Abstract:
:A blood sample was taken from children aged 13-15 years immediately before BCG vaccination and 8 weeks after. The children were tuberculin skin-test negative to PPD-S before vaccination and positive after. Mononuclear cells were separated from the blood, infected with Mycobacterium microti at a low bacterium/monocyte ratio and allowed to form monolayers in microtitre wells. The infected monolayers were rinsed daily and the change in number of live bacteria in monolayers and supernatants was monitored by colony counts on agar. The cells were bacteriostatic during the first day, thereafter growth accelerated in pre-vaccination monolayers. When monolayers received pulsed exposures to autologous lymphocytes that had been incubated with whole dead tubercle bacilli the growth rates of M. microti were increased. However, growth rates in lymphocyte-pulsed monolayers were significantly lower after vaccination than before. It is proposed that this difference reflects the protective effect of vaccination.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Cheng SH,Walker L,Poole J,Aber VR,Walker KB,Mitchison DA,Lowrie DBsubject
Has Abstractpub_date
1988-10-01 00:00:00pages
20-5issue
1eissn
0009-9104issn
1365-2249journal_volume
74pub_type
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