane antigens in patients.

    abstract：:Humoral antibodies to tumour associated membrane antigens of cultured human breast cancer cell lines were studied using the immune adherence (IA) test. Sera from 353 post-operative breast cancer patients and from twenty-five patients immunized by allogeneic breast cancer cells were tested against the MDA-MB-436 cell l...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Higuchi M,Robinson DS,Cailleau R,Irie RF,Morton DL

    更新日期：1980-01-01 00:00:00

  • Autoantibodies in sera of Thai patients with Plasmodium falciparum infection.

    abstract：:Serum from 98 Thai adults infected with Plasmodium falciparum were examined for the presence of autoantibodies. Malarial containing antibodies sera were also revealed positive for anti-nuclear antibodies with fluorescence speckled pattern, anti-smooth muscle antibodies, anti-mitochondria antibodies and rheumatoid fact...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Boonpucknavig S,Ekapanyakul G

    更新日期：1984-10-01 00:00:00

  • Complement fixation by Brazilian Pemphigus foliaceus autoantibodies.

    abstract：:This study was undertaken to determine if Brazilian Pemphigus foliaceus (BPF) autoantibodies will fix complement as do P. vulgaris (PV) autoantibodies. When sections of human skin were examined following indirect immunofluorescence (IF) staining, BPF autoantibodies reacted with the upper layers of epidermis, while PV ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Kawana S,Diaz LA,Rivitti EA,Geoghegan WD,Jordon RE

    更新日期：1988-03-01 00:00:00

  • Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models.

    abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting cartilaginous joints but also extra-articular tissues such as the nose and upper respiratory tract. We have investigated extra-articular cartilage involvement in two commonly used animal models for RA, collagen-induced and pristane-induced...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2002.01712.x

    authors： Hansson AS,Lu S,Holmdahl R

    更新日期：2002-01-01 00:00:00

  • Enhanced generation of reactive oxygen species in monocytes from patients with common variable immunodeficiency.

    abstract：:Monocyte and macrophage dysfunction may be important for both immunopathogenesis and clinical manifestations in subgroups of patients with primary hypogammaglobulinaemia. In the present study we examined the ability to generate reactive oxygen species (ROS) in isolated monocytes from these patients by two different me...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1994.tb06073.x

    authors： Aukrust P,Müller F,Frøland SS

    更新日期：1994-08-01 00:00:00

  • IL-2 production by intestinal lamina propria cells in normal inflamed and cancer-bearing colons.

    abstract：:Biologically significant levels of IL-2 activity were produced by isolated lamina propria mononuclear cells (LPMC) from normal intestine (n = 12), cancer-bearing colons (n = 35) and inflammatory bowel disease (IBD) affected tissue (n = 12). The levels of IL-2 produced were similar for all three sources of LPMC (normal...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1992.tb03052.x

    authors： Pullman WE,Doe WF

    更新日期：1992-04-01 00:00:00

  • Over-expression of the decoy receptor 3 (DcR3) gene in peripheral blood mononuclear cells (PBMC) derived from silicosis patients.

    abstract：:Dysregulation of apoptosis, particularly in the Fas/Fas ligand (FasL) pathway, is considered to be involved in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE). Recently, a soluble decoy receptor, termed decoy receptor 3 (DcR3), that binds FasL and inhibits FasL-induced apoptosis, has...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2000.01132.x

    authors： Otsuki T,Tomokuni A,Sakaguchi H,Aikoh T,Matsuki T,Isozaki Y,Hyodoh F,Ueki H,Kusaka M,Kita S,Ueki A

    更新日期：2000-02-01 00:00:00

  • Expression of Fc gamma and complement receptors in monocytes of X-linked agammaglobulinaemia and common variable immunodeficiency patients.

    abstract：:Recently we reported that monocyte phagocytosis and chemotaxis are impaired in X-linked agammaglobulinaemia (XLA) and common variable immunodeficiency (CVI) patients. Few data exist on the in vivo expression of receptors for the constant region of immunoglobulin (IgG) (Fc gammaR) and complement receptors (CR) in these...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2007.03512.x

    authors： Amoras AL,da Silva MT,Zollner RL,Kanegane H,Miyawaki T,Vilela MM

    更新日期：2007-12-01 00:00:00

  • The use of C1q, conglutinin and low affinity rabbit IgM antibody to human Fc in a ligand coctail radioassay for detecting and characterizing immune complexes in pathological sera.

    abstract：:A ligand radioassay for the detection of IC which utilizes C1q, bovine conglutinin and low affinity rabbit IgM anti-human Fc in a reagent coctail, is presented. IC are first isolated from serum by precipitation in polyethylene glycol, then analysed for their ability to react with the ligand coctail. Dual-label studies...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Harkiss GD,Brown DL

    更新日期：1980-03-01 00:00:00

  • Demonstration of increased anti-mycobacterial activity in peripheral blood monocytes after BCG vaccination in British school children.

    abstract：:A blood sample was taken from children aged 13-15 years immediately before BCG vaccination and 8 weeks after. The children were tuberculin skin-test negative to PPD-S before vaccination and positive after. Mononuclear cells were separated from the blood, infected with Mycobacterium microti at a low bacterium/monocyte ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Cheng SH,Walker L,Poole J,Aber VR,Walker KB,Mitchison DA,Lowrie DB

    更新日期：1988-10-01 00:00:00

  • T cells from chronic bone infection show reduced proliferation and a high proportion of CD28⁻ CD4 T cells.

    abstract：:Chronic bone infection is associated with bone resorption. From animal studies, CD3/CD28-activated T cells are known to enhance osteoclastogenesis and bone resorption. Because CD28 is expressed constitutively on T cells and its expression is down-regulated by chronic exposure to the inflammatory environment, we charac...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12245

    authors： Kumar G,Roger PM,Ticchioni M,Trojani C,Bernard de Dompsur R,Bronsard N,Carles M,Bernard E

    更新日期：2014-04-01 00:00:00

  • Glatiramer acetate attenuates the pro-migratory profile of adhesion molecules on various immune cell subsets in multiple sclerosis.

    abstract：:An altered expression pattern of adhesion molecules (AM) on the surface of immune cells is a premise for their extravasation into the central nervous system (CNS) and the formation of acute brain lesions in multiple sclerosis (MS). We evaluated the impact of glatiramer acetate (GA) on cell-bound and soluble AM in the ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12125

    authors： Sellner J,Koczi W,Harrer A,Oppermann K,Obregon-Castrillo E,Pilz G,Wipfler P,Afazel S,Haschke-Becher E,Trinka E,Kraus J

    更新日期：2013-09-01 00:00:00

  • Identification of Goodpasture antigens in human alveolar basement membrane.

    abstract：:Goodpasture (GP) antigens, protein components reactive with human autoantibodies against glomerular basement membrane (GBM), were identified in human alveolar basement membrane (ABM) using an enzyme-linked immunoassay (ELISA), Western blotting and immunoprecipitation. All six anti-GBM antisera studied, three obtained ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Yoshioka K,Iseki T,Okada M,Morimoto Y,Eryu N,Maki S

    更新日期：1988-12-01 00:00:00

  • IgG-mediated anaphylaxis via Fc gamma receptor in CD40-deficient mice.

    abstract：:Anaphylaxis denotes an immediate hypersensitivity reaction to allergen, exclusively mediated by IgE antibodies. However, IgE antibodies do not explain all the syndromes that are encountered. We investigated potent IgG-mediated anaphylaxis in CD40-deficient mice that lack the immunoglobulin class switching for T cell-d...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1998.00717.x

    authors： Wakayama H,Hasegawa Y,Kawabe T,Saito H,Kikutani H,Shimokata K

    更新日期：1998-11-01 00:00:00

  • The fine specificity of human T cell lines towards myelin basic protein peptides in southern Italian multiple sclerosis patients.

    abstract：:We studied the relationship between the HLA specificities associated with multiple sclerosis (MS) susceptibility in southern Italy and the reactivity of the human myelin basic protein (hMBP) immunogenic peptides 84-98 and 143-168, using short-term T-cell lines established from 9 MS patients and from 8 healthy individu...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2001.01457.x

    authors： Montanaro D,Sanna V,Matarese G,Larby BB,Racioppi L,Carrieri PB,Bruno R,Davey NJ,Zappacosta S,Fontana S

    更新日期：2001-02-01 00:00:00

  • Anti-CD2 (OX34) MoAb treatment of adjuvant arthritic rats: attenuation of established arthritis, selective depletion of CD4+ T cells, and CD2 down-modulation.

    abstract：:Anti-CD2 MoAbs have previously been shown to induce tolerance and to block B cell differentiation, T cell and monocyte activation. Since these immune functions are important in joint inflammation, we asked whether administration of the anti-CD2 MoAb OX34 has a beneficial effect on established rat adjuvant arthritis, a...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1997.4881385.x

    authors： Hoffmann JC,Herklotz C,Zeidler H,Bayer B,Westermann J

    更新日期：1997-10-01 00:00:00

  • Depressed natural killer cell function in thermally injured adults: successful in vivo and in vitro immunomodulation and the role of endotoxin.

    abstract：:Natural killer (NK) cells mediate host defense against infections and are regulated by interleukin 2 (IL-2) and other factors. We studied NK cell function in burn patients using a 51Cr release assay with K562 target cells. We found that peripheral blood lymphocytes from burn patients had depressed NK activity (target ...

    journal_title：Clinical and experimental immunology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Bender BS,Winchurch RA,Thupari JN,Proust JJ,Adler WH,Munster AM

    更新日期：1988-01-01 00:00:00

  • Naturally occurring human IgG antibodies to intracellular and cytoskeletal components of human platelets.

    abstract：:Immunoblotting of platelets that have been subjected to SDS-PAGE has revealed that sera from normal individuals contain IgG which binds to many platelet components. This binding was seen with autologous and heterologous platelets using serum of males and of nulliparous females who had not received blood transfusions. ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1990.tb08097.x

    authors： Pfueller SL,Logan D,Tran TT,Bilston RA

    更新日期：1990-03-01 00:00:00